{"schema_version":"reviewed-study-relationships-v1","catalogue_revision":"bbdd3a53e95441b6c84883be344da259b302a9022044d902a87e43f58090b666","generated_at_utc":"2026-11-12T02:27:49Z","checked_at":"2026-11-03","coverage":"selected reviewed families; not exhaustive","scope":"Selected source-checked study families; incomplete coverage. No automatic title, author or citation-based clustering. A shared study identity does not make every report the same analysis or participant subset.","family_count":3,"indexed_member_count":8,"families":[{"family_id":"jhu-mdd-nct03181529","label":"Johns Hopkins MDD waiting-list trial","nct_id":"NCT03181529","registry_url":"https://clinicaltrials.gov/study/NCT03181529","checked_at":"2026-11-03","note":"The primary report and 12-month follow-up describe the same trial cohort. Follow-up does not provide a new randomized comparison.","members":[{"id":2160,"title":"Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder: A Randomized Clinical Trial.","doi":"10.1001/jamapsychiatry.2020.3285","pubmed_id":"33146667","publication_year":2021,"publication_status":"published","role":"primary_report","record_url":"https://psilocybin-research.com/publication.php?id=2160","evidence":[{"url":"https://clinicaltrials.gov/study/NCT03181529","basis":"Registry references identify PMID 33146667."},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7643046/","basis":"Primary report identifies NCT03181529."}]},{"id":1827,"title":"Efficacy and safety of psilocybin-assisted treatment for major depressive disorder: Prospective 12-month follow-up.","doi":"10.1177/02698811211073759","pubmed_id":"35166158","publication_year":2022,"publication_status":"published","role":"follow_up","record_url":"https://psilocybin-research.com/publication.php?id=1827","evidence":[{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8864328/","basis":"Methods and introduction identify follow-up of the previously reported Davis trial."}]},{"id":3500,"title":"Effects of Psilocybin in Major Depressive Disorder","doi":null,"pubmed_id":null,"publication_year":2021,"publication_status":"clinical trial","role":"registration","record_url":"https://psilocybin-research.com/publication.php?id=3500","evidence":[{"url":"https://clinicaltrials.gov/study/NCT03181529","basis":"Exact registry identity; reports linked by the reviewed evidence above."}]}],"unindexed_reports":[]},{"family_id":"jhu-smoking-pilot-2014","label":"Johns Hopkins smoking cessation pilot cohort","nct_id":null,"registry_url":null,"checked_at":"2026-11-03","note":"The 2017 report follows the original 15-person pilot. Do not combine their sample sizes as independent cohorts. The later randomized smoking trial is separate.","members":[{"id":2555,"title":"Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction.","doi":"10.1177/0269881114548296","pubmed_id":"25213996","publication_year":2014,"publication_status":"published","role":"primary_report","record_url":"https://psilocybin-research.com/publication.php?id=2555","evidence":[{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5641975/","basis":"Introduction identifies the original 2014 pilot report and cohort."}]},{"id":2485,"title":"Long-term follow-up of psilocybin-facilitated smoking cessation.","doi":"10.3109/00952990.2016.1170135","pubmed_id":"27441452","publication_year":2017,"publication_status":"published","role":"follow_up","record_url":"https://psilocybin-research.com/publication.php?id=2485","evidence":[{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5641975/","basis":"Methods explicitly describe longer follow-up of that pilot cohort."}]}],"unindexed_reports":[]},{"family_id":"embrace-nct06072898","label":"EMBRACE depression neuroimaging trial","nct_id":"NCT06072898","registry_url":"https://clinicaltrials.gov/study/NCT06072898","checked_at":"2026-11-03","note":"These are protocol documents, including an earlier preprint. The preprint and published protocol describe different design versions; preserve the version-specific details. Neither is a completed results report.","members":[{"id":3164,"title":"Engaging Mood Brain Circuits with Psilocybin (EMBRACE): a study protocol for a randomized, proof-of-principle, placebo-controlled and crossover, neuroimaging trial in depression","doi":"10.21203/rs.3.rs-3474764/v1","pubmed_id":null,"publication_year":2023,"publication_status":"preprint","role":"protocol_preprint","record_url":"https://psilocybin-research.com/publication.php?id=3164","evidence":[{"url":"https://api.crossref.org/works/10.21203/rs.3.rs-3474764/v1","basis":"Publisher-deposited preprint metadata explicitly identifies NCT06072898."}]},{"id":1080,"title":"Engaging Mood Brain Circuits with Psilocybin (EMBRACE): a study protocol for a randomized, placebo-controlled and delayed-start, neuroimaging trial in depression.","doi":"10.1186/s13063-024-08268-6","pubmed_id":"38956594","publication_year":2024,"publication_status":"published","role":"protocol","record_url":"https://psilocybin-research.com/publication.php?id=1080","evidence":[{"url":"https://link.springer.com/article/10.1186/s13063-024-08268-6","basis":"Trial registration and administrative information identify NCT06072898 and protocol version 5."}]},{"id":3663,"title":"Engaging Mood Brain Circuits With Psilocybin: a Randomized Neuroimaging Trial in Depression","doi":null,"pubmed_id":null,"publication_year":2026,"publication_status":"clinical trial","role":"registration","record_url":"https://psilocybin-research.com/publication.php?id=3663","evidence":[{"url":"https://clinicaltrials.gov/study/NCT06072898","basis":"Exact registry identity; reports linked by the reviewed evidence above."}]}],"unindexed_reports":[]}],"interpretation":"Preserve every record ID. Study-family membership is not a duplicate-record deletion rule, an independent participant count, or proof of efficacy. Missing links are unknown; citation links and similar titles do not establish shared study identity.","record_count":5162}