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Psilocybin shows mixed results for patients with treatment-resistant depression

Patients with treatment-resistant depression who received psilocybin-assisted psychotherapy showed clinically meaningful improvement in depressive symptoms relative to placebo, a Phase 2b trial has found. However, the study did not show a significant effect on the primary outcome of treatment response 6 weeks after the first of two doses of psilocybin. Study results were published online March 18, 2026 in JAMA Psychiatry.

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Journal
The Brown University Psychopharmacology Update
Date
2026-05-28
Source
OpenAlex
DOI
10.1002/pu.31461
PubMed
Unavailable

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psilocybin DepressionChronic PainClinical TrialRandomized Controlled TrialTreatment-Resistant DepressionToxicity Randomized Controlled Trial PsilocybinMedicineDepression (economics)Depressive symptomsPsychiatryMajor depressive disorderClinical trialInternal medicinePrimary careRandomized controlled trialTreatment-resistant depressionMajor depressive episodePsychedelics and Drug StudiesPain Management and Placebo EffectForensic Toxicology and Drug Analysis

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Psilocybin shows mixed results for patients with treatment-resistant depression2026-05-28

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