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PTSD trial landscape

Psilocybin Clinical Trials for PTSD

Review psilocybin trial records whose registered conditions include post-traumatic stress or trauma-related terminology, with source-preserving facts and current status.

Explore this trial map All recruiting trials

Registry status is not a guarantee of local availability, eligibility, safety, or efficacy. Confirm every participation decision in the authoritative ClinicalTrials.gov record.

27matching trials
10currently recruiting
28registry-listed sites

Registry facts checkedAug 10, 2026 01:26 UTC

Live registry synthesis

Status, geography, and study phase

Registry labels vary between PTSD, post-traumatic stress disorder, and broader trauma-related wording. Matching is intentionally broad enough to support discovery while the original labels remain visible.

Recruitment status

  1. Recruiting10
  2. Not yet recruiting4
  3. Active, not recruiting4
  4. Unknown status4
  5. Terminated2
  6. Completed2
  7. Withdrawn1

Leading countries

  1. United States16
  2. Canada3
  3. United Kingdom2
  4. Israel1
  5. Pakistan1
  6. Switzerland1

Trial phases

  1. Phase 214
  2. Phase 18
  3. Phase 33
  4. Early Phase 11
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27 matching registry records

Every factual summary is crawlable without JavaScript. Use the direct registry link for current eligibility, contacts, and site availability.

Not yet recruitingNCT07745569

Precision Phenotyping of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies

University of New Mexico

Conditions
PTSD · PTSD - Post Traumatic Stress Disorder · Major Depression · Suicidality
Phase
Phase 2
Enrollment
150 estimated
Locations
No mapped site reported
Registry updated
2026-08-04
Open registry recordTracker record
RecruitingNCT07737054

Trauma-informed Psilocybin Assisted Psychotherapy (TiPAP) for Post-Traumatic Stress Disorder

Tel-Aviv Sourasky Medical Center

Conditions
Post-Traumatic Stress Disorder, PTSD
Phase
Early Phase 1
Enrollment
13 estimated
Locations
Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Registry updated
2026-07-30
Open registry recordTracker record
Active, not recruitingNCT07275970

An Open-Label, Phase 1 Study of the Safety Pharmacokinetic Profile, and Preliminary Efficacy, of Organic Whole Psilocybin-Containing Mushrooms in Patients Suffering From PTSD

Scottsdale Research Institute

Conditions
PTSD
Phase
Phase 1
Enrollment
24 estimated
Locations
Scottsdale Research Institute, Scottsdale, Arizona, United States
Registry updated
2026-07-29
Open registry recordTracker record
RecruitingNCT07703722

Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Trauma-Related Major Depressive Disorder: Randomized Controlled Trial

Khyber Medical University Peshawar

Conditions
Major Depressive Disorder · Post-Traumatic Stress Disorder (PTSD)
Phase
Phase 3
Enrollment
60 estimated
Locations
Institute of Health Science, Khyber Medical University, Islamabad, Capital, Pakistan · Hayatabad Medical Complex Peshawar, Peshawar, KPK, Pakistan · Khyber Medical University, Peshawar, KPK, Pakistan
Registry updated
2026-07-14
Open registry recordTracker record
TerminatedNCT06624137

Computationally, Electrophysiologically, and Qualitatively Characterizing Serotonergic Psychedelics; Transdiagnostic Therapeutic and Pro-Psychotic Effects

Yale University

Conditions
OCD · Major Depressive Disorder (MDD) · Alcohol Use Disorder (AUD) · Healthy Volunteer
Phase
Phase not reported
Enrollment
5 actual
Locations
Connecticut Mental Health Center, Hamden, Connecticut, United States · West Haven VA Medical Center, West Haven, Connecticut, United States
Registry updated
2026-07-09
Open registry recordTracker record
RecruitingNCT06902974

A Phase 2, Open-Label Study Investigating the Safety and Efficacy of Psilocybin-Assisted Therapy for Sexual Assault-Related Posttraumatic Stress Disorder (PTSD)

Sunstone Medical

Conditions
Post Traumatic Stress Disorder · PTSD
Phase
Phase 2
Enrollment
70 estimated
Locations
Sunstone Medical, PC, Rockville, Maryland, United States
Registry updated
2026-07-01
Open registry recordTracker record
RecruitingNCT06386003

Psilocybin-Assisted Massed Cognitive Processing Therapy for Chronic Posttraumatic Stress Disorder: An Open-label Trial

Unity Health Toronto

Conditions
Post Traumatic Stress Disorder · PTSD · Chronic PTSD
Phase
Phase 2
Enrollment
15 estimated
Locations
St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada
Registry updated
2026-06-26
Open registry recordTracker record
RecruitingNCT07104916

A Pilot Mechanistic RCT of Psilocybin With Mindfulness-based Therapy vs Support for Posttraumatic Stress Disorder (PTSD)

Anthony P King

Conditions
Post Traumatic Stress Disorder · Depression - Major Depressive Disorder
Phase
Phase 2
Enrollment
30 estimated
Locations
The Ohio State University Medical Center, Columbus, Ohio, United States
Registry updated
2026-06-25
Open registry recordTracker record
Active, not recruitingNCT06407635

Psilocybin for PTSD With or Without Psychotherapy: A Pilot Study of Safety and Efficacy

Johns Hopkins University

Conditions
Post Traumatic Stress Disorder
Phase
Phase 1
Enrollment
20 estimated
Locations
Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland, United States
Registry updated
2026-06-22
Open registry recordTracker record
Not yet recruitingNCT07332143

The Safety and Acceptability of Psilocybin With Support and With Massed Prolonged Exposure Therapy for PTSD

Emory University

Conditions
PTSD
Phase
Phase 2
Enrollment
150 estimated
Locations
Emory University Hospital, Atlanta, Georgia, United States
Registry updated
2026-05-26
Open registry recordTracker record
RecruitingNCT07506395

Group Psilocybin-Assisted Therapy for Post-Traumatic Stress Disorder

University of New Mexico

Conditions
PTSD
Phase
Phase 1
Enrollment
36 estimated
Locations
Interdisciplinary Substance Use and Brain Injury (ISUBI), Albuquerque, New Mexico, United States
Registry updated
2026-05-22
Open registry recordTracker record
Not yet recruitingNCT06885996

Psilocybin-assisted Therapy for Post-Traumatic Stress Disorder in Survivors of Intimate Partner Violence

University of Calgary

Conditions
Post Traumatic Stress Disorder PTSD · Intimate Partner Violence (IPV)
Phase
Phase 2
Enrollment
76 estimated
Locations
University of Calgary, Calgary, Alberta, Canada · The University of British Columbia - Okanagan Campus, Kelowna, British Columbia, Canada
Registry updated
2026-05-14
Open registry recordTracker record
Not yet recruitingNCT07570654

A Phase 2b/3, Multicentre, Randomised, Double-blind, Controlled Trial, With an Open Label Extension, to Investigate the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder

COMPASS Pathways

Conditions
PTSD - Post Traumatic Stress Disorder · PTSD · PTSD Symptoms · PTSD, Post Traumatic Stress Disorder
Phase
Phase 2 · Phase 3
Enrollment
300 estimated
Locations
No mapped site reported
Registry updated
2026-05-12
Open registry recordTracker record
RecruitingNCT06442423

Safety, Feasibility, and Tolerability of Psilocybin Treatment for Individuals With Functional Impairment Related to Mood, Anxiety, Trauma and/or Addiction Symptoms: An Open-label Proof-of-concept Study

Yale University

Conditions
Transdiagnostic · Depression - Major Depressive Disorder · Anxiety · PTSD Symptoms
Phase
Phase 1
Enrollment
50 estimated
Locations
Connecticut Mental Health Center - Yale School of Medicine, New Haven, Connecticut, United States
Registry updated
2026-03-11
Open registry recordTracker record
Active, not recruitingNCT05554094

Examining the Safety and Clinical Efficacy of Psilocybin Therapy for Veterans With PTSD: An Open-Label Proof-of-Concept Trial

Ohio State University

Conditions
PTSD · Stress Disorders, Traumatic · Stress Disorders, Post-Traumatic · Trauma and Stressor Related Disorders
Phase
Phase 2
Enrollment
15 estimated
Locations
Ohio State University Department of Psychiatry and Behavioral Health at the Davis Medical Research Center, Columbus, Ohio, United States
Registry updated
2026-03-04
Open registry recordTracker record
RecruitingNCT06888128

The STARLIGHT Protocol: State-Funded Trial Assessing Recovery and Long-Term Impact of Guided Psilocybin for Healing Trauma

Baylor College of Medicine

Conditions
PTSD
Phase
Phase 2
Enrollment
15 estimated
Locations
Baylor College of Medicine, Houston, Texas, United States
Registry updated
2026-01-22
Open registry recordTracker record
Active, not recruitingNCT07164287

Retrospective Observational Study of Intensity Effects in Psychedelic-assisted Treatment

University Hospital, Geneva

Conditions
Major Depressive Disorder (MDD) · Anxiety Disorders · Substance Use Disorder (SUD) · PTSD - Post Traumatic Stress Disorder
Phase
Phase not reported
Enrollment
376 estimated
Locations
Geneva University Hospital, Geneva, Switzerland
Registry updated
2025-10-02
Open registry recordTracker record
RecruitingNCT06989957

Psilocybin and MDMA for Post-traumatic Stress Disorder (PTSD)

Johns Hopkins University

Conditions
Posttraumatic Stress Disorder
Phase
Phase 1
Enrollment
40 estimated
Locations
Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland, United States
Registry updated
2025-10-01
Open registry recordTracker record
RecruitingNCT06853912

A Phase 2 Single-site, Double-blind, Placebo-controlled, Randomized Clinical Trial With an Open-label Extension Phase to Examine the Safety, Subjective Experiences, Acute Effects, and Suitability of Psilocybin Combined With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder (PTSD)

Nathan Brashares Sackett

Conditions
Alcohol Use Disorder (AUD) · PTSD
Phase
Phase 2
Enrollment
40 estimated
Locations
University of Washington Center for Novel Therapeutics in Addiction Psychiatry, Seattle, Washington, United States
Registry updated
2025-08-28
Open registry recordTracker record
CompletedNCT05312151

The Safety and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder

COMPASS Pathways

Conditions
Post Traumatic Stress Disorder
Phase
Phase 2
Enrollment
22 actual
Locations
Sunstone Therapies, Rockville, Maryland, United States · Icahn School of Medicine at Mount Sinai, New York, New York, United States · Kings College London, Institute of Psychiatry, Psychology and Neurology, London, United Kingdom
Registry updated
2025-06-13
Open registry recordTracker record
CompletedNCT05163496

A Randomized, Placebo-controlled Trial of Psychedelic-assisted Psychotherapy With Single Dose Psilocybin for Frontline Clinicians Experiencing COVID-related Symptoms of Depression and Burnout

University of Washington

Conditions
Burnout, Caregiver · Burnout, Professional · COVID-19 · Depression
Phase
Phase 3
Enrollment
30 actual
Locations
University of Washington, Seattle, Washington, United States
Registry updated
2025-03-18
Open registry recordTracker record
WithdrawnNCT05562973

Safety and Tolerability of Psilocybin in Post-Traumatic Stress Disorder

Johns Hopkins University

Conditions
Post-Traumatic Stress Disorder
Phase
Phase 1
Enrollment
0 actual
Locations
No mapped site reported
Registry updated
2024-01-05
Open registry recordTracker record
Unknown statusNCT06141876

A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability and Efficacy of Psilocybin-Assisted Psychotherapy in Treating Severe Depression Among Adults With Post-Traumatic Stress Disorder (PTSD).

Apex Labs Ltd.

Conditions
Post-traumatic Stress Disorder · Depression
Phase
Phase 2
Enrollment
160 estimated
Locations
No mapped site reported
Registry updated
2023-11-29
Open registry recordTracker record
TerminatedNCT03806985

Safety and Efficacy of Psilocybin for the Treatment of Headache Disorders: Sub-Study II

Yale University

Conditions
Post-Traumatic Headache
Phase
Phase 1
Enrollment
12 actual
Locations
VA Connecticut Healthcare System, West Haven, Connecticut, United States
Registry updated
2023-10-12
Open registry recordTracker record
Unknown statusNCT05243329

Investigating the Therapeutic Effects of Psilocybin in Treatment-Resistant Post-Traumatic Stress Disorder

Halucenex Life Sciences Inc.

Conditions
Treatment Resistant Disorders · Post Traumatic Stress Disorder
Phase
Phase 2
Enrollment
20 estimated
Locations
Halucenex Life Sciences Inc., Windsor, Nova Scotia, Canada
Registry updated
2023-06-29
Open registry recordTracker record
Unknown statusNCT05876481

Evaluation of the Acceptability, Safety, Feasibility, and Efficacy of Psilocybin-assisted Psychotherapy (PaP) for the Treatment of Post-traumatic Stress Disorder (PTSD) in Military Veterans

Combat Stress

Conditions
PTSD
Phase
Phase 2
Enrollment
8 estimated
Locations
Combat Stress, Leatherhead, Surrey, United Kingdom
Registry updated
2023-05-25
Open registry recordTracker record
Unknown statusNCT05042466

NW Trauma Therapies, Chronic Illness of Chronic Depression, PTSD, MS, HIV, and SARS-CoV-2, Long Haulers Syndrome. Treatment of Unregulaaible Trauma by the Treatment of Enhanced Micro Dosing the Levels of 0.15, Thru 0.33, With a Maintenance Dose of 1 Gram Per Month for Neural Pathway Increase of Non Synthesized Psilocybin, Using the Actual Plant to Regulate the Highjacked Nervous System.

NWTraumatherapies

Conditions
Trauma, Nervous System
Phase
Phase 1
Enrollment
30 estimated
Locations
Ross Allison NPI #1437519899 Administrator Of Study, Bozeman, Montana, United States
Registry updated
2022-11-16
Open registry recordTracker record
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