Recruitment status
- Recruiting7
- Completed7
- Active, not recruiting4
- Not yet recruiting1
Psilocybin-Research.comSearchable psilocybin and psilocin bibliometric database.
Oncology and distress landscape
Psilocybin Trials for Cancer-Related Distress
Find psilocybin clinical trials whose registered conditions connect cancer or life-threatening illness with anxiety, depression, distress, or palliative research contexts.
Registry status is not a guarantee of local availability, eligibility, safety, or efficacy. Confirm every participation decision in the authoritative ClinicalTrials.gov record.
19matching trials
7currently recruiting
25registry-listed sites
Registry facts checkedAug 10, 2026 01:26 UTC
Live registry synthesis
Status, geography, and study phase
The page groups trials through explicit cancer, oncology, neoplasm, palliative, and life-threatening-illness terms. Inspect each source record because populations and outcomes differ substantially.
Leading countries
- United States16
- Canada1
- Switzerland1
- Australia1
Trial phases
- Phase 213
- Phase 15
- Early Phase 12
- Phase 31
Server-rendered source index
19 matching registry records
Every factual summary is crawlable without JavaScript. Use the direct registry link for current eligibility, contacts, and site availability.
RecruitingNCT06001749
Feasibility Phase 2 Study of Psilocybin-Assisted Therapy for Opioid-Refractory Pain in Patients With Advanced Cancer
Yvan Beaussant, MD, MSci
- Conditions
- Opioid-Related Disorders · Pain Management · Pain Management and Care · Advanced Cancer
- Phase
- Phase 2
- Enrollment
- 15 estimated
- Locations
- Dana-Farber Cancer Institute, Boston, Massachusetts, United States
- Registry updated
- 2026-08-05
Active, not recruitingNCT07336238
A Phase 2a Study of Group Retreat Psilocybin Therapy for Cancer-Related Anxiety and Depression
University of Washington
- Conditions
- Anxiety · Depression · Hematopoietic and Lymphatic System Neoplasm · Metastatic Malignant Solid Neoplasm
- Phase
- Phase 2
- Enrollment
- 18 estimated
- Locations
- Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington, United States
- Registry updated
- 2026-07-31
RecruitingNCT06200155
TRIP - TReatment to Improve Depression and/or Anxiety Using Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy
M.D. Anderson Cancer Center
- Conditions
- Depression, Anxiety · Psilocybin-Assisted Psychotherapy · Advanced Cancer
- Phase
- Phase 2
- Enrollment
- 30 estimated
- Locations
- MD Anderson Cancer Center, Houston, Texas, United States
- Registry updated
- 2026-07-29
RecruitingNCT06801041
TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors
M.D. Anderson Cancer Center
- Conditions
- Depression · Anxiety · Cancer
- Phase
- Phase 2
- Enrollment
- 20 estimated
- Locations
- The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States
- Registry updated
- 2026-07-29
Not yet recruitingNCT06827054
Low-Dose Psilocybin Therapy for Palliative Care Patients With Chronic Cancer Pain Requiring Opioids
Roswell Park Cancer Institute
- Conditions
- Hematopoietic and Lymphatic System Neoplasm · Malignant Solid Neoplasm
- Phase
- Phase 2
- Enrollment
- 20 estimated
- Locations
- Roswell Park Cancer Institute, Buffalo, New York, United States
- Registry updated
- 2026-06-22
Active, not recruitingNCT06416085
Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced Cancer: A Phase II Open-Label Trial
University Health Network, Toronto
- Conditions
- Advanced Cancer · Stage IV Solid Tumor Cancer · Stage IV Sarcoma of Bone · Stage IV Lymphoma
- Phase
- Phase 2
- Enrollment
- 15 estimated
- Locations
- Princess Margaret Cancer Centre, Toronto, Ontario, Canada
- Registry updated
- 2026-06-22
Active, not recruitingNCT05947383
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of up to Two Doses of Psilocybin for the Treatment of Major Depressive Disorder in Adults With Cancer
Sunstone Medical
- Conditions
- Cancer · Major Depressive Disorder
- Phase
- Phase 2
- Enrollment
- 56 estimated
- Locations
- Sunstone Medical, PC, Rockville, Maryland, United States
- Registry updated
- 2026-05-06
Active, not recruitingNCT05220046
An Exploratory Pilot Study of Palliadelic Treatment to Reduce Psychological Distress in People With Pancreatobiliary and Other Advanced Gastrointestinal Cancers
University of Nebraska
- Conditions
- Pancreas Cancer · Biliary Tract Cancer · Psychological Distress · Gastrointestinal Cancer
- Phase
- Phase 1
- Enrollment
- 24 estimated
- Locations
- University of Nebraska Medical Center, Omaha, Nebraska, United States
- Registry updated
- 2026-05-06
RecruitingNCT05883540
Lysergic Acid Diethylamide (LSD) in Palliative Care: a Randomised, Double-blind, Active-placebo Controlled Phase II Study (LPC-Study)
University Hospital, Basel, Switzerland
- Conditions
- Palliative Care · Pain · Anxiety · Depression
- Phase
- Phase 2
- Enrollment
- 60 estimated
- Locations
- University Hospital Basel, Division of Clinical Pharmacology and Toxicology, Basel, Switzerland · University Hospital Geneva, Palliative medicine department, Collonge-Bellerive, Switzerland · Spital Uster AG, Division of Internal Medicine, Uster, Switzerland · +1 more
- Registry updated
- 2026-04-29
RecruitingNCT06430541
Study of Psilocybin Assisted Psychotherapy to Address Fear of Recurrence in Patients Diagnosed With Early-stage Breast Cancer and Ovarian Cancer in Remission
University of Colorado, Denver
- Conditions
- Breast Cancer · Ovarian Cancer
- Phase
- Phase 1
- Enrollment
- 20 estimated
- Locations
- Outpatient CTRC, Aurora, Colorado, United States · University of Colorado Cancer Center, Aurora, Colorado, United States
- Registry updated
- 2026-04-21
RecruitingNCT07072728
A Phase 2b Double-blind, Randomized, Low-dose Comparator-controlled Clinical Trial to Assess the Efficacy and Safety of NPX-5 in Psilocybin-assisted Psychotherapy for the Treatment of Adjustment Disorder Associated With Cancer.
Psyence Australia Pty Ltd
- Conditions
- Adjustment Disorder · Adjustment Disorder With Anxious Mood · Cancer · Cancer Cachexia
- Phase
- Phase 2
- Enrollment
- 87 estimated
- Locations
- Mind Medicine Australia Clinic, Abbotsford, Victoria, Australia · Paratus Clinical Research Melbourne, Northcote, Victoria, Australia · Empax Centre, Leederville, Western Australia, Australia
- Registry updated
- 2026-03-03
CompletedNCT04950608
Pilot Study of Psilocybin-Assisted Therapy for Demoralization in Patients Receiving Hospice Care - PATH Study
Yvan Beaussant, MD, MSci
- Conditions
- Hospice · Psilocybin · Demoralization · Terminal Illness
- Phase
- Phase 2
- Enrollment
- 15 actual
- Locations
- Care Dimensions, Danvers, Massachusetts, United States
- Registry updated
- 2026-02-17
RecruitingNCT05398484
A Phase 2b, Randomized, Double-blind, Placebo-controlled, Multi-center Study of the Effects of Psilocybin-assisted Psychotherapy on Psychiatric and Existential Distress in Advanced Cancer
NYU Langone Health
- Conditions
- Advanced Cancer
- Phase
- Phase 2 · Phase 3
- Enrollment
- 200 estimated
- Locations
- University of Colorado Anschutz Medical campus (CU AMC), Aurora, Colorado, United States · NYU Langone Health, New York, New York, United States
- Registry updated
- 2025-12-04
CompletedNCT05847686
A Phase 1/2 Study of a Group Model of Psilocybin-Assisted Therapy for Cancer-Related Anxiety in Patients With Metastatic Cancer
University of Washington
- Conditions
- Hematopoietic and Lymphatic System Neoplasm · Metastatic Malignant Solid Neoplasm
- Phase
- Phase 1 · Phase 2
- Enrollment
- 55 actual
- Locations
- Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington, United States
- Registry updated
- 2025-11-05
CompletedNCT06644170
A Phase 1 Study of a Second Psilocybin Group Retreat for Partial Responders With Anxiety Associated With Metastatic Cancer
University of Washington
- Conditions
- Hematopoietic and Lymphatic System Neoplasm · Metastatic Malignant Solid Neoplasm
- Phase
- Phase 1
- Enrollment
- 15 actual
- Locations
- Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington, United States
- Registry updated
- 2025-10-14
CompletedNCT05506982
The Safety, Feasibility, and Acceptability of Psilocybin Combined With Multidisciplinary Palliative Care in Demoralized Cancer Survivors With Chronic Pain (P-PC)
Emory University
- Conditions
- Hematopoietic and Lymphoid Cell Neoplasm · Malignant Solid Neoplasm
- Phase
- Phase 1
- Enrollment
- 11 actual
- Locations
- Emory University/Winship Cancer Institute, Atlanta, Georgia, United States · Brain Health Center at Executive Park, Atlanta, Georgia, United States
- Registry updated
- 2025-07-23
CompletedNCT04522804
A Pilot Study of Psilocybin Enhanced Group Psychotherapy in Patients With Cancer
University of Utah
- Conditions
- Cancer
- Phase
- Early Phase 1
- Enrollment
- 12 actual
- Locations
- Huntsman Cancer Institute, Salt Lake City, Utah, United States
- Registry updated
- 2024-03-20
CompletedNCT00957359
Effects of Psilocybin on Anxiety and Psychosocial Distress in Cancer Patients
NYU Langone Health
- Conditions
- Cancer
- Phase
- Early Phase 1
- Enrollment
- 29 actual
- Locations
- NYU College of Dentistry Bluestone Center for Clinical Research, New York, New York, United States
- Registry updated
- 2020-10-20
CompletedNCT00465595
Psychopharmacology of Psilocybin in Cancer Patients
Johns Hopkins University
- Conditions
- Depressive Symptoms · Anxiety · Cancer
- Phase
- Phase 2
- Enrollment
- 56 actual
- Locations
- Behavioral Pharmacology Research Unit, Johns Hopkins Bayview Campus, Baltimore, Maryland, United States
- Registry updated
- 2018-07-19
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Automatic refresh: counts, facets, records, and the map update from the tracker after scheduled ClinicalTrials.gov refreshes. The registry remains authoritative.
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Editorial review: collection definitions, limitations, corrections, and authorship are documented in the editorial and methodology policy.