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Alcohol-use research landscape

Psilocybin Clinical Trials for Alcohol Use Disorder

Explore clinical trials studying psilocybin in alcohol-related conditions, with current registry status, design facts, enrollment, study sites, and direct source links.

Explore this trial map All recruiting trials

Registry status is not a guarantee of local availability, eligibility, safety, or efficacy. Confirm every participation decision in the authoritative ClinicalTrials.gov record.

21matching trials
6currently recruiting
38registry-listed sites

Registry facts checkedAug 10, 2026 01:26 UTC

Live registry synthesis

Status, geography, and study phase

The collection matches alcohol-use and alcohol-dependence terminology found in registry condition fields. It is a discovery view, not an assessment of efficacy or eligibility.

Recruitment status

  1. Recruiting6
  2. Completed5
  3. Active, not recruiting4
  4. Unknown status3
  5. Not yet recruiting2
  6. Terminated1

Leading countries

  1. United States11
  2. Canada3
  3. France2
  4. Denmark2
  5. Finland1
  6. Belgium1
  7. Switzerland1

Trial phases

  1. Phase 217
  2. Phase 31
  3. Not applicable1
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21 matching registry records

Every factual summary is crawlable without JavaScript. Use the direct registry link for current eligibility, contacts, and site availability.

RecruitingNCT06349083

Neurobehavioral Mechanisms of Psilocybin-assisted Treatment for Alcohol Use Disorder

NYU Langone Health

Conditions
Alcohol Use Disorder
Phase
Phase 2
Enrollment
200 estimated
Locations
NYU Langone Health, New York, New York, United States
Registry updated
2026-08-07
Open registry recordTracker record
TerminatedNCT06624137

Computationally, Electrophysiologically, and Qualitatively Characterizing Serotonergic Psychedelics; Transdiagnostic Therapeutic and Pro-Psychotic Effects

Yale University

Conditions
OCD · Major Depressive Disorder (MDD) · Alcohol Use Disorder (AUD) · Healthy Volunteer
Phase
Phase not reported
Enrollment
5 actual
Locations
Connecticut Mental Health Center, Hamden, Connecticut, United States · West Haven VA Medical Center, West Haven, Connecticut, United States
Registry updated
2026-07-09
Open registry recordTracker record
RecruitingNCT07638553

Efficacy in Relapse Prevention: Psilocybin in Alcohol Use Disorder With Depressive Symptoms

Centre Hospitalier Universitaire de Nīmes

Conditions
Alcohol Use Disorder · Depressive Sympotoms · Psilocybin
Phase
Phase 3
Enrollment
172 estimated
Locations
Centre Hospitalier de la Côte Basque, Bayonne, France · CHU Besançon, Besançon, France · CHU de Bordeaux, Bordeaux, France · +5 more
Registry updated
2026-07-01
Open registry recordTracker record
Not yet recruitingNCT07296094

Psilocybin-Assisted Psychotherapy for the Treatment of Severe Alcohol Use Disorder: A Double-Blind, Dose-Comparison Concurrent Control Randomized Trial

Brigham and Women's Hospital

Conditions
Alcohol Use Disorder
Phase
Phase 2
Enrollment
36 estimated
Locations
Brigham and Women's Hospital, Boston, Massachusetts, United States
Registry updated
2026-06-15
Open registry recordTracker record
CompletedNCT05416229

The QUANTUM Trip Trial - Psilocybin-assisted Therapy for Reducing Alcohol Intake in Patients With Alcohol Use Disorder: A Randomized, Double-blinded, Placebo-controlled Clinical Trial.

Anders Fink-Jensen, MD, DMSci

Conditions
Alcohol Use Disorder
Phase
Phase 2
Enrollment
60 actual
Locations
Psychiatric Center Copenhagen, Frederiksberg Hospital, Frederiksberg, Denmark
Registry updated
2026-03-24
Open registry recordTracker record
Active, not recruitingNCT04620759

Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder

Johns Hopkins University

Conditions
Major Depressive Disorder · Alcohol Use Disorder
Phase
Phase 2
Enrollment
90 estimated
Locations
Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland, United States
Registry updated
2026-03-13
Open registry recordTracker record
Not yet recruitingNCT07405606

Psilocybin-assisted Therapy for Comorbid Major Depressive Disorder and Alcohol Use Disorder: A Pilot Randomized Clinical Trial

Centre for Addiction and Mental Health

Conditions
Major Depressive Disorder (MDD) · Alcohol Use Disorder (AUD)
Phase
Phase 2
Enrollment
30 estimated
Locations
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Registry updated
2026-02-12
Open registry recordTracker record
RecruitingNCT06405607

Psilocybin vs Ketamine for Alcohol Use Disorder

University of Iowa

Conditions
Alcohol Use Disorder · Alcohol Dependence · Alcohol Abuse
Phase
Phase 2
Enrollment
80 estimated
Locations
University of Iowa Health Care, Iowa City, Iowa, United States
Registry updated
2025-11-28
Open registry recordTracker record
Active, not recruitingNCT05421065

Psilocybin-Assisted vs Ketamine-Assisted Psychotherapy for Alcohol Use Disorder

Peggy C Nopoulos

Conditions
Alcohol Use Disorder
Phase
Phase 2
Enrollment
20 estimated
Locations
University of Iowa, Iowa City, Iowa, United States
Registry updated
2025-11-17
Open registry recordTracker record
Active, not recruitingNCT07189988

Observational Pilot Study to Explore the Social and Health Impacts of a New Model of Care in Oregon: Psilocybin Services on Alcoholism

Healing Advocacy Fund

Conditions
Alcohol Use Disorder
Phase
Phase not reported
Enrollment
20 actual
Locations
Innertrek Patient Service Center, Portland, Oregon, United States
Registry updated
2025-09-24
Open registry recordTracker record
RecruitingNCT06853912

A Phase 2 Single-site, Double-blind, Placebo-controlled, Randomized Clinical Trial With an Open-label Extension Phase to Examine the Safety, Subjective Experiences, Acute Effects, and Suitability of Psilocybin Combined With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder (PTSD)

Nathan Brashares Sackett

Conditions
Alcohol Use Disorder (AUD) · PTSD
Phase
Phase 2
Enrollment
40 estimated
Locations
University of Washington Center for Novel Therapeutics in Addiction Psychiatry, Seattle, Washington, United States
Registry updated
2025-08-28
Open registry recordTracker record
CompletedNCT06235411

Psilocybin in Alcohol Use Disorder With Comorbid Depression

Centre Hospitalier Universitaire de Nīmes

Conditions
Alcohol-Related Disorders · Depressive Disorder · Addiction
Phase
Not applicable
Enrollment
30 actual
Locations
CHU, Nîmes, Nîmes, France
Registry updated
2025-03-19
Open registry recordTracker record
Unknown statusNCT05646303

A 24-Week, Multicentre, Randomised, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 2 Clinical Trial to Evaluate Efficacy and Safety of Psilocybin-Assisted Psychotherapy in Adults With Alcohol Use Disorder (AUD)

Clairvoyant Therapeutics

Conditions
Alcohol Use Disorder
Phase
Phase 2
Enrollment
128 estimated
Locations
Sabi Mind, Calgary, Alberta, Canada · Okanagan Clinical Trials, Kelowna, British Columbia, Canada · Centre for Neurology Studies, Surrey, British Columbia, Canada · +9 more
Registry updated
2024-08-15
Open registry recordTracker record
RecruitingNCT06160232

Psilocybin-Assisted Therapy for Severe Alcohol Use Disorder: Feasibility, Clinical Efficacy & (Neuro)Cognitive Mechanisms

Brugmann University Hospital

Conditions
Severe Alcohol Use Disorder
Phase
Phase 2
Enrollment
62 estimated
Locations
Brugmann University Hospital, Brussels, Belgium
Registry updated
2024-08-07
Open registry recordTracker record
Unknown statusNCT04718792

Psilocybin for Treatment of Alcohol Use Disorder: a Feasibility Study

Anders Fink-Jensen, MD, DMSci

Conditions
Alcohol Use Disorder (AUD)
Phase
Phase 2
Enrollment
10 actual
Locations
Psychiatric Center Copenhagen, Copenhagen, Frederiksberg, Denmark
Registry updated
2024-07-12
Open registry recordTracker record
Unknown statusNCT06444243

A Multi-centre, Double-blinded, Placebo-controlled, Randomised, Phase II Clinical Trial for Psilocybin-assisted Therapy for Alcohol Use Disorder

University of Sydney

Conditions
Alcohol Use Disorder · Alcohol Dependence · Depression · Anxiety
Phase
Phase 2
Enrollment
90 estimated
Locations
No mapped site reported
Registry updated
2024-06-10
Open registry recordTracker record
RecruitingNCT05995769

Mechanisms Supporting Psilocybin-assisted Psychotherapy for Alcohol Use Disorder: A Randomized, Controlled Clinical Trial

University of Calgary

Conditions
Alcohol Use Disorder · Alcoholism
Phase
Phase 2
Enrollment
128 estimated
Locations
University of Calgary, Calgary, Alberta, Canada
Registry updated
2024-05-07
Open registry recordTracker record
CompletedNCT01534494

Effects and Therapeutic Potential of Psilocybin in Alcohol Dependence

University of New Mexico

Conditions
Alcohol Dependence
Phase
Phase 2
Enrollment
10 actual
Locations
University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States
Registry updated
2023-09-26
Open registry recordTracker record
CompletedNCT04141501

Phase II, Randomized, Double Blind, Placebo Controlled, Parallel Group, Single Center Study of Psilocybin Efficacy and Mechanism in Alcohol Use Disorder

University of Zurich

Conditions
Alcohol Use Disorder
Phase
Phase 2
Enrollment
37 actual
Locations
Psychiatrische Universitätsklinik Zürich, Zurich, Switzerland
Registry updated
2023-09-21
Open registry recordTracker record
Active, not recruitingNCT04410913

Pilot Trial of Visual Healing®, a Nature-themed Virtual Immersive Experience, to Optimize Set and Setting in Psilocybin-assisted Therapy for Alcohol Use Disorder

Keith Heinzerling

Conditions
Alcohol Use Disorder
Phase
Phase 2
Enrollment
20 actual
Locations
Pacific Treatment & Research in Psychedelics, Santa Monica, California, United States
Registry updated
2023-01-17
Open registry recordTracker record
CompletedNCT02061293

A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol Dependence

NYU Langone Health

Conditions
Alcohol Dependence
Phase
Phase 2
Enrollment
95 actual
Locations
University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States · Clinical and Translational Science Institute, NYU Langone Medical Center, New York, New York, United States
Registry updated
2022-11-08
Open registry recordTracker record
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