RationaleAlthough psilocybin and dextromethorphan (DXM) are hallucinogens, they have different receptor mechanisms of action and have not been directly compared.ObjectiveThis study compared subjective, behavioral, and physiological effects of psilocybin and dextromethorphan under conditions that minimized expectancy effects.MethodsSingle, acute oral doses of...

Details DOI 10.1007/s00213-017-4769-4 PubMed 29116367

Psychopharmacology 2017-11-06 Carbonaro TM, Johnson MW, Hurwitz E, Griffiths RR.

Europe PMC Published psilocybin Mechanism of Action Receptor Pharmacology Mystical Experience Observational Study Humans More

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Prediction of psilocybin response in healthy volunteers.

Responses to hallucinogenic drugs, such as psilocybin, are believed to be critically dependent on the user's personality, current mood state, drug pre-experiences, expectancies, and social and environmental variables. However, little is known about the order of importance of these variables and their effect sizes in comparison to drug dose. Hence, this study...

Details DOI 10.1371/journal.pone.0030800 PubMed 22363492

PLoS ONE 2012-02-16 Studerus E, Gamma A, Kometer M, Vollenweider FX.

Europe PMC Published psilocybin Anxiety Personality Change Emotional Processing Other Humans More

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Absorption, distribution, metabolism and excretion pharmacogenomics of drugs of abuse.

Pharmacologic and toxic effects of xenobiotics, such as drugs of abuse, depend on the genotype and phenotype of an individual, and conversely on the isoenzymes involved in their metabolism and transport. The current knowledge of such isoenzymes of frequently abused therapeutics such as opioids (oxycodone, hydrocodone, methadone, fentanyl, buprenorphine, tram...

Details DOI 10.2217/pgs.10.171 PubMed 21332315

Unknown journal 2011-01-31 Meyer MR, Maurer HH.

Europe PMC Published psilocybin psilocin Addiction Pharmacology Safety Other Humans More

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Investigation into the temporal stability of aqueous standard solutions of psilocin and psilocybin using high performance liquid chromatography.

This paper reports an investigation into the temporal stability of aqueous solutions of psilocin and psilocybin reference drug standards over a period of fourteen days. This study was performed using high performance liquid chromatography utilising a (95:5% v/v) methanol: 10 mM ammonium formate, pH 3.5 mobile phase and absorption detection at 269 nm. It was ...

Details DOI 10.1016/s1355-0306(06)71579-9 PubMed 17002211

Science & Justice 2006-03-31 Anastos N, Barnett NW, Pfeffer FM, Lewis SW.

Europe PMC Published psilocybin psilocin General Clinical Trial Hallucinogens More

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The determination of psilocin and psilocybin in hallucinogenic mushrooms by HPLC utilizing a dual reagent acidic potassium permanganate and tris(2,2'-bipyridyl)ruthenium(II) chemiluminescence detection system.

This paper describes a procedure for the determination of psilocin and psilocybin in mushroom extracts using high-performance liquid chromatography with postcolumn chemiluminescence detection. A number of extraction methods for psilocin and psilocybin in hallucinogenic mushrooms were investigated, with a simple methanolic extraction being found to be most ef...

Details DOI 10.1111/j.1556-4029.2005.00033.x PubMed 16423222

Journal of Forensic Sciences 2005-12-31 Anastos N, Lewis SW, Barnett NW, Sims DN.

Europe PMC Published psilocybin psilocin General Clinical Trial Agaricales More

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Handling of psilocybin and psilocin by everted sacs of rat jejunum and colon.

Psilocybin and psilocin at luminal concentrations of about 20 nmol/ml were incubated aerobically with everted sacs from rat jejunum and colon. When incubation was terminated, samples of the lumen and blood side solutions and of the intestinal tissue were analyzed for parent drug and metabolites by HPLC using a multidetector system. Both sacs caused hydrolysi...

Details PubMed 2610906

Unknown journal 1988-12-31 Eivindvik K, Rasmussen KE, Sund RB.

Europe PMC Published psilocybin psilocin Pharmacology Receptor Pharmacology Animal Study Animal Study Colon More

Psilocybin and psilocin research index

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Double-blind comparison of the two hallucinogens psilocybin and dextromethorphan: similarities and differences in subjective experiences.

Prediction of psilocybin response in healthy volunteers.

Absorption, distribution, metabolism and excretion pharmacogenomics of drugs of abuse.

Investigation into the temporal stability of aqueous standard solutions of psilocin and psilocybin using high performance liquid chromatography.

The determination of psilocin and psilocybin in hallucinogenic mushrooms by HPLC utilizing a dual reagent acidic potassium permanganate and tris(2,2'-bipyridyl)ruthenium(II) chemiluminescence detection system.

Handling of psilocybin and psilocin by everted sacs of rat jejunum and colon.