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Synthesis and bioactivity of psilocybin analogues containing a stable carbon-phosphorus bond

Psilocybin analogues have been synthesized comprising a non-hydrolysable P-C bond to evaluate the biological activity and the selectivity towards 5-HT2A R, 5-HT2B R and the TNAP receptor.

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Journal: RSC Medicinal Chemistry
Date: 2023-12-31
Source: OpenAlex
DOI: 10.1039/d4md00043a
PubMed: 38516602

Authors

Marthe Vandevelde Andreas Simoens Bavo Vandekerckhove Christian V. Stevens

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Topics and keywords

psilocybin Pharmacology Receptor Pharmacology Other Psilocybin Phosphorus Chemistry Carbon fibers Hallucinogen Organic chemistry Materials science Biology Pharmacology Composite number Composite material Psychedelics and Drug Studies Chemical synthesis and alkaloids Phenothiazines and Benzothiazines Synthesis and Activities

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Synthesis and bioactivity of psilocybin analogues containing a stable carbon-phosphorus bond2023-12-31

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