Psilocybin and psilocin research index

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Molecular Structure, Reactivity and Spectroscopic Properties of Hallucinogens Psilocybin, Mescaline and their Derivatives - A Computational Study

Medical hallucinogens have been important compounds of research interest in recent years. Computational chemistry methods like Density Functional Theory (DFT) calculations at BP86/Def2-TZVP level are carried out to get more insight into the structural preferences and mechanism of hallucinogens like psilocybin and mescaline derivatives at the molecular level....

Details DOI 10.33263/lianbs124.105 Copy citation Copy BibTeX

Letters in Applied NanoBioScience 2022-09-16 Gomathi Saminathan, Kavitha Kandasamy, Savitha Navaneethakrishnan, Mohana Ashokkumar, Brindha Veerappan, Krishnamoorthy Bellie Sundaram

OpenAlex Published psilocybin General Other Psilocybin More

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Use of plant-based hallucinogens and dissociative agents: U.S. Time Trends, 2002-2019.

AimsInformation on time trends in use of different plant-based hallucinogens is lacking. The current study used nationally representative U.S. data to assess overall and age-specific time trends in the prevalence of lifetime and 12-month use of plant-based hallucinogens and dissociative agents.MethodsParticipants were respondents aged ≥ 12 years (N = 1,006,0...

Details DOI 10.1016/j.abrep.2022.100454 PubMed 36119808 Copy citation Copy BibTeX

Addictive Behaviors Reports 2022-09-05 Walsh CA, Livne O, Shmulewitz D, Stohl M, Hasin DS.

Europe PMC Published psilocybin Observational StudyHealthcare Workers Observational Study More

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Differences across sexes on head-twitch behavior and 5-HT2A receptor signaling in C57BL/6J mice.

Psychedelics, also known as classical hallucinogens, affect processes related to perception, cognition and sensory processing mostly via the serotonin 5-HT2A receptor (5-HT2AR). This class of psychoactive substances, which includes lysergic acid diethylamide (LSD), psilocybin, mescaline and the substituted amphetamine 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopr...

Details DOI 10.1016/j.neulet.2022.136836 PubMed 35963476 Copy citation Copy BibTeX

Unknown journal 2022-08-09 Jaster AM, Younkin J, Cuddy T, de la Fuente Revenga M, Poklis JL, Dozmorov MG

Europe PMC Published psilocybin DepressionAddictionPharmacology Animal Study Animals More

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Psychedelics in the treatment of unipolar and bipolar depression.

This is a narrative review about the role of classic and two atypical psychedelics in the treatment of unipolar and bipolar depression. Since the 1990s, psychedelics experience a renaissance in biomedical research. The so-called classic psychedelics include lysergic acid diethylamide (LSD), psilocybin, mescaline and ayahuasca. Characteristic effects like alt...

Details DOI 10.1186/s40345-022-00265-5 PubMed 35788817 Copy citation Copy BibTeX

Unknown journal 2022-07-04 Bosch OG, Halm S, Seifritz E.

Europe PMC Published psilocybin DepressionMechanism of ActionReceptor Pharmacology Clinical Trial More

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Associations between classic psychedelics and nicotine dependence in a nationally representative sample.

Tobacco use is the single largest cause of preventable death worldwide, but none of the established treatments aimed at smoking cessation work for a majority of smokers. As such, there is an urgent need for interventions capable of reliably treating nicotine addiction. The use of classic psychedelics has been associated with lower odds of many forms of subst...

Details DOI 10.1038/s41598-022-14809-3 PubMed 35732796 Copy citation Copy BibTeX

Scientific Reports 2022-06-21 Jones G, Lipson J, Nock MK.

Europe PMC Published psilocybin AddictionObservational Study Observational Study Humans More

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New Paradigms of Old Psychedelics in Schizophrenia.

Psychedelics such as lysergic acid diethylamide (LSD), psilocybin (magic mushrooms), and mescaline exhibit intense effects on the human brain and behaviour. In recent years, there has been a surge in studies investigating these drugs because clinical studies have shown that these once banned drugs are well tolerated and efficacious in medically supervised lo...

Details DOI 10.3390/ph15050640 PubMed 35631466 Copy citation Copy BibTeX

Unknown journal 2022-05-22 Mahmood D, Alenezi SK, Anwar MJ, Azam F, Qureshi KA, Jaremko M.

Europe PMC Published psilocybin DepressionAnxietyPTSD Other More

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Associations between classic psychedelics and opioid use disorder in a nationally-representative U.S. adult sample.

Opioid use disorder (OUD) is a major source of morbidity and mortality in the U.S. and there is a pressing need to identify additional treatments for the disorder. Classic psychedelics (psilocybin, peyote, mescaline, LSD) have been linked to the alleviation of various substance use disorders and may hold promise as potential treatments for OUD. The aim of th...

Details DOI 10.1038/s41598-022-08085-4 PubMed 35393455 Copy citation Copy BibTeX

Scientific Reports 2022-04-06 Jones G, Ricard JA, Lipson J, Nock MK.

Europe PMC Published psilocybin AddictionClinical TrialObservational Study Clinical Trial Humans More

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Race, Ethnic, and Sex Differences in Prevalence of and Trends in Hallucinogen Consumption Among Lifetime Users in the United States Between 2015 and 2019.

BackgroundThe current study is one of the first to examine race, ethnic, and sex differences in the prevalence of and trends in hallucinogen use among lifetime users in the United States.MethodsData came from the 2015-2019 National Survey on Drug Use and Health and included respondent's reporting ever-using hallucinogens (n = 41,060; female = 40.4%). Descrip...

Details DOI 10.3389/fepid.2022.876706 PubMed 38455323 Copy citation Copy BibTeX

Frontiers in Epidemiology 2022-03-22 Davis AK, Arterberry BJ, Xin Y, Agin-Liebes G, Schwarting C, Williams MT.

Europe PMC Published psilocybin Observational StudySafety Observational Study More

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Effects of the 5-HT2A receptor antagonist volinanserin on head-twitch response and intracranial self-stimulation depression induced by different structural classes of psychedelics in rodents.

BackgroundClinical studies suggest that psychedelics exert robust therapeutic benefits in a number of psychiatric conditions including substance use disorder. Preclinical studies focused on safety and efficacy of these compounds are necessary to determine the full range of psychedelics' effects.ObjectivesThe present study explores the behavioral pharmacology...

Details DOI 10.1007/s00213-022-06092-x PubMed 35233648 Copy citation Copy BibTeX

Unknown journal 2022-03-01 Jaster AM, Elder H, Marsh SA, de la Fuente Revenga M, Negus SS, González-Maeso J.

Europe PMC Published psilocybin DepressionAddictionPharmacology Animal Study Animals More

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Adverse effects of psychedelics: From anecdotes and misinformation to systematic science.

Despite an increasing body of research highlighting their efficacy to treat a broad range of medical conditions, psychedelic drugs remain a controversial issue among the public and politicians, tainted by previous stigmatisation and perceptions of risk and danger. This narrative review examines the evidence for potential harms of the classic psychedelics by ...

Details DOI 10.1177/02698811211069100 PubMed 35107059 Copy citation Copy BibTeX

Journal of psychopharmacology (Oxford, England) 2022-02-28 Schlag AK, Aday J, Salam I, Neill JC, Nutt DJ

PubMed Published psilocybin Review ArticleHealthcare WorkersSafety Review Article Psilocybin More

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The Acceptance/Avoidance-Promoting Experiences Questionnaire (APEQ): A theory-based approach to psychedelic drugs' effects on psychological flexibility.

BackgroundMany benefits and some harms associated with psychedelic use could be attributable to these drugs' acceptance/avoidance-promoting effects and corresponding changes in psychological flexibility. Underlying psychological mechanisms are insufficiently understood.AimThe purpose of this study was the validation of a psychological model of acceptance/avo...

Details DOI 10.1177/02698811211073758 PubMed 35253518 Copy citation Copy BibTeX

Journal of Psychopharmacology 2022-02-28 Wolff M, Mertens LJ, Walter M, Enge S, Evens R.

Europe PMC Published psilocybin Mechanism of ActionPsychological FlexibilityObservational Study Observational Study Humans More

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Exploring protective associations between the use of classic psychedelics and cocaine use disorder: a population-based survey study.

Cocaine Use Disorder (CUD) is a significant public health problem associated with elevated morbidity and mortality within the United States. Current behavioral treatments have limited efficacy and there are currently no FDA approved pharmacological treatments for CUD. Classic psychedelics might be associated with lowered odds of substance misuse and may effe...

Details DOI 10.1038/s41598-022-06580-2 PubMed 35173246 Copy citation Copy BibTeX

Scientific Reports 2022-02-15 Jones GM, Nock MK.

Europe PMC Published psilocybin AddictionPersonality ChangeObservational Study Observational Study Humans More

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Hallucinogen Use and Misuse in Older Adults.

Hallucinogens, or psychedelics, are substances/drugs that have been used for over a millennium. The most well known are LSD, psilocybin, mescaline, and PCP. These substances may induce hallucinations as well as cause somatic and psychological symptoms. Because of the Controlled Substances Act of 1970, there has been very little research done to determine the...

Details DOI 10.1016/j.cger.2021.07.007 PubMed 34794703 Copy citation Copy BibTeX

Unknown journal 2022-01-31 Redden WM, Paracha SU, Sheheryar Q.

Europe PMC Published psilocybin AgingOlder Adults Other Humans More

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Lifetime use of MDMA/ecstasy and psilocybin is associated with reduced odds of major depressive episodes.

BackgroundDepression is a major mental health issue worldwide, with high rates of chronicity and non-recovery associated with the condition. Existing treatments such as antidepressant medication and psychological treatments have modest effectiveness, suggesting the need for alternative interventions.AimThe aim of this study was to examine the relationships b...

Details DOI 10.1177/02698811211066714 PubMed 34983261 Copy citation Copy BibTeX

Journal of Psychopharmacology 2022-01-04 Jones GM, Nock MK.

Europe PMC Published psilocybin DepressionAddictionChronic Pain Observational Study Humans More

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Dosing Psychedelics and MDMA.

Classic psychedelics, including psilocybin, lysergic acid diethylamide (LSD), dimethyltryptamine, and mescaline, and entactogens/empathogens, especially 3,4-methylenedioxymethamphetamine, have received renewed attention in psychiatric research and may be developed into medications for such indications as anxiety, depression, cluster headache, and posttraumat...

Details DOI 10.1007/7854_2021_270 PubMed 34734392 Copy citation Copy BibTeX

Unknown journal 2021-12-31 Liechti ME, Holze F.

Europe PMC Published psilocybin DepressionAnxietyPTSD Other N-Methyl-3 More

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Psilocybin use is associated with lowered odds of crime arrests in US adults: A replication and extension.

BackgroundThe United States boasts the largest prison population in the world, conferring significant direct and indirect costs (e.g. lost wages for the incarcerated, increased morbidity/mortality, etc.) to society. Recidivism rates are high for the imprisoned and most interventions to reduce criminality are minimally effective. Thus, in addition to the need...

Details DOI 10.1177/02698811211058933 PubMed 35090364 Copy citation Copy BibTeX

Journal of Psychopharmacology 2021-12-31 Jones GM, Nock MK.

Europe PMC Published psilocybin AddictionPersonality ChangeObservational Study Observational Study Humans More

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Classic Psychedelics in Addiction Treatment: The Case for Psilocybin in Tobacco Smoking Cessation.

This manuscript reviews research suggesting that classic psychedelics (5-HT2A receptor agonists) are effective in treating addictions including tobacco use disorder. I review historical research from the 1950s to 1970s suggesting that classic psychedelics are associated with addiction recovery across pharmacologically distinct drugs of addiction. I then revi...

Details DOI 10.1007/7854_2022_327 PubMed 35704271 Copy citation Copy BibTeX

Unknown journal 2021-12-31 Johnson MW.

Europe PMC Published psilocybin AddictionReceptor PharmacologyReview Article Review Article Humans More

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A systematic literature review of clinical trials and therapeutic applications of ibogaine.

BackgroundIboga and its primary alkaloids, ibogaine and noribogaine, have been of interest to researchers and practitioners, mainly due to their putative efficacy in treating substance use disorders (SUDs). For many SUDs, still no effective pharmacotherapies exist. Distinct psychoactive and somatic effects of the iboga alkaloids set them apart from classic h...

Details DOI 10.1016/j.jsat.2021.108717 PubMed 35012793 Copy citation Copy BibTeX

Unknown journal 2021-12-29 Köck P, Froelich K, Walter M, Lang U, Dürsteler KM.

Europe PMC Published psilocybin DepressionAddictionClinical Trial Randomized Controlled Trial Humans More

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Molecular insights into psychedelic drug action.

A confluence of factors has renewed interest in the scientific understanding and translational potential of psychedelic drugs such as lysergic acid diethylamide (LSD), mescaline, and psilocybin: the desire for additional approaches to mental health care, incremental progress in basic and clinical research, and the reconsideration and relaxation of existing d...

Details DOI 10.1111/jnc.15540 PubMed 34797943 Copy citation Copy BibTeX

Unknown journal 2021-11-30 Slocum ST, DiBerto JF, Roth BL.

Europe PMC Published psilocybin DepressionMechanism of ActionReview Article Review Article Lysergic Acid Diethylamide More

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Bibliometric Analysis of Academic Journal Articles Reporting Results of Psychedelic Clinical Studies

ABSTRACT After a decades long period of investigational dormancy, there is renewed interest in employing psychedelics as treatments for mental illness and addiction. The academic journals, journal articles, academic institutions, and countries that have helped sustain clinical psychedelic research and the evolution of the literature on clinical studies of ps...

Details DOI 10.1101/2021.11.22.21266718 Copy citation Copy BibTeX

medRxiv 2021-11-23 Weleff J, Akiki TJ, Barnett BS.

medRxiv PREPRINT (not peer reviewed) psilocybin AddictionSafety Other More