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Concise large-scale synthesis of psilocin and psilocybin, principal hallucinogenic constituents of "magic mushroom".

The concise large-scale syntheses of psilocin (1) and psilocybin (2), the principal hallucinogenic constituents of "magic mushroom", were achieved without chromatographic purification. The key step in the synthesis of 2 was the isolation of the dibenzyl-protected intermediate (7) as a zwitterionic derivative (8), which was completely identified by means of 2D NMR analyses.

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Bibliographic context

Journal: Unknown
Date: 2003-05-31
Source: Europe PMC
DOI: 10.1021/np030059u
PubMed: 12828485

Authors

Shirota O Hakamata W Goda Y.

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Topics and keywords

psilocybin psilocin General Other Agaricales Hallucinogens Nuclear Magnetic Resonance Biomolecular Combinatorial Chemistry Techniques Molecular Structure Psilocybin

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0 referenced DOIs found in stored source metadata. 4 indexed papers cite this DOI.

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Indexed papers citing this DOI

Unravelling a New Conformer of Psilocin Through Computational Methods2021-12-31 Observations concerning the synthesis of tryptamine homologues and branched tryptamine derivatives via the borrowing hydrogen process: synthesis of psilocin, bufotenin, and serotonin2016-04-30 Palladium-catalyzed synthesis of tryptamines and tryptamine homologues: synthesis of psilocin2009-10-31 Preparation of Monoclonal Antibodies Reactive to a Hallucinogenic Drug, Psilocin2003-12-31