Compare findings
Compare selected psilocybin depression and alcohol-use reports by population, design, sample, endpoint, finding and limitations with original source links.
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Compare selected original reports
This educational comparison reuses the original annotations in our evidence guides. It is a selected set, not a systematic review or an independently clinically reviewed treatment recommendation. Source-check dates belong to the annotations and do not advance when the page is rebuilt.
| Report and population | Design and sample | Endpoint | Finding | Limitations |
|---|---|---|---|---|
| Griffiths et al. · 2016 People with a life-threatening cancer diagnosis and depression or anxiety symptoms Source checked 2026-10-09 | Randomized double-blind crossover: high versus very low psilocybin dose with psychological support 51 participants | Clinician- and self-rated anxiety and depressive symptoms; randomized comparison before crossover | Pre-crossover comparison favored high dose The high-dose condition showed greater symptom reductions. Improvements were also observed at six months after both sequences had received the high dose. | The six-month observations are not a continuing untreated-control comparison. Small, screened sample; expectancy and recognizable drug effects complicate blinding. |
| Ross et al. · 2016 People with cancer-related anxiety and depression Source checked 2026-10-09 | Randomized double-blind crossover: psilocybin versus niacin, both with psychotherapy 29 participants | Anxiety and depression measures before crossover at seven weeks | Pre-crossover comparisons favored psilocybin Pre-crossover comparisons favored psilocybin on the anxiety and depression measures. Later observations suggested persistence after both groups had received psilocybin. | After crossover the study cannot establish a sustained between-group causal effect. A small selected cancer population does not establish efficacy for generalized anxiety disorder. |
2 reports shown