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Psilocybin and psilocin research index

Find psilocybin and psilocin papers, preprints, trials, and citations with clear source context.

Searches titles, authors, journals, identifiers, indexed metadata, and derived research topics. Use Filters to narrow by source, status, substance, study type, or date.

Database 4,961 indexed records Auto-updated on Aug 19, 2026 01:24 UTC

Executed search Sources: Crossref 405 matching records are displayed.

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Database

4,742 Psilocybin Records 673 Psilocin Records 1,461 Journals 66 Research Topics

Published 4,223 Peer-reviewed / formal records Preprints 435 Marked as not peer reviewed Clinical trials 300 ClinicalTrials.gov records R toolkit visNetwork Bibliometrics, live SQLite analysis, HTML graph, and PDF export

Top journals 1,461 indexed journals

Journal	Records
Journal of psychopharmacology (Oxford, England)	148
Journal of psychoactive drugs	97
Frontiers in psychiatry	90
Psychopharmacology	85
Neuroscience Applied	57
Journal of Psychedelic Studies	48
Psychedelic medicine (New Rochelle, N.Y.)	39
Scientific reports	37
Biological Psychiatry	32
Journal of affective disorders	32

Research topics 66 topic filters

Depression 1,737 Receptor Pharmacology 1,281 Safety 1,203 Mechanism of Action 1,072 Review Article 1,072 Clinical Trial 977 Anxiety 883 Addiction 824 Pharmacology 752 General 538 Aging 524 Animal Study 524 Observational Study 515 Brain Imaging 481 Treatment-Resistant Depression 417 Emotional Processing 409 PTSD 400 Neuroplasticity 399

Source coverage 8 active sources

Source	Count	Share	Status
PubMed	2,566	51.7%	Active
OpenAlex	1,155	23.3%	Active
Crossref	405	8.2%	Active
ClinicalTrials.gov	300	6%	Active
Europe PMC	188	3.8%	Active
PsyArXiv	186	3.7%	Active
bioRxiv	123	2.5%	Active

Publication timeline 3,858 dated records

3,858 records since 2020

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Substances Psilocybin 4742 Psilocin 673

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Executed search Sources: Crossref 405 matching records are displayed.

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405 matching records for Sources: Crossref.

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Psilocin, A Psychedelic Drug, Exerts Anticonvulsant Effects Against PTZ- and MES-Induced Seizures in Mice via 5-HT1A and CB1 Receptors: Involvement of Nitrergic, Opioidergic, and Kynurenine Pathways

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1002/prp2.70079 PubMed 39996441

Pharmacology Research & Perspectives 2025-04-01 Balabandian Mohammad, Manavi Mohammad Amin, Lesani Ali, Mohammad Jafari Razieh, Shafaroodi Hamed, Heidari Navid

Crossref Published psilocybin psilocin Addiction Mechanism of Action Receptor Pharmacology Animal Study More

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Extraction Yields of Psilocybin and Psilocin: A Short Review of Current Methods and Their Implications

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.3390/ph18030380 PubMed 40143157

Pharmaceuticals 2025-03-07 Galdino Taynah P., Oliveira Lucas C., Luz Mateus A., Jesus Raquel A., Lima Eunice P. N., Torres Maria C. M.

Crossref Published psilocybin psilocin Systematic Review Review Article Toxicity Systematic Review More

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Elucidating the Phase I metabolism of psilocin in vitro

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1007/s00204-024-03952-7 PubMed 39751877

Archives of Toxicology 2025-03-01 Chen Junqi, Wang Ziteng, Yong Ching Yee, Goh Evelyn Mei Ling, Moy Hooi Yan, Chan Eric Chun Yong

Crossref Published psilocin Pharmacology Clinical Trial In Vitro Study Clinical Trial More

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Molecular insights into the modulation of the 5 HT2 A receptor by serotonin, psilocin, and the G protein subunit Gqα

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1002/1873-3468.15099 PubMed 39865564

FEBS Letters 2025-03-01 Viohl Niklas, Hakami Zanjani Ali Asghar, Khandelia Himanshu

Crossref Published psilocin Pharmacology Receptor Pharmacology Healthcare Workers Other More

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Correction: Clinical Pharmacokinetics of Psilocin After Psilocybin Administration: A Systematic Review and Post-Hoc Analysis

No abstract availability was recorded for this entry.

Details DOI 10.1007/s40262-025-01487-3 PubMed 39982684

Clinical Pharmacokinetics 2025-03-01 Otto Marije E., van der Heijden Katelijne V., Schoones Jan W., van Esdonk Michiel J., Borghans Laura G. J. M., Jacobs Gabriel E.

Crossref Published psilocybin psilocin Pharmacology Systematic Review Review Article Systematic Review More

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Alternative therapy for neurological and psychiatric disorders using psilocybin

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.5327/1516-3180.cpn.1123

São Paulo Medical Journal 2025-01-01 Machado Henrique Tofoli Vieira, Seixas Geovana Mendes de, Silva Luis Gustavo Alves, Brito Mariana Duarte Garcia, Castro Giovanna Miziara

Crossref Published psilocybin Depression Anxiety PTSD Systematic Review More

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In Silico Evaluation of Tryptamine-Derived Schiff Bases as Modulators of the Serotonin 5-HT₂A Receptor

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.46793/iccbikg25.477k

Book of Proceedings 2025-01-01 Kostić Marina D., Nedić Jana, Dragojević Jovana S., Divac Vera M.

Crossref Published psilocybin Depression Anxiety Headache / Migraine Other More

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Clinical Pharmacokinetics of Psilocin After Psilocybin Administration: A Systematic Review and Post-Hoc Analysis

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1007/s40262-024-01454-4 PubMed 39812743

Clinical Pharmacokinetics 2025-01-01 Otto Marije E., van der Heijden Katelijne V., Schoones Jan W., van Esdonk Michiel J., Borghans Laura G. J. M., Jacobs Gabriel E.

Crossref Published psilocybin psilocin Pharmacology Systematic Review Review Article Systematic Review More

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Theoretical Description for Psilocin and Coprine Electrochemical Determination in Mushroom Pulp and Biological Liquids over Cobalt (II) Oxyhydroxide-Modified Electrode

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.33263/lianbs134.173

Letters in Applied NanoBioScience 2024-12-30 Volodymyr V. Tkach, Tetiana V. Morozova, Marta V. Kushnir, Sílvio C. de Oliveira, Viktor V. Kryvetskyi, Inna I. Kryvetska

Crossref Published psilocin General Other More

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Advanced Delivery Systems and Novel Psilocin Derivatives for Enhanced Therapeutic Applications

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Details DOI 10.1021/acsmedchemlett.4c00521 PubMed 39691529

ACS Medicinal Chemistry Letters 2024-12-12 Kargbo Robert B.

Crossref Published psilocin General Other More

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Psilocybin Microdosing for Anxiety Relief in Young Adults: A Comparative Review of Emerging Evidence

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.70389/pjs.100036

Premier Journal of Science 2024-12-01 Shabir Kanwal

Crossref Published psilocybin Anxiety Neuroplasticity Mechanism of Action Review Article More

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The molecular structure, vibrational spectra, solvation effect, non-covalent interactions investigations of psilocin

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.saa.2024.124600 PubMed 38852303

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2024-11-01 Holikulov Utkirjon, Kazachenko Aleksandr S., Issaoui Noureddine, Kazachenko Anna S., Raja Murugesan, Al-Dossary Omar M.

Crossref Published psilocin Drug Interactions Other More

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Psilocin, the Psychoactive Metabolite of Psilocybin, Modulates Select Neuroimmune Functions of Microglial Cells in a 5-HT2 Receptor-Dependent Manner

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.3390/molecules29215084 PubMed 39519725

Molecules 2024-10-28 Wiens Kennedy R., Brooks Noah A. H., Riar Ishvin, Greuel Bridget K., Lindhout Ivan A., Klegeris Andis

Crossref Published psilocybin psilocin Receptor Pharmacology Oxidative Stress Inflammation Other More

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Addressing a major interference in the quantification of psilocin in mouse plasma: Development of a validated liquid chromatography tandem mass spectrometry method

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Details DOI 10.1016/j.chroma.2024.465123 PubMed 38981146

Journal of Chromatography A 2024-08-01 Khajavinia Amir, Michel Deborah, Ezeaka Udoka C., Purves Randy W., Laprairie Robert B., El-Aneed Anas

Crossref Published psilocin Animal Study Animal Study More

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Effects of psilocin and psilocybin on human 5-HT4 serotonin receptors in atrial preparations of transgenic mice and humans

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Details DOI 10.1016/j.toxlet.2024.06.006 PubMed 38876450

Toxicology Letters 2024-07-01 Neumann Joachim, Dimov Kiril, Azatsian Karyna, Hofmann Britt, Gergs Ulrich

Crossref Published psilocybin psilocin Receptor Pharmacology Animal Study Animal Study More

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Structural characterization and comparative analysis of polymorphic forms of psilocin (4-hydroxy-N,N-dimethyltryptamine)

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Details DOI 10.1107/s2056989024004201 PubMed 38845717

Acta Crystallographica Section E Crystallographic Communications 2024-06-01 Zeller Matthias, Parent Stephan, Schultheiss Nate

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Efficacy of Psilocybin in the Treatment of Substance and Alcohol Use Disorders

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.31986/issn.2689-0690_rdw.stratford_research_day.149_2024

Research Posters 2024-05-02 Brancaccio Hanna

Crossref Published psilocybin Depression Anxiety Addiction Clinical Trial More

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Brain Connectivity Pattern Changes Associated With Psychedelic-Assisted Psychotherapy

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.31986/issn.2689-0690_rdw.stratford_research_day.179_2024

Research Poster 2024-05-02 Patel Prince, Gollapudi Samrat, Mathew Brian Joseph, Patel Bhaumik

Crossref Published psilocybin Brain Imaging Mechanism of Action Default Mode Network Review Article More

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In vitro and in vivo metabolism of psilocybin’s active metabolite psilocin

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Details DOI 10.3389/fphar.2024.1391689 PubMed 38741590

Frontiers in Pharmacology 2024-04-29 Thomann Jan, Kolaczynska Karolina E., Stoeckmann Oliver V., Rudin Deborah, Vizeli Patrick, Hoener Marius C.

Crossref Published psilocybin psilocin Pharmacology Mechanism of Action Receptor Pharmacology Clinical Trial More

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Inhibition of cytochrome P450 3A4 enzyme activity by alkaloid psilocin from magic mushrooms: potential for drug interactions

No abstract availability was recorded for this entry.

Details DOI 10.1016/j.dmpk.2023.100829

Drug Metabolism and Pharmacokinetics 2024-04-01 Wilson Lavonne, Babumon Muthiramalil T., Irvine William, Morrison Isaac, Foster Kimberly, Delgoda Rupika

Crossref Published psilocybin psilocin Drug Interactions Other More