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Psilocybin and psilocin research index

Find psilocybin and psilocin papers, preprints, trials, and citations with clear source context.

Searches titles, authors, journals, identifiers, indexed metadata, and derived research topics. Use Filters to narrow by source, status, substance, study type, or date.

Database 4,959 indexed records Auto-updated on Aug 17, 2026 01:21 UTC

Executed search Sources: bioRxiv 122 matching records are displayed.

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Database

4,740 Psilocybin Records 673 Psilocin Records 1,461 Journals 66 Research Topics

Published 4,221 Peer-reviewed / formal records Preprints 435 Marked as not peer reviewed Clinical trials 300 ClinicalTrials.gov records R toolkit visNetwork Bibliometrics, live SQLite analysis, HTML graph, and PDF export

Top journals 1,461 indexed journals

Journal	Records
Journal of psychopharmacology (Oxford, England)	147
Journal of psychoactive drugs	97
Frontiers in psychiatry	90
Psychopharmacology	85
Neuroscience Applied	57
Journal of Psychedelic Studies	48
Psychedelic medicine (New Rochelle, N.Y.)	39
Scientific reports	37
bioRxiv : the preprint server for biology	33
Biological Psychiatry	32

Research topics 66 topic filters

Depression 1,736 Receptor Pharmacology 1,282 Safety 1,201 Mechanism of Action 1,070 Review Article 1,070 Clinical Trial 975 Anxiety 882 Addiction 823 Pharmacology 753 General 537 Aging 524 Animal Study 524 Observational Study 515 Brain Imaging 481 Treatment-Resistant Depression 417 Emotional Processing 409 PTSD 400 Neuroplasticity 399

Source coverage 8 active sources

Source	Count	Share	Status
PubMed	2,567	51.8%	Active
OpenAlex	1,154	23.3%	Active
Crossref	404	8.1%	Active
ClinicalTrials.gov	300	6%	Active
Europe PMC	187	3.8%	Active
PsyArXiv	187	3.8%	Active
bioRxiv	122	2.5%	Active

Publication timeline 3,856 dated records

3,856 records since 2020

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Substances Psilocybin 4740 Psilocin 673

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Executed search Sources: bioRxiv 122 matching records are displayed.

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122 matching records for Sources: bioRxiv.

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Psilocybin rapidly, but not immediately, reverses reward learning deficits in a durable manner in an inflammatory rat model of depressive symptoms

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.64898/2026.01.14.699553

bioRxiv 2026-01-15 Hinchcliffe JK, Thomas CW, Gilmour G, Robinson ES.

bioRxiv PREPRINT (not peer reviewed) psilocybin Depression Mechanism of Action Animal Study Animal Study More

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The one that abstained: Psilocybe fuscofulva genome suggests two recent origins of the psilocybin gene cluster in Psilocybe

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.64898/2025.12.30.697041

bioRxiv 2026-01-02 Slot J, Bradshaw A, Dentinger B, Borovička J, Konkel Z, Rockefeller A

bioRxiv PREPRINT (not peer reviewed) psilocybin Mechanism of Action Genomics Other More

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Psilocybin decreases reward-seeking behavior accompanied by increased activity of parvalbumin neurons with perineuronal nets in the medial prefrontal cortex

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.64898/2025.12.22.696123

bioRxiv 2025-12-26 Houff J, Williams A, Allen O, Gisabella B, Pantazopoulos H, Del Arco A.

bioRxiv PREPRINT (not peer reviewed) psilocybin Addiction Receptor Pharmacology Biomarkers Clinical Trial More

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Psilocybin modulates social behaviour in male and female mice in a time-dependent manner

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.64898/2025.12.18.695064

bioRxiv 2025-12-22 Shadani S, McCoy K, Ong L, Greaves E, Conn K, Andrews ZB

bioRxiv PREPRINT (not peer reviewed) psilocybin Depression Anxiety Eating Disorders Animal Study More

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A Naturalistic Study on the Combined Neural and Psychological Effects of Psilocybin and Compassion Focused Imagery

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Details DOI 10.64898/2025.12.17.694940

bioRxiv 2025-12-22 Pallavicini C, Llobenes L, Cavanna F, de la Fuente LA, Muller S, Costa M

bioRxiv PREPRINT (not peer reviewed) psilocybin Brain Imaging Default Mode Network Aging Other More

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Wherefore the magic? The evolutionary role of psilocybin in nature

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.64898/2025.12.17.694186

bioRxiv 2025-12-19 Matthews Nicholass K, Flis I, Hanley M, Knight M, Lane S, Littlejohn G

bioRxiv PREPRINT (not peer reviewed) psilocybin Mechanism of Action Receptor Pharmacology Drug Interactions Other More

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Unmixing the Psychedelic Connectome: Brain Network Traits of Psilocybin

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Details DOI 10.1101/2025.11.17.688834

bioRxiv 2025-11-17 Bhavaraju KP, Mason NL, Mallaroni P, Heinke D, Toennes SW, Ramaekers JG

bioRxiv PREPRINT (not peer reviewed) psilocybin psilocin Brain Imaging Consciousness Healthy Volunteers Other More

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Ketamine and Psilocybin Differentially Impact Sensory Learning During the Mismatch Negativity

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1101/2025.11.06.687023

bioRxiv 2025-11-07 Allohverdi SG, Soltanzadeh M, Schmidt A, Charlton CE, Hauke DJ, Karvelis P

bioRxiv PREPRINT (not peer reviewed) psilocybin Depression Brain Imaging Mechanism of Action Other More

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Psilocybin exerts differential effects on social behaviour and inflammation in mice in contexts of activity-based anorexia (ABA)

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Details DOI 10.1101/2025.10.14.682467

bioRxiv 2025-10-15 Shadani S, Greaves E, Andrews ZB, Foldi CJ.

bioRxiv PREPRINT (not peer reviewed) psilocybin Depression Anxiety OCD Animal Study More

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Gestational LSD exposure in mouse rapidly reaches embryonic CSF and is associated with altered choroid plexus signaling, cerebral cortical development, and offspring behavior

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Details DOI 10.1101/2025.09.30.677638

bioRxiv 2025-10-01 Courtney Y, Anderson JM, Lagares-Linares C, Wenthur CJ, Lehtinen MK.

bioRxiv PREPRINT (not peer reviewed) psilocybin Mechanism of Action Receptor Pharmacology Biomarkers Observational Study More

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Psychedelics Relax Priors and Reshape Orbitofrontal Dynamics

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1101/2025.09.18.677110

bioRxiv 2025-09-19 Delgado-Sallent C, Ahmed SA, Khawaja-Lopez A, Lee BS, Senne R, Scott BB

bioRxiv PREPRINT (not peer reviewed) psilocybin Brain Imaging Mechanism of Action Aging Animal Study More

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Psilocybin ameliorates neuropathic pain-like behaviour in mice and facilitates gabapentin-mediated analgesia

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1101/2025.09.15.676273

bioRxiv 2025-09-17 Askey T, Allen-Ross D, Luzyanin D, Lasrado R, Gilmour G, Hunt SP

bioRxiv PREPRINT (not peer reviewed) psilocybin Chronic Pain Mechanism of Action Receptor Pharmacology Animal Study More

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Effective connectivity of the human claustrum: Triple networks, subcortical circuits, and psychedelic modulation

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Details DOI 10.1101/2025.09.07.674759

bioRxiv 2025-09-12 Masjedi NS, Razi A.

bioRxiv PREPRINT (not peer reviewed) psilocybin Brain Imaging Mechanism of Action Other More

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Context-dependent structurally informed effective connectivity under psilocybin

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Details DOI 10.1101/2025.08.18.671000

bioRxiv 2025-08-22 Greaves MD, Barta T, Novelli L, Stoliker D, Razi A.

bioRxiv PREPRINT (not peer reviewed) psilocybin Brain Imaging Mechanism of Action Mystical Experience Other More

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Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1101/2025.08.06.668927

bioRxiv 2025-08-06 Jiang Q, Shao L, Yao S, Savalia NK, Gilbert AD, Davoudian PA

bioRxiv PREPRINT (not peer reviewed) psilocybin Neuroplasticity Default Mode Network Animal Study Animal Study More

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Electrophysiological effects of psilocybin co-administered with midazolam

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Details DOI 10.1101/2025.07.25.666887

bioRxiv 2025-07-29 Sutherland MH, Nicholas CR, Lennertz RC, Wenthur CJ, Krause BM, Sauder CJ

bioRxiv PREPRINT (not peer reviewed) psilocybin Neuroplasticity Brain Imaging Consciousness Other More

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Epigenome-wide Association Study of Psilocybin-Induced Methylome Changes in Alcohol Use Disorder

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Details DOI 10.1101/2025.07.18.664368

bioRxiv 2025-07-18 Urban MM, Zillich L, Rieser NM, Herdener M, Vollenweider FX, Spanagel R

bioRxiv PREPRINT (not peer reviewed) psilocybin Depression Addiction Neuroplasticity Observational Study More

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Accurate and Interpretable Prediction of Antidepressant Treatment Response from Receptor-informed Neuroimaging

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Details DOI 10.1101/2025.07.02.662710

bioRxiv 2025-07-03 Tolle HM, Luppi AI, Lawn T, Roseman L, Nutt D, Carhart-Harris RL

bioRxiv PREPRINT (not peer reviewed) psilocybin Depression Brain Imaging Mechanism of Action Clinical Trial More

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Converging pathways: shared brain circuitry engaged by monoaminergic antidepressants, ketamine and psilocybin

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Details DOI 10.1101/2025.05.26.655791

bioRxiv 2025-05-30 Joseph K, Collins J, Genovese T, Maxwell M, Lieberman JA, Osten P.

bioRxiv PREPRINT (not peer reviewed) psilocybin Depression Neuroplasticity Mechanism of Action Animal Study More

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Psilocybin-induced modulation of visual salience processing

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Details DOI 10.1101/2025.05.10.652897

bioRxiv 2025-05-12 Muller S, Cavanna F, de la Fuente LA, Bruno N, D’Amelio TA, Pallavicini C

bioRxiv PREPRINT (not peer reviewed) psilocybin Brain Imaging Other More