Psilocybin and psilocin research index

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Exploring the first use of psychedelic macrodoses in Latin American adults: Sociodemographic profiles, consumption factors, and subjective experiences

Abstract This study explores the first-time use of psychedelic macrodoses among Latin American adults, addressing a gap in the literature regarding naturalistic use outside clinical settings. A total of 4,810 participants from six Latin American countries completed an online survey assessing sociodemographic characteristics, substances used, consumption cont...

Details DOI 10.1556/2054.2025.00454 Copy citation Copy BibTeX

Journal of Psychedelic Studies 2025-11-19 Óscar Véliz-García, Marcos Domic-Siede

OpenAlex Published psilocybin AddictionWellbeingSpirituality Observational Study Psilocybin More

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With great power comes great responsibility: Promise and caution in the new psychedelic renaissance

Clinicians and researchers are showing increased interest in psychedelic-assisted therapy for patients who don't show improvement from using conventional antidepressants. This updated review integrates recent developments, including data on lesser-studied compounds like DMT and 5-MeO-DMT, findings from large clinical trials, and evolving regulatory landscape...

Details DOI 10.1016/j.dscb.2025.100286 Copy citation Copy BibTeX

Brain Disorders 2025-09-22 Matthew Halma, R. Levy, Joseph Varón

OpenAlex Published psilocybin DepressionAddictionConsciousness Clinical Trial Psilocybin More

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Psychedelic minimalism: the case against music in psychedelic therapy settings

Psychedelic Minimalism: The Case Against Music in Psychedelic Therapy SettingsIn response to: Kaelen et al. (2018), “The Hidden Therapist: Evidence for a Central Role ofMusic in Psychedelic Therapy.”Introduction: Reframing the Role of SettingIn recent years, renewed attention has been given to the centrality of set and setting inpsychedelic-assisted therapy....

Details DOI 10.3389/fpsyt.2025.1652568 PubMed 40933801 Copy citation Copy BibTeX

Frontiers in Psychiatry 2025-08-25 Samir A Nader

OpenAlex Published psilocybin AnxietyConsciousnessPersonality Change Clinical Trial Minimalism (technical communication) More

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Why N,N-dimethyltryptamine matters: unique features and therapeutic potential beyond classical psychedelics

"Iracema comes with the pot full of the green liquor. The shaman decrees the dreams to each warrior and distributes the wine of jurema, which carries the brave Tabajara to heaven." José de Alencar, in his poetic novel “Iracema” (1865)1. IntroductionThe "wine of jurema", used in ancient Brazilian shamanic rituals, is rich in N,N-dimethyltryptamine (DMT), a na...

Details DOI 10.3389/fpsyt.2024.1485337 PubMed 39568756 Copy citation Copy BibTeX

Frontiers in Psychiatry 2024-11-05 Cristiano Chaves, Rafael G. dos Santos, Serdar Dursun, Massimo Tusconi, Mauro Giovanni Carta, Elisa Brietzke

OpenAlex Published psilocybin DepressionAnxietyPTSD Review Article Hallucinogen More

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Psychoactive substances for the treatment of neuropsychiatric disorders.

In the contemporary landscape of psychiatric medicine, critical advancements have been noted in the utilization of psychoactive substances such as hallucinogens, 3,4-methylenedioxymethamphetamine (MDMA), and ketamine for the treatment of severe mental health disorders. This review provides a detailed evaluation of these substances, focusing on their mechanis...

Details DOI 10.1016/j.ajp.2024.104193 PubMed 39243659 Copy citation Copy BibTeX

Unknown journal 2024-09-02 Zhen Z, Sun X, Yuan S, Zhang J.

Europe PMC Published psilocybin DepressionAnxietyPTSD Review Article Humans More

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PTSD Treatment: An Inquiry into the Promising Potential of Psilocybin

Post-Traumatic Stress Disorder (PTSD) is a debilitating mental health condition that can occur after experiencing or witnessing a traumatic event. The impact of PTSD extends beyond the individual, affecting families, communities, and society as a whole. This study aims to investigate the potential of psilocybin as a treatment for PTSD. Psilocybin, after bein...

Details DOI 10.9734/jammr/2024/v36i85525 Copy citation Copy BibTeX

Journal of Advances in Medicine and Medical Research 2024-07-23 Ibrahim Lanre Folorunsho, Nkechinyere Mary Harry, Chukwubueze Obiajunwa, Oluwatosin Arubuolawe, Adeniyi Kayode Busari, Chidalu Ibeneme

OpenAlex Published psilocybinpsilocin AnxietyPTSDNeurogenesis Review Article Psilocybin More

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Psilocybin therapy: A novel approach to treating depression

The COVID-19 pandemic has resulted in a surge in depression cases, a pervasive and debilitating mental illness1. This trend is evident in the increased prescriptions for antidepressants. Depression is a chronic condition that affects a significant proportion of the global population, with ~280 million people, or about 3.8%, suffering from it. As a result, it...

Details DOI 10.1097/gh9.0000000000000175 Copy citation Copy BibTeX

International Journal of Surgery Global Health 2023-06-01 Tooba Noor, Areej Shakil, Aimen Waqar Khan, Syeda Mahrukh Fatima Zaidi, Hussain Sohail Rangwala, Burhanuddin Sohail Rangwala

OpenAlex Published psilocybinpsilocin DepressionAnxietyAddiction Clinical Trial Depression (economics) More

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Evaluation of the Acceptability, Safety, Feasibility, and Efficacy of Psilocybin-assisted Psychotherapy (PaP) for the Treatment of Post-traumatic Stress Disorder (PTSD) in Military Veterans

Post-Traumatic Stress Disorder (PTSD) is a mental health condition that occurs as a result of a traumatic experience. Symptoms include feeling anxious, flashbacks, nightmares and difficulty sleeping. Several studies indicate that psilocybin-assisted psychotherapy (PaP) may be an effective treatment for a number of mental health conditions. This has led to Pa...

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ClinicalTrials.gov 2023-05-24 Combat Stress

ClinicalTrials.gov CLINICAL TRIAL psilocybin DepressionAnxietyPTSD Other PTSD More

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Unique Effects of Sedatives, Dissociatives, Psychedelics, Stimulants, and Cannabinoids on Episodic Memory: A Review and Reanalysis of Acute Drug Effects on Recollection, Familiarity, and Metamemory

Despite distinct classes of psychoactive drugs producing putatively unique states of consciousness, there is surprising overlap in terms of their effects on episodic memory and cognition more generally. Episodic memory is supported by multiple subprocesses that have been mostly overlooked in psychopharmacology and could differentiate drug classes. Here, we r...

Details DOI 10.1101/2022.05.20.492842 Copy citation Copy BibTeX

bioRxiv 2022-05-23 Doss MK, Samaha J, Barrett FS, Griffiths RR, de Wit H, Gallo DA

bioRxiv PREPRINT (not peer reviewed) psilocybin PharmacologyMechanism of ActionConsciousness Systematic Review More

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Serotonergic psychedelics for depression: What do we know about neurobiological mechanisms of action?

Current treatment options for major depressive disorder (MDD) have limited efficacy and are associated with adverse effects. Recent studies investigating the antidepressant effect of serotonergic psychedelics-also known as classic psychedelics-have promising preliminary results with large effect sizes. In this context, we conducted a review of the putative n...

Details DOI 10.3389/fpsyt.2022.1076459 PubMed 36844032 Copy citation Copy BibTeX

Frontiers in psychiatry 2021-12-31 Husain MI, Ledwos N, Fellows E, Baer J, Rosenblat JD, Blumberger DM

PubMed Published psilocybin DepressionBrain ImagingMechanism of Action Review Article LSD More

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Psychedelics: A new era of treatment?

Introduction Psychedelics - including LSD (lysergic acid diethylamide), psilocybin, DMT (N, N-dimethyltryptamine), ayahuasca and mescaline - have an ancient history across various civilizations. In 1950, after LSD’s discovery by Hofmann, psychedelics enjoyed a short-lived relationship with psychiatry, before prohibitive legislature emerging in response to th...

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Unknown journal 2021-08-12 Torres S.

Europe PMC Published psilocybin DepressionAnxietyAddiction Randomized Controlled Trial More

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Psychedelic-Assisted Psychotherapy for Post-Traumatic Stress Disorder, Anxiety Disorders, Mood Disorders, or Substance Use Disorders

Hallucinogens include many different drugs, which are often called “psychedelic” drugs. The US National Institute on Drug Abuse categorizes these drugs into 2 categories: classic hallucinogens and dissociative drugs. Both types of psychedelics can lead to hallucinations - sensations and images that seem real although they are imaginary. In addition, an indiv...

Details PubMed 36170470 Copy citation Copy BibTeX

Canadian Agency for Drugs and Technologies in Health, Ottawa (ON) 2021-05-31 Chao YS, Horton J.

Europe PMC Published psilocybin DepressionAnxietyPTSD Clinical Trial More

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Therapeutic use of serotoninergic hallucinogens: A review of the evidence and of the biological and psychological mechanisms.

Serotoninergic hallucinogens include drugs such as lysergic acid diethylamide (LSD), dimethyltryptamine (DMT) and psilocybin. Recent trials with single/few doses of these compounds show that they induce rapid and sustained antidepressive, anxiolytic, and antiaddictive effects. These effects are also observed in religious groups using the DMT-containing brew ...

Details DOI 10.1016/j.neubiorev.2019.12.001 PubMed 31809772 Copy citation Copy BibTeX

Unknown journal 2019-12-02 Dos Santos RG, Hallak JEC.

Europe PMC Published psilocybin DepressionNeuroplasticityMechanism of Action Review Article Limbic System More

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Classical hallucinogens and neuroimaging: A systematic review of human studies: Hallucinogens and neuroimaging.

Serotonergic hallucinogens produce alterations of perceptions, mood, and cognition, and have anxiolytic, antidepressant, and antiaddictive properties. These drugs act as agonists of frontocortical 5-HT2A receptors, but the neural basis of their effects are not well understood. Thus, we conducted a systematic review of neuroimaging studies analyzing the effec...

Details DOI 10.1016/j.neubiorev.2016.10.026 PubMed 27810345 Copy citation Copy BibTeX

Unknown journal 2016-10-30 Dos Santos RG, Osório FL, Crippa JAS, Hallak JEC.

Europe PMC Published psilocybin Brain ImagingReceptor PharmacologyDefault Mode Network Systematic Review Cerebral Cortex More

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A Phenomenological Examination of Psilocybin and its Positive and Persisting Aftereffects

This study is an examination of the positive and persisting psychological and behavioral aftereffects in eight individuals who reported consumption of psilocybin-containing mushrooms. Mushrooms containing psilocybin have been used for healing and spiritual purposes for thousands of years, and the therapeutic applications of psilocybin were scientifically exa...

Details DOI 10.14704/nq.2016.14.2.943 Copy citation Copy BibTeX

NeuroQuantology 2016-05-23 Joseph A. Zamaria

OpenAlex Published psilocybin DepressionAnxietyOCD Other Psilocybin More

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The psychedelic state induced by ayahuasca modulates the activity and connectivity of the default mode network.

The experiences induced by psychedelics share a wide variety of subjective features, related to the complex changes in perception and cognition induced by this class of drugs. A remarkable increase in introspection is at the core of these altered states of consciousness. Self-oriented mental activity has been consistently linked to the Default Mode Network (...

Details DOI 10.1371/journal.pone.0118143 PubMed 25693169 Copy citation Copy BibTeX

PLoS ONE 2015-02-17 Palhano-Fontes F, Andrade KC, Tofoli LF, Santos AC, Crippa JA, Hallak JE

Europe PMC Published psilocybin Brain ImagingDefault Mode NetworkConsciousness Other Gyrus Cinguli More

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A survey of hallucinogenic mushroom use, factors related to usage, and perceptions of use among college students.

BackgroundRecreational usage and attitudes toward psilocybin-containing hallucinogenic mushrooms among college students are seldom explored.MethodsWe surveyed 882 randomly selected undergraduates at Skidmore College in upstate New York and quantified whether participants had ever used psilocybin mushrooms, their attitudes toward the drug, and polydrug use.Re...

Details DOI 10.1016/j.drugalcdep.2012.11.010 PubMed 23265089 Copy citation Copy BibTeX

Unknown journal 2012-12-20 Hallock RM, Dean A, Knecht ZA, Spencer J, Taverna EC.

Europe PMC Published psilocybin AddictionMystical ExperienceObservational Study Observational Study Humans More

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Functional connectivity measures after psilocybin inform a novel hypothesis of early psychosis.

Psilocybin is a classic psychedelic and a candidate drug model of psychosis. This study measured the effects of psilocybin on resting-state network and thalamocortical functional connectivity (FC) using functional magnetic resonance imaging (fMRI). Fifteen healthy volunteers received intravenous infusions of psilocybin and placebo in 2 task-free resting-stat...

Details DOI 10.1093/schbul/sbs117 PubMed 23044373 Copy citation Copy BibTeX

Schizophrenia Bulletin 2012-10-07 Carhart-Harris RL, Leech R, Erritzoe D, Williams TM, Stone JM, Evans J

Europe PMC Published psilocybin Brain ImagingDefault Mode NetworkAging Other Thalamus More