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A validated method for quantitation of psilocin in plasma by LC-MS/MS and study of stability.

A liquid chromatography-electrospray ionization/tandem mass spectrometry method for the quantitation of psilocin in plasma is presented. Sample workup was performed with mixed-mode solid-phase extraction using ascorbic acid and nitrogen for drying to protect the unstable analyte. Calibration curves were linear from 2 to 100 ng/mL, and no selectivity problems occurred. The limit of detection was 0.1 ng/mL, and the limit of quantitation was 0.34 ng/mL. Recovery was >86% and matrix effects were

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Journal: Unknown
Date: 2011-12-02
Source: Europe PMC
DOI: 10.1007/s00414-011-0652-8
PubMed: 22138681

Authors

Martin R Schürenkamp J Pfeiffer H Köhler H.

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Topics and keywords

psilocybin psilocin General Clinical Trial Humans Hallucinogens Blood Specimen Collection Chromatography Liquid Spectrometry Mass Electrospray Ionization Predictive Value of Tests Substance Abuse Detection Dose-Response Relationship Drug Tandem Mass Spectrometry Psilocybin

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Sensitive quantitative analysis of psilocin and psilocybin in hair samples from suspected users and their distribution in seized hallucinogenic mushrooms2021-06-30