Abstract Pholiotina cyanopus was collected from wood chips and other woody remnants of undetermined tree species. Its basidiomata were found in June within the area of closed sawmill in the central part of Żywiec city (SW Poland). Description and illustration of Ph. cyanopus based on Polish specimens are provided and its ecology, general distribution and com...
Research on psychedelic substances is re-emerging. Here we review chemical and physiological effects in addition to medical uses for psychedelic substances. The most common substances included here as psychedelics are lysergic acid diethylamide (LSD), psilocybin, and peyote. Safety is the priority underlying the majority of the following studies.
Human UDP-glucuronosyltransferases (UGTs) are important in the metabolic elimination of xenobiotics and endogenous compounds from the body. These enzymes transfer glucuronic acid moiety from the cosubstrate, UDP-glucuronic acid (UDPGA), to nucleophilic groups of small organic molecules, such as hydroxyl, carboxylic, or amino group. The conjugation of these m...
Mescaline, phencyclidine (PCP) and psilocybin are potent hallucinogenic drugs strongly affecting both human and animal behavior. However, these compounds have not been previously investigated in zebrafish (Danio rerio), rapidly gaining popularity as a model in psychopharmacology research. Here, we examine the effects of mescaline, PCP and psilocybin in multi...
Objective To explore the effects of flavone glycoside on psilocybin-induced oxidative damage in rats.Methods Five group Sprague-Dawley rats(10 for each group) were received vehicle(Con),low dose of psilocybin(i.p.,0.5 μg/kg body weight)(LD),high dose of psilocybin(i.p.,1.5 μg/kg body weight)(HD),low dose of psilocybin(i.p.) plus flavone glycoside(i.p.100 mg/...
Several experiments show that there is a cell to cell communicaton by light in different cell types. The most convincing experiment shows that baby hamster kidney cells can communicate their spatial orientation through a glass film, this can only happen by photon signals. If so, it can be assumed that the cells with the highest differentiation, the neurons a...
I. Psilocybe cubensis was cultured successfully in two media. Medium A was devised by Catalfomo and Tyler and Medium B was a modification of a medium which has been used for ergot alkaloid production by Claviceps purpurea. Only when the fungus was kept on Sabouraud agar plates.did it subsequently produce psilocybin when transferred to liquid media. A quantit...
Psilocybe argentipes is a hallucinogenic mushroom. The present study examined the effects of P. argentipes on marble-burying behavior, which is considered an animal model of obsessive-compulsive disorder. P. argentipes significantly inhibited marble-burying behavior without affecting locomotor activity as compared with the same dose of authentic psilocybin. ...
In this experiment, tryptamine is used as a psilocin analog and is dispersed onto a Fisher brand cellulose laboratory sponge to simulate dehydrated mushrooms. The resulting “mushroom” material is ground, molded into chocolate, and presented to student groups for real-world and applied analyses. Students isolate the tryptamine from the chocolate using their k...
Accompanying the resumption of human research with the entheogen (psychedelic drug), psilocybin, the range of states of consciousness reported during its action, including both nonmystical and mystical forms of experience, is surveyed and defined. The science and art of facilitating mystical experiences is discussed on the basis of research experience. The p...
Although psilocybin has been trained in the rat as a discriminative stimulus, little is known of the pharmacological receptors essential for stimulus control. In the present investigation rats were trained with psilocybin and tests were then conducted employing a series of other hallucinogens and presumed antagonists. An intermediate degree of antagonism of ...
RETURN TO ISSUEPREVNewsNEXTPSILOCYBIN STUDIES TURN A NEW LEAFScientists aim to set psychedelics research on a sound scientific footingIVAN AMATOCite this: Chem. Eng. News 2006, 84, 29, 10Publication Date (Print):July 17, 2006Publication History Published online14 November 2010Published inissue 17 July 2006https://pubs.acs.org/doi/10.1021/cen-v084n029.p010aht...
The human serotonin 2A receptor (h5-HT2A R) plays an essential role in cognition, and is the principal target for serotonergic hallucinogens as well as atypical antipsychotics. Utilizing our in silico -activated h5-HT2A R homology model, an interaction was predicted between Asn343(6.55) in TM6 and the carbonyl of LSD. Virtual docking simulations of a new cla...
In this study a fatal case caused by the ingestion of magic mushrooms is reported. After a trip to the Netherlands a young girl had ingested a handful of psilocybe mushrooms with a soft drink. Soon later, she was trying to fly from the window and died in the street while falling from a room situated on the second floor of a house. The victim was not known by...
