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Psilocybin and psilocin research index

Find psilocybin and psilocin papers, preprints, trials, and citations with clear source context.

Searches titles, authors, journals, identifiers, indexed metadata, and derived research topics. Use Filters to narrow by source, status, substance, study type, or date.

Database 4,967 indexed records Auto-updated on Aug 20, 2026 01:29 UTC

Executed search Topic: Randomized Controlled Trial 310 matching records are displayed.

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Database

4,748 Psilocybin Records 673 Psilocin Records 1,461 Journals 66 Research Topics

Published 4,226 Peer-reviewed / formal records Preprints 437 Marked as not peer reviewed Clinical trials 301 ClinicalTrials.gov records R toolkit visNetwork Bibliometrics, live SQLite analysis, HTML graph, and PDF export

Top journals 1,461 indexed journals

Journal	Records
Journal of psychopharmacology (Oxford, England)	148
Journal of psychoactive drugs	97
Frontiers in psychiatry	90
Psychopharmacology	85
Neuroscience Applied	57
Journal of Psychedelic Studies	48
Psychedelic medicine (New Rochelle, N.Y.)	39
Scientific reports	37
Biological Psychiatry	32
Journal of affective disorders	32

Research topics 66 topic filters

Depression 1,738 Receptor Pharmacology 1,282 Safety 1,208 Review Article 1,075 Mechanism of Action 1,072 Clinical Trial 978 Anxiety 884 Addiction 825 Pharmacology 752 General 538 Animal Study 525 Aging 524 Observational Study 516 Brain Imaging 482 Treatment-Resistant Depression 417 Emotional Processing 409 PTSD 401 Neuroplasticity 399

Source coverage 8 active sources

Source	Count	Share	Status
PubMed	2,566	51.7%	Active
OpenAlex	1,156	23.3%	Active
Crossref	407	8.2%	Active
ClinicalTrials.gov	301	6.1%	Active
Europe PMC	188	3.8%	Active
PsyArXiv	186	3.7%	Active
bioRxiv	124	2.5%	Active

Publication timeline 3,864 dated records

3,864 records since 2020

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Substances Psilocybin 4748 Psilocin 673

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Executed search Topic: Randomized Controlled Trial 310 matching records are displayed.

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310 matching records for Topic: Randomized Controlled Trial.

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Comparative oral monotherapy of psilocybin, lysergic acid diethylamide, 3,4-methylenedioxymethamphetamine, ayahuasca, and escitalopram for depressive symptoms: systematic review and Bayesian network meta-analysis.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1136/bmj-2023-078607 PubMed 39168500

BMJ (Clinical research ed.) 2024-08-21 Hsu TW, Tsai CK, Kao YC, Thompson T, Carvalho AF, Yang FC

PubMed Published psilocybin Depression Clinical Trial Randomized Controlled Trial Randomized Controlled Trial More

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Different hierarchical reconfigurations in the brain by psilocybin and escitalopram for depression

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1038/s44220-024-00298-y

Nature Mental Health 2024-08-05 Gustavo Deco, Yonatan Sanz Perl, Samuel Johnson, Niamh Bourke, Robin Carhart-Harris, Morten L. Kringelbach

OpenAlex Published psilocybin Depression Anxiety Brain Imaging Randomized Controlled Trial More

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Protocols and practices in psilocybin assisted psychotherapy for depression: A systematic review.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.jpsychires.2024.05.051 PubMed 38850581

Journal of psychiatric research 2024-08-01 Chisamore N, Johnson D, Chen MJQ, Offman H, Chen-Li D, Kaczmarek ES

PubMed Published psilocybin Depression End-of-Life Distress Clinical Trial Randomized Controlled Trial More

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Psilocybin in the Management of Substance Use Disorders: A Summary ofCurrent Evidence

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.2174/0122115560288779240628043307

Current Psychopharmacologye 2024-07-04 Hussein El Bourji, Aziz Farhat, Zahi Hamdan, Ritvij Satodiya, Rashmi Shukla, Samer El Hayek

OpenAlex Published psilocybin Depression Anxiety Addiction Randomized Controlled Trial More

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Engaging Mood Brain Circuits with Psilocybin (EMBRACE): a study protocol for a randomized, placebo-controlled and delayed-start, neuroimaging trial in depression.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1186/s13063-024-08268-6 PubMed 38956594

Trials 2024-07-03 Poulin JM, Bigford GE, Lanctôt KL, Giacobbe P, Schaffer A, Sinyor M

PubMed Published psilocybin Depression Neuroplasticity Brain Imaging Randomized Controlled Trial More

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Striking Long Term Beneficial Effects of Single Dose Psilocybin and Psychedelic Mushroom Extract in the SAPAP3 Rodent Model of OCD-Like Excessive Self-Grooming.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1101/2024.06.25.600634 PubMed 38979304

bioRxiv: the preprint server for biology 2024-06-29 Brownstien M, Lazar M, Botvinnik A, Shevakh C, Blakolmer K, Lerer L

PubMed Published psilocybin Anxiety OCD Mechanism of Action Randomized Controlled Trial More

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Rapid and prolonged antidepressant and antianxiety effects of psilocybin, lysergic acid diethylamide, ayahuasca, and 3, 4-methylenedioxy-methamphetamine. A systematic review and meta-analysis of randomized controlled trials

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1101/2024.06.17.24308787

medRxiv 2024-06-20 Fluyau D, Kailasam VK, Revadigar N.

medRxiv PREPRINT (not peer reviewed) psilocybin Depression Anxiety PTSD Randomized Controlled Trial More

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A Multi-centre, Double-blinded, Placebo-controlled, Randomised, Phase II Clinical Trial for Psilocybin-assisted Therapy for Alcohol Use Disorder

Abstract available at the source but not redistributed here. Read at source.

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ClinicalTrials.gov 2024-06-10 University of Sydney

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression Anxiety Addiction Randomized Controlled Trial More

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In the new era of psychedelic assisted therapy: A systematic review of study methodology in randomized controlled trials.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1007/s00213-024-06598-6 PubMed 38683460

Psychopharmacology 2024-06-01 Soliman PS, Curley DE, Capone C, Eaton E, Haass-Koffler CL

PubMed Published psilocybin Randomized Controlled Trial Systematic Review Review Article Randomized Controlled Trial More

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Impact of Psilocybin on Peripheral Cytokine Production.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1089/psymed.2023.0039 PubMed 40051582

Psychedelic medicine (New Rochelle, N.Y.) 2024-06-01 DiRenzo D, Barrett FS, Perin J, Darrah E, Christopher-Stine L, Griffiths RR

PubMed Published psilocybin Depression Anxiety Addiction Randomized Controlled Trial More

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Current Understanding on Psilocybin for Major Depressive Disorder: A Review Focusing on Clinical Trials.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.9758/cpn.23.1134 PubMed 38627070

Clinical psychopharmacology and neuroscience: the official scientific journal of the Korean College of Neuropsychopharmacology 2024-05-31 Wang SM, Kim S, Choi WS, Lim HK, Woo YS, Pae CU

PubMed Published psilocybin Depression Anxiety Receptor Pharmacology Clinical Trial More

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Effect of MDMA-assisted therapy on mood and anxiety symptoms in advanced-stage cancer (EMMAC): study protocol for a double-blind, randomised controlled trial.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1186/s13063-024-08174-x PubMed 38773523

Trials 2024-05-21 Bhagavan C, Glue P, Evans W, Reynolds L, Turner T, King C

PubMed Published psilocybin Depression Anxiety End-of-Life Distress Randomized Controlled Trial More

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Psilocybin pulse regimen reduces cluster headache attack frequency in the blinded extension phase of a randomized controlled trial.

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Details DOI 10.1016/j.jns.2024.122993 PubMed 38581739

Journal of the neurological sciences 2024-05-15 Schindler EAD, Sewell RA, Gottschalk CH, Flynn LT, Zhu Y, Pittman BP

PubMed Published psilocybin Headache / Migraine Randomized Controlled Trial Safety Randomized Controlled Trial More

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Psychedelics and the 'inner healer': Myth or mechanism?

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1177/02698811241239206 PubMed 38605658

Journal of psychopharmacology (Oxford, England) 2024-05-01 Peill J, Marguilho M, Erritzoe D, Barba T, Greenway KT, Rosas F

PubMed Published psilocybin Depression Mechanism of Action Randomized Controlled Trial Randomized Controlled Trial More

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Therapeutics Uses of Psychedelics in patients with psychiatric disorders A Systematic Review

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.56570/jimgs.v1i1.155

Journal For International Medical Graduates 2024-04-18 Sarosh Nawaz, Abdulaziz Mohammed Althwanay, Esraa M. AlEdani MB Ch B, Harleen Kaur, Malik Kasapoglu, Rajesh Yadavalli

OpenAlex Published psilocybin Depression Anxiety PTSD Randomized Controlled Trial More

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Psychedelic therapists, pharma collaborate on clinical trial

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Details DOI 10.1002/mhw.34009

Mental Health Weekly 2024-04-13 Valerie A. Canady

OpenAlex Published psilocybin Clinical Trial Randomized Controlled Trial Randomized Controlled Trial More

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A comparison between psilocybin and esketamine in treatment-resistant depression using number needed to treat (NNT): A systematic review.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.jad.2024.01.142 PubMed 38244804

Journal of affective disorders 2024-04-01 Wong S, Kwan ATH, Teopiz KM, Le GH, Meshkat S, Ho R

PubMed Published psilocybin Depression Headache / Migraine Randomized Controlled Trial Randomized Controlled Trial More

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Psilocybin, an Effective Treatment for Major Depressive Disorder in Adults - A Systematic Review.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.9758/cpn.23.1120 PubMed 38247407

Clinical psychopharmacology and neuroscience: the official scientific journal of the Korean College of Neuropsychopharmacology 2024-02-29 Watford T, Masood N

PubMed Published psilocybin Depression Receptor Pharmacology Randomized Controlled Trial Randomized Controlled Trial More

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Reports of self-compassion and affect regulation in psilocybin-assisted therapy for alcohol use disorder: An interpretive phenomenological analysis.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1037/adb0000935 PubMed 37276086

Psychology of addictive behaviors: journal of the Society of Psychologists in Addictive Behaviors 2024-02-01 Agin-Liebes G, Nielson EM, Zingman M, Kim K, Haas A, Owens LT

PubMed Published psilocybin Addiction Chronic Pain Mechanism of Action Randomized Controlled Trial More

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The development of psilocybin therapy for treatment-resistant depression: an update.

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Details DOI 10.1192/bjb.2023.25 PubMed 37357767

BJPsych bulletin 2024-02-01 Borissova A, Rucker JJ

PubMed Published psilocybin Depression Anxiety Aging Randomized Controlled Trial More