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Psilocybin and psilocin research index

Find psilocybin and psilocin papers, preprints, trials, and citations with clear source context.

Searches titles, authors, journals, identifiers, indexed metadata, and derived research topics. Use Filters to narrow by source, status, substance, study type, or date.

Database 4,967 indexed records Auto-updated on Aug 20, 2026 01:29 UTC

Executed search Topic: Pharmacology 1,688 matching records are displayed.

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Database

4,748 Psilocybin Records 673 Psilocin Records 1,461 Journals 66 Research Topics

Published 4,226 Peer-reviewed / formal records Preprints 437 Marked as not peer reviewed Clinical trials 301 ClinicalTrials.gov records R toolkit visNetwork Bibliometrics, live SQLite analysis, HTML graph, and PDF export

Top journals 1,461 indexed journals

Journal	Records
Journal of psychopharmacology (Oxford, England)	148
Journal of psychoactive drugs	97
Frontiers in psychiatry	90
Psychopharmacology	85
Neuroscience Applied	57
Journal of Psychedelic Studies	48
Psychedelic medicine (New Rochelle, N.Y.)	39
Scientific reports	37
Biological Psychiatry	32
Journal of affective disorders	32

Research topics 66 topic filters

Depression 1,738 Receptor Pharmacology 1,282 Safety 1,208 Review Article 1,075 Mechanism of Action 1,072 Clinical Trial 978 Anxiety 884 Addiction 825 Pharmacology 752 General 538 Animal Study 525 Aging 524 Observational Study 516 Brain Imaging 482 Treatment-Resistant Depression 417 Emotional Processing 409 PTSD 401 Neuroplasticity 399

Source coverage 8 active sources

Source	Count	Share	Status
PubMed	2,566	51.7%	Active
OpenAlex	1,156	23.3%	Active
Crossref	407	8.2%	Active
ClinicalTrials.gov	301	6.1%	Active
Europe PMC	188	3.8%	Active
PsyArXiv	186	3.7%	Active
bioRxiv	124	2.5%	Active

Publication timeline 3,864 dated records

3,864 records since 2020

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Substances Psilocybin 4748 Psilocin 673

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Executed search Topic: Pharmacology 1,688 matching records are displayed.

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1,688 matching records for Topic: Pharmacology.

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Psychedelics and women's mental health: the effects of female sex hormones on psychedelics' efficacy and tolerability.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1038/s41380-026-03801-2 PubMed 42552418

Molecular psychiatry 2026-08-04 Kuypers KPC, Mason NL, Carlier A, Totomanova I, Haijen-Bongers ECHM.

New this month Europe PMC Published psilocin Depression Anxiety Brain Imaging Review Article More

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Simulated 5-HT2A receptor activation accounts for the high complexity of brain activity during psychedelic states

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1101/2025.10.20.683366

bioRxiv 2026-08-04 Martin, H. M.; Cofre, R.; Destexhe, A.

New this month bioRxiv PREPRINT (not peer reviewed) psilocybin Mechanism of Action Receptor Pharmacology Other More

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Serotonergic psychedelics induce distinct patterns of metabolic activity and covariance within biologically informed rat brain networks

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1038/s41467-026-75890-0

Nature Communications 2026-08-03 Frederik Gudmundsen, Julia Czurylo, Daniel Ryskamp Rijsketic, Camilla Trang Vo, Janika Ruuska, Naja S. Jessen

New this month OpenAlex Published psilocybin Pharmacology Mechanism of Action Receptor Pharmacology Animal Study More

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Music for Psilocybin Therapy and the Temporal Arc of Psychedelic Experience

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.21203/rs.3.rs-10403919/v1

Research Square 2026-08-03 Gómez-Cañón JS, Leininger C, Mayall D, Dougherty RF, Bowling DL.

New this month Europe PMC PREPRINT (not peer reviewed) psilocybin Pharmacology Clinical Trial More

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Where is the sweet spot for psychedelic-enhanced fear extinction? An integrative quantitative synthesis of dose-effect patterns in rodent models.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1177/02698811261464979 PubMed 42544550

Journal of psychopharmacology (Oxford, England) 2026-08-03 Werle I, Probst MEC, Bertoglio LJ.

New this month Europe PMC Published psilocybin Anxiety Receptor Pharmacology Animal Study Animal Study More

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Psilocybin induces stereotyped movements and reduces defensive responding in planarians through 5-hydroxytryptamine mechanisms

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1097/fbp.0000000000000879 PubMed 42186402

Behavioural Pharmacology 2026-08-01 Akbar Razeen J., Stringer Amy D., Wiah Sonita, Dachepalli Meghana, Daws Stephanie E., Inan Saadet

New this month Crossref Published psilocybin Pharmacology Mechanism of Action Receptor Pharmacology Other More

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A systematic review of the pharmacokinetics of classical serotonergic psychedelic compounds in healthy adult subjects.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1177/02698811261453938 PubMed 42212869

Journal of psychopharmacology (Oxford, England) 2026-08-01 Hampsey E, Martin K, Kalfas M, Benson L, Wihlborg S, Jelen L

New this month PubMed Published psilocybin Pharmacology Systematic Review Review Article Systematic Review More

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Classic psychedelics and personality: An updated systematic review.

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Details DOI 10.1177/02698811261449386 PubMed 42218644

Journal of psychopharmacology (Oxford, England) 2026-08-01 Vicentini AB, de Paula CC, Silva Reis JA, Bouso JC, Hallak JEC, Dos Santos RG

New this month PubMed Published psilocybin Mechanism of Action Receptor Pharmacology Microdosing Randomized Controlled Trial More

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Current status and future prospects of research on psilocybin's regulation of neurotransmitters and their receptors related to the pathogenesis of tinnitus.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.heares.2026.109701 PubMed 42289149

Hearing research 2026-08-01 Lu S, Zhang Z, Xue X, Jiang Y, Zhang C, Liu P

New this month PubMed Published psilocybin Depression Anxiety End-of-Life Distress Clinical Trial More

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Pharmacokinetic and pharmacodynamic rational for expanding the therapeutic landscape of psilocybin beyond depression

No abstract availability was recorded for this entry.

Details DOI 10.1016/j.phrs.2026.108290 PubMed 42276399

Pharmacological Research 2026-08-01 Mingardi J., Molteni R., Bifari F.

New this month Crossref Published psilocybin Depression Pharmacology Other More

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Anxiety-related platform in zebrafish (Danio rerio) larvae: An integrated analysis of behavioural and molecular assay in drug screening research.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.biopha.2026.119680 PubMed 42308914

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2026-08-01 Potoczna M, Kasica N, Chmielewska-Krzesińska M, Dybalska-Szczepanek J, Wąsowicz K, Sokołowska E

New this month PubMed Published psilocybin Anxiety Pharmacology Mechanism of Action Other More

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Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)

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ClinicalTrials.gov 2026-07-30 Centre for Addiction and Mental Health

New this month ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression Neuroplasticity Brain Imaging Clinical Trial More

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An Open-Label, Phase 1 Study of the Safety Pharmacokinetic Profile, and Preliminary Efficacy, of Organic Whole Psilocybin-Containing Mushrooms in Patients Suffering From PTSD

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ClinicalTrials.gov 2026-07-29 Scottsdale Research Institute

New this month ClinicalTrials.gov CLINICAL TRIAL psilocybin PTSD Pharmacology Clinical Trial Clinical Trial More

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Is BOLD Measurement-Invariant Across Pharmacological State? A Pre-Registered Test of Haemodynamic Response Function Drug-Invariance Using Simultaneous EEG-fMRI (PsiConnect)

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.17605/osf.io/hba3y

Open MIND 2026-07-28 Kareem Soliman

New this month OpenAlex Published psilocybin Chronic Pain Brain Imaging Receptor Pharmacology Other More

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Convergent neuroimmune signaling underlying rapid antidepressant response to ketamine and psychedelics.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1038/s41380-026-03777-z PubMed 42521762

Molecular psychiatry 2026-07-28 Jones GH, Gilbert JR, Johnston JN, Akula N, Schulmann A, Arakelian M

New this month PubMed Published psilocybin Depression Mechanism of Action Receptor Pharmacology Other More

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Identifying factors that contribute to the behavioral effects of psilocybin in preclinical mouse models

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.64898/2026.07.24.740586

bioRxiv 2026-07-28 Fleury S, Chang LJ, Nautiyal KM.

New this month bioRxiv PREPRINT (not peer reviewed) psilocybin Anxiety Mechanism of Action Receptor Pharmacology Animal Study More

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Evaluating the Feasibility, Clinical Effects, and Safety of Psilocybin-assisted Psychotherapy for Treatment-resistant Obsessive-compulsive Disorder: An Open-label Clinical Trial

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ClinicalTrials.gov 2026-07-28 Centre for Addiction and Mental Health

New this month ClinicalTrials.gov CLINICAL TRIAL psilocybin Addiction OCD Brain Imaging Randomized Controlled Trial More

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Network Pharmacology-Guided Discovery of Fungal Autophagy Modulators for Tauopathies: Structural and Proteomic Evidence

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.64898/2026.07.24.740367

bioRxiv 2026-07-27 Torres Mc Cook, A. R.; Mimura, C. B.; Alvarez, L. D.; Liberman, A. C.

New this month bioRxiv PREPRINT (not peer reviewed) psilocybin Pharmacology Receptor Pharmacology Toxicity Other More

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Comparing synthetic and biological therapy for the treatment of cluster headache: what is needed and when?

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Details DOI 10.1080/14737175.2026.2706794 PubMed 42493477

Expert review of neurotherapeutics 2026-07-23 Parr BA, Young WB, Silberstein SD

New this month PubMed Published psilocybin Chronic Pain Headache / Migraine Receptor Pharmacology Clinical Trial More

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Estimating Cardiac 5-HT2B Safety Margins for Repeated Low-Dose Psilocybin Using an Exposure-Response Model

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.64898/2026.07.19.739440

bioRxiv 2026-07-23 Tyler WJ, Sellers E, McDonnell MB.

New this month bioRxiv PREPRINT (not peer reviewed) psilocybin psilocin Anxiety Mechanism of Action Receptor Pharmacology Observational Study More