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Kalin\",\"orcid\":\"https://orcid.org/0000-0003-1184-0868\"}],\"primary_location\":{\"source_id\":\"https://openalex.org/S205482884\",\"source_display_name\":\"Biological Psychiatry\",\"landing_page_url\":\"https://doi.org/10.1016/j.biopsych.2025.02.295\",\"is_oa\":false}}", "topic_tags": "Pharmacology", "study_type": "Other", "hidden": 0, "false_positive": 0, "curation_notes": null, "merged_into_id": null, "curation_locked": 0, "publication_status": "published", "openalex_id": "https://openalex.org/W4409280771" }, { "id": 4397, "title": "166. Dynamic Mediodorsal Thalamus Activity Predicts and Reflects Longitudinal Treatment Outcomes in Psilocybin Therapy for Treatment-Resistant Depression", "normalized_title": "166 dynamic mediodorsal thalamus activity predicts and reflects longitudinal treatment outcomes in psilocybin therapy for treatment resistant depression", "authors": "Xue Zhang, Emily Zhai, Claire Bertrand, Sara Ellis, Isabelle Wydler, Anna J. Donnelly, Trisha Suppes, Leanne M. Williams", "abstract": "", "journal": "Biological Psychiatry", "publication_date": "2025-04-08", "publication_year": 2025, "doi": "10.1016/j.biopsych.2025.02.403", "pubmed_id": null, "source_url": "https://doi.org/10.1016/j.biopsych.2025.02.403", "keywords": "Psilocybin, Depression (economics), Treatment-resistant depression, Psychology, Thalamus, Medicine, Psychotherapist, Hallucinogen, Neuroscience, Psychiatry, Major depressive disorder, Amygdala, Economics, Macroeconomics, Psychedelics and Drug Studies, Digital Mental Health Interventions, Mental Health Research Topics", "substance_tags": "psilocybin", "source_name": "OpenAlex", "date_added": "2026-07-04 06:34:40", "last_checked": "2026-07-04 07:00:33", "raw_json": "{\"openalex_id\":\"https://openalex.org/W4409280673\",\"openalex_url\":\"https://openalex.org/W4409280673\",\"openalex_relevance_score\":6,\"openalex_relevance_reasons\":[\"title:psilocybin\",\"metadata:psilocybin\"],\"openalex_type\":\"article\",\"openalex_work_type\":null,\"cited_by_count\":0,\"referenced_works\":[],\"authorships\":[{\"id\":\"https://openalex.org/A5100445881\",\"display_name\":\"Xue Zhang\",\"orcid\":\"https://orcid.org/0000-0003-4279-899X\"},{\"id\":\"https://openalex.org/A5031042980\",\"display_name\":\"Emily Zhai\",\"orcid\":\"https://orcid.org/0000-0001-5341-1178\"},{\"id\":\"https://openalex.org/A5014918486\",\"display_name\":\"Claire Bertrand\",\"orcid\":\"https://orcid.org/0000-0001-5595-0677\"},{\"id\":\"https://openalex.org/A5108335177\",\"display_name\":\"Sara Ellis\",\"orcid\":null},{\"id\":\"https://openalex.org/A5117083151\",\"display_name\":\"Isabelle Wydler\",\"orcid\":null},{\"id\":\"https://openalex.org/A5102767216\",\"display_name\":\"Anna J. Donnelly\",\"orcid\":\"https://orcid.org/0009-0005-1992-2763\"},{\"id\":\"https://openalex.org/A5006219749\",\"display_name\":\"Trisha Suppes\",\"orcid\":null},{\"id\":\"https://openalex.org/A5083848316\",\"display_name\":\"Leanne M. Williams\",\"orcid\":\"https://orcid.org/0000-0001-9987-7360\"}],\"primary_location\":{\"source_id\":\"https://openalex.org/S205482884\",\"source_display_name\":\"Biological Psychiatry\",\"landing_page_url\":\"https://doi.org/10.1016/j.biopsych.2025.02.403\",\"is_oa\":false}}", "topic_tags": "Depression,Treatment-Resistant Depression", "study_type": "Other", "hidden": 0, "false_positive": 0, "curation_notes": null, "merged_into_id": null, "curation_locked": 0, "publication_status": "published", "openalex_id": "https://openalex.org/W4409280673" }, { "id": 4396, "title": "13. Safety, Feasibility, and Tolerability of Psilocybin in Older Adults With Amnestic MCI: Preliminary Data From a SV2a PET Imaging Study", "normalized_title": "13 safety feasibility and tolerability of psilocybin in older adults with amnestic mci preliminary data from a sv2a pet imaging study", "authors": "Danielle Bukovsky, Aron Amaev, Jianmeng Song, Edgardo Torres Carmona, S. Lauren Kyte, Fumihiko Ueno, Vincenzo De Luca, Christopher R. Bowie, Alastair J. Flint, Muhammad Ishrat Husain, Ariel Graff-Guerrero, Philip Gerretsen", "abstract": "", "journal": "Biological Psychiatry", "publication_date": "2025-04-08", "publication_year": 2025, "doi": "10.1016/j.biopsych.2025.02.250", "pubmed_id": null, "source_url": "https://doi.org/10.1016/j.biopsych.2025.02.250", "keywords": "Psilocybin, Tolerability, Medicine, Neuroscience, Psychology, Psychiatry, Internal medicine, Adverse effect, Hallucinogen, Psychedelics and Drug Studies, Forensic Toxicology and Drug Analysis, Neurotransmitter Receptor Influence on Behavior", "substance_tags": "psilocybin", "source_name": "OpenAlex", "date_added": "2026-07-04 06:34:40", "last_checked": "2026-07-04 07:00:33", "raw_json": "{\"openalex_id\":\"https://openalex.org/W4409280654\",\"openalex_url\":\"https://openalex.org/W4409280654\",\"openalex_relevance_score\":6,\"openalex_relevance_reasons\":[\"title:psilocybin\",\"metadata:psilocybin\"],\"openalex_type\":\"article\",\"openalex_work_type\":null,\"cited_by_count\":0,\"referenced_works\":[],\"authorships\":[{\"id\":\"https://openalex.org/A5117083140\",\"display_name\":\"Danielle Bukovsky\",\"orcid\":null},{\"id\":\"https://openalex.org/A5081312231\",\"display_name\":\"Aron Amaev\",\"orcid\":null},{\"id\":\"https://openalex.org/A5030191843\",\"display_name\":\"Jianmeng Song\",\"orcid\":\"https://orcid.org/0000-0001-8223-8845\"},{\"id\":\"https://openalex.org/A5110764509\",\"display_name\":\"Edgardo Torres Carmona\",\"orcid\":null},{\"id\":\"https://openalex.org/A5079547878\",\"display_name\":\"S. Lauren Kyte\",\"orcid\":null},{\"id\":\"https://openalex.org/A5026307364\",\"display_name\":\"Fumihiko Ueno\",\"orcid\":\"https://orcid.org/0000-0003-3463-5672\"},{\"id\":\"https://openalex.org/A5028939354\",\"display_name\":\"Vincenzo De Luca\",\"orcid\":\"https://orcid.org/0000-0002-5421-3584\"},{\"id\":\"https://openalex.org/A5007991853\",\"display_name\":\"Christopher R. Bowie\",\"orcid\":\"https://orcid.org/0000-0002-1983-8861\"},{\"id\":\"https://openalex.org/A5010961636\",\"display_name\":\"Alastair J. Flint\",\"orcid\":\"https://orcid.org/0000-0001-6806-0235\"},{\"id\":\"https://openalex.org/A5078217449\",\"display_name\":\"Muhammad Ishrat Husain\",\"orcid\":\"https://orcid.org/0000-0001-5771-5750\"},{\"id\":\"https://openalex.org/A5044840695\",\"display_name\":\"Ariel Graff-Guerrero\",\"orcid\":\"https://orcid.org/0000-0001-9301-2171\"},{\"id\":\"https://openalex.org/A5017059941\",\"display_name\":\"Philip Gerretsen\",\"orcid\":\"https://orcid.org/0000-0003-4053-6814\"}],\"primary_location\":{\"source_id\":\"https://openalex.org/S205482884\",\"source_display_name\":\"Biological Psychiatry\",\"landing_page_url\":\"https://doi.org/10.1016/j.biopsych.2025.02.250\",\"is_oa\":false}}", "topic_tags": "Brain Imaging,Receptor Pharmacology,Aging,Older Adults,Safety,Toxicity", "study_type": "Other", "hidden": 0, "false_positive": 0, "curation_notes": null, "merged_into_id": null, "curation_locked": 0, "publication_status": "published", "openalex_id": "https://openalex.org/W4409280654" }, { "id": 4395, "title": "595. Psilocybin-Assisted Therapy for Relapse Prevention in Alcohol Use Disorder: A RCT", "normalized_title": "595 psilocybin assisted therapy for relapse prevention in alcohol use disorder a rct", "authors": "Nathalie M. Rieser, Raoul Bitar, Halm Simon, Christina Rossgoderer, Ladina P Gubser, Maeva Thévenaz, Yara Kreis, Robin von Rotz, Carlos Nordt, Flora Moujaes, Etna Engeli, Andres Ort, Erich Seifritz, Franz X. Vollenweider, Katrin H. Preller", "abstract": "", "journal": "Biological Psychiatry", "publication_date": "2025-04-08", "publication_year": 2025, "doi": "10.1016/j.biopsych.2025.02.834", "pubmed_id": null, "source_url": "https://doi.org/10.1016/j.biopsych.2025.02.834", "keywords": "Psilocybin, Relapse prevention, Randomized controlled trial, Alcohol use disorder, Psychiatry, Psychotherapist, Medicine, Psychology, Alcohol, Hallucinogen, Internal medicine, Biochemistry, Chemistry, Psychedelics and Drug Studies", "substance_tags": "psilocybin", "source_name": "OpenAlex", "date_added": "2026-07-04 06:34:40", "last_checked": "2026-07-04 07:00:33", "raw_json": "{\"openalex_id\":\"https://openalex.org/W4409280291\",\"openalex_url\":\"https://openalex.org/W4409280291\",\"openalex_relevance_score\":6,\"openalex_relevance_reasons\":[\"title:psilocybin\",\"metadata:psilocybin\"],\"openalex_type\":\"article\",\"openalex_work_type\":null,\"cited_by_count\":0,\"referenced_works\":[],\"authorships\":[{\"id\":\"https://openalex.org/A5050105328\",\"display_name\":\"Nathalie M. Rieser\",\"orcid\":\"https://orcid.org/0000-0002-5804-1409\"},{\"id\":\"https://openalex.org/A5022150947\",\"display_name\":\"Raoul Bitar\",\"orcid\":null},{\"id\":null,\"display_name\":\"Halm Simon\",\"orcid\":null},{\"id\":\"https://openalex.org/A5066226340\",\"display_name\":\"Christina Rossgoderer\",\"orcid\":null},{\"id\":\"https://openalex.org/A5055186073\",\"display_name\":\"Ladina P Gubser\",\"orcid\":null},{\"id\":\"https://openalex.org/A5116616854\",\"display_name\":\"Maeva Thévenaz\",\"orcid\":null},{\"id\":\"https://openalex.org/A5093582215\",\"display_name\":\"Yara Kreis\",\"orcid\":null},{\"id\":\"https://openalex.org/A5058976475\",\"display_name\":\"Robin von Rotz\",\"orcid\":\"https://orcid.org/0000-0003-4087-3650\"},{\"id\":\"https://openalex.org/A5030523325\",\"display_name\":\"Carlos Nordt\",\"orcid\":\"https://orcid.org/0000-0002-1156-152X\"},{\"id\":\"https://openalex.org/A5039540919\",\"display_name\":\"Flora Moujaes\",\"orcid\":\"https://orcid.org/0000-0002-0843-0393\"},{\"id\":\"https://openalex.org/A5010288025\",\"display_name\":\"Etna Engeli\",\"orcid\":\"https://orcid.org/0000-0001-7176-8728\"},{\"id\":\"https://openalex.org/A5090501438\",\"display_name\":\"Andres Ort\",\"orcid\":null},{\"id\":\"https://openalex.org/A5045362944\",\"display_name\":\"Erich Seifritz\",\"orcid\":\"https://orcid.org/0000-0002-7311-4426\"},{\"id\":\"https://openalex.org/A5086283052\",\"display_name\":\"Franz X. Vollenweider\",\"orcid\":\"https://orcid.org/0000-0001-9053-6164\"},{\"id\":\"https://openalex.org/A5040977207\",\"display_name\":\"Katrin H. Preller\",\"orcid\":\"https://orcid.org/0000-0003-0413-7672\"}],\"primary_location\":{\"source_id\":\"https://openalex.org/S205482884\",\"source_display_name\":\"Biological Psychiatry\",\"landing_page_url\":\"https://doi.org/10.1016/j.biopsych.2025.02.834\",\"is_oa\":false}}", "topic_tags": "Addiction,Randomized Controlled Trial", "study_type": "Randomized Controlled Trial", "hidden": 0, "false_positive": 0, "curation_notes": null, "merged_into_id": null, "curation_locked": 0, "publication_status": "published", "openalex_id": "https://openalex.org/W4409280291" }, { "id": 4394, "title": "323. Comparing Antidepressant Effects of Psilocybin-Assisted Psychotherapy in Individuals That Were Unmedicated at Initial Screening Versus Individuals Discontinuing Medications for Study Participation", "normalized_title": "323 comparing antidepressant effects of psilocybin assisted psychotherapy in individuals that were unmedicated at initial screening versus individuals discontinuing medications for study participation", "authors": "Noah Chisamore, Erica Kaczmarek, Zoe Doyle, Danica E. Johnson, Rodrigo B. Mansur, Roger S. McIntyre, Joshua D. Rosenblat", "abstract": "", "journal": "Biological Psychiatry", "publication_date": "2025-04-08", "publication_year": 2025, "doi": "10.1016/j.biopsych.2025.02.561", "pubmed_id": null, "source_url": "https://doi.org/10.1016/j.biopsych.2025.02.561", "keywords": "Psilocybin, Antidepressant, Psychiatry, Psychology, Antidepressant medication, Psychotherapist, Clinical psychology, Medicine, Hallucinogen, Anxiety, Psychedelics and Drug Studies, Chemical synthesis and alkaloids, Digital Mental Health Interventions", "substance_tags": "psilocybin", "source_name": "OpenAlex", "date_added": "2026-07-04 06:34:40", "last_checked": "2026-07-04 07:00:33", "raw_json": "{\"openalex_id\":\"https://openalex.org/W4409280220\",\"openalex_url\":\"https://openalex.org/W4409280220\",\"openalex_relevance_score\":6,\"openalex_relevance_reasons\":[\"title:psilocybin\",\"metadata:psilocybin\"],\"openalex_type\":\"article\",\"openalex_work_type\":null,\"cited_by_count\":0,\"referenced_works\":[],\"authorships\":[{\"id\":\"https://openalex.org/A5046135404\",\"display_name\":\"Noah Chisamore\",\"orcid\":\"https://orcid.org/0000-0003-3325-5854\"},{\"id\":\"https://openalex.org/A5104243612\",\"display_name\":\"Erica Kaczmarek\",\"orcid\":null},{\"id\":\"https://openalex.org/A5048402159\",\"display_name\":\"Zoe Doyle\",\"orcid\":\"https://orcid.org/0000-0002-0140-8994\"},{\"id\":\"https://openalex.org/A5038440185\",\"display_name\":\"Danica E. Johnson\",\"orcid\":\"https://orcid.org/0000-0003-2000-7691\"},{\"id\":\"https://openalex.org/A5032613018\",\"display_name\":\"Rodrigo B. Mansur\",\"orcid\":\"https://orcid.org/0000-0002-3968-3297\"},{\"id\":\"https://openalex.org/A5112813064\",\"display_name\":\"Roger S. McIntyre\",\"orcid\":null},{\"id\":\"https://openalex.org/A5050740394\",\"display_name\":\"Joshua D. Rosenblat\",\"orcid\":\"https://orcid.org/0000-0002-4773-2191\"}],\"primary_location\":{\"source_id\":\"https://openalex.org/S205482884\",\"source_display_name\":\"Biological Psychiatry\",\"landing_page_url\":\"https://doi.org/10.1016/j.biopsych.2025.02.561\",\"is_oa\":false}}", "topic_tags": "Anxiety", "study_type": "Other", "hidden": 0, "false_positive": 0, "curation_notes": null, "merged_into_id": null, "curation_locked": 0, "publication_status": "published", "openalex_id": "https://openalex.org/W4409280220" }, { "id": 4635, "title": "1. Psilocybin and 4-Bromo-2,5-Dimethoxyphenethylamine (2C-B) at Encoding Distort Episodic Familiarity and Positively Bias Emotional Metamemory", "normalized_title": "1 psilocybin and 4 bromo 2 5 dimethoxyphenethylamine 2c b at encoding distort episodic familiarity and positively bias emotional metamemory", "authors": "Manoj K. Doss, Pablo Mallaroni, Natasha L. Mason, Jan Ramaekers", "abstract": "", "journal": "Biological Psychiatry", "publication_date": "2024-04-28", "publication_year": 2024, "doi": "10.1016/j.biopsych.2024.02.179", "pubmed_id": null, "source_url": "https://doi.org/10.1016/j.biopsych.2024.02.179", "keywords": "Psilocybin, Metamemory, Psychology, Episodic memory, Encoding (memory), Cognitive psychology, Neuroscience, Cognition, Hallucinogen, Psychiatry, Metacognition, Psychedelics and Drug Studies, Chemical synthesis and alkaloids", "substance_tags": "psilocybin", "source_name": "OpenAlex", "date_added": "2026-07-04 06:34:43", "last_checked": "2026-07-04 07:00:35", "raw_json": "{\"openalex_id\":\"https://openalex.org/W4396235155\",\"openalex_url\":\"https://openalex.org/W4396235155\",\"openalex_relevance_score\":6,\"openalex_relevance_reasons\":[\"title:psilocybin\",\"metadata:psilocybin\"],\"openalex_type\":\"article\",\"openalex_work_type\":null,\"cited_by_count\":0,\"referenced_works\":[],\"authorships\":[{\"id\":\"https://openalex.org/A5084261335\",\"display_name\":\"Manoj K. Doss\",\"orcid\":\"https://orcid.org/0000-0003-2939-2522\"},{\"id\":\"https://openalex.org/A5063711942\",\"display_name\":\"Pablo Mallaroni\",\"orcid\":\"https://orcid.org/0000-0002-0959-2837\"},{\"id\":\"https://openalex.org/A5041055116\",\"display_name\":\"Natasha L. Mason\",\"orcid\":\"https://orcid.org/0000-0001-7115-0389\"},{\"id\":\"https://openalex.org/A5104355183\",\"display_name\":\"Jan Ramaekers\",\"orcid\":null}],\"primary_location\":{\"source_id\":\"https://openalex.org/S205482884\",\"source_display_name\":\"Biological Psychiatry\",\"landing_page_url\":\"https://doi.org/10.1016/j.biopsych.2024.02.179\",\"is_oa\":false}}", "topic_tags": "Emotional Processing", "study_type": "Other", "hidden": 0, "false_positive": 0, "curation_notes": null, "merged_into_id": null, "curation_locked": 0, "publication_status": "published", "openalex_id": "https://openalex.org/W4396235155" }, { "id": 1097, "title": "Neural Mechanisms of Resting-State Networks and the Amygdala Underlying the Cognitive and Emotional Effects of Psilocybin", "normalized_title": "neural mechanisms of resting state networks and the amygdala underlying the cognitive and emotional effects of psilocybin", "authors": "Devon Stoliker, Leonardo Novelli, Franz X. Vollenweider, Gary F. Egan, Katrin H. Preller, Adeel Razi", "abstract": "BACKGROUND: Serotonergic psychedelics, such as psilocybin, alter perceptual and cognitive systems that are functionally integrated with the amygdala. These changes can alter cognition and emotions that are hypothesized to contribute to their therapeutic utility. However, the neural mechanisms of cognitive and subcortical systems altered by psychedelics are not well understood. METHODS: We used resting-state functional magnetic resonance images collected during a randomized, double-blind, placebo-controlled clinical trial of 24 healthy adults under 0.2 mg/kg psilocybin to estimate the directed (i.e., effective) changes between the amygdala and 3 large-scale resting-state networks involved in cognition. These networks are the default mode network, the salience network, and the central executive network. RESULTS: We found a pattern of decreased top-down effective connectivity from these resting-state networks to the amygdala. Effective connectivity decreased within the default mode network and salience network but increased within the central executive network. These changes in effective connectivity were statistically associated with behavioral measures of altered cognition and emotion under the influence of psilocybin. CONCLUSIONS: Our findings suggest that temporary amygdala signal attenuation is associated with mechanistic changes to resting-state network connectivity. These changes are significant for altered cognition and perception and suggest targets for research investigating the efficacy of psychedelic therapy for internalizing psychiatric disorders. More broadly, our study suggests the value of quantifying the brain's hierarchical organization using effective connectivity to identify important mechanisms for basic cognitive function and how they are integrated to give rise to subjective experiences.", "journal": "Biological Psychiatry", "publication_date": "2024-01-04", "publication_year": 2024, "doi": "10.1016/j.biopsych.2024.01.002", "pubmed_id": "38185235", "source_url": "https://doi.org/10.1016/j.biopsych.2024.01.002", "keywords": "Psilocybin, Amygdala, Neuroscience, Psychology, Cognition, Resting state fMRI, Functional connectivity, Cognitive psychology, Hallucinogen, Psychiatry, Psychedelics and Drug Studies, Paranormal Experiences and Beliefs, Forensic Toxicology and Drug Analysis", "substance_tags": "psilocybin", "source_name": "OpenAlex", "date_added": "2026-07-01 06:48:05", "last_checked": "2026-07-04 07:00:36", "raw_json": 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Pilot Study Evaluation of Psilocybin Therapy for Anorexia Nervosa: Safety, Acceptability, and Preliminary Efficacy", "normalized_title": "p450 pilot study evaluation of psilocybin therapy for anorexia nervosa safety acceptability and preliminary efficacy", "authors": "Stéphanie Knatz Peck, Samatha Shao, Susan Murray, Walter H. 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Kaye\",\"orcid\":\"https://orcid.org/0000-0002-4478-4906\"}],\"primary_location\":{\"source_id\":\"https://openalex.org/S205482884\",\"source_display_name\":\"Biological Psychiatry\",\"landing_page_url\":\"https://doi.org/10.1016/j.biopsych.2022.02.686\",\"is_oa\":false}}", "topic_tags": "Eating Disorders,Receptor Pharmacology,Safety", "study_type": "Other", "hidden": 0, "false_positive": 0, "curation_notes": null, "merged_into_id": null, "curation_locked": 0, "publication_status": "published", "openalex_id": "https://openalex.org/W4293242421" }, { "id": 5100, "title": "Altered Prediction-Error Processing May Underlie Psilocybin-Induced Changes in Self-Processing", "normalized_title": "altered prediction error processing may underlie psilocybin induced changes in self processing", "authors": "Katrin H. Preller", "abstract": "", "journal": "Biological Psychiatry", "publication_date": "2021-04-26", "publication_year": 2021, "doi": "10.1016/j.biopsych.2021.02.036", "pubmed_id": null, "source_url": "https://doi.org/10.1016/j.biopsych.2021.02.036", "keywords": "Psilocybin, Anorexia nervosa, Psychology, Perception, Neuroscience, Cognitive psychology, Depression (economics), Anorexia, Hallucinogen, Clinical psychology, Medicine, Psychiatry, Eating disorders, Internal medicine, Economics, Macroeconomics, Psychedelics and Drug Studies, Neurotransmitter Receptor Influence on Behavior, Nicotinic Acetylcholine Receptors Study", "substance_tags": "psilocybin", "source_name": "OpenAlex", "date_added": "2026-07-04 06:51:59", "last_checked": "2026-07-04 07:00:38", "raw_json": "{\"openalex_id\":\"https://openalex.org/W3159723459\",\"openalex_url\":\"https://openalex.org/W3159723459\",\"openalex_relevance_score\":6,\"openalex_relevance_reasons\":[\"title:psilocybin\",\"metadata:psilocybin\"],\"openalex_type\":\"article\",\"openalex_work_type\":null,\"cited_by_count\":1,\"referenced_works\":[],\"authorships\":[{\"id\":\"https://openalex.org/A5040977207\",\"display_name\":\"Katrin H. 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Franco-Corso, Stephen Ross", "abstract": "", "journal": "Biological Psychiatry", "publication_date": "2021-04-26", "publication_year": 2021, "doi": "10.1016/j.biopsych.2021.02.591", "pubmed_id": null, "source_url": "https://doi.org/10.1016/j.biopsych.2021.02.591", "keywords": "Psilocybin, Suicidal ideation, Cancer, Intervention (counseling), Psychiatry, Medicine, Clinical psychology, Hallucinogen, Psychology, Oncology, Suicide prevention, Poison control, Internal medicine, Medical emergency, Psychedelics and Drug Studies, Body Image and Dysmorphia Studies, Psychotherapy Techniques and Applications", "substance_tags": "psilocybin", "source_name": "OpenAlex", "date_added": "2026-07-04 06:51:59", "last_checked": "2026-07-04 07:00:38", "raw_json": "{\"openalex_id\":\"https://openalex.org/W3157975835\",\"openalex_url\":\"https://openalex.org/W3157975835\",\"openalex_relevance_score\":6,\"openalex_relevance_reasons\":[\"title:psilocybin\",\"metadata:psilocybin\"],\"openalex_type\":\"article\",\"openalex_work_type\":null,\"cited_by_count\":3,\"referenced_works\":[],\"authorships\":[{\"id\":\"https://openalex.org/A5052441153\",\"display_name\":\"Julia Benville\",\"orcid\":null},{\"id\":\"https://openalex.org/A5041698353\",\"display_name\":\"Gabrielle Agin-Liebes\",\"orcid\":\"https://orcid.org/0000-0002-9754-229X\"},{\"id\":\"https://openalex.org/A5004385044\",\"display_name\":\"Daniel E. Roberts\",\"orcid\":\"https://orcid.org/0000-0002-9375-6354\"},{\"id\":\"https://openalex.org/A5028101461\",\"display_name\":\"Sharon L. Lo\",\"orcid\":null},{\"id\":\"https://openalex.org/A5012044626\",\"display_name\":\"Leila Ghazal\",\"orcid\":null},{\"id\":\"https://openalex.org/A5056248617\",\"display_name\":\"Silvia J. Franco-Corso\",\"orcid\":null},{\"id\":\"https://openalex.org/A5007445878\",\"display_name\":\"Stephen Ross\",\"orcid\":\"https://orcid.org/0000-0002-7807-3037\"}],\"primary_location\":{\"source_id\":\"https://openalex.org/S205482884\",\"source_display_name\":\"Biological Psychiatry\",\"landing_page_url\":\"https://doi.org/10.1016/j.biopsych.2021.02.591\",\"is_oa\":false}}", "topic_tags": "End-of-Life Distress,Cancer Patients", "study_type": "Other", "hidden": 0, "false_positive": 0, "curation_notes": null, "merged_into_id": null, "curation_locked": 0, "publication_status": "published", "openalex_id": "https://openalex.org/W3157975835" }, { "id": 2263, "title": "Psilocybin Induces Time-Dependent Changes in Global Functional Connectivity", "normalized_title": "psilocybin induces time dependent changes in global functional connectivity", "authors": "Katrin H. Preller, Patricia Duerler, Joshua B. Burt, Jie Lisa Ji, Brendan Adkinson, Philipp Stämpfli, Erich Seifritz, Grega Repovš, John H. Krystal, John D. Murray, Alan Anticevic, Franz X. Vollenweider", "abstract": "", "journal": "Biological Psychiatry", "publication_date": "2020-01-12", "publication_year": 2020, "doi": "10.1016/j.biopsych.2019.12.027", "pubmed_id": "32111343", "source_url": "https://doi.org/10.1016/j.biopsych.2019.12.027", "keywords": "Psilocybin, Neuroscience, Psychology, Functional magnetic resonance imaging, Hallucinogen, Sensory system, Serotonin, Functional connectivity, Medicine, Pharmacology, Receptor, Internal medicine, Psychedelics and Drug Studies, Forensic Toxicology and Drug Analysis, Pain Management and Placebo Effect", "substance_tags": "psilocybin", "source_name": "OpenAlex", "date_added": "2026-07-01 06:54:14", "last_checked": "2026-07-04 07:00:39", "raw_json": "{\"openalex_id\":\"https://openalex.org/W2999279320\",\"openalex_url\":\"https://openalex.org/W2999279320\",\"openalex_relevance_score\":6,\"openalex_relevance_reasons\":[\"title:psilocybin\",\"metadata:psilocybin\"],\"openalex_type\":\"article\",\"openalex_work_type\":null,\"cited_by_count\":198,\"referenced_works\":[\"https://openalex.org/W1970365815\",\"https://openalex.org/W1987323424\",\"https://openalex.org/W2003424951\",\"https://openalex.org/W2009341243\",\"https://openalex.org/W2020974659\",\"https://openalex.org/W2022888479\",\"https://openalex.org/W2026832357\",\"https://openalex.org/W2030041890\",\"https://openalex.org/W2033134445\",\"https://openalex.org/W2036231449\",\"https://openalex.org/W2051426845\",\"https://openalex.org/W2053750947\",\"https://openalex.org/W2055655674\",\"https://openalex.org/W2063393199\",\"https://openalex.org/W2068751924\",\"https://openalex.org/W2075238613\",\"https://openalex.org/W2100182643\",\"https://openalex.org/W2107441654\",\"https://openalex.org/W2110572089\",\"https://openalex.org/W2122335802\",\"https://openalex.org/W2122459973\",\"https://openalex.org/W2124291611\",\"https://openalex.org/W2126693856\",\"https://openalex.org/W2133402952\",\"https://openalex.org/W2145095988\",\"https://openalex.org/W2161555895\",\"https://openalex.org/W2170596036\",\"https://openalex.org/W2284048615\",\"https://openalex.org/W2306810735\",\"https://openalex.org/W2336591896\",\"https://openalex.org/W2396675581\",\"https://openalex.org/W2517085860\",\"https://openalex.org/W2529479229\",\"https://openalex.org/W2537382818\",\"https://openalex.org/W2553251493\",\"https://openalex.org/W2557111525\",\"https://openalex.org/W2558412547\",\"https://openalex.org/W2559739670\",\"https://openalex.org/W2561419573\",\"https://openalex.org/W2582692487\",\"https://openalex.org/W2624901555\",\"https://openalex.org/W2735984207\",\"https://openalex.org/W2767725891\",\"https://openalex.org/W2767910296\",\"https://openalex.org/W2790184875\",\"https://openalex.org/W2886680918\",\"https://openalex.org/W2950564037\",\"https://openalex.org/W4211211437\",\"https://openalex.org/W6678553313\",\"https://openalex.org/W6728220495\"],\"authorships\":[{\"id\":\"https://openalex.org/A5040977207\",\"display_name\":\"Katrin H. Preller\",\"orcid\":\"https://orcid.org/0000-0003-0413-7672\"},{\"id\":\"https://openalex.org/A5032942211\",\"display_name\":\"Patricia Duerler\",\"orcid\":\"https://orcid.org/0000-0002-1068-3234\"},{\"id\":\"https://openalex.org/A5084953630\",\"display_name\":\"Joshua B. Burt\",\"orcid\":\"https://orcid.org/0000-0002-5605-2091\"},{\"id\":\"https://openalex.org/A5079398127\",\"display_name\":\"Jie Lisa Ji\",\"orcid\":\"https://orcid.org/0000-0002-6280-9070\"},{\"id\":\"https://openalex.org/A5036732582\",\"display_name\":\"Brendan Adkinson\",\"orcid\":\"https://orcid.org/0000-0003-3196-8674\"},{\"id\":\"https://openalex.org/A5064966055\",\"display_name\":\"Philipp Stämpfli\",\"orcid\":\"https://orcid.org/0000-0003-1684-2416\"},{\"id\":\"https://openalex.org/A5045362944\",\"display_name\":\"Erich Seifritz\",\"orcid\":\"https://orcid.org/0000-0002-7311-4426\"},{\"id\":\"https://openalex.org/A5063201290\",\"display_name\":\"Grega Repovš\",\"orcid\":\"https://orcid.org/0000-0003-1837-3879\"},{\"id\":\"https://openalex.org/A5071039477\",\"display_name\":\"John H. Krystal\",\"orcid\":\"https://orcid.org/0000-0001-6952-1726\"},{\"id\":\"https://openalex.org/A5024452548\",\"display_name\":\"John D. Murray\",\"orcid\":\"https://orcid.org/0000-0003-4115-8181\"},{\"id\":\"https://openalex.org/A5003407293\",\"display_name\":\"Alan Anticevic\",\"orcid\":\"https://orcid.org/0000-0002-4324-0536\"},{\"id\":\"https://openalex.org/A5086283052\",\"display_name\":\"Franz X. Vollenweider\",\"orcid\":\"https://orcid.org/0000-0001-9053-6164\"}],\"primary_location\":{\"source_id\":\"https://openalex.org/S205482884\",\"source_display_name\":\"Biological Psychiatry\",\"landing_page_url\":\"https://doi.org/10.1016/j.biopsych.2019.12.027\",\"is_oa\":false}}", "topic_tags": "Chronic Pain,Brain Imaging,Pharmacology,Receptor Pharmacology,Aging,Toxicity", "study_type": "Other", "hidden": 0, "false_positive": 0, "curation_notes": null, "merged_into_id": null, "curation_locked": 0, "publication_status": "published", "openalex_id": "https://openalex.org/W2999279320" }, { "id": 3935, "title": "T137. Psilocybin-Assisted Group Therapy for Demoralization in Long-Term AIDS Survivors", "normalized_title": "t137 psilocybin assisted group therapy for demoralization in long term aids survivors", "authors": "B. Anderson, Alicia Danforth, Robert B. Daroff, Christopher S. Stauffer, James Dilley, Jennifer Mitchell, Joshua Woolley", "abstract": "", "journal": "Biological Psychiatry", "publication_date": "2019-04-30", "publication_year": 2019, "doi": "10.1016/j.biopsych.2019.03.460", "pubmed_id": null, "source_url": "https://doi.org/10.1016/j.biopsych.2019.03.460", "keywords": "Psilocybin, Learned helplessness, Psychotherapist, Psychology, Anxiety, Psychiatry, Group psychotherapy, Depression (economics), Clinical psychology, Hallucinogen, Economics, Macroeconomics, Psychedelics and Drug Studies, Chemical synthesis and alkaloids", "substance_tags": "psilocybin", "source_name": "OpenAlex", "date_added": "2026-07-02 20:42:13", "last_checked": "2026-07-04 07:00:39", "raw_json": "{\"openalex_id\":\"https://openalex.org/W2946285292\",\"openalex_url\":\"https://openalex.org/W2946285292\",\"openalex_relevance_score\":6,\"openalex_relevance_reasons\":[\"title:psilocybin\",\"metadata:psilocybin\"],\"openalex_type\":\"article\",\"openalex_work_type\":null,\"cited_by_count\":5,\"referenced_works\":[],\"authorships\":[{\"id\":\"https://openalex.org/A5009662036\",\"display_name\":\"B. Anderson\",\"orcid\":\"https://orcid.org/0000-0001-5023-660X\"},{\"id\":\"https://openalex.org/A5051293419\",\"display_name\":\"Alicia Danforth\",\"orcid\":\"https://orcid.org/0000-0001-8726-046X\"},{\"id\":\"https://openalex.org/A5033176865\",\"display_name\":\"Robert B. Daroff\",\"orcid\":null},{\"id\":\"https://openalex.org/A5077197149\",\"display_name\":\"Christopher S. Stauffer\",\"orcid\":\"https://orcid.org/0000-0002-0888-095X\"},{\"id\":\"https://openalex.org/A5054356516\",\"display_name\":\"James Dilley\",\"orcid\":\"https://orcid.org/0000-0002-1108-0048\"},{\"id\":\"https://openalex.org/A5078452831\",\"display_name\":\"Jennifer Mitchell\",\"orcid\":\"https://orcid.org/0000-0002-7567-8129\"},{\"id\":\"https://openalex.org/A5101826991\",\"display_name\":\"Joshua Woolley\",\"orcid\":\"https://orcid.org/0000-0001-6753-2093\"}],\"primary_location\":{\"source_id\":\"https://openalex.org/S205482884\",\"source_display_name\":\"Biological Psychiatry\",\"landing_page_url\":\"https://doi.org/10.1016/j.biopsych.2019.03.460\",\"is_oa\":false}}", "topic_tags": "Depression,Anxiety", "study_type": "Other", "hidden": 0, "false_positive": 0, "curation_notes": null, "merged_into_id": null, "curation_locked": 0, "publication_status": "published", "openalex_id": "https://openalex.org/W2946285292" }, { "id": 5162, "title": "T263. Psilocybin Improves Cognitive Control and Downregulates Parietal Cortex in Treatment-Seeking Smokers", "normalized_title": "t263 psilocybin improves cognitive control and downregulates parietal cortex in treatment seeking smokers", "authors": "Michael C. McKenna, John R. Fedota, Albert Garcia-Romeu, Matthew R. Johnson, Roland R. Griffiths, Elliot A. Stein", "abstract": "", "journal": "Biological Psychiatry", "publication_date": "2018-04-08", "publication_year": 2018, "doi": "10.1016/j.biopsych.2018.02.600", "pubmed_id": null, "source_url": "https://doi.org/10.1016/j.biopsych.2018.02.600", "keywords": "Psilocybin, Cognition, Agonist, Posterior parietal cortex, Smoking cessation, Neuroscience, Psychology, Medicine, Psychiatry, Hallucinogen, Receptor, Internal medicine, Pathology, Psychedelics and Drug Studies, Nicotinic Acetylcholine Receptors Study, Olfactory and Sensory Function Studies", "substance_tags": "psilocybin", "source_name": "OpenAlex", "date_added": "2026-07-04 06:52:02", "last_checked": "2026-07-04 07:00:40", "raw_json": "{\"openalex_id\":\"https://openalex.org/W2797159874\",\"openalex_url\":\"https://openalex.org/W2797159874\",\"openalex_relevance_score\":6,\"openalex_relevance_reasons\":[\"title:psilocybin\",\"metadata:psilocybin\"],\"openalex_type\":\"article\",\"openalex_work_type\":null,\"cited_by_count\":3,\"referenced_works\":[],\"authorships\":[{\"id\":\"https://openalex.org/A5008744346\",\"display_name\":\"Michael C. McKenna\",\"orcid\":\"https://orcid.org/0000-0002-8124-591X\"},{\"id\":\"https://openalex.org/A5091208629\",\"display_name\":\"John R. Fedota\",\"orcid\":null},{\"id\":\"https://openalex.org/A5091708678\",\"display_name\":\"Albert Garcia-Romeu\",\"orcid\":\"https://orcid.org/0000-0003-2182-1644\"},{\"id\":\"https://openalex.org/A5069405557\",\"display_name\":\"Matthew R. Johnson\",\"orcid\":\"https://orcid.org/0000-0003-3953-8898\"},{\"id\":\"https://openalex.org/A5002583244\",\"display_name\":\"Roland R. Griffiths\",\"orcid\":\"https://orcid.org/0000-0001-5185-7854\"},{\"id\":\"https://openalex.org/A5023565994\",\"display_name\":\"Elliot A. Stein\",\"orcid\":\"https://orcid.org/0000-0003-0593-0269\"}],\"primary_location\":{\"source_id\":\"https://openalex.org/S205482884\",\"source_display_name\":\"Biological Psychiatry\",\"landing_page_url\":\"https://doi.org/10.1016/j.biopsych.2018.02.600\",\"is_oa\":false}}", "topic_tags": "Addiction,Receptor Pharmacology", "study_type": "Other", "hidden": 0, "false_positive": 0, "curation_notes": null, "merged_into_id": null, "curation_locked": 0, "publication_status": "published", "openalex_id": "https://openalex.org/W2797159874" }, { "id": 2530, "title": "Psilocybin-Induced Decrease in Amygdala Reactivity Correlates with Enhanced Positive Mood in Healthy Volunteers.", "normalized_title": "psilocybin induced decrease in amygdala reactivity correlates with enhanced positive mood in healthy volunteers", "authors": "Kraehenmann R, Preller KH, Scheidegger M, Pokorny T, Bosch OG, Seifritz E, Vollenweider FX.", "abstract": "BackgroundThe amygdala is a key structure in serotonergic emotion-processing circuits. In healthy volunteers, acute administration of the serotonin 1A/2A/2C receptor agonist psilocybin reduces neural responses to negative stimuli and induces mood changes toward positive states. However, it is little-known whether psilocybin reduces amygdala reactivity to negative stimuli and whether any change in amygdala reactivity is related to mood change.MethodsThis study assessed the effects of acute administration of the hallucinogen psilocybin (.16 mg/kg) versus placebo on amygdala reactivity to negative stimuli in 25 healthy volunteers using blood oxygen level-dependent functional magnetic resonance imaging. Mood changes were assessed using the Positive and Negative Affect Schedule and the state portion of the State-Trait Anxiety Inventory. A double-blind, randomized, cross-over design was used with volunteers counterbalanced to receive psilocybin and placebo in two separate sessions at least 14 days apart.ResultsAmygdala reactivity to negative and neutral stimuli was lower after psilocybin administration than after placebo administration. The psilocybin-induced attenuation of right amygdala reactivity in response to negative stimuli was related to the psilocybin-induced increase in positive mood state.ConclusionsThese results demonstrate that acute treatment with psilocybin decreased amygdala reactivity during emotion processing and that this was associated with an increase of positive mood in healthy volunteers. These findings may be relevant to the normalization of amygdala hyperactivity and negative mood states in patients with major depression.", "journal": "Biological Psychiatry", "publication_date": "2014-04-25", "publication_year": 2014, "doi": "10.1016/j.biopsych.2014.04.010", "pubmed_id": "24882567", "source_url": "https://doi.org/10.1016/j.biopsych.2014.04.010", "keywords": "Amygdala, Humans, Hallucinogens, Magnetic Resonance Imaging, Cross-Over Studies, Double-Blind Method, Depression, Affect, Psychiatric Status Rating Scales, Adult, Female, Male, Young Adult, Healthy Volunteers, Psilocybin", "substance_tags": "psilocybin", "source_name": "Europe PMC", "date_added": "2026-07-01 06:54:14", "last_checked": "2026-07-04 07:00:41", "raw_json": "{\"europe_pmc_id\":\"24882567\",\"source\":\"MED\",\"pub_type\":null,\"publisher\":null,\"importer\":\"Europe PMC\",\"openalex_enrichment\":{\"openalex_id\":\"https://openalex.org/W2093203605\",\"openalex_url\":\"https://openalex.org/W2093203605\",\"openalex_relevance_score\":6,\"openalex_relevance_reasons\":[\"title:psilocybin\",\"metadata:psilocybin\"],\"openalex_type\":\"article\",\"openalex_work_type\":null,\"cited_by_count\":324,\"referenced_works\":[\"https://openalex.org/W1547500656\",\"https://openalex.org/W1552978522\",\"https://openalex.org/W1607171655\",\"https://openalex.org/W1919168435\",\"https://openalex.org/W1968806178\",\"https://openalex.org/W1968837585\",\"https://openalex.org/W1968912840\",\"https://openalex.org/W1969392677\",\"https://openalex.org/W1972426098\",\"https://openalex.org/W1974074998\",\"https://openalex.org/W1974077854\",\"https://openalex.org/W1976753688\",\"https://openalex.org/W1987599891\",\"https://openalex.org/W1997058647\",\"https://openalex.org/W1998637554\",\"https://openalex.org/W2000681816\",\"https://openalex.org/W2009134620\",\"https://openalex.org/W2015011531\",\"https://openalex.org/W2016660677\",\"https://openalex.org/W2018013323\",\"https://openalex.org/W2020974659\",\"https://openalex.org/W2022272156\",\"https://openalex.org/W2023118385\",\"https://openalex.org/W2026832357\",\"https://openalex.org/W2030462630\",\"https://openalex.org/W2030472555\",\"https://openalex.org/W2038593489\",\"https://openalex.org/W2040537810\",\"https://openalex.org/W2044264234\",\"https://openalex.org/W2045411897\",\"https://openalex.org/W2050472078\",\"https://openalex.org/W2051271111\",\"https://openalex.org/W2053750947\",\"https://openalex.org/W2054428623\",\"https://openalex.org/W2058046532\",\"https://openalex.org/W2060926272\",\"https://openalex.org/W2062089925\",\"https://openalex.org/W2062190490\",\"https://openalex.org/W2062577826\",\"https://openalex.org/W2066231855\",\"https://openalex.org/W2068751924\",\"https://openalex.org/W2077188072\",\"https://openalex.org/W2079346309\",\"https://openalex.org/W2082076406\",\"https://openalex.org/W2082369948\",\"https://openalex.org/W2087209021\",\"https://openalex.org/W2088160189\",\"https://openalex.org/W2091715004\",\"https://openalex.org/W2095986387\",\"https://openalex.org/W2096407697\",\"https://openalex.org/W2096626991\",\"https://openalex.org/W2097031641\",\"https://openalex.org/W2102343823\",\"https://openalex.org/W2103880802\",\"https://openalex.org/W2109661582\",\"https://openalex.org/W2110290939\",\"https://openalex.org/W2111464173\",\"https://openalex.org/W2117590310\",\"https://openalex.org/W2117693696\",\"https://openalex.org/W2118492070\",\"https://openalex.org/W2118707925\",\"https://openalex.org/W2119134849\",\"https://openalex.org/W2121748618\",\"https://openalex.org/W2130755626\",\"https://openalex.org/W2136148200\",\"https://openalex.org/W2136485397\",\"https://openalex.org/W2136794022\",\"https://openalex.org/W2138538218\",\"https://openalex.org/W2147351252\",\"https://openalex.org/W2148905283\",\"https://openalex.org/W2149721894\",\"https://openalex.org/W2152817345\",\"https://openalex.org/W2155690750\",\"https://openalex.org/W2161085199\",\"https://openalex.org/W2161555895\",\"https://openalex.org/W2168778334\",\"https://openalex.org/W2169615651\",\"https://openalex.org/W2169957979\",\"https://openalex.org/W2171055927\",\"https://openalex.org/W2173531201\",\"https://openalex.org/W2274313778\",\"https://openalex.org/W2285774466\",\"https://openalex.org/W2438505389\",\"https://openalex.org/W2913421382\",\"https://openalex.org/W4211150788\",\"https://openalex.org/W4292994367\"],\"authorships\":[{\"id\":\"https://openalex.org/A5086978778\",\"display_name\":\"Rainer Kraehenmann\",\"orcid\":\"https://orcid.org/0000-0003-1218-0726\"},{\"id\":\"https://openalex.org/A5040977207\",\"display_name\":\"Katrin H. Preller\",\"orcid\":\"https://orcid.org/0000-0003-0413-7672\"},{\"id\":\"https://openalex.org/A5050503083\",\"display_name\":\"Milan Scheidegger\",\"orcid\":\"https://orcid.org/0000-0003-1313-2208\"},{\"id\":\"https://openalex.org/A5009222806\",\"display_name\":\"Thomas Pokorny\",\"orcid\":\"https://orcid.org/0000-0001-8185-8874\"},{\"id\":\"https://openalex.org/A5002125925\",\"display_name\":\"Oliver G. Bosch\",\"orcid\":\"https://orcid.org/0000-0002-5807-0859\"},{\"id\":\"https://openalex.org/A5045362944\",\"display_name\":\"Erich Seifritz\",\"orcid\":\"https://orcid.org/0000-0002-7311-4426\"},{\"id\":\"https://openalex.org/A5086283052\",\"display_name\":\"Franz X. Vollenweider\",\"orcid\":\"https://orcid.org/0000-0001-9053-6164\"}],\"primary_location\":{\"source_id\":\"https://openalex.org/S205482884\",\"source_display_name\":\"Biological Psychiatry\",\"landing_page_url\":\"https://doi.org/10.1016/j.biopsych.2014.04.010\",\"is_oa\":false}}}", "topic_tags": "Depression,Anxiety,Brain Imaging,Receptor Pharmacology,Aging,Emotional Processing,Healthy Volunteers", "study_type": "Clinical Trial", "hidden": 0, "false_positive": 0, "curation_notes": null, "merged_into_id": null, "curation_locked": 0, "publication_status": "published", "openalex_id": "https://openalex.org/W2093203605" }, { "id": 2597, "title": "Psilocybin biases facial recognition, goal-directed behavior, and mood state toward positive relative to negative emotions through different serotonergic subreceptors.", "normalized_title": "psilocybin biases facial recognition goal directed behavior and mood state toward positive relative to negative emotions through different serotonergic subreceptors", "authors": "Kometer M, Schmidt A, Bachmann R, Studerus E, Seifritz E, Vollenweider FX.", "abstract": "BackgroundSerotonin (5-HT) 1A and 2A receptors have been associated with dysfunctional emotional processing biases in mood disorders. These receptors further predominantly mediate the subjective and behavioral effects of psilocybin and might be important for its recently suggested antidepressive effects. However, the effect of psilocybin on emotional processing biases and the specific contribution of 5-HT2A receptors across different emotional domains is unknown.MethodsIn a randomized, double-blind study, 17 healthy human subjects received on 4 separate days placebo, psilocybin (215 μg/kg), the preferential 5-HT2A antagonist ketanserin (50 mg), or psilocybin plus ketanserin. Mood states were assessed by self-report ratings, and behavioral and event-related potential measurements were used to quantify facial emotional recognition and goal-directed behavior toward emotional cues.ResultsPsilocybin enhanced positive mood and attenuated recognition of negative facial expression. Furthermore, psilocybin increased goal-directed behavior toward positive compared with negative cues, facilitated positive but inhibited negative sequential emotional effects, and valence-dependently attenuated the P300 component. Ketanserin alone had no effects but blocked the psilocybin-induced mood enhancement and decreased recognition of negative facial expression.ConclusionsThis study shows that psilocybin shifts the emotional bias across various psychological domains and that activation of 5-HT2A receptors is central in mood regulation and emotional face recognition in healthy subjects. These findings may not only have implications for the pathophysiology of dysfunctional emotional biases but may also provide a framework to delineate the mechanisms underlying psylocybin's putative antidepressant effects.", "journal": "Biological Psychiatry", "publication_date": "2012-05-09", "publication_year": 2012, "doi": "10.1016/j.biopsych.2012.04.005", "pubmed_id": "22578254", "source_url": "https://doi.org/10.1016/j.biopsych.2012.04.005", "keywords": "Cerebral Cortex, Humans, Ketanserin, Receptors, Serotonin, Hallucinogens, Electroencephalography, Double-Blind Method, Emotions, Affect, Goals, Neuropsychological Tests, Evoked Potentials, Adult, Female, Male, Serotonin 5-HT2 Receptor Antagonists, Psilocybin, Recognition, Psychology", "substance_tags": "psilocybin", "source_name": "Europe PMC", "date_added": "2026-07-01 06:54:14", "last_checked": "2026-07-04 07:00:41", "raw_json": "{\"europe_pmc_id\":\"22578254\",\"source\":\"MED\",\"pub_type\":null,\"publisher\":null,\"importer\":\"Europe PMC\",\"openalex_enrichment\":{\"openalex_id\":\"https://openalex.org/W1974074998\",\"openalex_url\":\"https://openalex.org/W1974074998\",\"openalex_relevance_score\":6,\"openalex_relevance_reasons\":[\"title:psilocybin\",\"metadata:psilocybin\"],\"openalex_type\":\"article\",\"openalex_work_type\":null,\"cited_by_count\":299,\"referenced_works\":[\"https://openalex.org/W1607171655\",\"https://openalex.org/W1972426098\",\"https://openalex.org/W1972524714\",\"https://openalex.org/W1979086264\",\"https://openalex.org/W1981740630\",\"https://openalex.org/W1982282806\",\"https://openalex.org/W1990644324\",\"https://openalex.org/W1994271186\",\"https://openalex.org/W1994511912\",\"https://openalex.org/W1997058647\",\"https://openalex.org/W2000571766\",\"https://openalex.org/W2001854690\",\"https://openalex.org/W2002469918\",\"https://openalex.org/W2009122980\",\"https://openalex.org/W2014019620\",\"https://openalex.org/W2019885188\",\"https://openalex.org/W2020444257\",\"https://openalex.org/W2022816995\",\"https://openalex.org/W2026736418\",\"https://openalex.org/W2027680810\",\"https://openalex.org/W2034119223\",\"https://openalex.org/W2034860560\",\"https://openalex.org/W2036575795\",\"https://openalex.org/W2038593489\",\"https://openalex.org/W2039391993\",\"https://openalex.org/W2040285006\",\"https://openalex.org/W2040383829\",\"https://openalex.org/W2040624569\",\"https://openalex.org/W2042298460\",\"https://openalex.org/W2042593075\",\"https://openalex.org/W2043009728\",\"https://openalex.org/W2045618160\",\"https://openalex.org/W2055098509\",\"https://openalex.org/W2060926272\",\"https://openalex.org/W2067512259\",\"https://openalex.org/W2067901581\",\"https://openalex.org/W2068751924\",\"https://openalex.org/W2069947117\",\"https://openalex.org/W2071743179\",\"https://openalex.org/W2073547940\",\"https://openalex.org/W2073805480\",\"https://openalex.org/W2074739635\",\"https://openalex.org/W2075969679\",\"https://openalex.org/W2078806205\",\"https://openalex.org/W2083894864\",\"https://openalex.org/W2091600396\",\"https://openalex.org/W2103296974\",\"https://openalex.org/W2104640717\",\"https://openalex.org/W2105909330\",\"https://openalex.org/W2108384452\",\"https://openalex.org/W2115308878\",\"https://openalex.org/W2116650724\",\"https://openalex.org/W2123750279\",\"https://openalex.org/W2127699202\",\"https://openalex.org/W2134822928\",\"https://openalex.org/W2140443081\",\"https://openalex.org/W2141820378\",\"https://openalex.org/W2148905283\",\"https://openalex.org/W2149522089\",\"https://openalex.org/W2149823098\",\"https://openalex.org/W2150407416\",\"https://openalex.org/W2151985832\",\"https://openalex.org/W2153159895\",\"https://openalex.org/W2153590575\",\"https://openalex.org/W2157574960\",\"https://openalex.org/W2158718741\",\"https://openalex.org/W2161555895\",\"https://openalex.org/W2163431819\",\"https://openalex.org/W2170151899\",\"https://openalex.org/W2170904543\",\"https://openalex.org/W2970485787\",\"https://openalex.org/W3171418018\",\"https://openalex.org/W4211150788\",\"https://openalex.org/W4292994367\",\"https://openalex.org/W4294333904\",\"https://openalex.org/W7074234824\"],\"authorships\":[{\"id\":\"https://openalex.org/A5021802006\",\"display_name\":\"Michael Kometer\",\"orcid\":null},{\"id\":\"https://openalex.org/A5054234763\",\"display_name\":\"André Schmidt\",\"orcid\":\"https://orcid.org/0000-0001-6055-8397\"},{\"id\":\"https://openalex.org/A5022192518\",\"display_name\":\"Rosilla Bachmann\",\"orcid\":null},{\"id\":\"https://openalex.org/A5034712307\",\"display_name\":\"Erich Studerus\",\"orcid\":\"https://orcid.org/0000-0003-4233-0182\"},{\"id\":\"https://openalex.org/A5045362944\",\"display_name\":\"Erich Seifritz\",\"orcid\":\"https://orcid.org/0000-0002-7311-4426\"},{\"id\":\"https://openalex.org/A5086283052\",\"display_name\":\"Franz X. Vollenweider\",\"orcid\":\"https://orcid.org/0000-0001-9053-6164\"}],\"primary_location\":{\"source_id\":\"https://openalex.org/S205482884\",\"source_display_name\":\"Biological Psychiatry\",\"landing_page_url\":\"https://doi.org/10.1016/j.biopsych.2012.04.005\",\"is_oa\":false}}}", "topic_tags": "Depression,Mechanism of Action,Receptor Pharmacology,Emotional Processing", "study_type": "Clinical Trial", "hidden": 0, "false_positive": 0, "curation_notes": null, "merged_into_id": null, "curation_locked": 0, "publication_status": "published", "openalex_id": "https://openalex.org/W1974074998" }, { "id": 2624, "title": "The 5-HT2A/1A agonist psilocybin disrupts modal object completion associated with visual hallucinations.", "normalized_title": "the 5 ht2a 1a agonist psilocybin disrupts modal object completion associated with visual hallucinations", "authors": "Kometer M, Cahn BR, Andel D, Carter OL, Vollenweider FX.", "abstract": "BackgroundRecent findings suggest that the serotonergic system and particularly the 5-HT2A/1A receptors are implicated in visual processing and possibly the pathophysiology of visual disturbances including hallucinations in schizophrenia and Parkinson's disease.MethodsTo investigate the role of 5-HT2A/1A receptors in visual processing the effect of the hallucinogenic 5-HT2A/1A agonist psilocybin (125 and 250 μg/kg vs. placebo) on the spatiotemporal dynamics of modal object completion was assessed in normal volunteers (n = 17) using visual evoked potential recordings in conjunction with topographic-mapping and source analysis. These effects were then considered in relation to the subjective intensity of psilocybin-induced visual hallucinations quantified by psychometric measurement.ResultsPsilocybin dose-dependently decreased the N170 and, in contrast, slightly enhanced the P1 component selectively over occipital electrode sites. The decrease of the N170 was most apparent during the processing of incomplete object figures. Moreover, during the time period of the N170, the overall reduction of the activation in the right extrastriate and posterior parietal areas correlated positively with the intensity of visual hallucinations.ConclusionsThese results suggest a central role of the 5-HT2A/1A-receptors in the modulation of visual processing. Specifically, a reduced N170 component was identified as potentially reflecting a key process of 5-HT2A/1A receptor-mediated visual hallucinations and aberrant modal object completion potential.", "journal": "Biological Psychiatry", "publication_date": "2010-12-02", "publication_year": 2010, "doi": "10.1016/j.biopsych.2010.10.002", "pubmed_id": "21126732", "source_url": "https://doi.org/10.1016/j.biopsych.2010.10.002", "keywords": "Occipital Lobe, Visual Cortex, Humans, Parkinson Disease, Consciousness Disorders, Receptor, Serotonin, 5-HT1A, Receptor, Serotonin, 5-HT2A, Hallucinogens, Electroencephalography, Cluster Analysis, Photic Stimulation, Perceptual Closure, Reaction Time, Schizophrenia, Neuropsychological Tests, Psychometrics, Dose-Response Relationship, Drug, Adult, Female, Male, Serotonin Receptor Agonists, Psilocybin", "substance_tags": "psilocybin", "source_name": "Europe PMC", "date_added": "2026-07-01 06:54:14", "last_checked": "2026-07-04 07:00:41", "raw_json": "{\"europe_pmc_id\":\"21126732\",\"source\":\"MED\",\"pub_type\":null,\"publisher\":null,\"importer\":\"Europe PMC\",\"openalex_enrichment\":{\"openalex_id\":\"https://openalex.org/W2038593489\",\"openalex_url\":\"https://openalex.org/W2038593489\",\"openalex_relevance_score\":6,\"openalex_relevance_reasons\":[\"title:psilocybin\",\"metadata:psilocybin\"],\"openalex_type\":\"article\",\"openalex_work_type\":null,\"cited_by_count\":101,\"referenced_works\":[\"https://openalex.org/W245658\",\"https://openalex.org/W56041172\",\"https://openalex.org/W1578550907\",\"https://openalex.org/W1676514359\",\"https://openalex.org/W1966203834\",\"https://openalex.org/W1966928238\",\"https://openalex.org/W1967630951\",\"https://openalex.org/W1969273085\",\"https://openalex.org/W1969549633\",\"https://openalex.org/W1976837885\",\"https://openalex.org/W1986425243\",\"https://openalex.org/W1987088819\",\"https://openalex.org/W1995045083\",\"https://openalex.org/W1997058647\",\"https://openalex.org/W2000127039\",\"https://openalex.org/W2004172377\",\"https://openalex.org/W2008292361\",\"https://openalex.org/W2009122980\",\"https://openalex.org/W2009134620\",\"https://openalex.org/W2011974485\",\"https://openalex.org/W2020770340\",\"https://openalex.org/W2022044536\",\"https://openalex.org/W2024942419\",\"https://openalex.org/W2026136738\",\"https://openalex.org/W2035398019\",\"https://openalex.org/W2036060834\",\"https://openalex.org/W2042593075\",\"https://openalex.org/W2042899905\",\"https://openalex.org/W2044210895\",\"https://openalex.org/W2048509938\",\"https://openalex.org/W2054831953\",\"https://openalex.org/W2055389171\",\"https://openalex.org/W2069168835\",\"https://openalex.org/W2072968427\",\"https://openalex.org/W2086590261\",\"https://openalex.org/W2087200563\",\"https://openalex.org/W2088475367\",\"https://openalex.org/W2094277538\",\"https://openalex.org/W2096610047\",\"https://openalex.org/W2098418070\",\"https://openalex.org/W2099239993\",\"https://openalex.org/W2101430675\",\"https://openalex.org/W2106959550\",\"https://openalex.org/W2107394985\",\"https://openalex.org/W2107505948\",\"https://openalex.org/W2114789681\",\"https://openalex.org/W2125671859\",\"https://openalex.org/W2130031954\",\"https://openalex.org/W2133410812\",\"https://openalex.org/W2134498737\",\"https://openalex.org/W2135719514\",\"https://openalex.org/W2135861595\",\"https://openalex.org/W2138790588\",\"https://openalex.org/W2139276378\",\"https://openalex.org/W2144806037\",\"https://openalex.org/W2146175554\",\"https://openalex.org/W2155690750\",\"https://openalex.org/W2155757287\",\"https://openalex.org/W2157551763\",\"https://openalex.org/W2162054698\",\"https://openalex.org/W2162792044\",\"https://openalex.org/W2163813092\",\"https://openalex.org/W2401157625\",\"https://openalex.org/W2764423798\",\"https://openalex.org/W4211150788\",\"https://openalex.org/W6600012500\"],\"authorships\":[{\"id\":\"https://openalex.org/A5021802006\",\"display_name\":\"Michael Kometer\",\"orcid\":null},{\"id\":\"https://openalex.org/A5018321179\",\"display_name\":\"B. Rael Cahn\",\"orcid\":\"https://orcid.org/0000-0003-1949-0647\"},{\"id\":\"https://openalex.org/A5054829951\",\"display_name\":\"David Andel\",\"orcid\":null},{\"id\":\"https://openalex.org/A5060157509\",\"display_name\":\"Olivia Carter\",\"orcid\":\"https://orcid.org/0000-0001-7708-6154\"},{\"id\":\"https://openalex.org/A5086283052\",\"display_name\":\"Franz X. Vollenweider\",\"orcid\":\"https://orcid.org/0000-0001-9053-6164\"}],\"primary_location\":{\"source_id\":\"https://openalex.org/S205482884\",\"source_display_name\":\"Biological Psychiatry\",\"landing_page_url\":\"https://doi.org/10.1016/j.biopsych.2010.10.002\",\"is_oa\":false}}}", "topic_tags": "Receptor Pharmacology,Consciousness", "study_type": "Other", "hidden": 0, "false_positive": 0, "curation_notes": null, "merged_into_id": null, "curation_locked": 0, "publication_status": "published", "openalex_id": "https://openalex.org/W2038593489" } ] }