Daily self-assessment within a regimen of microdosing indicates enhanced psychological functioning on microdosing days relative to non-microdosing days.

Repeated self-administration of small doses of psychedelics, known as microdosing, has been associated with perceived improvements in psychological functioning. However, few studies have examined effects at the daily level. Drawing on data from a naturalistic, prospective, international survey of adults who microdose (N = 1435), we assessed self-reported within-person changes between microdosing days and non-microdosing days across six domains of psychological functioning. Using multi-level modeling, we identified higher (p Given the observational and exploratory nature of this study, these findings should be interpreted with caution; nonetheless, the prospective data provides valuable real-time insights while reducing recall bias.