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Sexual identity as a moderator of associations between lifetime MDMA/ecstasy or psilocybin use and mental health outcomes: An exploratory analysis of a nationally representative sample using NSDUH 2015-2019
Abstract Purpose Lifetime MDMA/ecstasy and psilocybin use have been associated with lower odds of psychological distress, suicidality, and depressive episodes, but these associations may vary by marginalized identity. Building on minorities' diminished psychedelic returns (MDPR) framework and extending Jones and Nock's race/ethnicity moderation work, this st...
Consciousness and Psilocybin Effects on Well-Being: The CoPEWell Study
This study is exploring how psilocybin (a psychedelic drug) may improve mood and wellbeing. Many people report feeling better after taking psilocybin, but it is not clear why. The CoPEWell study will test whether these improvements come from the psychedelic experience itself (the "trip") or from direct effects on the brain. To study this, up to 120 participa...
Meskalin / Mescaline
# FORSCH-0351 - Meskalin / Mescaline Eigenständiges bilinguales Vollwerk (DE+EN). Transdisziplinäre wissenschaftliche Übersicht zu Meskalin entlang acht Disziplinen, mit expliziter Geltungsstufen-Kennzeichnung (gesichert / wahrscheinlich / offen). **Schwesterwerke (gleiche Struktur):** FORSCH-0291 (LSD) · FORSCH-0350 (Psilocybin) **Theorieanker:** FORSCH-008...
DMT und Ayahuasca / DMT and Ayahuasca
DMT und Ayahuasca / DMT and Ayahuasca Eigenständiges bilinguales Vollwerk (DE+EN). Transdisziplinäre wissenschaftliche Übersicht zu DMT und Ayahuasca entlang acht Disziplinen, mit expliziter Geltungsstufen-Kennzeichnung (gesichert / wahrscheinlich / offen). **Schwesterwerke (gleiche Struktur):** FORSCH-0291 (LSD) · FORSCH-0350 (Psilocybin) · FORSCH-0351 (Mes...
DMT und Ayahuasca / DMT and Ayahuasca
DMT und Ayahuasca / DMT and Ayahuasca Eigenständiges bilinguales Vollwerk (DE+EN). Transdisziplinäre wissenschaftliche Übersicht zu DMT und Ayahuasca entlang acht Disziplinen, mit expliziter Geltungsstufen-Kennzeichnung (gesichert / wahrscheinlich / offen). **Schwesterwerke (gleiche Struktur):** FORSCH-0291 (LSD) · FORSCH-0350 (Psilocybin) · FORSCH-0351 (Mes...
Neuroestimulantes naturales: de rituales ancestrales a terapias de vanguardia
La psilocibina, presente en los “hongos mágicos”, y la 5-MeO-DMT, secretada por el sapo Incilius alvarius, fueron empleadas ancestralmente en rituales espirituales en México. Hoy, la ciencia las reconoce como terapias prometedoras contra depresión, ansiedad, estrés postraumático y adicciones resistentes a tratamientos convencionales. Actúan sobre receptores ...
Meskalin / Mescaline
# FORSCH-0351 - Meskalin / Mescaline Eigenständiges bilinguales Vollwerk (DE+EN). Transdisziplinäre wissenschaftliche Übersicht zu Meskalin entlang acht Disziplinen, mit expliziter Geltungsstufen-Kennzeichnung (gesichert / wahrscheinlich / offen). **Schwesterwerke (gleiche Struktur):** FORSCH-0291 (LSD) · FORSCH-0350 (Psilocybin) **Theorieanker:** FORSCH-008...
Usos recreativos, medicinales y etnobotánicos de hongos alucinógenos: una revisión
This research involved a literature review on the recreational, Western medicinal and ethnobotanical uses of hallucinogenic mushrooms. Search engines such as PubMed and Google Scholar, among others, and Boolean operators were used. A total of 60 scientific papers in both Spanish and English were analyzed. Since the 11th century, Japan has recorded the consum...
Convergent biosynthesis of psilocybin in an ectomycorrhizal lineage: is the psychoactive end-product the selected trait?
The fungivore-deterrence hypothesis, that psilocybin evolved as a chemical defence against arthropod fungivores via 5-HT receptor agonism, has become the working consensus in fungal chemical ecology, despite resting on a phylogenomic pattern of horizontal gene transfer among saprotrophs and remarkably little direct experimental evidence. Recent biochemistry ...
Past-Year Psilocybin and Alcohol Co-Use: Associations With Mental Health Symptoms
Interest has grown in the effects of psilocybin on mental health, but little is known about its naturalistic use alongside alcohol and its relationship to depression and/or anxiety symptoms. Data from the nationally-representative 2024 National Survey Investigating Hallucinogenic Trends of participants who did ( n = 1234) or did not ( n = 1607) report past-y...
Investigating the impact of serotonergic psychedelic drugs, MDMA and ketamine on social cognition in psychiatric disorders: A scoping review.
RationaleInterest in psychedelic drugs has increased rapidly because of their potential therapeutic role in psychiatric disorders. Impairments in the sociocognitive skills needed to build and maintain social relationships are prominent features of many psychiatric and neurodevelopmental disorders. Emerging evidence suggests that compounds such as 3,4-methyle...
Efficacy in Relapse Prevention: Psilocybin in Alcohol Use Disorder With Depressive Symptoms
Up to 40% of individuals with alcohol use disorder (AUD) experience depression, which increases the risk of early relapse. Depression can cause relapse to occur 3 times faster in individuals with AUD who experience depressive symptoms at discharge. No treatments have been approved for individuals with both AUD and depression. Psilocybin, a psychedelic, shows...
A Phase 2, Open-Label Study Investigating the Safety and Efficacy of Psilocybin-Assisted Therapy for Sexual Assault-Related Posttraumatic Stress Disorder (PTSD)
A Phase 2, Open-Label Study to explore the efficacy, safety, and tolerability of psilocybin-assisted therapy in women with sexual assault-related Posttraumatic Stress Disorder (PTSD).
Psilocybin shows mixed results for patients with treatment-resistant depression
Patients with treatment-resistant depression who received psilocybin-assisted psychotherapy showed clinically meaningful improvement in depressive symptoms relative to placebo, a Phase 2b trial has found. However, the study did not show a significant effect on the primary outcome of treatment response 6 weeks after the first of two doses of psilocybin. Study...
Blinding Integrity in Psychedelic Randomized Clinical Trials: A Systematic Review.
ImportancePsychedelic drugs possess acute psychoactive effects that can compromise blinding integrity in randomized clinical trials (RCTs). Functional unblinding, when participants or raters correctly identify treatment allocation based on subjective effects, may bias outcomes through expectancy effects, challenging the validity of efficacy estimates and reg...
Implementing psilocybin-assisted therapy in palliative care settings: A survey of stakeholders.
While the adoption of psilocybin-assisted therapy for existential distress offers promising support for patients with life-threatening illnesses, implementing this intervention into palliative care settings presents significant real-world challenges. To examine palliative care stakeholders' knowledge and attitudes regarding psilocybin-assisted therapy, and i...
MFCC-DFT mapping of ligand recognition at the 5-HT2A receptor: energetic analysis of the interactions between serotonin, psychedelics, and antipsychotics.
Mental disorders represent a major global health problem, with depression being one of the most prevalent and disabling conditions worldwide. Growing evidence suggests that the serotonergic system, particularly the 5-HT2A receptor, plays an important role in modulating mood and cognitive processes, constituting a key pharmacological target for several psycho...