Open research · Psilocybin & psilocin

Countries and organisations

Explore psilocybin trials by country, sponsor and research facility. Compare registry status, study-start trends, conditions and mapped research sites.

Free access · No subscription for research tools or data exports

Explore registry geography and organisations

Trial, condition or NCT IDCountrySponsorPhaseStatusConditionReset

31 trials match this view; 15 mapped facilities. Latest indexed registry check Oct 9, 2026 01:24 UTC. Country membership uses reported locations, including locations without coordinates; Mapped-facility counts cover all sites of matching trials, including international sites, and require valid coordinates.

Enrollment sum: 1,071 across 31 records with a reported count. Planned and actual counts are mixed; this is not a count of unique treated participants.

Export filtered registry facts · JSONInteractive world map Germany source-checked report

Recorded study-start years

200711

200811

200911

201311

201411

201511

201722

201911

202122

202233

202322

202455

202566

202633

202711

Current indexed registry status

Recruiting1313

Completed1212

Active, not recruiting33

Withdrawn33

Reported research conditions

Healthy66

Opioid Use Disorder33

Psilocybin22

Psychedelic Effects in Healthy Volunteers22

Depressive Symptoms22

Depression22

Major Depressive Disorder22

Mood (Psychological Function)11

Well Being11

Mood11

Music Intervention11

Obsessive-Compulsive Disorder11

Counts describe indexed registry records, not efficacy or total research activity. A trial can count under several conditions or countries. Unknown dates are excluded from the start-year chart; future years reflect planned starts. Stopped studies may reflect recruitment, funding or strategy and are not automatically treatment failures.

Matching trial records

31 matching registry records. Dates are registry milestones, not promised results announcements.
Trial	Sponsor and phase	Status	Enrollment	Start / primary completion / completion
PRISMatic: A Phase 1b Randomized, Double-Armed, Parallel-Group, Placebo-Controlled Trial of Psilocybin Efficacy With or Without Pimavanserin Pretreatment NCT07610135 Mood (Psychological Function) · Well Being · Mood · Healthy	Johns Hopkins University PHASE1, PHASE2	Recruiting Registry updated 2026-10-01	20 ESTIMATED	2026-10-30 2028-06 2028-12
PRoMiSS: Psilocybin and the Role of Music in Set and Setting NCT07180108 Psilocybin · Music Intervention	Johns Hopkins University PHASE1	Recruiting Registry updated 2026-09-15	100 ESTIMATED	2025-08-12 2028-06 2028-08
Psilocybin Administration With 5-HT1a Blockade NCT07565493 Psychedelic Effects in Healthy Volunteers	Johns Hopkins University EARLY_PHASE1	Recruiting Registry updated 2026-09-14	18 ESTIMATED	2026-08-12 2028-06-15 2028-06-15
Effects of Psilocybin in Obsessive Compulsive Disorder NCT05546658 Obsessive-Compulsive Disorder	Johns Hopkins University EARLY_PHASE1	Active, not recruiting Registry updated 2026-09-04	35 ACTUAL	2022-11-28 2026-12-30 2027-09-12
Pilot Study of Serotonin 2A Receptor (5-HT2A) Agonist Psilocybin for Depression in Patients With Mild Cognitive Impairment or Early Alzheimer's Disease NCT04123314 Depressive Symptoms · Depression · Alzheimer Disease · Mild Cognitive Impairment	Johns Hopkins University EARLY_PHASE1	Recruiting Registry updated 2026-09-04	20 ESTIMATED	2021-03-24 2027-06-30 2027-09-30
Psilocybin and Affective Function in Chronic Lower Back Pain Depression NCT06355414 Chronic Low-back Pain · Depression	Johns Hopkins University PHASE1	Recruiting Registry updated 2026-09-04	40 ESTIMATED	2024-04-22 2026-12-30 2026-12-30
Psilocybin and MDMA for Post-traumatic Stress Disorder (PTSD) NCT06989957 Posttraumatic Stress Disorder	Johns Hopkins University PHASE1	Recruiting Registry updated 2026-09-04	40 ESTIMATED	2025-09-17 2028-08 2029-08
Safety for Home Administration of Microdose Psilocybin Use NCT06450210 Psychedelic Experiences	Johns Hopkins University PHASE1	Completed Registry updated 2026-08-14	17 ACTUAL	2024-12-06 2026-07-31 2026-07-31
Effects of Psilocybin in Patients With Amyotrophic Lateral Sclerosis NCT06656702 Amyotrophic Lateral Sclerosis	Johns Hopkins University EARLY_PHASE1	Recruiting Registry updated 2026-08-11	24 ESTIMATED	2025-04-09 2027-01-30 2027-07-01
Open Label Psilocybin Brain Stimulation and Imaging Pilot Study NCT06835699 Healthy Volunteers	Johns Hopkins University PHASE1	Completed Registry updated 2026-08-07	10 ACTUAL	2025-04-18 2026-05-21 2026-05-21
Effects of Psilocybin on Electrophysiology and the Dynamic Content of Thought NCT05301608 Healthy	Johns Hopkins University PHASE1, PHASE2	Recruiting Registry updated 2026-07-23	30 ESTIMATED	2022-03-03 2026-12-01 2027-01-01
Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder: a Randomized Double-blind Trial NCT06067737 Opioid Use Disorder	Johns Hopkins University PHASE2	Recruiting Registry updated 2026-07-17	90 ESTIMATED	2024-02-08 2028-07 2029-05
5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder NCT05452772 Tobacco Use Disorder	Johns Hopkins University PHASE2	Recruiting Registry updated 2026-06-29	66 ESTIMATED	2023-11-01 2026-12 2027-05
Psilocybin for PTSD With or Without Psychotherapy: A Pilot Study of Safety and Efficacy NCT06407635 Post Traumatic Stress Disorder	Johns Hopkins University PHASE1	Active, not recruiting Registry updated 2026-06-22	20 ESTIMATED	2024-06-07 2026-03-09 2027-05
Pilot Study of Psilocybin-assisted Treatment for Cannabis Use Disorder NCT06660381 Cannabis Use Disorder	Johns Hopkins University PHASE1	Recruiting Registry updated 2026-03-18	12 ESTIMATED	2024-11-08 2026-11 2026-12
Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder NCT04620759 Major Depressive Disorder · Alcohol Use Disorder	Johns Hopkins University PHASE2	Active, not recruiting Registry updated 2026-03-13	90 ESTIMATED	2021-04-14 2026-03-02 2027-03-30
Inpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder: a Randomized Double-blind Trial NCT06005662 Opioid Use Disorder	Johns Hopkins University PHASE2	Withdrawn Registry updated 2026-02-23	0 ACTUAL	2027-04 2028-07 2028-07
Investigation of Psychedelic Effects in Psychoactive Substances NCT06772753 Psychedelic Effects in Healthy Volunteers	Johns Hopkins University PHASE1	Recruiting Registry updated 2026-02-23	50 ESTIMATED	2025-02-05 2027-06 2027-12
Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability NCT07053917 Stroke · Chronic Stroke · Intracerebral Haemorrhage · Intracerebral Haemorrhage (ICH) · Intracerebral Hemorrhage Basal Ganglia · Ischemic Stroke · Ischemic Stroke and Hemorrhagic Stroke · Hemiparesis After Stroke · Hemiplegia Following Ischemic Stroke · Hemiplegia and Hemiparesis · Hemiplegia and/or Hemiparesis Following Stroke · Middle Cerebral Artery Stroke	Johns Hopkins University PHASE1	Recruiting Registry updated 2026-02-13	20 ESTIMATED	2026-02-09 2027-02 2027-03
Effects of Psilocybin in Post-Treatment Lyme Disease NCT05305105 Post-Treatment Lyme Disease · Chronic Lyme Disease · Lyme Disease, Chronic	Johns Hopkins University PHASE1	Completed Registry updated 2025-08-20	20 ACTUAL	2022-07-01 2024-10-26 2025-04-07
Psilocybin-facilitated Smoking Cessation Treatment: A Pilot Study NCT01943994 Nicotine Dependence	Johns Hopkins University NA	Completed Registry updated 2025-05-25	82 ACTUAL	2008-09 2023-05-01 2023-11-14
Effects of Psilocybin-facilitated Experience on the Psychology and Effectiveness of Professional Leaders in Religion NCT02243813 Healthy	Johns Hopkins University PHASE1	Completed Registry updated 2024-06-18	24 ACTUAL	2015-03 2024-05-31 2024-05-31
A Randomized, Double-Blind Study of Psilocybin for Opioid Use Disorder in Patients on Methadone Maintenance With Ongoing Opioid Use NCT05242029 Opioid Use Disorder	Johns Hopkins University PHASE2	Withdrawn Registry updated 2024-02-02	0 ACTUAL	2023-12 2024-02 2024-12
Safety and Tolerability of Psilocybin in Post-Traumatic Stress Disorder NCT05562973 Post-Traumatic Stress Disorder	Johns Hopkins University PHASE1	Withdrawn Registry updated 2024-01-05	0 ACTUAL	2025-01 2025-12 2025-12
Effects of Psilocybin in Anorexia Nervosa NCT04052568 Anorexia Nervosa	Johns Hopkins University PHASE1	Completed Registry updated 2023-05-06	22 ACTUAL	2019-08-26 2022-01-05 2023-04-20
Effects of Psilocybin in Major Depressive Disorder NCT03181529 Major Depressive Disorder	Johns Hopkins University PHASE2	Completed Registry updated 2021-12-15	27 ACTUAL	2017-08-10 2020-12-02 2020-12-02
Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term Meditators NCT02145091 Healthy	Johns Hopkins University PHASE1	Completed Registry updated 2019-12-30	40 ACTUAL	2014-05 2019-12-26 2019-12-26
Measurement of Persisting Changes in Emotional Brain Functioning Produced by Psilocybin NCT02971605 Healthy	Johns Hopkins University PHASE1, PHASE2	Completed Registry updated 2019-09-10	13 ACTUAL	2017-07-01 2018-08-21 2018-08-21
Psychopharmacology of Psilocybin in Cancer Patients NCT00465595 Depressive Symptoms · Anxiety · Cancer	Johns Hopkins University PHASE2	Completed Registry updated 2018-07-19	56 ACTUAL	2007-04 2014-12 2016-12
Effects of Psilocybin and Spiritual Practice on Persisting Changes in Attitudes and Behavior NCT00802282 Healthy	Johns Hopkins University PHASE1	Completed Registry updated 2016-02-24	75 ACTUAL	2009-08 2014-02 2014-05
Pilot Study: Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term Meditators NCT01988311 Psilocybin · Hallucinogens · Pharmacologic Actions · Central Nervous System Agents · Therapeutic Uses · Psychotropic Drugs	Johns Hopkins University PHASE1	Completed Registry updated 2014-05-20	10 ESTIMATED	2013-05 2014-01 2014-05

Reported research facilities

Johns Hopkins Center for Psychedelic and Consciousness ResearchBaltimore, Maryland, United States

Center for Psychedelics and Consciousness Research in the Behavioral Biology Research CenterBaltimore, Maryland, United States

Center for Psychedelics and Consciousness ResearchBaltimore, Maryland, United States

Johns Hopkins University School of MedicineBaltimore, Maryland, United States

5510 Nathan Shock DriveBaltimore, Maryland, United States

Johns Hopkins School of MedicineBaltimore, Maryland, United States

University of Alabama at BirminghamBirmingham, Alabama, United States

New York UniversityNew York, New York, United States

Johns Hopkins UniversityBaltimore, Maryland, United States

Johns HopkinsBaltimore, Maryland, United States

Behavioral Pharmacology Research UnitBaltimore, Maryland, United States

Neuroimaging Research Branch, NIDA-IRPBaltimore, Maryland, United States

Behavioral Biology Research Center, Johns Hopkins BayviewBaltimore, Maryland, United States

Behavioral Pharmacology Research Unit, Johns Hopkins Bayview Medical CenterBaltimore, Maryland, United States

Behavioral Pharmacology Research Unit, Johns Hopkins Bayview CampusBaltimore, Maryland, United States

This list includes mapped sites of matching trials, including international sites; locations without usable coordinates are omitted. Facilities are registry-reported trial sites, not an independently verified clinic or research-centre directory. Current services and contact details must be checked at the source.