Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term Meditators

This is a double-blind placebo-controlled study investigating the acute and persisting effects of psilocybin on meditation, spirituality, health, well-being, prosocial attitudes, and brain functioning. This study will use questionnaires and functional magnetic resonance imaging (fMRI) to examine the acute and persisting effects of psilocybin on brain functio...

ClinicalTrials.gov 2019-12-29 Johns Hopkins University

ClinicalTrials.gov CLINICAL TRIAL psilocybin Brain ImagingPharmacologyAgingWellbeingSpirituality Other HealthyModerately-high dose of psilocybin

Measurement of Persisting Changes in Emotional Brain Functioning Produced by Psilocybin

The proposed pilot study will assess whether ingestion of a classic hallucinogen (psilocybin) leads to changes in emotion processing and neural circuitry that may predict repeated self-administration of this drug and underlie an atypical mechanism of abuse liability, which may vitally contribute to the understanding of the potential for abuse and the underly...

ClinicalTrials.gov 2019-09-09 Johns Hopkins University

ClinicalTrials.gov CLINICAL TRIAL psilocybin Mechanism of ActionEmotional ProcessingAbuse Liability Other HealthyPsilocybin

A Randomised, Balanced, Double-blind Two-way Crossover Design Study to Evaluate the Effects of SRC Kinase Inhibitor, Saracatinib, on Brain Activity Associated With Visual Processing in Patients With Parkinson's Disease Psychosis.

Parkinson's disease is often characterised by movement symptoms such as rigidity and bradykinesia, however, there are a number of non-motor symptoms that can have a significant impact on quality of life. One of the most common non-motor symptoms of Parkinson's disease is visual hallucinations (where someone sees things that don't exist outside their mind).. ...

ClinicalTrials.gov 2019-08-12 King's College London

ClinicalTrials.gov CLINICAL TRIAL psilocybin Brain ImagingPharmacologyMechanism of ActionReceptor PharmacologyDefault Mode NetworkAgingHealthy Volunteers Other Parkinson Disease PsychosisSaracatinib

Psychopharmacology of Psilocybin in Cancer Patients

This research is being done to study the psychological effects of psilocybin in cancer patients. Psilocybin is a naturally occurring substance found in some mushrooms that some cultures have used for centuries in religious practices. This research is being done to study the psychological effects of psilocybin in cancer patients. Psilocybin is a naturally occ...

ClinicalTrials.gov 2018-07-18 Johns Hopkins University

ClinicalTrials.gov CLINICAL TRIAL psilocybin DepressionAnxietyPharmacologyConsciousnessSpiritualityHealthy VolunteersCancer Patients Other Depressive SymptomsAnxiety

Psilocybin and Depression - Assessing the Long-term Effects of a Single Administration of Psilocybin on the Psychiatric Symptoms and Brain Activity of Patients With Severe Depression

The main aim of the study is to investigate the possible long-term therapeutic effects of psilocybin on the symptoms of severe depression, as well as the brain mechanisms underlying these changes. Depression severity is assessed before and after (i.e., 1 week, 3 months and 6 months after) a single dose of psilocybin and compared to respective scores of a gro...

ClinicalTrials.gov 2017-12-20 University of Helsinki

ClinicalTrials.gov CLINICAL TRIAL psilocybin DepressionBrain ImagingMechanism of ActionBiomarkersAgingEmotional Processing Other Severe DepressionPsilocybin

Effects of Psilocybin and Spiritual Practice on Persisting Changes in Attitudes and Behavior

This study will investigate the effects of psilocybin dose and the frequency and intensity of support activities for spiritual practice (e.g., meditation) on a battery of attitudinal and behavioral outcome measures in 75 healthy volunteers who are interested in pursuing a program of spiritual practices with the intention applying spiritual insights and knowl...

ClinicalTrials.gov 2016-02-23 Johns Hopkins University

ClinicalTrials.gov CLINICAL TRIAL psilocybin SpiritualityHealthy Volunteers Other Healthypsilocybin

Pilot Study: Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term Meditators

This is a pilot study to finalize methods for a larger study being planned for the future. This research is being done to characterize performance of tasks, brain functioning, and the effects of psilocybin in individuals with a long-term meditation practice. There are three different parts of the pilot study: 1. Effects of psilocybin on psychological functio...

ClinicalTrials.gov 2014-05-19 Johns Hopkins University

ClinicalTrials.gov CLINICAL TRIAL psilocybin Brain ImagingAging Other PsilocybinHallucinogens

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ClinicalTrials.gov	287	7.2%	Active
OpenAlex	283	7.1%	Active
PsyArXiv	216	5.4%	Active
Crossref	157	3.9%	Active
bioRxiv	142	3.6%	Active

Psilocybin Research Publication Tracker

Research search

Latest Publications

Ethical Complexities and Best Practices in Informed Consent Processes for Psilocybin Services: A Qualitative Study

Sexual identity as a moderator of associations between lifetime MDMA/ecstasy or psilocybin use and mental health outcomes: An exploratory analysis of a nationally representative sample using NSDUH 2015-2019

Consciousness and Psilocybin Effects on Well-Being: The CoPEWell Study

Meskalin / Mescaline

DMT und Ayahuasca / DMT and Ayahuasca

DMT und Ayahuasca / DMT and Ayahuasca

Neuroestimulantes naturales: de rituales ancestrales a terapias de vanguardia

Meskalin / Mescaline

Usos recreativos, medicinales y etnobotánicos de hongos alucinógenos: una revisión

Convergent biosynthesis of psilocybin in an ectomycorrhizal lineage: is the psychoactive end-product the selected trait?

Past-Year Psilocybin and Alcohol Co-Use: Associations With Mental Health Symptoms

Investigating the impact of serotonergic psychedelic drugs, MDMA and ketamine on social cognition in psychiatric disorders: A scoping review.

Efficacy in Relapse Prevention: Psilocybin in Alcohol Use Disorder With Depressive Symptoms

A Phase 2, Open-Label Study Investigating the Safety and Efficacy of Psilocybin-Assisted Therapy for Sexual Assault-Related Posttraumatic Stress Disorder (PTSD)

Psilocybin shows mixed results for patients with treatment-resistant depression

Single-dose psilocybin with CBT more effective than nicotine patch for smoking cessation

Revealing shortcomings in the assessment of psilocybin effects on OCD-related symptoms in preclinical and clinical studies: A systematic review

Blinding Integrity in Psychedelic Randomized Clinical Trials: A Systematic Review.

Implementing psilocybin-assisted therapy in palliative care settings: A survey of stakeholders.

MFCC-DFT mapping of ligand recognition at the 5-HT2A receptor: energetic analysis of the interactions between serotonin, psychedelics, and antipsychotics.