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Acute Effects of Psilocybin and Salvinorin-A on Functional Connectivity

This work utilized fMRI to assess the influence of the psychedelics, Psilocybin, a serotonergic agonist, and Salvinorin-A, a kappa-opioid receptor (KOR) agonist, on functional connectivity (FC) in non-human primates. We used a seed-based FC analysis, probing regions of interest associated with psychedelic hallucinogens. Our findings highlight the overlapping and differing influence of these substances on FC relative to the subcomponents of the default mode network and the claustrum. This work may provide insight on the mechanisms of action of psychedelics that target differing receptor systems. Key Words: Functional connectivity; Claustrum; DMN; Psychedelics.

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Journal: Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Date: 2024-08-13
Source: OpenAlex
DOI: 10.58530/2023/3494
PubMed: Unavailable

Authors

Frederick A. Bagdasarian Hanne D. Hansen Chi-Hyeon Yoo Michael S. Placzek Jacob M. Hooker Hsiao-Ying Wey

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Acute Effects of Psilocybin and Salvinorin-A on Functional Connectivity2024-08-13

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