Psilocybin and psilocin research index

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First molecular record of Panaeolus subbalteatus (Psathyrellaceae, Agaricales) from Pakistan.

Understanding the distribution of agaric fungi through molecular phylogeny is critical for biodiversity assessment. This comprehensive investigation documented the presence of Panaeolus subbalteatus, a previously unreported agaric fungus, addressing a significant gap in the country's knowledge of fungal diversity. This psilocybin-containing mushroom species,...

Details DOI 10.1007/s10482-026-02361-3 PubMed 42423967 Copy citation Copy BibTeX

Unknown journal 2026-07-08 Rukhsar S, Yousaf N, Sadaf, Fazal M, Hanif M, Muhammad M

New this week Europe PMC Published psilocybin General Other Agaricales More

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Mushroom poisoning of Panaeolus subbalteatus from Ningxia, northwest China, with species identification and tryptamine detection.

Mushroom poisoning is a significant contributor to foodborne disease outbreaks in China. This study focuses on two Panaeolus subbalteatus poisoning incidents accompanied by epidemiological investigations, species identification, and toxin detection in Ningxia, northwest China. In these two poisoning incidents, some patients exhibited gastrointestinal or neur...

Details DOI 10.1016/j.toxicon.2024.107849 PubMed 38971474 Copy citation Copy BibTeX

Unknown journal 2024-07-03 Yao Y, Zhang YZ, Liang JQ, Liu F, Li ZF, Li HJ

Europe PMC Published psilocybinpsilocin Aging Other Humans More

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Phylogenomics of the psychoactive mushroom genus Psilocybe and evolution of the psilocybin biosynthetic gene cluster

Psychoactive mushrooms in the genus Psilocybe have immense cultural value and have been used for centuries in Mesoamerica. Despite a recent surge in interest in these mushrooms due to emerging evidence that psilocybin, the main psychoactive compound, is a promising therapeutic for a variety of mental illnesses, their phylogeny and taxonomy remain substantial...

Details DOI 10.1101/2022.12.13.520147 Copy citation Copy BibTeX

bioRxiv 2022-12-14 Bradshaw AJ, Ramírez-Cruz V, Awan AR, Furci G, Guzmán-Dávalos L, Stamets P

bioRxiv PREPRINT (not peer reviewed) psilocybin Genomics Other More

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Psychedelics, Sociality, and Human Evolution.

Our hominin ancestors inevitably encountered and likely ingested psychedelic mushrooms throughout their evolutionary history. This assertion is supported by current understanding of: early hominins' paleodiet and paleoecology; primate phylogeny of mycophagical and self-medicative behaviors; and the biogeography of psilocybin-containing fungi. These lines of ...

Details DOI 10.3389/fpsyg.2021.729425 PubMed 34659037 Copy citation Copy BibTeX

Frontiers in Psychology 2021-09-28 Rodríguez Arce JM, Winkelman MJ.

Europe PMC Published psilocybin Mechanism of ActionReceptor PharmacologyWellbeing Other More

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Monoamine Biosynthesis via a Noncanonical Calcium-Activatable Aromatic Amino Acid Decarboxylase in Psilocybin Mushroom.

Aromatic l-amino acid decarboxylases (AAADs) are a phylogenetically diverse group of enzymes responsible for the decarboxylation of aromatic amino acid substrates into their corresponding aromatic arylalkylamines. AAADs have been extensively studied in mammals and plants as they catalyze the first step in the production of neurotransmitters and bioactive phy...

Details DOI 10.1021/acschembio.8b00821 PubMed 30484626 Copy citation Copy BibTeX

ACS Chemical Biology 2018-12-09 Torrens-Spence MP, Liu CT, Pluskal T, Chung YK, Weng JK.

Europe PMC Published psilocybin End-of-Life DistressTranscriptomics Other Yeasts More

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Phylogenetic and chemical studies in the potential psychotropic species complex of Psilocybe atrobrunnea with taxonomic and nomenclatural notes.

Five Psilocybe species with unresolved systematic position (P. atrobrunnea, P. laetissima, P. medullosa, P. pelliculosa, and P. silvatica) were investigated using four molecular markers (EF1-α, ITS, LSU, and IGS). Phylogenetic analysis revealed that with the exception of P. laetissima, which is now rightfully classified in the genus Leratiomyces, all investi...

Details DOI 10.3767/003158515x685283 PubMed 26240441 Copy citation Copy BibTeX

Persoonia - Molecular Phylogeny and Evolution of Fungi 2014-10-20 Borovička J, Oborník M, Stříbrný J, Noordeloos ME, Parra Sánchez LA, Gryndler M.

Europe PMC Published psilocybinpsilocin BiomarkersIn Vitro Study In Vitro Study More

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Evolution of the toxins muscarine and psilocybin in a family of mushroom-forming fungi.

Mushroom-forming fungi produce a wide array of toxic alkaloids. However, evolutionary analyses aimed at exploring the evolution of muscarine, a toxin that stimulates the parasympathetic nervous system, and psilocybin, a hallucinogen, have never been performed. The known taxonomic distribution of muscarine within the Inocybaceae is limited, based only on assa...

Details DOI 10.1371/journal.pone.0064646 PubMed 23717644 Copy citation Copy BibTeX

Unknown journal 2013-05-22 Kosentka P, Sprague SL, Ryberg M, Gartz J, May AL, Campagna SR

Europe PMC Published psilocybin Review Article Review Article Animals More

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Phylogenetic relationship of psychoactive fungi based on rRNA gene for a large subunit and their identification using the TaqMan assay (II).

"Magic mushroom (MM)" is the name most commonly given to psychoactive fungi containing the hallucinogenic components: psilocin (1) and psilocybin (2). We investigated the rRNA gene (internal transcribed spacer (ITS) and large subunit (LSU)) of two Panaeolus species and four Psilocybe species fungi (of these, two are non-psilocybin species). On the basis of s...

Details DOI 10.1016/j.forsciint.2004.10.028 PubMed 16343833 Copy citation Copy BibTeX

Unknown journal 2005-12-14 Maruyama T, Kawahara N, Yokoyama K, Makino Y, Fukiharu T, Goda Y.

Europe PMC Published psilocybinpsilocin General Other Humans More

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Forensic analysis of hallucinogenic fungi: a DNA-based approach.

Hallucinogenic fungi synthesize two controlled substances, psilocin and psilocybin. Possession of the fungal species that contain these compounds is a criminal offence in North America. Some related species that are morphologically similar, do not contain the controlled substances. Therefore, unambiguous identification of fungi to the species level is critic...

Details DOI 10.1016/j.forsciint.2003.11.022 PubMed 15036436 Copy citation Copy BibTeX

Unknown journal 2004-02-29 Nugent KG, Saville BJ.

Europe PMC Published psilocybinpsilocin General Other Humans More