Healthy-volunteer research landscape

Psilocybin Clinical Trials in Healthy Volunteers

Review psilocybin studies whose registry condition fields identify healthy participants or healthy volunteers, including early-phase and mechanistic research.

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43matching trials

13currently recruiting

36registry-listed sites

Registry facts checkedAug 10, 2026 01:26 UTC

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“Healthy” is reproduced from registry condition terminology and does not establish individual eligibility. Protocol definitions and exclusion criteria must be checked at the source.

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43 matching registry records

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CompletedNCT06835699

Open Label Psilocybin Brain Stimulation and Imaging Pilot Study

Conditions: Healthy Volunteers
Phase: Phase 1
Enrollment: 10 actual
Locations: Johns Hopkins School of Medicine, Baltimore, Maryland, United States
Registry updated: 2026-08-07

Psilocybin Clinical Trials in Healthy Volunteers

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43 matching registry records

Open Label Psilocybin Brain Stimulation and Imaging Pilot Study

Activating Neuroplasticity to ENHANCE the Perception Box Expanding Effects of Psilocybin

Changes in Self-awareness Induced by Psychoactive Substances: an Experimental Study With Psilocybin.

Effects of Psilocybin on Electrophysiology and the Dynamic Content of Thought

PRISMatic: A Phase 1b Randomized, Double-Armed, Parallel-Group, Placebo-Controlled Trial of Psilocybin Efficacy With or Without Pimavanserin Pretreatment

A Randomized, Double-Blind, Single Ascending Dose Study to Identify a Safe and Non-Psychedelic Dose of Psilocybin

Computationally, Electrophysiologically, and Qualitatively Characterizing Serotonergic Psychedelics; Transdiagnostic Therapeutic and Pro-Psychotic Effects

A Multicenter Phase 1 Safety and Tolerability Trial of Psilocybin in Healthy Older Adults

Acute Effects of MDMA Co-administration on the Response to Psilocybin in Healthy Subjects

Psilocybin Administration With 5-HT1a Blockade

The Acute Effects of Psilocybin on Cognition, Memory, and Brain Function

A Double Blind, Randomized Trial Investigating the Safety, Feasibility, and Mechanisms of Psychedelics in Healthy Older Adults With Low Well-being as Moderated by Biomarkers for Preclinical Alzheimer's Disease

Multivariate Neural and Physiological Correlates of Psychedelic Sub-states: a Within-subjects, Healthy Volunteer Study With Experience-sampling

2 x 2 Factorial, Double-blind, Randomized Trial of 'Set and Setting': a Translational Study in Healthy Volunteers

Acute Analgesic Effects of DMT on Experimentally Induced Acute Nociceptive Pain, Hyperalgesia and Allodynia in Healthy Participants

The Effects of Psilocybin in Healthy Volunteers: Psychological, Biochemical and Electrophysiological Biomarkers.

Investigation of Psychedelic Effects in Psychoactive Substances

A Phase 1 Translational Study to Assess Brain Activity Using Functional Magnetic Resonance Imaging (fMRI) and to Evaluate the Safety, Tolerability, and Pharmacokinetics of Multiple Doses of MLS101 (Psilocybin) in Healthy Volunteers

Safety and Psychological Effects of Psilocybin and D-Serine Formulation in Healthy Volunteers

Digital Intervention for Psychedelic Preparation (DIPP): A Randomised Controlled Feasibility Trial Comparing Meditation and Music-Based Programs in Healthy Volunteers.

Does Serotonin System Stimulation Increase Pro-social Behavior? - A Comparative Pharmacological Neuroscientific Study in Healthy Humans

A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Multiple Doses of MLS101 (Psilocybin) in Healthy Participants

Comparison of the Effects of PEX20 (Oral Psilocin), PEX30 (Sublingual Psilocin), and PEX10 (Oral Psilocybin) in Healthy Adults

Role of the Serotonin 2A Receptor in Psilocybin-induced Altered States of Consciousness (PDR-Study)

Consciousness and Psilocybin Effects on Well-Being (The CoPE Study): Pilot Phase

Acute Dose-dependent Effects of DMT-bolus Applications in Healthy Subjects: A Placebo-controlled Cross-over Study (DMT BDR-Study).

Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in a Randomized, Placebo-controlled, Cross-over Trial in Healthy Participants (LPD-Study)

Acute Effects of 2C-B Compared With MDMA and Psilocybin in Healthy Subjects

A Phase 1 Dose Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of MLS101 (psilocybin) in Healthy Participants

Effects of Psilocybin-facilitated Experience on the Psychology and Effectiveness of Professional Leaders in Religion

Acute Dose-dependent Effects of DMT in Healthy Subjects: A Placebo-controlled Cross-over Study

Comparative Acute Effects of LSD, Psilocybin and Mescaline in a Random-Order Placebo-Controlled Cross-Over Study in Healthy Subjects

Mindfulness and Psychedelics: A Combined Neurophenomenological and Pharmacological Approach to the Characterization of Mindfulness States in Experienced Meditators

A Phase 1 Study Comparing the Pharmacokinetics and Safety of Intravenous and Oral Psilocybin

Role of the Serotonin 5-HT2A Receptor in Mescaline-induced Altered States of Consciousness

Characterization of Altered Waking States of Consciousness in Healthy Humans

Direct Comparison of Altered States of Consciousness Induced by LSD and Psilocybin in a Random-order Placebo-controlled Cross-over Study in Healthy Subjects

Effects of Serotonin Transporter Inhibition on the Subjective Response to Psilocybin in Healthy Subjects

Beyond the Self and Back: Neuropharmacological Mechanisms Underlying the Dissolution of the Self

Pharmacokinetics of Psilocybin in Normal Adult Volunteers

Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term Meditators

Measurement of Persisting Changes in Emotional Brain Functioning Produced by Psilocybin

Effects of Psilocybin and Spiritual Practice on Persisting Changes in Attitudes and Behavior

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