CLINICAL TRIAL

Psilocybin in Patients With Fibromyalgia: EEG-measured Brain Biomarkers of Action

The purpose of this study is to assess brain activity under Psilocybin in a cohort of people with fibromyalgia. This mechanistic (Non-CTIMP) study will utilise a within-subjects design to examine a candidate brain biomarker of increased plasticity under Psilocybin. Up to 25mg of Psilocybin will be administered under standardised conditions on two occasions, separated by four weeks with in-dosing EEG recordings. The primary end-point will take place 8 weeks from the first dosing session after which patients will be remotely monitored monthly for 6 months.

Open source BibTeX RIS

Bibliographic context

Journal: ClinicalTrials.gov
Date: 2024-01-18
Source: ClinicalTrials.gov
DOI: Unavailable
PubMed: Unavailable

Authors

Imperial College London

Watch author

Topics and keywords

psilocybin Neuroplasticity Brain Imaging Biomarkers Observational Study Observational Study Fibromyalgia Psilocybin O-phosphoryl-4-hydroxy-N N-dimethyltryptamine Therapeutic support UNKNOWN

Citation graph

0 referenced DOIs found in stored source metadata. 0 indexed papers cite this DOI.

Open citation network

Related papers

Prenatal stress, excitatory-inhibitory imbalance, and ADHD risk: a hypothesis-driven perspective on psilocybin-induced neuroplasticityTranslational Psychiatry · 2026-06-04 Psilocybin reduces fear memory and restores neuroplasticity in the hippocampus and medial prefrontal cortex.Journal of Psychopharmacology · 2026-06-27 Psilocybin Decreases Preference for Large Rewards Accompanied by Increased Activity of Parvalbumin Neurons With Perineuronal Nets in the Medial Prefrontal CortexEuropean Journal of Neuroscience · 2026-05-31 Psilocybin for Treatment-Resistant Depression: A Comprehensive Review of Mechanisms and Therapeutic PotentialDigital Showcase Research, Scholarship, & Creative Works (University of Lynchburg) · 2026-05-21 Psilocybin-Assisted Therapy in the Management of Anxiety and Depression Among Cancer PatientsDigital Showcase Research, Scholarship, & Creative Works (University of Lynchburg) · 2026-05-21 PsiConnect: Multimodal Neuroimaging of Context-Dependent Brain and Behaviour Dynamics under PsilocybinScientific Data · 2026-05-20 Trajectories of psychedelic-assisted change: An observational study of a psilocybin retreat program followed by psychotherapeutic interventionsJournal of Psychedelic Studies · 2026-07-02 Past-Year Psilocybin and Alcohol Co-Use: Associations With Mental Health SymptomsJournal of Drug Issues · 2026-06-30