Metabolic regulation strategies have been developed to redirect metabolic fluxes to production pathways. However, it is difficult to screen out target genes that, when repressed, improve yield without affecting cell growth. Here, we report a strategy using a quorum-sensing system to control small RNA transcription, allowing cell-density-dependent repression ...
Emerging evidence from randomized, double-blind, placebo-controlled clinical trials suggests psychedelic compounds such as 3,4-methylenedioxymethamphetamine (MDMA), psilocybin, and lysergic acid diethylamide (LSD), when administered as an adjunct to psychotherapy, that is, psychedelic-assisted psychotherapy (PAP), may be beneficial for treating substance use...
Psychedelics are new, promising candidate molecules for clinical use in psychiatric disorders such as Treatment-Resistant Depression (TRD) and Post Traumatic Stress Disorder (PTSD). They were recently also proposed as molecules supporting neural tissue repair by anti-inflammatory properties. Here we reported that two classic psychedelics, DMT and psilocin, c...
In the wake of a turning tide on the legalization of medicinal and recreational marijuana, and with the recent decriminalization of psilocybin in Denver, a psychedelic renaissance may too be on the horizon. Psychedelics have again become the subject of rigorous study at institutions such as Yale, UCLA, NYU, and Johns Hopkins. Many clinical accounts underscor...
Experiences of intoxication elude scientific research because of their immediate and ‘inner’ nature for the intoxicated individual. In this chapter, we show how ‘trip reports’ - reports of psychedelic intoxication - from online drug information forums and libraries allow for further understanding the experience of psychedelic intoxication from LSD, DMT and p...
We study the significance of stories about bad trips among users of psychedelics. Drawing on narrative theory, we describe the characteristics of such stories and explore the work they do. In-depth qualitative interviews with 50 Norwegian users of psychedelics. Almost all participants had frightening experiences when using psychedelics and many described the...
‘Why is psychedelic culture dominated by privileged white men?’ asks historian Mike Jay, referring to a recent study of psychedelic users who are more than likely to be college-educated white males.1 This appears logical, given the figureheads (such as Timothy Leary) who attained cult-like status half a century ago. Many today continue to view psychedelics a...
Psychedelics are back in vogue. In popular culture, political legislation, and scientific research, we appear to be witnessing an early twenty-first century renaissance of the heady acid days of the 1960s. The success of Michael Pollan’s 2018 New York Times bestseller, How to Change Your Mind, the decriminalization of psilocybin-containing mushrooms in Denve...
This paper formulates the action of psychedelics by integrating the free-energy principle and entropic brain hypothesis. We call this formulation relaxed beliefs under psychedelics (REBUS) and the anarchic brain, founded on the principle that-via their entropic effect on spontaneous cortical activity-psychedelics work to relax the precision of high-level pri...
Naturally occurring and psychedelic drug-occasioned experiences interpreted as personal encounters with God are well described but have not been systematically compared. In this study, five groups of individuals participated in an online survey with detailed questions characterizing the subjective phenomena, interpretation, and persisting changes attributed ...
RationaleMicrodosing psychedelics-the regular consumption of small amounts of psychedelic substances such as LSD or psilocybin-is a growing trend in popular culture. Recent studies on full-dose psychedelic psychotherapy reveal promising benefits for mental well-being, especially for depression and end-of-life anxiety. While full-dose therapies include percep...
Microdosing psychedelics - the regular consumption of small amounts of psychedelic substances such as LSD or psilocybin - is a growing trend in popular culture. Recent studies on full-dose psychedelic psychotherapy reveal promising benefits for mental well-being, especially for depression and end-of-life anxiety. While full-dose therapies include perception-...
Microdosing psychedelics - the regular consumption of small amounts of psychedelic substances such as LSD or psilocybin - is a growing trend in popular culture. Recent studies on full-dose psychedelic psychotherapy reveal promising benefits for mental well-being, especially for depression and end-of-life anxiety. While full-dose therapies include perception-...
Penelitian ini bertujuan mekstraksi senyawa halusinogen dalam magic mushroom yang dilakukan dengan metode SPE (Solid Phase Extraction) menggunakan pelarut methanol dilanjutkan dengan penentuan kandungan senyawanya dengan kromatografi gas-spektrofotometer massa (GC-MS). Hasil analisis dengan GC-MS menghasilkan dua puncak spektrum dengan spektrum dominan yang ...
Given the plethora of new studies and published papers in the scientific press and the increasingly emerging presence of articles about positive psychedelic experiences appearing in the popular media, there is little doubt that we are in the midst of a Psychedelic Renaissance. The classical psychedelic drugs LSD and psilocybin and the entactogen MDMA are sho...
Psilocybin and other 5-hydroxytryptamine2A agonist classic psychedelics have been used for centuries as sacraments within indigenous cultures. In the mid-twentieth century they were a focus within psychiatry as both probes of brain function and experimental therapeutics. By the late 1960s and early 1970s these scientific inquires fell out of favor because cl...
The taxonomic identification of the biological material contained in the hallucinogenic mushrooms culture media, was carried out using a DNA-based approach, thus highlighting the usefulness of this approach in the forensic identification of illegal samples also when they are present as basidiospores mixed in culture media and spore-bearing fruiting body are ...
Earlier this year I joined some friends at a performance by the New York Philharmonic of Verdi’s Requiem Mass. Not one of us was Catholic or professed any creed threatening an afterlife of eternal suffering for the wicked. No perpetual willies over Judgment Day. Nevertheless, when the massed voices of chorus and orchestra unleashed their frenzy in the climac...
The serotonin 5-HT(2A) receptor is a primary target of psychedelic hallucinogens such as lysergic acid diethylamine, mescaline, and psilocybin, which reproduce some of the core symptoms of schizophrenia. An incompletely resolved paradox is that only some 5-HT(2A) receptor agonists exhibit hallucinogenic activity, whereas structurally related agonists with co...
BackgroundInterpreting the symbols found in the rock art of an extinct culture is hampered by the fact that such symbols are culturally determined. How does one break the circularity inherent in the fact that the knowledge of both the symbols and the culture comes from the same source? In this study, the circularity is broken for the Bradshaw rock art of the...
