Recruiting Psilocybin Clinical Trials

RecruitingNCT06349083

Neurobehavioral Mechanisms of Psilocybin-assisted Treatment for Alcohol Use Disorder

NYU Langone Health

Conditions

Alcohol Use Disorder

Phase

Phase 2

Enrollment

200 estimated

Locations

NYU Langone Health, New York, New York, United States

Registry updated

2026-08-07

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RecruitingNCT06455293

The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease

Joshua Woolley, MD, PhD

Conditions

Parkinson Disease · Depression

Phase

Phase 2

Enrollment

60 estimated

Locations

University of California, San Francisco, San Francisco, California, United States

Registry updated

2026-08-07

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RecruitingNCT06233344

An Exploratory Study of Feasibility, Efficacy, and Mechanisms of Mindfulness-Assisted Psychedelic Therapy

University of Southern California

Conditions

Mental Health

Phase

Phase 2

Enrollment

40 estimated

Locations

Univeristy of Southern California Brain and Creativity Institute, Los Angeles, California, United States

Registry updated

2026-08-06

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RecruitingNCT06001749

Feasibility Phase 2 Study of Psilocybin-Assisted Therapy for Opioid-Refractory Pain in Patients With Advanced Cancer

Yvan Beaussant, MD, MSci

Conditions

Opioid-Related Disorders · Pain Management · Pain Management and Care · Advanced Cancer

Phase

Phase 2

Enrollment

15 estimated

Locations

Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Registry updated

2026-08-05

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RecruitingNCT07118332

Psilocybin as a Treatment for Chronic Pain in Smokers

Yale University

Conditions

Smokers With Chronic Pain

Phase

Early Phase 1

Enrollment

10 estimated

Locations

Department of Veterans Affairs, West Haven, Connecticut, United States

Registry updated

2026-08-03

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RecruitingNCT07737054

Trauma-informed Psilocybin Assisted Psychotherapy (TiPAP) for Post-Traumatic Stress Disorder

Tel-Aviv Sourasky Medical Center

Conditions

Post-Traumatic Stress Disorder, PTSD

Phase

Early Phase 1

Enrollment

13 estimated

Locations

Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

Registry updated

2026-07-30

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RecruitingNCT06512220

Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)

Centre for Addiction and Mental Health

Conditions

Treatment Resistant Depression

Phase

Phase 2

Enrollment

12 estimated

Locations

Centre for Addiction and Mental Health, Toronto, Ontario, Canada

Registry updated

2026-07-30

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RecruitingNCT06518720

Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND): An Open-Label Clinical Trial

Centre for Addiction and Mental Health

Conditions

Treatment Resistant Depression · Chronic Pain

Phase

Phase 2

Enrollment

16 estimated

Locations

Centre for Addiction and Mental Health, Toronto, Ontario, Canada

Registry updated

2026-07-30

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RecruitingNCT06706232

Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality

The University of Texas Health Science Center, Houston

Conditions

Bipolar II Disorder · Depression, Bipolar · Suicidality

Phase

Phase 2

Enrollment

10 estimated

Locations

The University of Texas Health Science Center at Houston, Houston, Texas, United States

Registry updated

2026-07-30

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RecruitingNCT07211438

Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant Depression: A Pilot Randomized Clinical Trial

Centre for Addiction and Mental Health

Conditions

Treatment-Resistant Depression

Phase

Phase 2

Enrollment

40 estimated

Locations

Toronto Western Hospital (University Health Network), Toronto, Ontario, Canada · Centre for Addiction and Mental Health, Toronto, Ontario, Canada

Registry updated

2026-07-30

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RecruitingNCT06200155

TRIP - TReatment to Improve Depression and/or Anxiety Using Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy

M.D. Anderson Cancer Center

Conditions

Depression, Anxiety · Psilocybin-Assisted Psychotherapy · Advanced Cancer

Phase

Phase 2

Enrollment

30 estimated

Locations

MD Anderson Cancer Center, Houston, Texas, United States

Registry updated

2026-07-29

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RecruitingNCT06801041

TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors

M.D. Anderson Cancer Center

Conditions

Depression · Anxiety · Cancer

Phase

Phase 2

Enrollment

20 estimated

Locations

The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States

Registry updated

2026-07-29

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RecruitingNCT05866471

Activating Neuroplasticity to ENHANCE the Perception Box Expanding Effects of Psilocybin

University of Wisconsin, Madison

Conditions

Healthy · Psychedelic Experiences · Vagus Nerve Stimulation

Phase

Phase 1

Enrollment

108 estimated

Locations

University of Wisconsin - Madison, Madison, Wisconsin, United States

Registry updated

2026-07-29

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RecruitingNCT07732166

Changes in Self-awareness Induced by Psychoactive Substances: an Experimental Study With Psilocybin.

Pontifícia Universidade Católica do Rio de Janeiro

Conditions

Healthy Adults

Phase

Early Phase 1

Enrollment

100 estimated

Locations

Centro de Pesquisas Matteo Ricci, Rio de Janeiro, Rio de Janeiro, Brazil

Registry updated

2026-07-28

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RecruitingNCT06355414

Psilocybin and Affective Function in Chronic Lower Back Pain Depression

Johns Hopkins University

Conditions

Chronic Low-back Pain · Depression

Phase

Phase 1

Enrollment

40 estimated

Locations

Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

Registry updated

2026-07-24

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RecruitingNCT07347405

A Randomized Double-masked Dose-controlled Trial to Assess the Tolerability, Safety, Subjective Experience, and Efficacy of Repeated Administration of Three Different Doses of Psilocybin Whole Mushroom for the Treatment of Obsessive-compulsive Disorder.

Francisco A Moreno

Conditions

Obsessive-Compulsive Disorder

Phase

Phase 1

Enrollment

30 estimated

Locations

The Clinical and Translational Sciences Research Center, Tucson, Arizona, United States

Registry updated

2026-07-23

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RecruitingNCT05301608

Effects of Psilocybin on Electrophysiology and the Dynamic Content of Thought

Johns Hopkins University

Conditions

Healthy

Phase

Phase 1 · Phase 2

Enrollment

30 estimated

Locations

Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland, United States

Registry updated

2026-07-23

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RecruitingNCT06820723

A Randomized, Double-Blind, Placebo-Controlled Mechanistic Study to Assess a Single Oral Dose of CYB003 in Participants With Major Depressive Disorder (MDD) and Moderate to Severe Anxiety

Ohio State University

Conditions

Depression · Anxiety · Major Depressive Disorder

Phase

Phase 2

Enrollment

40 estimated

Locations

The Ohio State University Department of Psychiatry, Columbus, Ohio, United States

Registry updated

2026-07-23

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RecruitingNCT07610135

PRISMatic: A Phase 1b Randomized, Double-Armed, Parallel-Group, Placebo-Controlled Trial of Psilocybin Efficacy With or Without Pimavanserin Pretreatment

Johns Hopkins University

Conditions

Mood (Psychological Function) · Well Being · Mood · Healthy

Phase

Phase 1 · Phase 2

Enrollment

20 estimated

Locations

Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland, United States

Registry updated

2026-07-21

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RecruitingNCT06814522

Psilocybin-Assisted Therapy for Physician Well-Being and Burnout: Feasibility, Safety, Clinical Effectiveness and Biomarkers of Response [PAT-B (Psilocybin-Assisted Therapy for Physician Well-Being and Burnout)]

University of California, San Diego

Conditions

Burnout · Burnout, Healthcare Workers

Phase

Phase 1 · Phase 2

Enrollment

10 estimated

Locations

UC San Diego, San Diego, California, United States

Registry updated

2026-07-21

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RecruitingNCT07610369

The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease

Yale University

Conditions

Depression · Parkinson's Disease (PD)

Phase

Phase 2

Enrollment

40 estimated

Locations

Yale University, New Haven, Connecticut, United States

Registry updated

2026-07-20

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RecruitingNCT06067737

Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder: a Randomized Double-blind Trial

Johns Hopkins University

Conditions

Opioid Use Disorder

Phase

Phase 2

Enrollment

90 estimated

Locations

Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland, United States

Registry updated

2026-07-17

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RecruitingNCT06247839

The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder

Sharmin Ghaznavi

Conditions

Major Depressive Disorder

Phase

Phase 3

Enrollment

20 estimated

Locations

Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, United States

Registry updated

2026-07-17

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RecruitingNCT07703722

Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Trauma-Related Major Depressive Disorder: Randomized Controlled Trial

Khyber Medical University Peshawar

Conditions

Major Depressive Disorder · Post-Traumatic Stress Disorder (PTSD)

Phase

Phase 3

Enrollment

60 estimated

Locations

Institute of Health Science, Khyber Medical University, Islamabad, Capital, Pakistan · Hayatabad Medical Complex Peshawar, Peshawar, KPK, Pakistan · Khyber Medical University, Peshawar, KPK, Pakistan

Registry updated

2026-07-14

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RecruitingNCT06464367

Mechanistic Studies of Psilocybin in Headache Disorders

Yale University

Conditions

Migraine

Phase

Early Phase 1

Enrollment

50 estimated

Locations

VA Connecticut Healthcare System, West Haven, Connecticut, United States

Registry updated

2026-07-13

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RecruitingNCT07063862

PSilocybin Microdose for psYCHological and Existential Distress in PALliative Care (PSYCHED-PAL): A Multi-site Phase 3 Double-blind, Placebo-controlled, Parallel-arm Clinical Trial

Bruyère Health Research Institute.

Conditions

Psychological Distress

Phase

Phase 3

Enrollment

120 estimated

Locations

William Osler Health System, Brampton, Ontario, Canada · Providence Care Hospital, Kingston, Ontario, Canada · St. Joseph's Healthcare, London, Ontario, Canada · +4 more

Registry updated

2026-07-10

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RecruitingNCT05265546

Investigating the Mechanisms of the Effects of Psilocybin on Visual Perception and Visual Representations in the Brain

University of California, Berkeley

Conditions

Perception Disorders

Phase

Phase 1

Enrollment

80 estimated

Locations

University of California, Berkeley, Berkeley, California, United States

Registry updated

2026-07-10

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RecruitingNCT06810310

Psilocybin: Capturing Brain Mechanisms of Motivation and Neurocognition in Individuals With Opioid Use Disorder

University of Pennsylvania

Conditions

Opioid Use Disorder

Phase

Phase 2

Enrollment

24 estimated

Locations

University of Pennsylvania, Philadelphia, Pennsylvania, United States

Registry updated

2026-07-09

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RecruitingNCT04161066

Phase I Study of the Safety and Adjunctive Effects of Psilocybin in Adults With Opioid Use Disorder Maintained on a Buprenorphine/Naloxone Formulation

University of Wisconsin, Madison

Conditions

Opioid Use Disorder

Phase

Phase 1

Enrollment

10 estimated

Locations

University of Wisconsin, Madison, Wisconsin, United States

Registry updated

2026-07-07

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RecruitingNCT06160284

Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD)

Yale University

Conditions

Opioid Use Disorder

Phase

Phase 1

Enrollment

12 estimated

Locations

Yale University, New Haven, Connecticut, United States

Registry updated

2026-07-07

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RecruitingNCT07516405

A Multicenter Phase 1 Safety and Tolerability Trial of Psilocybin in Healthy Older Adults

University of Colorado, Denver

Conditions

Healthy Volunteer · Older Adults (65-85 Years)

Phase

Phase 1

Enrollment

40 estimated

Locations

University of California San Francisco (UCSF) Department of Neurology, San Francisco, California, United States · University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States · Emory University Brain Health Center, Atlanta, Georgia, United States · +3 more

Registry updated

2026-07-06

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RecruitingNCT07638553

Efficacy in Relapse Prevention: Psilocybin in Alcohol Use Disorder With Depressive Symptoms

Centre Hospitalier Universitaire de Nīmes

Conditions

Alcohol Use Disorder · Depressive Sympotoms · Psilocybin

Phase

Phase 3

Enrollment

172 estimated

Locations

Centre Hospitalier de la Côte Basque, Bayonne, France · CHU Besançon, Besançon, France · CHU de Bordeaux, Bordeaux, France · +5 more

Registry updated

2026-07-01

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RecruitingNCT06902974

A Phase 2, Open-Label Study Investigating the Safety and Efficacy of Psilocybin-Assisted Therapy for Sexual Assault-Related Posttraumatic Stress Disorder (PTSD)

Sunstone Medical

Conditions

Post Traumatic Stress Disorder · PTSD

Phase

Phase 2

Enrollment

70 estimated

Locations

Sunstone Medical, PC, Rockville, Maryland, United States

Registry updated

2026-07-01

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RecruitingNCT05452772

5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder

Johns Hopkins University

Conditions

Tobacco Use Disorder

Phase

Phase 2

Enrollment

66 estimated

Locations

University of Alabama at Birmingham, Birmingham, Alabama, United States · Johns Hopkins University School of Medicine, Baltimore, Maryland, United States · New York University, New York, New York, United States

Registry updated

2026-06-29

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RecruitingNCT06386003

Psilocybin-Assisted Massed Cognitive Processing Therapy for Chronic Posttraumatic Stress Disorder: An Open-label Trial

Unity Health Toronto

Conditions

Post Traumatic Stress Disorder · PTSD · Chronic PTSD

Phase

Phase 2

Enrollment

15 estimated

Locations

St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada

Registry updated

2026-06-26

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RecruitingNCT07104916

A Pilot Mechanistic RCT of Psilocybin With Mindfulness-based Therapy vs Support for Posttraumatic Stress Disorder (PTSD)

Anthony P King

Conditions

Post Traumatic Stress Disorder · Depression - Major Depressive Disorder

Phase

Phase 2

Enrollment

30 estimated

Locations

The Ohio State University Medical Center, Columbus, Ohio, United States

Registry updated

2026-06-25

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RecruitingNCT07565493

Psilocybin Administration With 5-HT1a Blockade

Johns Hopkins University

Conditions

Psychedelic Effects in Healthy Volunteers

Phase

Early Phase 1

Enrollment

18 estimated

Locations

Center for Psychedelics and Consciousness Research, Baltimore, Maryland, United States

Registry updated

2026-06-25

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RecruitingNCT07048743

Psilocybin-assisted Existential, Attachment and Relational (PEARL) Therapy for Caregivers of Patients With Advanced Cancer: A Phase II Open-Label Trial

University Health Network, Toronto

Conditions

Caregiver Distress

Phase

Phase 2

Enrollment

15 estimated

Locations

Toronto General Hospital, Toronto, Ontario, Canada

Registry updated

2026-06-23

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RecruitingNCT06724289

Psilocybin-Assisted Therapy for Prolonged Grief

University of Virginia

Conditions

Prolonged Grief Disorder

Phase

Early Phase 1

Enrollment

12 estimated

Locations

University of Virginia, Charlottesville, Virginia, United States

Registry updated

2026-06-23

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RecruitingNCT07386730

A Double Blind, Randomized Trial Investigating the Safety, Feasibility, and Mechanisms of Psychedelics in Healthy Older Adults With Low Well-being as Moderated by Biomarkers for Preclinical Alzheimer's Disease

Jennifer Mitchell

Conditions

Anhedonia in Healthy Volunteers · Older Adults (50-90 Years)

Phase

Phase 1

Enrollment

80 estimated

Locations

University of California San Francisco, Sandler Neuroscience Building, San Francisco, California, United States

Registry updated

2026-06-08

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RecruitingNCT06626139

2 x 2 Factorial, Double-blind, Randomized Trial of 'Set and Setting': a Translational Study in Healthy Volunteers

Robin Carhart-Harris, PhD, MA

Conditions

Healthy Participants With Lower-than-average Mental Well-being

Phase

Phase 2

Enrollment

120 estimated

Locations

UCSF Mission Bay, San Francisco, California, United States

Registry updated

2026-06-04

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RecruitingNCT06768944

The Role of the Subjective Experience in Supporting Positive Effects Following Psilocybin: a Randomized, Controlled Clinical Trial Using Risperidone in Healthy Adults

University of Calgary

Conditions

Investigating the Importance of the Subjective Psychedelic Experience

Phase

Phase 2

Enrollment

128 estimated

Locations

University of Calgary, Calgary, Alberta, Canada

Registry updated

2026-06-02

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RecruitingNCT07506395

Group Psilocybin-Assisted Therapy for Post-Traumatic Stress Disorder

University of New Mexico

Conditions

PTSD

Phase

Phase 1

Enrollment

36 estimated

Locations

Interdisciplinary Substance Use and Brain Injury (ISUBI), Albuquerque, New Mexico, United States

Registry updated

2026-05-22

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RecruitingNCT07216404

Exploring the Safety, Acceptability, and Efficacy of Psilocybin Among Non-Small Cell Lung Cancer Patients With Major Depressive Disorder: A Proof-of-Concept Trial (DREAM LUNG STUDY)

Alan Davis

Conditions

Lung Non-Small Cell Carcinoma · Unipolar Depression

Phase

Phase 2

Enrollment

10 estimated

Locations

Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

Registry updated

2026-05-14

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RecruitingNCT06782724

The Safety and Efficacy of Psilocybin Therapy Compared to Low-dose Control in Reducing Depressive Symptoms in Patients With COPD, ALS, MS, or APD.

University Medical Center Groningen

Conditions

COPD (Chronic Obstructive Pulmonary Disease) · ALS (Amyotrophic Lateral Sclerosis) · MS (Multiple Sclerosis) · Major Depressive Disorder (MDD)

Phase

Phase 2

Enrollment

108 estimated

Locations

National Institute of Mental Health, Prague, Czechia · Bispebjerg Hospital, Copenhagen, Denmark · University Medical Center Groningen, Groningen, Provincie Groningen, Netherlands · +1 more

Registry updated

2026-05-08

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RecruitingNCT07251491

Safety, Tolerability, Outcomes of Psilocybin for Depression (STOP Depression) in Veterans With Spinal Cord Injury

James J. Peters Veterans Affairs Medical Center

Conditions

Spinal Cord Injury · Depression - Major Depressive Disorder · Veteran

Phase

Phase 1 · Phase 2

Enrollment

30 estimated

Locations

James J. Peters Department of Veterans Affairs Medical Center, The Bronx, New York, United States

Registry updated

2026-05-04

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RecruitingNCT05883540

Lysergic Acid Diethylamide (LSD) in Palliative Care: a Randomised, Double-blind, Active-placebo Controlled Phase II Study (LPC-Study)

University Hospital, Basel, Switzerland

Conditions

Palliative Care · Pain · Anxiety · Depression

Phase

Phase 2

Enrollment

60 estimated

Locations

University Hospital Basel, Division of Clinical Pharmacology and Toxicology, Basel, Switzerland · University Hospital Geneva, Palliative medicine department, Collonge-Bellerive, Switzerland · Spital Uster AG, Division of Internal Medicine, Uster, Switzerland · +1 more

Registry updated

2026-04-29

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RecruitingNCT06430541

Study of Psilocybin Assisted Psychotherapy to Address Fear of Recurrence in Patients Diagnosed With Early-stage Breast Cancer and Ovarian Cancer in Remission

University of Colorado, Denver

Conditions

Breast Cancer · Ovarian Cancer

Phase

Phase 1

Enrollment

20 estimated

Locations

Outpatient CTRC, Aurora, Colorado, United States · University of Colorado Cancer Center, Aurora, Colorado, United States

Registry updated

2026-04-21

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RecruitingNCT06319378

CAPSI - Cancer Related Major Depression Treated With a Single Dose of Psilocybin: A Multicenter Randomized Placebo Controlled Double Blind Clinical Trial

Section for Affective Disorders; Northern Stockholm Psychiatry

Conditions

MDD

Phase

Phase 2

Enrollment

100 estimated

Locations

region Västra Götaland, Gothenburg, Göteborg, Sweden · Norra Stockholms Psykiatri, Stockholm, Stockholm County, Sweden · Psykiatriska Kliniken, Akademiska Sjukhuset, Uppsala, Uppsala County, Sweden · +1 more

Registry updated

2026-04-13

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RecruitingNCT06692192

Role of Experience, Conscious Awareness, and Plasticity in Psilocybin's Behavioral Effects - Follow-Up Study (The RECAP 2 Study)

University of Wisconsin, Madison

Conditions

Psilocybin

Phase

Phase 1

Enrollment

60 estimated

Locations

UW School of Medicine and Public Health, Madison, Wisconsin, United States

Registry updated

2026-04-03

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RecruitingNCT06072898

Engaging Mood Brain Circuits With Psilocybin: a Randomized Neuroimaging Trial in Depression

Sunnybrook Health Sciences Centre

Conditions

Depressive Disorder · Major Depressive Disorder

Phase

Phase 2

Enrollment

50 estimated

Locations

Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

Registry updated

2026-03-30

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RecruitingNCT06898606

Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression

Federal University of Latin American Integration

Conditions

Depressive Disorder

Phase

Phase 1 · Phase 2

Enrollment

24 estimated

Locations

Federal University of Latin American Integration, Foz do Iguaçu, Paraná, Brazil

Registry updated

2026-03-27

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RecruitingNCT07490353

Elucidating the Relevance of the Psychedelic Experience to Psilocybin's Anti-Anhedonic Effects: A Randomized, Open-Label, Cross-Over Functional Magnetic Resonance Imaging Trial

Medical University of Vienna

Conditions

Depression - Major Depressive Disorder · Anhedonia

Phase

Phase 1

Enrollment

85 estimated

Locations

Medical University of Vienna, Department of Psychiatry and Psychotherapy, Division of General Psychiatry, Vienna, State of Vienna, Austria

Registry updated

2026-03-24

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RecruitingNCT06660381

Pilot Study of Psilocybin-assisted Treatment for Cannabis Use Disorder

Johns Hopkins University

Conditions

Cannabis Use Disorder

Phase

Phase 1

Enrollment

12 estimated

Locations

Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland, United States

Registry updated

2026-03-18

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RecruitingNCT06818994

Safety and Efficacy of Psilocybin-assisted Psychotherapy for Demoralization Syndrome in Patients Diagnosed With Advanced Stage Cancer: a Pilot Study

Gustavo Vazquez

Conditions

Demoralization · Safety

Phase

Phase 1

Enrollment

15 estimated

Locations

Queen's University, Kingston, Ontario, Canada

Registry updated

2026-03-18

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RecruitingNCT04123314

Pilot Study of Serotonin 2A Receptor (5-HT2A) Agonist Psilocybin for Depression in Patients With Mild Cognitive Impairment or Early Alzheimer's Disease

Johns Hopkins University

Conditions

Depressive Symptoms · Depression · Alzheimer Disease · Mild Cognitive Impairment

Phase

Early Phase 1

Enrollment

20 estimated

Locations

Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland, United States

Registry updated

2026-03-16

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RecruitingNCT05068791

Psilocybin-facilitated Treatment for Chronic Pain

University of Alabama at Birmingham

Conditions

Fibromyalgia, Primary

Phase

Early Phase 1

Enrollment

30 estimated

Locations

UAB Beacon Tower, Birmingham, Alabama, United States

Registry updated

2026-03-11

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RecruitingNCT06442423

Safety, Feasibility, and Tolerability of Psilocybin Treatment for Individuals With Functional Impairment Related to Mood, Anxiety, Trauma and/or Addiction Symptoms: An Open-label Proof-of-concept Study

Yale University

Conditions

Transdiagnostic · Depression - Major Depressive Disorder · Anxiety · PTSD Symptoms

Phase

Phase 1

Enrollment

50 estimated

Locations

Connecticut Mental Health Center - Yale School of Medicine, New Haven, Connecticut, United States

Registry updated

2026-03-11

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RecruitingNCT07169747

The Therapeutic Potential of Psilocybin in Anorexia Nervosa in Young Adults

Region Skane

Conditions

Anorexia Nervosa

Phase

Phase 2

Enrollment

40 estimated

Locations

Psykiatrikliniken, Baravägen 1, Lund, Sweden

Registry updated

2026-03-06

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RecruitingNCT07072728

A Phase 2b Double-blind, Randomized, Low-dose Comparator-controlled Clinical Trial to Assess the Efficacy and Safety of NPX-5 in Psilocybin-assisted Psychotherapy for the Treatment of Adjustment Disorder Associated With Cancer.

Psyence Australia Pty Ltd

Conditions

Adjustment Disorder · Adjustment Disorder With Anxious Mood · Cancer · Cancer Cachexia

Phase

Phase 2

Enrollment

87 estimated

Locations

Mind Medicine Australia Clinic, Abbotsford, Victoria, Australia · Paratus Clinical Research Melbourne, Northcote, Victoria, Australia · Empax Centre, Leederville, Western Australia, Australia

Registry updated

2026-03-03

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RecruitingNCT06399263

Study of Psilocybin for Anorexia in Young Adults

Marissa Raymond-Flesch, MD, MPH

Conditions

Anorexia Nervosa

Phase

Phase 2

Enrollment

40 estimated

Locations

University of California, San Francisco, San Francisco, California, United States

Registry updated

2026-03-03

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RecruitingNCT06450210

Safety for Home Administration of Microdose Psilocybin Use

Johns Hopkins University

Conditions

Psychedelic Experiences

Phase

Phase 1

Enrollment

20 estimated

Locations

5510 Nathan Shock Drive, Baltimore, Maryland, United States

Registry updated

2026-02-23

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RecruitingNCT06772753

Investigation of Psychedelic Effects in Psychoactive Substances

Johns Hopkins University

Conditions

Psychedelic Effects in Healthy Volunteers

Phase

Phase 1

Enrollment

50 estimated

Locations

Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland, United States

Registry updated

2026-02-23

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RecruitingNCT07053917

Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability

Johns Hopkins University

Conditions

Stroke · Chronic Stroke · Intracerebral Haemorrhage · Intracerebral Haemorrhage (ICH)

Phase

Phase 1

Enrollment

20 estimated

Locations

Johns Hopkins, Baltimore, Maryland, United States

Registry updated

2026-02-13

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RecruitingNCT07281352

Psilocybin-Assisted Cognitive Behavioral Therapy for Depression

University of California, Los Angeles

Conditions

Major Depressive Diorder

Phase

Phase 1 · Phase 2

Enrollment

50 estimated

Locations

UCLA Semel Institute, Los Angeles, California, United States

Registry updated

2026-02-12

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RecruitingNCT07079930

Safety and Psychological Effects of Psilocybin and D-Serine Formulation in Healthy Volunteers

Hadassah Medical Organization

Conditions

Healthy Volunteers

Phase

Phase 1

Enrollment

10 estimated

Locations

Hadassah Medical Organization, Jerusalem, Israel, Jerusalem, Israel

Registry updated

2026-02-05

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RecruitingNCT06796062

A Phase 2 Trial of Psilocybin as an Adjunctive Treatment for OUD Patients Who Continue to Use Illicit Opioids Despite Adherence to Methadone Treatment

NYU Langone Health

Conditions

Opioid Use Disorder

Phase

Phase 2

Enrollment

480 estimated

Locations

Duke City Recovery Toolbox, Albuquerque, New Mexico, United States · University of New Mexico, Albuquerque, New Mexico, United States · StartCare, Brooklyn, New York, United States · +2 more

Registry updated

2026-01-23

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RecruitingNCT06888128

The STARLIGHT Protocol: State-Funded Trial Assessing Recovery and Long-Term Impact of Guided Psilocybin for Healing Trauma

Baylor College of Medicine

Conditions

PTSD

Phase

Phase 2

Enrollment

15 estimated

Locations

Baylor College of Medicine, Houston, Texas, United States

Registry updated

2026-01-22

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RecruitingNCT06656702

Effects of Psilocybin in Patients With Amyotrophic Lateral Sclerosis

Johns Hopkins University

Conditions

Amyotrophic Lateral Sclerosis

Phase

Early Phase 1

Enrollment

24 estimated

Locations

Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland, United States

Registry updated

2026-01-12

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RecruitingNCT06615908

A Randomized Double-blinded Controlled Trial for the Treatment of Persisting Symptoms After Concussion With Psilocybin-assisted Therapy: A Safety and Feasibility Trial

University of Calgary

Conditions

Persisting Symptoms After Concussion

Phase

Phase 1

Enrollment

40 estimated

Locations

University of Calgary, Calgary, Alberta, Canada

Registry updated

2025-12-30

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RecruitingNCT06798636

Investigating the Effects of a Psychedelic-augmented Mental Imagery-based Intervention for Young People With Self-harm Behaviour: an Experimental Medicine Study

Imperial College London

Conditions

Self Harm

Phase

Early Phase 1

Enrollment

30 estimated

Locations

Imperial College London, London, United Kingdom

Registry updated

2025-12-05

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RecruitingNCT05585229

Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid Medication in Patients With Chronic Pain: an Open-label Feasibility Study

University of British Columbia

Conditions

Opioid Dependence · Chronic Pain

Phase

Phase 2

Enrollment

10 estimated

Locations

University of British Columbia - Okanagan Campus, Kelowna, British Columbia, Canada

Registry updated

2025-12-04

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RecruitingNCT05398484

A Phase 2b, Randomized, Double-blind, Placebo-controlled, Multi-center Study of the Effects of Psilocybin-assisted Psychotherapy on Psychiatric and Existential Distress in Advanced Cancer

NYU Langone Health

Conditions

Advanced Cancer

Phase

Phase 2 · Phase 3

Enrollment

200 estimated

Locations

University of Colorado Anschutz Medical campus (CU AMC), Aurora, Colorado, United States · NYU Langone Health, New York, New York, United States

Registry updated

2025-12-04

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RecruitingNCT06405607

Psilocybin vs Ketamine for Alcohol Use Disorder

University of Iowa

Conditions

Alcohol Use Disorder · Alcohol Dependence · Alcohol Abuse

Phase

Phase 2

Enrollment

80 estimated

Locations

University of Iowa Health Care, Iowa City, Iowa, United States

Registry updated

2025-11-28

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RecruitingNCT06815653

Digital Intervention for Psychedelic Preparation (DIPP): A Randomised Controlled Feasibility Trial Comparing Meditation and Music-Based Programs in Healthy Volunteers.

University College, London

Conditions

Healthy

Phase

Phase 1

Enrollment

40 estimated

Locations

University College London, London, United Kingdom

Registry updated

2025-11-26

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RecruitingNCT06132178

Assessing the Safety, Tolerability, and Efficacy of Psilocybin Therapy Followed by Accelerated Intermittent Theta Burst (aiTBS) Repetitive Transcranial Magnetic Stimulation (rTMS) for Treatment-Resistant Major Depressive Disorder

University of Texas at Austin

Conditions

Treatment Resistant Depression · MDD · Major Depressive Disorder · Recurrent Depression

Phase

Phase 2

Enrollment

100 estimated

Locations

Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600, Austin, Texas, United States

Registry updated

2025-11-26

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RecruitingNCT05403086

Pragmatic Trial of Psilocybin Therapy in Palliative Care (PT2PC): A Multicenter Triple-blind Phase 2 Randomized Controlled Trial of Psilocybin Therapy for Demoralized Adults Near the End of Life

Charles S. Grob, M.D.

Conditions

Demoralization

Phase

Phase 2

Enrollment

100 estimated

Locations

Marin Cancer Care, Greenbrae, California, United States · University of California, Los Angeles, Los Angeles, California, United States · University of San Francisco, San Francisco, California, United States · +2 more

Registry updated

2025-11-25

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RecruitingNCT07183748

A Double-blind, Phase II Feasibility Study to Assess the Safety and Efficacy of Psilocybin Microdosing Combined With Psychotherapy in Treatment-resistant Depression

Beersheva Mental Health Center

Conditions

Treatment Resistant Depression

Phase

Phase 2

Enrollment

20 estimated

Locations

Mental Health Center Beer Sheva, Beersheba, Israel

Registry updated

2025-11-19

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RecruitingNCT04882839

Open Label, Phase 2 Study for Evaluating the Feasibility, Safety and Efficacy of Psychotherapy Assisted Psilocybin for Treatment of Severe Obsessive Compulsive Disorder (OCD) in Drug and/or Psychotherapy Resistant Patients.

Beersheva Mental Health Center

Conditions

Obsessive-compulsive Disorder

Phase

Phase 2

Enrollment

15 estimated

Locations

Beer Sheva Mental Health Center, Beersheba, Israel

Registry updated

2025-11-19

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RecruitingNCT06786325

A Wellcome Leap for the Opioid Crisis: Can the 5HT2A Agonist Psilocybin Improve Brain, Behavioral, and Clinical Outcomes in Opioid Use Disorder (OUD)?

Anna Rose Childress, Ph.D.

Conditions

Opioid Use Disorder

Phase

Phase 2

Enrollment

36 estimated

Locations

University of Pennsylvania, Philadelphia, Pennsylvania, United States

Registry updated

2025-10-29

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RecruitingNCT06367738

Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults

University of California, Berkeley

Conditions

Aging

Phase

Phase 1

Enrollment

40 estimated

Locations

University of California, Berkeley, Berkeley, California, United States

Registry updated

2025-10-21

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RecruitingNCT06899594

A Pilot Study in North Louisiana to Assess the Tolerability of Psilocybin as Well as Its Capacity to Promote Abstinence From Methamphetamine

Kevin Murnane

Conditions

Methamphetamine Use Disorder

Phase

Early Phase 1

Enrollment

20 estimated

Locations

LSU Health Shreveport, Shreveport, Louisiana, United States

Registry updated

2025-10-07

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RecruitingNCT06989957

Psilocybin and MDMA for Post-traumatic Stress Disorder (PTSD)

Johns Hopkins University

Conditions

Posttraumatic Stress Disorder

Phase

Phase 1

Enrollment

40 estimated

Locations

Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland, United States

Registry updated

2025-10-01

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RecruitingNCT06368492

The Impact of Psilocybin on Pain in Fibromyalgia Patients: a Multicentre Trial.

Maastricht University

Conditions

Fibromyalgia

Phase

Not applicable

Enrollment

35 estimated

Locations

Maastricht University, Maastricht, Limburg, Netherlands · Leiden University Medical Center, Leiden, South Holland, Netherlands

Registry updated

2025-09-15

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RecruitingNCT06899165

Processing Intergenerational Trauma With Psilocybin-Assisted Therapy

Rachel Yehuda

Conditions

Psychological Stress · Depression · Anxiety

Phase

Phase 2

Enrollment

100 estimated

Locations

The Parsons Research Center for Psychedelic Healing, New York, New York, United States

Registry updated

2025-09-08

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RecruitingNCT06853912

A Phase 2 Single-site, Double-blind, Placebo-controlled, Randomized Clinical Trial With an Open-label Extension Phase to Examine the Safety, Subjective Experiences, Acute Effects, and Suitability of Psilocybin Combined With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder (PTSD)

Nathan Brashares Sackett

Conditions

Alcohol Use Disorder (AUD) · PTSD

Phase

Phase 2

Enrollment

40 estimated

Locations

University of Washington Center for Novel Therapeutics in Addiction Psychiatry, Seattle, Washington, United States

Registry updated

2025-08-28

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RecruitingNCT06796361

Role of the Serotonin 2A Receptor in Psilocybin-induced Altered States of Consciousness (PDR-Study)

University Hospital, Basel, Switzerland

Conditions

Healthy

Phase

Phase 1

Enrollment

16 estimated

Locations

Clinical Trial Unit, Basel, Canton of Basel-City, Switzerland

Registry updated

2025-05-28

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RecruitingNCT06512194

An Investigation of Strategies to Understand and Optimize the Antidepressant Effects of Psilocybin (The OPTIMIZE Study)

Charles Raison

Conditions

Depression

Phase

Phase 2

Enrollment

141 estimated

Locations

Vail Health Behavioral Health, Edwards, Colorado, United States

Registry updated

2025-05-23

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RecruitingNCT06592833

Investigating the Role of Serotonin in the Mechanism of Action of Psilocybin in Patients With Major Depressive Disorder

Icahn School of Medicine at Mount Sinai

Conditions

Major Depressive Disorder

Phase

Phase 2

Enrollment

60 estimated

Locations

Icahn School of Medicine at Mount Sinai, Center for Psychedelic Therapy Research, New York, New York, United States

Registry updated

2025-05-14

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RecruitingNCT06969170

A Phase 2a, Placebo-Controlled Randomized, Double-Blind Trial to Evaluate the Safety, Tolerability, and Preliminary Efficacy of Psilocybin Oral Solution in Adults With Generalized Anxiety Disorder

Queen's University

Conditions

Generalized Anxiety Disorder (GAD)

Phase

Phase 2

Enrollment

50 estimated

Locations

Kingston General Health Research Institute, Kingston, Ontario, Canada

Registry updated

2025-05-13

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RecruitingNCT06731335

Psilocybin for Enhanced Analgesia in Chronic nEuropathic PAIN

Unity Health Toronto

Conditions

Chronic Neuropathic Pain · Pain Management

Phase

Phase 2

Enrollment

30 estimated

Locations

St. Michael's Hospital. Unity Health Toronto, Toronto, Ontario, Canada

Registry updated

2025-03-30

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RecruitingNCT06899334

Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in a Randomized, Placebo-controlled, Cross-over Trial in Healthy Participants (LPD-Study)

University Hospital, Basel, Switzerland

Conditions

Healthy

Phase

Phase 1

Enrollment

24 estimated

Locations

University Hospital, Basel, Switzerland

Registry updated

2025-03-27

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RecruitingNCT06225232

An 8-week Phase 2 Clinical Trial to Evaluate the Safety, Tolerability and Efficacy of Psilocybin-assisted-psychotherapy in Adults With Cannabis Use Disorder: A Proof-of-Concept Study

McMaster University

Conditions

Cannabis Use Disorder, Moderate · Cannabis Use Disorder, Severe

Phase

Phase 2

Enrollment

16 estimated

Locations

MacAnxiety Research Centre, Hamilton, Ontario, Canada

Registry updated

2025-03-19

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RecruitingNCT03289949

The Neurobiological Effect of 5-HT2AR Modulation

Gitte Moos Knudsen

Conditions

Basic Science

Phase

Phase 1

Enrollment

200 estimated

Locations

Neurobiology Research Unit, Rigshospitalet, Copenhagen, Denmark

Registry updated

2024-12-16

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RecruitingNCT06506019

Neurobiological Effects of Psilocybin in Treatment Resistant Bipolar Depression: An Emotional-Processing fMRI Pilot Study

University Health Network, Toronto

Conditions

Bipolar Depression

Phase

Phase 1

Enrollment

30 estimated

Locations

Toronto Western Hospital - University Health Network, Toronto, Ontario, Canada

Registry updated

2024-10-18

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RecruitingNCT06378229

Psilocybin-assisted Psychotherapy in the Treatment of Patients Hospitalized for Treatment-resistant Depression: an Open-label Feasibility Study with an Experiential and Systemic Focus

University Hospital, Ghent

Conditions

Treatment Resistant Depression

Phase

Phase 2

Enrollment

100 estimated

Locations

Ghent University Hospital, Ghent, Oost-Vlaanderen, Belgium

Registry updated

2024-09-19

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RecruitingNCT06160232

Psilocybin-Assisted Therapy for Severe Alcohol Use Disorder: Feasibility, Clinical Efficacy & (Neuro)Cognitive Mechanisms

Brugmann University Hospital

Conditions

Severe Alcohol Use Disorder

Phase

Phase 2

Enrollment

62 estimated

Locations

Brugmann University Hospital, Brussels, Belgium

Registry updated

2024-08-07

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RecruitingNCT05995769

Mechanisms Supporting Psilocybin-assisted Psychotherapy for Alcohol Use Disorder: A Randomized, Controlled Clinical Trial

University of Calgary

Conditions

Alcohol Use Disorder · Alcoholism

Phase

Phase 2

Enrollment

128 estimated

Locations

University of Calgary, Calgary, Alberta, Canada

Registry updated

2024-05-07

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