Recruitment status
- Completed8
- Recruiting7
- Active, not recruiting3
- Not yet recruiting2
Psilocybin-Research.comSearchable psilocybin and psilocin bibliometric database.
Oncology and distress landscape
Psilocybin Trials for Cancer-Related Distress
Find psilocybin clinical trials whose registered conditions connect cancer or life-threatening illness with anxiety, depression, distress, or palliative research contexts.
Registry status is not a guarantee of local availability, eligibility, safety, or efficacy. Confirm every participation decision in the authoritative ClinicalTrials.gov record.
20matching trials
7currently recruiting
27registry-listed sites
Registry facts checkedAug 31, 2026 01:27 UTC
Live registry synthesis
Status, geography, and study phase
The page groups trials through explicit cancer, oncology, neoplasm, palliative, and life-threatening-illness terms. Inspect each source record because populations and outcomes differ substantially.
Leading countries
- United States16
- Canada2
- Switzerland1
- Australia1
Trial phases
- Phase 214
- Phase 15
- Early Phase 12
- Phase 31
Server-rendered source index
20 matching registry records
Every factual summary is crawlable without JavaScript. Use the direct registry link for current eligibility, contacts, and site availability.
Not yet recruitingNCT07791901
High vs. Low-Dose Group-Based Psilocybin-Assisted Therapy (PAT) With or Without Mindfulness-Based (MB) Preparation and Integration for Demoralization in Adults With Advanced Cancer (PAT-MIND): A Pilot Feasibility 2x2 Factorial Multisite Trial
University of Calgary
- Conditions
- Advanced Cancer · Demoralization · Existential Distress · Psychological Distress
- Phase
- Phase 2
- Enrollment
- 60 estimated
- Locations
- Arthur Child Comprehensive Cancer Centre, Calgary, Alberta, Canada · Providence Care Hospital, Kingston, Ontario, Canada
- Registry updated
- 2026-08-28
CompletedNCT05220046
An Exploratory Pilot Study of Palliadelic Treatment to Reduce Psychological Distress in People With Pancreatobiliary and Other Advanced Gastrointestinal Cancers
University of Nebraska
- Conditions
- Pancreas Cancer · Biliary Tract Cancer · Psychological Distress · Gastrointestinal Cancer
- Phase
- Phase 1
- Enrollment
- 18 actual
- Locations
- University of Nebraska Medical Center, Omaha, Nebraska, United States
- Registry updated
- 2026-08-19
RecruitingNCT06200155
TRIP - TReatment to Improve Depression and/or Anxiety Using Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy
M.D. Anderson Cancer Center
- Conditions
- Depression, Anxiety · Psilocybin-Assisted Psychotherapy · Advanced Cancer
- Phase
- Phase 2
- Enrollment
- 30 estimated
- Locations
- MD Anderson Cancer Center, Houston, Texas, United States
- Registry updated
- 2026-08-12
RecruitingNCT06801041
TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors
M.D. Anderson Cancer Center
- Conditions
- Depression · Anxiety · Cancer
- Phase
- Phase 2
- Enrollment
- 20 estimated
- Locations
- The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States
- Registry updated
- 2026-08-12
Not yet recruitingNCT06827054
Low-Dose Psilocybin Therapy for Palliative Care Patients With Chronic Cancer Pain Requiring Opioids
Roswell Park Cancer Institute
- Conditions
- Hematopoietic and Lymphatic System Neoplasm · Malignant Solid Neoplasm
- Phase
- Phase 2
- Enrollment
- 20 estimated
- Locations
- Roswell Park Cancer Institute, Buffalo, New York, United States
- Registry updated
- 2026-08-12
RecruitingNCT06001749
Feasibility Phase 2 Study of Psilocybin-Assisted Therapy for Opioid-Refractory Pain in Patients With Advanced Cancer
Yvan Beaussant, MD, MSci
- Conditions
- Opioid-Related Disorders · Pain Management · Pain Management and Care · Advanced Cancer
- Phase
- Phase 2
- Enrollment
- 15 estimated
- Locations
- Dana-Farber Cancer Institute, Boston, Massachusetts, United States
- Registry updated
- 2026-08-05
Active, not recruitingNCT07336238
A Phase 2a Study of Group Retreat Psilocybin Therapy for Cancer-Related Anxiety and Depression
University of Washington
- Conditions
- Anxiety · Depression · Hematopoietic and Lymphatic System Neoplasm · Metastatic Malignant Solid Neoplasm
- Phase
- Phase 2
- Enrollment
- 18 estimated
- Locations
- Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington, United States
- Registry updated
- 2026-07-31
Active, not recruitingNCT06416085
Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced Cancer: A Phase II Open-Label Trial
University Health Network, Toronto
- Conditions
- Advanced Cancer · Stage IV Solid Tumor Cancer · Stage IV Sarcoma of Bone · Stage IV Lymphoma
- Phase
- Phase 2
- Enrollment
- 15 estimated
- Locations
- Princess Margaret Cancer Centre, Toronto, Ontario, Canada
- Registry updated
- 2026-06-22
Active, not recruitingNCT05947383
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of up to Two Doses of Psilocybin for the Treatment of Major Depressive Disorder in Adults With Cancer
Sunstone Medical
- Conditions
- Cancer · Major Depressive Disorder
- Phase
- Phase 2
- Enrollment
- 56 estimated
- Locations
- Sunstone Medical, PC, Rockville, Maryland, United States
- Registry updated
- 2026-05-06
RecruitingNCT05883540
Lysergic Acid Diethylamide (LSD) in Palliative Care: a Randomised, Double-blind, Active-placebo Controlled Phase II Study (LPC-Study)
University Hospital, Basel, Switzerland
- Conditions
- Palliative Care · Pain · Anxiety · Depression
- Phase
- Phase 2
- Enrollment
- 60 estimated
- Locations
- University Hospital Basel, Division of Clinical Pharmacology and Toxicology, Basel, Switzerland · University Hospital Geneva, Palliative medicine department, Collonge-Bellerive, Switzerland · Spital Uster AG, Division of Internal Medicine, Uster, Switzerland · +1 more
- Registry updated
- 2026-04-29
RecruitingNCT06430541
Study of Psilocybin Assisted Psychotherapy to Address Fear of Recurrence in Patients Diagnosed With Early-stage Breast Cancer and Ovarian Cancer in Remission
University of Colorado, Denver
- Conditions
- Breast Cancer · Ovarian Cancer
- Phase
- Phase 1
- Enrollment
- 20 estimated
- Locations
- Outpatient CTRC, Aurora, Colorado, United States · University of Colorado Cancer Center, Aurora, Colorado, United States
- Registry updated
- 2026-04-21
RecruitingNCT07072728
A Phase 2b Double-blind, Randomized, Low-dose Comparator-controlled Clinical Trial to Assess the Efficacy and Safety of NPX-5 in Psilocybin-assisted Psychotherapy for the Treatment of Adjustment Disorder Associated With Cancer.
Psyence Australia Pty Ltd
- Conditions
- Adjustment Disorder · Adjustment Disorder With Anxious Mood · Cancer · Cancer Cachexia
- Phase
- Phase 2
- Enrollment
- 87 estimated
- Locations
- Mind Medicine Australia Clinic, Abbotsford, Victoria, Australia · Paratus Clinical Research Melbourne, Northcote, Victoria, Australia · Empax Centre, Leederville, Western Australia, Australia
- Registry updated
- 2026-03-03
CompletedNCT04950608
Pilot Study of Psilocybin-Assisted Therapy for Demoralization in Patients Receiving Hospice Care - PATH Study
Yvan Beaussant, MD, MSci
- Conditions
- Hospice · Psilocybin · Demoralization · Terminal Illness
- Phase
- Phase 2
- Enrollment
- 15 actual
- Locations
- Care Dimensions, Danvers, Massachusetts, United States
- Registry updated
- 2026-02-17
RecruitingNCT05398484
A Phase 2b, Randomized, Double-blind, Placebo-controlled, Multi-center Study of the Effects of Psilocybin-assisted Psychotherapy on Psychiatric and Existential Distress in Advanced Cancer
NYU Langone Health
- Conditions
- Advanced Cancer
- Phase
- Phase 2 · Phase 3
- Enrollment
- 200 estimated
- Locations
- University of Colorado Anschutz Medical campus (CU AMC), Aurora, Colorado, United States · NYU Langone Health, New York, New York, United States
- Registry updated
- 2025-12-04
CompletedNCT05847686
A Phase 1/2 Study of a Group Model of Psilocybin-Assisted Therapy for Cancer-Related Anxiety in Patients With Metastatic Cancer
University of Washington
- Conditions
- Hematopoietic and Lymphatic System Neoplasm · Metastatic Malignant Solid Neoplasm
- Phase
- Phase 1 · Phase 2
- Enrollment
- 55 actual
- Locations
- Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington, United States
- Registry updated
- 2025-11-05
CompletedNCT06644170
A Phase 1 Study of a Second Psilocybin Group Retreat for Partial Responders With Anxiety Associated With Metastatic Cancer
University of Washington
- Conditions
- Hematopoietic and Lymphatic System Neoplasm · Metastatic Malignant Solid Neoplasm
- Phase
- Phase 1
- Enrollment
- 15 actual
- Locations
- Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington, United States
- Registry updated
- 2025-10-14
CompletedNCT05506982
The Safety, Feasibility, and Acceptability of Psilocybin Combined With Multidisciplinary Palliative Care in Demoralized Cancer Survivors With Chronic Pain (P-PC)
Emory University
- Conditions
- Hematopoietic and Lymphoid Cell Neoplasm · Malignant Solid Neoplasm
- Phase
- Phase 1
- Enrollment
- 11 actual
- Locations
- Emory University/Winship Cancer Institute, Atlanta, Georgia, United States · Brain Health Center at Executive Park, Atlanta, Georgia, United States
- Registry updated
- 2025-07-23
CompletedNCT04522804
A Pilot Study of Psilocybin Enhanced Group Psychotherapy in Patients With Cancer
University of Utah
- Conditions
- Cancer
- Phase
- Early Phase 1
- Enrollment
- 12 actual
- Locations
- Huntsman Cancer Institute, Salt Lake City, Utah, United States
- Registry updated
- 2024-03-20
CompletedNCT00957359
Effects of Psilocybin on Anxiety and Psychosocial Distress in Cancer Patients
NYU Langone Health
- Conditions
- Cancer
- Phase
- Early Phase 1
- Enrollment
- 29 actual
- Locations
- NYU College of Dentistry Bluestone Center for Clinical Research, New York, New York, United States
- Registry updated
- 2020-10-20
CompletedNCT00465595
Psychopharmacology of Psilocybin in Cancer Patients
Johns Hopkins University
- Conditions
- Depressive Symptoms · Anxiety · Cancer
- Phase
- Phase 2
- Enrollment
- 56 actual
- Locations
- Behavioral Pharmacology Research Unit, Johns Hopkins Bayview Campus, Baltimore, Maryland, United States
- Registry updated
- 2018-07-19
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