Phase 1 Psilocybin Clinical Trials

CompletedNCT06835699

Open Label Psilocybin Brain Stimulation and Imaging Pilot Study

Johns Hopkins University

Conditions

Healthy Volunteers

Phase

Phase 1

Enrollment

10 actual

Locations

Johns Hopkins School of Medicine, Baltimore, Maryland, United States

Registry updated

2026-08-07

Open registry recordTracker record

Not yet recruitingNCT07406828

Single Dose Psilocybin for a Post-surgical Trauma Inpatient Population for Pain, Mood, and Opioid Use Disorder

Trent Emerick

Conditions

Pain Management · Postoperative Pain

Phase

Phase 1

Enrollment

70 estimated

Locations

UPMC Presbyterian, Pittsburgh, Pennsylvania, United States

Registry updated

2026-08-06

Open registry recordTracker record

Active, not recruitingNCT06731621

Psilocybin for Treatment-Resistant Depression in Autism: a Pilot Trial With Pre-Post Brain and Cognitive Measurement to Understand Mechanism

Centre for Addiction and Mental Health

Conditions

Treatment Resistant Depression · Autism Spectrum Disorder

Phase

Phase 1

Enrollment

20 estimated

Locations

Centre for Addiction and Mental Health, Toronto, Ontario, Canada

Registry updated

2026-08-06

Open registry recordTracker record

Not yet recruitingNCT06988319

Psilocybin for Chronic Pelvic Pain (CPP) in Women: A Pilot Feasibility Study

Oregon Health and Science University

Conditions

Chronic Pelvic Pain

Phase

Phase 1

Enrollment

15 estimated

Locations

Oregon Health & Science University, Portland, Oregon, United States

Registry updated

2026-08-03

Open registry recordTracker record

Active, not recruitingNCT07275970

An Open-Label, Phase 1 Study of the Safety Pharmacokinetic Profile, and Preliminary Efficacy, of Organic Whole Psilocybin-Containing Mushrooms in Patients Suffering From PTSD

Scottsdale Research Institute

Conditions

PTSD

Phase

Phase 1

Enrollment

24 estimated

Locations

Scottsdale Research Institute, Scottsdale, Arizona, United States

Registry updated

2026-07-29

Open registry recordTracker record

RecruitingNCT05866471

Activating Neuroplasticity to ENHANCE the Perception Box Expanding Effects of Psilocybin

University of Wisconsin, Madison

Conditions

Healthy · Psychedelic Experiences · Vagus Nerve Stimulation

Phase

Phase 1

Enrollment

108 estimated

Locations

University of Wisconsin - Madison, Madison, Wisconsin, United States

Registry updated

2026-07-29

Open registry recordTracker record

Active, not recruitingNCT06299319

Evaluating the Feasibility, Clinical Effects, and Safety of Psilocybin-assisted Psychotherapy for Treatment-resistant Obsessive-compulsive Disorder: An Open-label Clinical Trial

Centre for Addiction and Mental Health

Conditions

Obsessive-Compulsive Disorder

Phase

Phase 1

Enrollment

10 estimated

Locations

Centre for Addiction and Mental Health, Toronto, Ontario, Canada

Registry updated

2026-07-28

Open registry recordTracker record

Not yet recruitingNCT07719088

An Examination of Psilocybin Effects on Biomarkers of Longevity, Healthy Aging, and Purpose in Life

Charles Raison

Conditions

Aging · Longevity · Biomarkers of Aging

Phase

Phase 1

Enrollment

50 estimated

Locations

Vail Health Behavioral Health, Edwards, Colorado, United States

Registry updated

2026-07-24

Open registry recordTracker record

RecruitingNCT06355414

Psilocybin and Affective Function in Chronic Lower Back Pain Depression

Johns Hopkins University

Conditions

Chronic Low-back Pain · Depression

Phase

Phase 1

Enrollment

40 estimated

Locations

Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

Registry updated

2026-07-24

Open registry recordTracker record

RecruitingNCT07347405

A Randomized Double-masked Dose-controlled Trial to Assess the Tolerability, Safety, Subjective Experience, and Efficacy of Repeated Administration of Three Different Doses of Psilocybin Whole Mushroom for the Treatment of Obsessive-compulsive Disorder.

Francisco A Moreno

Conditions

Obsessive-Compulsive Disorder

Phase

Phase 1

Enrollment

30 estimated

Locations

The Clinical and Translational Sciences Research Center, Tucson, Arizona, United States

Registry updated

2026-07-23

Open registry recordTracker record

RecruitingNCT05301608

Effects of Psilocybin on Electrophysiology and the Dynamic Content of Thought

Johns Hopkins University

Conditions

Healthy

Phase

Phase 1 · Phase 2

Enrollment

30 estimated

Locations

Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland, United States

Registry updated

2026-07-23

Open registry recordTracker record

RecruitingNCT07610135

PRISMatic: A Phase 1b Randomized, Double-Armed, Parallel-Group, Placebo-Controlled Trial of Psilocybin Efficacy With or Without Pimavanserin Pretreatment

Johns Hopkins University

Conditions

Mood (Psychological Function) · Well Being · Mood · Healthy

Phase

Phase 1 · Phase 2

Enrollment

20 estimated

Locations

Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland, United States

Registry updated

2026-07-21

Open registry recordTracker record

RecruitingNCT06814522

Psilocybin-Assisted Therapy for Physician Well-Being and Burnout: Feasibility, Safety, Clinical Effectiveness and Biomarkers of Response [PAT-B (Psilocybin-Assisted Therapy for Physician Well-Being and Burnout)]

University of California, San Diego

Conditions

Burnout · Burnout, Healthcare Workers

Phase

Phase 1 · Phase 2

Enrollment

10 estimated

Locations

UC San Diego, San Diego, California, United States

Registry updated

2026-07-21

Open registry recordTracker record

CompletedNCT07710027

A Randomized, Double-Blind, Single Ascending Dose Study to Identify a Safe and Non-Psychedelic Dose of Psilocybin

Diamond Therapeutics Inc.

Conditions

Healthy Controls

Phase

Phase 1

Enrollment

56 actual

Locations

BioPharma Services Inc., Toronto, Ontario, Canada

Registry updated

2026-07-17

Open registry recordTracker record

Active, not recruitingNCT04754061

PSilocybin for psYCHological and Existential Distress in PALliative Care (PSYCHED-PAL): A Multi-site, Open-label, Single Arm Phase I/II Proof-of-concept, Dose-finding, and Feasibility Clinical Trial

Ottawa Hospital Research Institute

Conditions

Depression, Anxiety · Distress, Emotional

Phase

Phase 1 · Phase 2

Enrollment

20 estimated

Locations

The Ottawa Hospital, Ottawa, Ontario, Canada · Bruyere Continuing Care, Ottawa, Ontario, Canada

Registry updated

2026-07-10

Open registry recordTracker record

RecruitingNCT05265546

Investigating the Mechanisms of the Effects of Psilocybin on Visual Perception and Visual Representations in the Brain

University of California, Berkeley

Conditions

Perception Disorders

Phase

Phase 1

Enrollment

80 estimated

Locations

University of California, Berkeley, Berkeley, California, United States

Registry updated

2026-07-10

Open registry recordTracker record

Not yet recruitingNCT07693153

The Effects of Psilocybin on Social Connectedness

Yale University

Conditions

Loneliness · Grief

Phase

Phase 1

Enrollment

51 estimated

Locations

Connecticut Mental Health Center, New Haven, Connecticut, United States

Registry updated

2026-07-09

Open registry recordTracker record

RecruitingNCT04161066

Phase I Study of the Safety and Adjunctive Effects of Psilocybin in Adults With Opioid Use Disorder Maintained on a Buprenorphine/Naloxone Formulation

University of Wisconsin, Madison

Conditions

Opioid Use Disorder

Phase

Phase 1

Enrollment

10 estimated

Locations

University of Wisconsin, Madison, Wisconsin, United States

Registry updated

2026-07-07

Open registry recordTracker record

RecruitingNCT06160284

Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD)

Yale University

Conditions

Opioid Use Disorder

Phase

Phase 1

Enrollment

12 estimated

Locations

Yale University, New Haven, Connecticut, United States

Registry updated

2026-07-07

Open registry recordTracker record

RecruitingNCT07516405

A Multicenter Phase 1 Safety and Tolerability Trial of Psilocybin in Healthy Older Adults

University of Colorado, Denver

Conditions

Healthy Volunteer · Older Adults (65-85 Years)

Phase

Phase 1

Enrollment

40 estimated

Locations

University of California San Francisco (UCSF) Department of Neurology, San Francisco, California, United States · University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States · Emory University Brain Health Center, Atlanta, Georgia, United States · +3 more

Registry updated

2026-07-06

Open registry recordTracker record

Not yet recruitingNCT07360301

Consciousness and Psilocybin Effects on Well-Being: The CoPEWell Study

University of Wisconsin, Madison

Conditions

Well-Being, Psychological · Psychedelic Experiences

Phase

Phase 1

Enrollment

120 estimated

Locations

University of Wisconsin, Madison, Wisconsin, United States

Registry updated

2026-07-02

Open registry recordTracker record

CompletedNCT06884514

Acute Effects of MDMA Co-administration on the Response to Psilocybin in Healthy Subjects

University Hospital, Basel, Switzerland

Conditions

Healthy

Phase

Phase 1

Enrollment

24 actual

Locations

University Hospital Basel, Basel, Switzerland

Registry updated

2026-06-25

Open registry recordTracker record

Active, not recruitingNCT06407635

Psilocybin for PTSD With or Without Psychotherapy: A Pilot Study of Safety and Efficacy

Johns Hopkins University

Conditions

Post Traumatic Stress Disorder

Phase

Phase 1

Enrollment

20 estimated

Locations

Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland, United States

Registry updated

2026-06-22

Open registry recordTracker record

Not yet recruitingNCT07079852

The Acute Effects of Psilocybin on Cognition, Memory, and Brain Function

Manoj Doss

Conditions

Healthy

Phase

Phase 1 · Phase 2

Enrollment

48 estimated

Locations

The University of Texas at Austin Dell Medical School, Austin, Texas, United States

Registry updated

2026-06-15

Open registry recordTracker record

RecruitingNCT07386730

A Double Blind, Randomized Trial Investigating the Safety, Feasibility, and Mechanisms of Psychedelics in Healthy Older Adults With Low Well-being as Moderated by Biomarkers for Preclinical Alzheimer's Disease

Jennifer Mitchell

Conditions

Anhedonia in Healthy Volunteers · Older Adults (50-90 Years)

Phase

Phase 1

Enrollment

80 estimated

Locations

University of California San Francisco, Sandler Neuroscience Building, San Francisco, California, United States

Registry updated

2026-06-08

Open registry recordTracker record

Active, not recruitingNCT05698511

Multivariate Neural and Physiological Correlates of Psychedelic Sub-states: a Within-subjects, Healthy Volunteer Study With Experience-sampling

Robin Carhart-Harris, PhD, MA

Conditions

Psychedelic Experiences · Neuroimaging · Healthy Volunteers

Phase

Phase 1

Enrollment

12 estimated

Locations

University of California, San Francisco, San Francisco, California, United States

Registry updated

2026-06-05

Open registry recordTracker record

Active, not recruitingNCT05370911

Effects of Repeated Dosing of Psilocybin on Obsessive-Compulsive Disorder: A Randomized, Waitlist-Controlled Study

Yale University

Conditions

Obsessive-Compulsive Disorder

Phase

Phase 1

Enrollment

28 actual

Locations

Enact Research Collaborative (40 Temple St, 4th Floor), New Haven, Connecticut, United States · Yale Program for Psychedelic Research, New Haven, Connecticut, United States

Registry updated

2026-06-04

Open registry recordTracker record

Not yet recruitingNCT07607938

Targeting Reward Circuits: Psilocybin as a Novel Therapy for Residual Anhedonia

NYU Langone Health

Conditions

Anhedonia · Emotional Blunting

Phase

Phase 1

Enrollment

90 estimated

Locations

NYU Langone Health, New York, New York, United States

Registry updated

2026-05-27

Open registry recordTracker record

RecruitingNCT07506395

Group Psilocybin-Assisted Therapy for Post-Traumatic Stress Disorder

University of New Mexico

Conditions

PTSD

Phase

Phase 1

Enrollment

36 estimated

Locations

Interdisciplinary Substance Use and Brain Injury (ISUBI), Albuquerque, New Mexico, United States

Registry updated

2026-05-22

Open registry recordTracker record

CompletedNCT05227612

Psilocybin-assisted Cognitive Behavioral Therapy for Depression

University of California, Los Angeles

Conditions

Major Depressive Disorder

Phase

Phase 1

Enrollment

16 actual

Locations

UCLA Semel Institute, Los Angeles, California, United States

Registry updated

2026-05-19

Open registry recordTracker record

Not yet recruitingNCT06992999

Psilocybin for Treatment of Obsessive Compulsive Disorder

Francisco A Moreno

Conditions

Obsessive - Compulsive Disorder

Phase

Phase 1 · Phase 2

Enrollment

20 estimated

Locations

University of Arizona-Tucson, Tucson, Arizona, United States

Registry updated

2026-05-12

Open registry recordTracker record

TerminatedNCT05322954

Safety and Feasibility of Psilocybin in Methamphetamine Use Disorder in a Community-Based Sample

University of Wisconsin, Madison

Conditions

Methamphetamine Use Disorder · Substance-Related Disorders · Chemically-Induced Disorders · Substance Use Disorders

Phase

Phase 1

Enrollment

5 actual

Locations

University of Wisconsin, Madison, Wisconsin, United States

Registry updated

2026-05-12

Open registry recordTracker record

Active, not recruitingNCT05220046

An Exploratory Pilot Study of Palliadelic Treatment to Reduce Psychological Distress in People With Pancreatobiliary and Other Advanced Gastrointestinal Cancers

University of Nebraska

Conditions

Pancreas Cancer · Biliary Tract Cancer · Psychological Distress · Gastrointestinal Cancer

Phase

Phase 1

Enrollment

24 estimated

Locations

University of Nebraska Medical Center, Omaha, Nebraska, United States

Registry updated

2026-05-06

Open registry recordTracker record

RecruitingNCT07251491

Safety, Tolerability, Outcomes of Psilocybin for Depression (STOP Depression) in Veterans With Spinal Cord Injury

James J. Peters Veterans Affairs Medical Center

Conditions

Spinal Cord Injury · Depression - Major Depressive Disorder · Veteran

Phase

Phase 1 · Phase 2

Enrollment

30 estimated

Locations

James J. Peters Department of Veterans Affairs Medical Center, The Bronx, New York, United States

Registry updated

2026-05-04

Open registry recordTracker record

Active, not recruitingNCT05351541

A Double-blind, Randomized Trial Examining the Preliminary Efficacy of Psilocybin Therapy for People With Chronic Low Back Pain

Joshua Woolley, MD, PhD

Conditions

Chronic Low-back Pain

Phase

Phase 1 · Phase 2

Enrollment

30 estimated

Locations

University of California San Francisco, San Francisco, California, United States

Registry updated

2026-04-29

Open registry recordTracker record

Active, not recruitingNCT04982796

Psilocybin-Enhanced Psychotherapy for Methamphetamine Use Disorder

Portland VA Research Foundation, Inc

Conditions

Amphetamine-Related Disorders

Phase

Phase 1 · Phase 2

Enrollment

30 estimated

Locations

Portland VA Health Care System, Vancouver, Washington, United States

Registry updated

2026-04-22

Open registry recordTracker record

RecruitingNCT06430541

Study of Psilocybin Assisted Psychotherapy to Address Fear of Recurrence in Patients Diagnosed With Early-stage Breast Cancer and Ovarian Cancer in Remission

University of Colorado, Denver

Conditions

Breast Cancer · Ovarian Cancer

Phase

Phase 1

Enrollment

20 estimated

Locations

Outpatient CTRC, Aurora, Colorado, United States · University of Colorado Cancer Center, Aurora, Colorado, United States

Registry updated

2026-04-21

Open registry recordTracker record

RecruitingNCT06692192

Role of Experience, Conscious Awareness, and Plasticity in Psilocybin's Behavioral Effects - Follow-Up Study (The RECAP 2 Study)

University of Wisconsin, Madison

Conditions

Psilocybin

Phase

Phase 1

Enrollment

60 estimated

Locations

UW School of Medicine and Public Health, Madison, Wisconsin, United States

Registry updated

2026-04-03

Open registry recordTracker record

CompletedNCT06180759

Acute Analgesic Effects of DMT on Experimentally Induced Acute Nociceptive Pain, Hyperalgesia and Allodynia in Healthy Participants

University Hospital, Basel, Switzerland

Conditions

Healthy

Phase

Phase 1

Enrollment

17 actual

Locations

Clinical Pharmacology & Toxicology, University Hospital Basel, Basel, Basel, Switzerland

Registry updated

2026-04-02

Open registry recordTracker record

Not yet recruitingNCT07499583

Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder

Indiana University

Conditions

Treatment Resistant Depression · Substance Use Disorders

Phase

Phase 1 · Phase 2

Enrollment

50 estimated

Locations

Goodman Hall, Dept of Psychiatry, Indiana University, Indianapolis, Indiana, United States · The Stark Neuroscience Building (Goodman Hall), Indianapolis, Indiana, United States

Registry updated

2026-03-30

Open registry recordTracker record

RecruitingNCT06898606

Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression

Federal University of Latin American Integration

Conditions

Depressive Disorder

Phase

Phase 1 · Phase 2

Enrollment

24 estimated

Locations

Federal University of Latin American Integration, Foz do Iguaçu, Paraná, Brazil

Registry updated

2026-03-27

Open registry recordTracker record

RecruitingNCT07490353

Elucidating the Relevance of the Psychedelic Experience to Psilocybin's Anti-Anhedonic Effects: A Randomized, Open-Label, Cross-Over Functional Magnetic Resonance Imaging Trial

Medical University of Vienna

Conditions

Depression - Major Depressive Disorder · Anhedonia

Phase

Phase 1

Enrollment

85 estimated

Locations

Medical University of Vienna, Department of Psychiatry and Psychotherapy, Division of General Psychiatry, Vienna, State of Vienna, Austria

Registry updated

2026-03-24

Open registry recordTracker record

RecruitingNCT06660381

Pilot Study of Psilocybin-assisted Treatment for Cannabis Use Disorder

Johns Hopkins University

Conditions

Cannabis Use Disorder

Phase

Phase 1

Enrollment

12 estimated

Locations

Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland, United States

Registry updated

2026-03-18

Open registry recordTracker record

RecruitingNCT06818994

Safety and Efficacy of Psilocybin-assisted Psychotherapy for Demoralization Syndrome in Patients Diagnosed With Advanced Stage Cancer: a Pilot Study

Gustavo Vazquez

Conditions

Demoralization · Safety

Phase

Phase 1

Enrollment

15 estimated

Locations

Queen's University, Kingston, Ontario, Canada

Registry updated

2026-03-18

Open registry recordTracker record

RecruitingNCT06442423

Safety, Feasibility, and Tolerability of Psilocybin Treatment for Individuals With Functional Impairment Related to Mood, Anxiety, Trauma and/or Addiction Symptoms: An Open-label Proof-of-concept Study

Yale University

Conditions

Transdiagnostic · Depression - Major Depressive Disorder · Anxiety · PTSD Symptoms

Phase

Phase 1

Enrollment

50 estimated

Locations

Connecticut Mental Health Center - Yale School of Medicine, New Haven, Connecticut, United States

Registry updated

2026-03-11

Open registry recordTracker record

Not yet recruitingNCT07433452

The Effects of Psilocybin in Healthy Volunteers: Psychological, Biochemical and Electrophysiological Biomarkers.

Gabriella Gobbi

Conditions

Healthy Participants · Placebo - Control · Psilocybin

Phase

Phase 1

Enrollment

50 estimated

Locations

No mapped site reported

Registry updated

2026-02-25

Open registry recordTracker record

RecruitingNCT06450210

Safety for Home Administration of Microdose Psilocybin Use

Johns Hopkins University

Conditions

Psychedelic Experiences

Phase

Phase 1

Enrollment

20 estimated

Locations

5510 Nathan Shock Drive, Baltimore, Maryland, United States

Registry updated

2026-02-23

Open registry recordTracker record

RecruitingNCT06772753

Investigation of Psychedelic Effects in Psychoactive Substances

Johns Hopkins University

Conditions

Psychedelic Effects in Healthy Volunteers

Phase

Phase 1

Enrollment

50 estimated

Locations

Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland, United States

Registry updated

2026-02-23

Open registry recordTracker record

CompletedNCT07050368

A Phase 1 Translational Study to Assess Brain Activity Using Functional Magnetic Resonance Imaging (fMRI) and to Evaluate the Safety, Tolerability, and Pharmacokinetics of Multiple Doses of MLS101 (Psilocybin) in Healthy Volunteers

MycoMedica Life Sciences PBC

Conditions

Healthy Volunteer

Phase

Phase 1

Enrollment

20 actual

Locations

Hammersmith Medicines Research (HMR), London, United Kingdom

Registry updated

2026-02-13

Open registry recordTracker record

RecruitingNCT07053917

Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability

Johns Hopkins University

Conditions

Stroke · Chronic Stroke · Intracerebral Haemorrhage · Intracerebral Haemorrhage (ICH)

Phase

Phase 1

Enrollment

20 estimated

Locations

Johns Hopkins, Baltimore, Maryland, United States

Registry updated

2026-02-13

Open registry recordTracker record

RecruitingNCT07281352

Psilocybin-Assisted Cognitive Behavioral Therapy for Depression

University of California, Los Angeles

Conditions

Major Depressive Diorder

Phase

Phase 1 · Phase 2

Enrollment

50 estimated

Locations

UCLA Semel Institute, Los Angeles, California, United States

Registry updated

2026-02-12

Open registry recordTracker record

RecruitingNCT07079930

Safety and Psychological Effects of Psilocybin and D-Serine Formulation in Healthy Volunteers

Hadassah Medical Organization

Conditions

Healthy Volunteers

Phase

Phase 1

Enrollment

10 estimated

Locations

Hadassah Medical Organization, Jerusalem, Israel, Jerusalem, Israel

Registry updated

2026-02-05

Open registry recordTracker record

CompletedNCT05224336

Behavioral and Neural Mechanisms Supporting Psilocybin-assisted Therapy for Phantom Limb Pain

University of California, San Diego

Conditions

Phantom Limb Pain

Phase

Phase 1

Enrollment

10 actual

Locations

University of California, San Diego, San Diego, California, United States

Registry updated

2026-01-09

Open registry recordTracker record

RecruitingNCT06615908

A Randomized Double-blinded Controlled Trial for the Treatment of Persisting Symptoms After Concussion With Psilocybin-assisted Therapy: A Safety and Feasibility Trial

University of Calgary

Conditions

Persisting Symptoms After Concussion

Phase

Phase 1

Enrollment

40 estimated

Locations

University of Calgary, Calgary, Alberta, Canada

Registry updated

2025-12-30

Open registry recordTracker record

RecruitingNCT06815653

Digital Intervention for Psychedelic Preparation (DIPP): A Randomised Controlled Feasibility Trial Comparing Meditation and Music-Based Programs in Healthy Volunteers.

University College, London

Conditions

Healthy

Phase

Phase 1

Enrollment

40 estimated

Locations

University College London, London, United Kingdom

Registry updated

2025-11-26

Open registry recordTracker record

CompletedNCT06081179

Does Serotonin System Stimulation Increase Pro-social Behavior? - A Comparative Pharmacological Neuroscientific Study in Healthy Humans

University of Zurich

Conditions

Healthy

Phase

Phase 1

Enrollment

122 actual

Locations

Psychiatrische Universitätsklinik Zürich, Zurich, Canton of Zurich, Switzerland

Registry updated

2025-11-19

Open registry recordTracker record

Active, not recruitingNCT03554174

Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder

Yale University

Conditions

Major Depressive Disorder

Phase

Phase 1

Enrollment

18 estimated

Locations

VA Connecticut Healthcare System, West Haven Campus, West Haven, Connecticut, United States

Registry updated

2025-11-05

Open registry recordTracker record

CompletedNCT05847686

A Phase 1/2 Study of a Group Model of Psilocybin-Assisted Therapy for Cancer-Related Anxiety in Patients With Metastatic Cancer

University of Washington

Conditions

Hematopoietic and Lymphatic System Neoplasm · Metastatic Malignant Solid Neoplasm

Phase

Phase 1 · Phase 2

Enrollment

55 actual

Locations

Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington, United States

Registry updated

2025-11-05

Open registry recordTracker record

RecruitingNCT06367738

Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults

University of California, Berkeley

Conditions

Aging

Phase

Phase 1

Enrollment

40 estimated

Locations

University of California, Berkeley, Berkeley, California, United States

Registry updated

2025-10-21

Open registry recordTracker record

CompletedNCT06644170

A Phase 1 Study of a Second Psilocybin Group Retreat for Partial Responders With Anxiety Associated With Metastatic Cancer

University of Washington

Conditions

Hematopoietic and Lymphatic System Neoplasm · Metastatic Malignant Solid Neoplasm

Phase

Phase 1

Enrollment

15 actual

Locations

Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington, United States

Registry updated

2025-10-14

Open registry recordTracker record

RecruitingNCT06989957

Psilocybin and MDMA for Post-traumatic Stress Disorder (PTSD)

Johns Hopkins University

Conditions

Posttraumatic Stress Disorder

Phase

Phase 1

Enrollment

40 estimated

Locations

Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland, United States

Registry updated

2025-10-01

Open registry recordTracker record

Enrolling by invitationNCT07180108

PRoMiSS: Psilocybin and the Role of Music in Set and Setting

Johns Hopkins University

Conditions

Psilocybin · Music Intervention

Phase

Phase 1

Enrollment

100 estimated

Locations

Center for Psychedelics and Consciousness Research in the Behavioral Biology Research Center, Baltimore, Maryland, United States

Registry updated

2025-09-18

Open registry recordTracker record

CompletedNCT05305105

Effects of Psilocybin in Post-Treatment Lyme Disease

Johns Hopkins University

Conditions

Post-Treatment Lyme Disease · Chronic Lyme Disease · Lyme Disease, Chronic

Phase

Phase 1

Enrollment

20 actual

Locations

Behavioral Pharmacology Research Unit, Baltimore, Maryland, United States

Registry updated

2025-08-20

Open registry recordTracker record

CompletedNCT05506982

The Safety, Feasibility, and Acceptability of Psilocybin Combined With Multidisciplinary Palliative Care in Demoralized Cancer Survivors With Chronic Pain (P-PC)

Emory University

Conditions

Hematopoietic and Lymphoid Cell Neoplasm · Malignant Solid Neoplasm

Phase

Phase 1

Enrollment

11 actual

Locations

Emory University/Winship Cancer Institute, Atlanta, Georgia, United States · Brain Health Center at Executive Park, Atlanta, Georgia, United States

Registry updated

2025-07-23

Open registry recordTracker record

TerminatedNCT04424225

Visual Surround Suppression and Perceptual Expectation Under Psilocybin

University of Minnesota

Conditions

Perception Disturbance · Visual Suppression · Psychedelic Experiences

Phase

Phase 1

Enrollment

10 actual

Locations

University of Minnesota, Minneapolis, Minnesota, United States

Registry updated

2025-06-27

Open registry recordTracker record

CompletedNCT06643637

A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Multiple Doses of MLS101 (Psilocybin) in Healthy Participants

MycoMedica Life Sciences PBC

Conditions

Healthy Volunteers

Phase

Phase 1

Enrollment

16 actual

Locations

CMAX Clinical Research, Adelaide, South Australia, Australia

Registry updated

2025-06-12

Open registry recordTracker record

Active, not recruitingNCT05317689

Comparison of the Effects of PEX20 (Oral Psilocin), PEX30 (Sublingual Psilocin), and PEX10 (Oral Psilocybin) in Healthy Adults

University of California, San Francisco

Conditions

Healthy

Phase

Phase 1

Enrollment

20 estimated

Locations

University of California, San Francisco, San Francisco, California, United States

Registry updated

2025-06-10

Open registry recordTracker record

Enrolling by invitationNCT06919640

Psilocybin With Intracranial Neural Sensing

Joshua Woolley, MD, PhD

Conditions

Chronic Pain

Phase

Phase 1

Enrollment

20 estimated

Locations

University of California, San Francisco, San Francisco, California, United States

Registry updated

2025-06-06

Open registry recordTracker record

RecruitingNCT06796361

Role of the Serotonin 2A Receptor in Psilocybin-induced Altered States of Consciousness (PDR-Study)

University Hospital, Basel, Switzerland

Conditions

Healthy

Phase

Phase 1

Enrollment

16 estimated

Locations

Clinical Trial Unit, Basel, Canton of Basel-City, Switzerland

Registry updated

2025-05-28

Open registry recordTracker record

CompletedNCT05592379

Consciousness and Psilocybin Effects on Well-Being (The CoPE Study): Pilot Phase

University of Wisconsin, Madison

Conditions

Healthy · Psychedelic Experiences · Sleep

Phase

Phase 1

Enrollment

6 actual

Locations

University of Wisconsin Hospital and Clinics, Madison, Wisconsin, United States

Registry updated

2025-05-16

Open registry recordTracker record

CompletedNCT05695495

Acute Dose-dependent Effects of DMT-bolus Applications in Healthy Subjects: A Placebo-controlled Cross-over Study (DMT BDR-Study).

University Hospital, Basel, Switzerland

Conditions

Healthy

Phase

Phase 1

Enrollment

36 actual

Locations

Clinical Pharmacology & Toxicology, University Hospital Basel, Basel, Switzerland

Registry updated

2025-04-11

Open registry recordTracker record

RecruitingNCT06899334

Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in a Randomized, Placebo-controlled, Cross-over Trial in Healthy Participants (LPD-Study)

University Hospital, Basel, Switzerland

Conditions

Healthy

Phase

Phase 1

Enrollment

24 estimated

Locations

University Hospital, Basel, Switzerland

Registry updated

2025-03-27

Open registry recordTracker record

CompletedNCT06252506

Molecular Imaging Study of Harmine/DMT: a Basic Research Approach

Insel Gruppe AG, University Hospital Bern

Conditions

Neuropharmacological Investigation of Ayahuasca Constituents DMT and Harmine

Phase

Phase 1

Enrollment

17 actual

Locations

Department of Nuclear Medicine, Bern University Hospital, Bern, Switzerland · Psychiatric University Hospital Zurich, Zurich, Switzerland

Registry updated

2025-03-19

Open registry recordTracker record

CompletedNCT00302744

Effects of Psilocybin in Advanced-Stage Cancer Patients With Anxiety

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

Conditions

Anxiety

Phase

Phase 1 · Phase 2

Enrollment

12 actual

Locations

Harbor-UCLA Medical Center, Torrance, California, United States

Registry updated

2025-03-13

Open registry recordTracker record

CompletedNCT05523401

Acute Effects of 2C-B Compared With MDMA and Psilocybin in Healthy Subjects

University Hospital, Basel, Switzerland

Conditions

Healthy

Phase

Phase 1

Enrollment

24 actual

Locations

University Hospital Basel, Basel, Switzerland

Registry updated

2025-03-05

Open registry recordTracker record

RecruitingNCT03289949

The Neurobiological Effect of 5-HT2AR Modulation

Gitte Moos Knudsen

Conditions

Basic Science

Phase

Phase 1

Enrollment

200 estimated

Locations

Neurobiology Research Unit, Rigshospitalet, Copenhagen, Denmark

Registry updated

2024-12-16

Open registry recordTracker record

CompletedNCT03356483

Psilocybin Treatment in Obsessive-Compulsive Disorder: a Preliminary Efficacy Study and Exploratory Investigation of Neural Correlates.

Yale University

Conditions

Obsessive-Compulsive Disorder

Phase

Phase 1

Enrollment

31 actual

Locations

Connecticut Mental Health Center, New Haven, Connecticut, United States

Registry updated

2024-11-20

Open registry recordTracker record

CompletedNCT05557643

PAPR: Psilocybin-assisted Psychotherapy + Mindfulness-Based Stress Reduction (MBSR) for Front-line Healthcare Provider COVID-19 Related Burnout

University of Utah

Conditions

Depression · Burnout, Professional

Phase

Phase 1

Enrollment

24 actual

Locations

Huntsman Mental Health Institute, Salt Lake City, Utah, United States

Registry updated

2024-11-12

Open registry recordTracker record

CompletedNCT06258031

PsilOCD: Evaluating the Effects of the 5-HT2A Agonist Psilocybin on the Neurocognitive and Clinical Correlates of Compulsivity (A Pharmacological-Challenge Feasibility Study)

Imperial College London

Conditions

Obsessive-Compulsive Disorder

Phase

Phase 1

Enrollment

19 actual

Locations

CIPPRes Clinic, London, United Kingdom

Registry updated

2024-11-06

Open registry recordTracker record

RecruitingNCT06506019

Neurobiological Effects of Psilocybin in Treatment Resistant Bipolar Depression: An Emotional-Processing fMRI Pilot Study

University Health Network, Toronto

Conditions

Bipolar Depression

Phase

Phase 1

Enrollment

30 estimated

Locations

Toronto Western Hospital - University Health Network, Toronto, Ontario, Canada

Registry updated

2024-10-18

Open registry recordTracker record

CompletedNCT06326606

A Phase 1 Dose Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of MLS101 (psilocybin) in Healthy Participants

MycoMedica Life Sciences PBC

Conditions

Healthy Volunteers

Phase

Phase 1

Enrollment

24 actual

Locations

CMAX Clinical Research Pty Ltd, Adelaide, South Australia, Australia

Registry updated

2024-10-09

Open registry recordTracker record

CompletedNCT03300947

Psilocybin for Treatment of Obsessive Compulsive Disorder

University of Arizona

Conditions

Obsessive-compulsive Disorder (OCD)

Phase

Phase 1

Enrollment

15 actual

Locations

University of Arizona, Tucson, Arizona, United States

Registry updated

2024-08-30

Open registry recordTracker record

Unknown statusNCT06471959

Assessing the Feasibility of a Custom Psychedelic-assisted Group Program on Mental and Physical Health in First Responders

Empower Research Inc

Conditions

Psilocybin · Psychotherapy, Group

Phase

Phase 1 · Phase 2

Enrollment

32 estimated

Locations

Centre for Neurology Studies, Surrey, British Columbia, Canada

Registry updated

2024-06-24

Open registry recordTracker record

CompletedNCT02243813

Effects of Psilocybin-facilitated Experience on the Psychology and Effectiveness of Professional Leaders in Religion

Johns Hopkins University

Conditions

Healthy

Phase

Phase 1

Enrollment

24 actual

Locations

Behavioral Biology Research Center, Johns Hopkins Bayview, Baltimore, Maryland, United States

Registry updated

2024-06-18

Open registry recordTracker record

CompletedNCT04505189

Psilocybin as a Treatment for Anorexia Nervosa: A Pilot Study

Imperial College London

Conditions

Anorexia Nervosa

Phase

Phase 1 · Phase 2

Enrollment

21 actual

Locations

Imperial College Hammersmith campus, London, United Kingdom

Registry updated

2024-06-17

Open registry recordTracker record

CompletedNCT05384678

Acute Dose-dependent Effects of DMT in Healthy Subjects: A Placebo-controlled Cross-over Study

University Hospital, Basel, Switzerland

Conditions

Healthy

Phase

Phase 1

Enrollment

24 actual

Locations

Universtity Hospital Basel, Basel, Switzerland

Registry updated

2024-04-25

Open registry recordTracker record

CompletedNCT04218539

Repeat Dosing of Psilocybin in Headache Disorders

Yale University

Conditions

Migraine Headache

Phase

Phase 1

Enrollment

18 actual

Locations

VA Connecticut Healthcare System, West Haven, Connecticut, United States

Registry updated

2024-02-09

Open registry recordTracker record

CompletedNCT04227756

Comparative Acute Effects of LSD, Psilocybin and Mescaline in a Random-Order Placebo-Controlled Cross-Over Study in Healthy Subjects

University Hospital, Basel, Switzerland

Conditions

Healthy

Phase

Phase 1

Enrollment

32 actual

Locations

University Hospital Basel, Clinical Trial Unit, Basel, Canton of Basel-City, Switzerland

Registry updated

2024-01-24

Open registry recordTracker record

WithdrawnNCT05562973

Safety and Tolerability of Psilocybin in Post-Traumatic Stress Disorder

Johns Hopkins University

Conditions

Post-Traumatic Stress Disorder

Phase

Phase 1

Enrollment

0 actual

Locations

No mapped site reported

Registry updated

2024-01-05

Open registry recordTracker record

CompletedNCT02981173

Safety and Efficacy of Psilocybin for the Treatment of Headache Disorders

Yale University

Conditions

Cluster Headache

Phase

Phase 1

Enrollment

25 actual

Locations

VA Connecticut Healthcare System, West Haven, Connecticut, United States

Registry updated

2023-12-15

Open registry recordTracker record

TerminatedNCT03806985

Safety and Efficacy of Psilocybin for the Treatment of Headache Disorders: Sub-Study II

Yale University

Conditions

Post-Traumatic Headache

Phase

Phase 1

Enrollment

12 actual

Locations

VA Connecticut Healthcare System, West Haven, Connecticut, United States

Registry updated

2023-10-12

Open registry recordTracker record

CompletedNCT03341689

Safety and Efficacy of Psilocybin for the Treatment of Headache Disorders: Sub-Study I

Yale University

Conditions

Migraine Headache

Phase

Phase 1

Enrollment

14 actual

Locations

VA Connecticut Healthcare System, West Haven Campus, West Haven, Connecticut, United States

Registry updated

2023-10-12

Open registry recordTracker record

CompletedNCT06035900

Phase 1, Open-Label, One-Treatment, Single-Dose, One-Period, Pharmacokinetic Study of Psilocin 4 mg as Its Mucic Acid Salt (L-130) Form, in Healthy Subjects Under Fasted Conditions

Lobe Sciences Ltd.

Conditions

Side Effect of Drug

Phase

Phase 1

Enrollment

10 actual

Locations

Pharmaceutical Research Unit, Amman, Jordan

Registry updated

2023-09-13

Open registry recordTracker record

CompletedNCT05478278

A Phase 1, Two-Part Study in Healthy Volunteers to Evaluate The Effect of Psilocybin on Cardiac Repolarization and The Effect of Food on Psilocybin Pharmacokinetics

Usona Institute

Conditions

QTc Interval · Pharmacokinetics

Phase

Phase 1

Enrollment

60 actual

Locations

Altasciences Clinical Kansas, Inc, Overland Park, Kansas, United States

Registry updated

2023-08-15

Open registry recordTracker record

CompletedNCT04842045

Recall of Experience and Conscious Awareness in Psilocybin Treatment of Depression (The RECAP Study): Pilot Phase in Healthy Adult Volunteers

University of Wisconsin, Madison

Conditions

Psychedelic Experiences · Amnesia

Phase

Phase 1

Enrollment

8 actual

Locations

UWHealth, 600 Highland Avenue, Madison, Wisconsin, United States

Registry updated

2023-05-19

Open registry recordTracker record

WithdrawnNCT05467761

A Phase 1 Study Comparing the Pharmacokinetics and Safety of Intravenous and Oral Psilocybin

University of Wisconsin, Madison

Conditions

Healthy

Phase

Phase 1

Enrollment

0 actual

Locations

University of Wisconsin, Madison, Wisconsin, United States

Registry updated

2023-05-15

Open registry recordTracker record

CompletedNCT04052568

Effects of Psilocybin in Anorexia Nervosa

Johns Hopkins University

Conditions

Anorexia Nervosa

Phase

Phase 1

Enrollment

22 actual

Locations

Behavioral Pharmacology Research Unit, Baltimore, Maryland, United States

Registry updated

2023-05-06

Open registry recordTracker record

CompletedNCT04849013

Role of the Serotonin 5-HT2A Receptor in Mescaline-induced Altered States of Consciousness

University Hospital, Basel, Switzerland

Conditions

Healthy

Phase

Phase 1

Enrollment

16 actual

Locations

University Hospital Basel, Clinical Trial Unit, Basel, Canton of Basel-City, Switzerland

Registry updated

2023-03-29

Open registry recordTracker record

Unknown statusNCT05042466

NW Trauma Therapies, Chronic Illness of Chronic Depression, PTSD, MS, HIV, and SARS-CoV-2, Long Haulers Syndrome. Treatment of Unregulaaible Trauma by the Treatment of Enhanced Micro Dosing the Levels of 0.15, Thru 0.33, With a Maintenance Dose of 1 Gram Per Month for Neural Pathway Increase of Non Synthesized Psilocybin, Using the Actual Plant to Regulate the Highjacked Nervous System.

NWTraumatherapies

Conditions

Trauma, Nervous System

Phase

Phase 1

Enrollment

30 estimated

Locations

Ross Allison NPI #1437519899 Administrator Of Study, Bozeman, Montana, United States

Registry updated

2022-11-16

Open registry recordTracker record

TerminatedNCT04905121

An Exploratory Open-Label, Phase 1b, Ascending Dose Study to Evaluate the Effects of Oral 3-[2-(Dimethylamino)Ethyl]-1h-indol-4-yl Dihydrogen Phosphate (Psilocybin, BPL-PSILO) on Cognition in Patients With Chronic Short-Lasting Unilateral Neuralgiform Headache Attacks (SUNHA)

Beckley Psytech Limited

Conditions

Short Lasting Unilateral Neuralgiform Headache Attacks

Phase

Phase 1

Enrollment

4 actual

Locations

King's College London, London, United Kingdom

Registry updated

2022-10-12

Open registry recordTracker record

TerminatedNCT04280055

Prophylactic Effects of Psilocybin on Chronic Cluster Headache: an Open-label Clinical Trial and Neuroimaging Study

Gitte Moos Knudsen

Conditions

Cluster Headache

Phase

Phase 1 · Phase 2

Enrollment

10 actual

Locations

Neurobiology Research Unit, Rigshospitalet, Copenhagen, Denmark

Registry updated

2022-08-10

Open registry recordTracker record

CompletedNCT02421263

A Randomized Controlled Trial of the Effects of Psilocybin-Facilitated Experience on the Psychology and Effectiveness of Professional Leaders in Religion

NYU Langone Health

Conditions

Religious or Spiritual Problem

Phase

Phase 1

Enrollment

12 actual

Locations

NYU Langone Medical Center/Tisch Hospital, New York, New York, United States

Registry updated

2022-02-14

Open registry recordTracker record

CompletedNCT02950467

Psilocybin-assisted Group Therapy for Demoralization in Long-term AIDS Survivors

Joshua Woolley

Conditions

Distress · Depression · Grief

Phase

Phase 1

Enrollment

30 actual

Locations

University of California, San Francisco, San Francisco, California, United States

Registry updated

2021-01-07

Open registry recordTracker record

CompletedNCT03912974

Effects of Serotonin Transporter Inhibition on the Subjective Response to Psilocybin in Healthy Subjects

University Hospital, Basel, Switzerland

Conditions

Healthy

Phase

Phase 1

Enrollment

27 actual

Locations

University Hospital Basel, Clinical Trial Unit, Basel, Canton of Basel-City, Switzerland

Registry updated

2020-12-01

Open registry recordTracker record

CompletedNCT02163707

Pharmacokinetics of Psilocybin in Normal Adult Volunteers

University of Wisconsin, Madison

Conditions

Healthy

Phase

Phase 1

Enrollment

12 actual

Locations

University of Wisconsin, School of Pharmacy, Madison, Wisconsin, United States

Registry updated

2020-04-15

Open registry recordTracker record

CompletedNCT02145091

Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term Meditators

Johns Hopkins University

Conditions

Healthy

Phase

Phase 1

Enrollment

40 actual

Locations

Behavioral Pharmacology Research Unit, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, United States

Registry updated

2019-12-30

Open registry recordTracker record

CompletedNCT02971605

Measurement of Persisting Changes in Emotional Brain Functioning Produced by Psilocybin

Johns Hopkins University

Conditions

Healthy

Phase

Phase 1 · Phase 2

Enrollment

13 actual

Locations

Behavioral Pharmacology Research Unit, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, United States

Registry updated

2019-09-10

Open registry recordTracker record

CompletedNCT00802282

Effects of Psilocybin and Spiritual Practice on Persisting Changes in Attitudes and Behavior

Johns Hopkins University

Conditions

Healthy

Phase

Phase 1

Enrollment

75 actual

Locations

Behavioral Pharmacology Research Unit, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, United States

Registry updated

2016-02-24

Open registry recordTracker record

CompletedNCT01988311

Pilot Study: Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term Meditators

Johns Hopkins University

Conditions

Psilocybin · Hallucinogens · Pharmacologic Actions · Central Nervous System Agents

Phase

Phase 1

Enrollment

10 estimated

Locations

Behavioral Pharmacology Research Unit, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, United States

Registry updated

2014-05-20

Open registry recordTracker record