Psilocybin and psilocin research index

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Elucidating the Phase I metabolism of psilocin in vitro.

Psilocin is a well-studied controlled substance with potential psychotherapeutic applications. However, research gaps remain regarding its metabolism. Our objective was to elucidate a comprehensive Phase I metabolic profile of psilocin to support its forensic management and clinical development. We utilized human enzymes from various sources to characterize ...

Details DOI 10.1007/s00204-024-03952-7 PubMed 39751877 Copy citation Copy BibTeX

Unknown journal 2025-01-02 Chen J, Wang Z, Yong CY, Goh EML, Moy HY, Chan ECY.

Europe PMC Published psilocybinpsilocin End-of-Life DistressPharmacologyMechanism of Action Clinical Trial Liver More

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In vitro and in vivo metabolism of psilocybin’s active metabolite psilocin

In vivo, psilocybin is rapidly dephosphorylated to psilocin which induces psychedelic effects by interacting with the 5-HT2A receptor. Psilocin primarily undergoes glucuronidation or conversion to 4-hydroxyindole-3-acetic acid (4-HIAA). Herein, we investigated psilocybin’s metabolic pathways in vitro and in vivo, conducting a thorough analysis of the enzymes...

Details DOI 10.3389/fphar.2024.1391689 PubMed 38741590 Copy citation Copy BibTeX

Frontiers in Pharmacology 2024-04-28 Jan Thomann, Karolina E. Kolaczynska, Oliver V Stoeckmann, Deborah Rudin, Patrick Vizeli, Marius C. Hoener

OpenAlex Published psilocybinpsilocin PharmacologyMechanism of ActionReceptor Pharmacology Clinical Trial Metabolite More

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Analytical profile, in vitro metabolism and behavioral properties of the lysergamide 1P-AL-LAD.

Lysergic acid diethylamide (LSD) is known to induce powerful psychoactive effects in humans, which cemented its status as an important tool for clinical research. A range of analogues and derivatives has been investigated over the years, including those classified as new psychoactive substances. This study presents the characterization of the novel lysergami...

Details DOI 10.1002/dta.3281 PubMed 35524430 Copy citation Copy BibTeX

Drug Testing and Analysis 2022-05-28 Brandt SD, Kavanagh PV, Westphal F, Pulver B, Schwelm HM, Whitelock K

Europe PMC Published psilocybin PharmacologyReceptor PharmacologyAnimal Study Animal Study Animals More

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Tentative identification of in vitro metabolites of O-acetylpsilocin (psilacetin, 4-AcO-DMT) by UHPLC-Q-Orbitrap MS.

4-Acetoxy-N,N-dimethyltryptamine (4-AcO-DMT, psilacetin, O-acetylpsilocin) is a synthetic tryptamine with psychedelic properties. Psilacetin may also act as precursor drug of psilocin, similar to psilocybin, but little is known about its metabolism. In this study, the phase I and phase II in vitro metabolism of 4-AcO-DMT was investigated with pooled human li...

Details DOI 10.1002/dta.3255 PubMed 35312166 Copy citation Copy BibTeX

Drug Testing and Analysis 2022-03-28 Zhai W, Li L, Zhao J, Xiang P, Liu M, Shi Y

Europe PMC Published psilocybinpsilocin PharmacologyBiomarkersEpigenetics Clinical Trial Microsomes More

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Activity and Enzyme Kinetics of Human UDP-Glucuronosyltransferases: Studies of Psilocin Glucuronidation and the Effects of Albumin on the Enzyme Kinetic Mechanism

Human UDP-glucuronosyltransferases (UGTs) are important in the metabolic elimination of xenobiotics and endogenous compounds from the body. These enzymes transfer glucuronic acid moiety from the cosubstrate, UDP-glucuronic acid (UDPGA), to nucleophilic groups of small organic molecules, such as hydroxyl, carboxylic, or amino group. The conjugation of these m...

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Työväentutkimus Vuosikirja 2013-03-06 Nenad Manevski

OpenAlex Published psilocin PharmacologyAnimal StudyIn Vitro Study Animal Study Glucuronidation More

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Enzyme-assisted synthesis of the glucuronide conjugate of psilocin, an hallucinogenic component of magic mushrooms.

An enzyme-assisted synthesis of psilocin glucuronide (PCG), a metabolite excreted in the urine of magic mushroom (MM) users, is described. In the presence of Aroclor 1254 pretreated rat liver microsomes, psilocin and the cofactor UDPGA were incubated for 20 h. Purification by HPLC gave PCG in 19% yield (3.6 mg). The compound structure was characterized by MS...

Details DOI 10.1002/dta.244 PubMed 21960543 Copy citation Copy BibTeX

Unknown journal 2011-02-01 Shoda T, Fukuhara K, Goda Y, Okuda H.

Europe PMC Published psilocybinpsilocin Animal Study Animal Study Microsomes More

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Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases.

We have examined the glucuronidation of psilocin, a hallucinogenic indole alkaloid, by the 19 recombinant human UDP-glucuronosyltransferases (UGTs) of subfamilies 1A, 2A, and 2B. The glucuronidation of 4-hydroxyindole, a related indole that lacks the N,N-dimethylaminoethyl side chain, was studied as well. UGT1A10 exhibited the highest psilocin glucuronidatio...

Details DOI 10.1124/dmd.109.031138 PubMed 20007669 Copy citation Copy BibTeX

Unknown journal 2009-12-09 Manevski N, Kurkela M, Höglund C, Mauriala T, Court MH, Yli-Kauhaluoma J

Europe PMC Published psilocybinpsilocin Clinical Trial Clinical Trial Liver More