Psilocybin can occasion mystical-type experiences with participant-attributed increases in well-being. However, little research has examined enduring changes in traits. This study administered psilocybin to participants who undertook a program of meditation/spiritual practices. Healthy participants were randomized to three groups (25 each): (1) very low-dose...
Recent randomized controlled trials of psilocybin-assisted psychotherapy for patients with cancer suggest that this treatment results in large-magnitude reductions in anxiety and depression as well as improvements in attitudes toward disease progression and death, quality of life, and spirituality. To better understand these findings, we sought to identify p...
Presented at a conference titled “Psychedelic Science 2013,” highlighting the resumption of investigations with psychedelic substances (i.e., psilocybin, DMT, LSD, MMDA, etc.) in the United States and Europe after a dormant period of more than two decades, the author presents insights and perspectives gleaned from his 25 years of clinical research experience...
Earlier this year I joined some friends at a performance by the New York Philharmonic of Verdi’s Requiem Mass. Not one of us was Catholic or professed any creed threatening an afterlife of eternal suffering for the wicked. No perpetual willies over Judgment Day. Nevertheless, when the massed voices of chorus and orchestra unleashed their frenzy in the climac...
Substances of plant origin have been used to induce hallucinations for a long time, in religious ceremonies and rituals as well as in pain relief. Psilocybin and psilocin naturally occur in the fungal genus Psilocybe. Due to the psychedelic effects and relative harmlessness of these substances and the fact that they do not cause physical addiction, psilocybi...
Entheogens or psychedelic drugs such as lysergic acid diethylamide (LSD) and psilocybin are associated with mystical states of experience. Drug laws currently limit research, but important new work is under way at major biomedical research facilities showing that entheogens reliably occasion mystical experiences and thereby allow research into brain states d...
This presentation will discuss Stan Grof’s impact on the resurgent field of psychedelic research, particularly in regard to the development of the psilocybin treatment of advanced-cancer anxiety studies that were conducted in the early 2000s. After decades of repression, we are on the threshold of demonstrating that the field Stan and his colleagues courageo...
Since 1990, FDA has been willing to approve research with psychedelic drugs. Currently Phase II studies have been conducted or are underway for MDMA-assisted psychotherapy for posttraumatic stress disorder (PTSD), LSD, psilocybin or MDMA for end-of-life anxiety, MDMA for autistic adults with social anxiety, psilocybin for addiction, psilocybin as an adjunct ...
A large body of historical evidence describes the use of hallucinogenic compounds, such as psilocybin mushrooms, for religious purposes. But few scientific studies have attempted to measure or characterize hallucinogen-occasioned spiritual experiences. The present study examined the factor structure of the Mystical Experience Questionnaire (MEQ), a self-repo...
Anthropologists have studied the use of hallucinogens as a spiritual tool by indigenous populations since the turn of the 20th century. However, literature is sparse in describing use by non-indigenous populations. Using a study population of students from a university in the Southwest United States, the current study investigated the spiritual development a...
Even if ingesting the hallucinogen psilocybin can increase positive feelings of bliss or oneness with the universe, it is questionable whether such feelings represent authentic mystical experience or spiritual growth.
BackgroundPsilocybin is a well-characterized classic hallucinogen (psychedelic) with a long history of religious use by indigenous cultures, and nonmedical use in modern societies. Although psilocybin is structurally related to migraine medications, and case studies suggest that psilocybin may be efficacious in treatment of cluster headache, little is known ...
Psilocybin has been used for centuries for religious purposes; however, little is known scientifically about its long-term effects. We previously reported the effects of a double-blind study evaluating the psychological effects of a high psilocybin dose. This report presents the 14-month follow-up and examines the relationship of the follow-up results to dat...
Accompanying the resumption of human research with the entheogen (psychedelic drug), psilocybin, the range of states of consciousness reported during its action, including both nonmystical and mystical forms of experience, is surveyed and defined. The science and art of facilitating mystical experiences is discussed on the basis of research experience. The p...
This paper addresses the question of what happens to consciousness under the influence of psychedelic drugs-specifically of psilocybin, or “magic” mushrooms- and performs a Foucauldian discourse analysis upon the answers that have been variously proposed. Predominant societally legitimated answers (the pathological, psychological, and prohibition discourses)...
Hallucinogens. Nichols DE. Pharmacol Ther. 2004;101:131-181National Institute on Drug Abuse Web Site. Available at http://www.drugabuse.govThe Psychopharmacology of Hallucinogens. Abraham HD, Aldridge AM, Gogia P. Neuropsychopharmacol. 1996;14:285-298Toxic Psychoses as Pharmacological Models of Schizophrenia. Potvin S, Stip E, Roy J. Curr Psychiatr Rev. 2005...
RationaleAlthough psilocybin has been used for centuries for religious purposes, little is known scientifically about its acute and persisting effects.ObjectivesThis double-blind study evaluated the acute and longer-term psychological effects of a high dose of psilocybin relative to a comparison compound administered under comfortable, supportive conditions....
Joseph Havens, A Working Paper: Memo on the Religious Implications of the Consciousness-Changing Drugs (LSD, Mescalin, Psilocybin), Journal for the Scientific Study of Religion, Vol. 3, No. 2 (Spring, 1964), pp. 216-226
