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Psilocybin and psilocin research index

Find psilocybin and psilocin papers, preprints, trials, and citations with clear source context.

Searches titles, authors, journals, identifiers, indexed metadata, and derived research topics. Use Filters to narrow by source, status, substance, study type, or date.

Database 4,961 indexed records Auto-updated on Aug 19, 2026 01:24 UTC

Executed search Topic: Biomarkers 191 matching records are displayed.

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Database

4,742 Psilocybin Records 673 Psilocin Records 1,461 Journals 66 Research Topics

Published 4,223 Peer-reviewed / formal records Preprints 435 Marked as not peer reviewed Clinical trials 300 ClinicalTrials.gov records R toolkit visNetwork Bibliometrics, live SQLite analysis, HTML graph, and PDF export

Top journals 1,461 indexed journals

Journal	Records
Journal of psychopharmacology (Oxford, England)	148
Journal of psychoactive drugs	97
Frontiers in psychiatry	90
Psychopharmacology	85
Neuroscience Applied	57
Journal of Psychedelic Studies	48
Psychedelic medicine (New Rochelle, N.Y.)	39
Scientific reports	37
Biological Psychiatry	32
Journal of affective disorders	32

Research topics 66 topic filters

Depression 1,737 Receptor Pharmacology 1,281 Safety 1,203 Mechanism of Action 1,072 Review Article 1,072 Clinical Trial 977 Anxiety 883 Addiction 824 Pharmacology 752 General 538 Aging 524 Animal Study 524 Observational Study 515 Brain Imaging 481 Treatment-Resistant Depression 417 Emotional Processing 409 PTSD 400 Neuroplasticity 399

Source coverage 8 active sources

Source	Count	Share	Status
PubMed	2,566	51.7%	Active
OpenAlex	1,155	23.3%	Active
Crossref	405	8.2%	Active
ClinicalTrials.gov	300	6%	Active
Europe PMC	188	3.8%	Active
PsyArXiv	186	3.7%	Active
bioRxiv	123	2.5%	Active

Publication timeline 3,858 dated records

3,858 records since 2020

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Substances Psilocybin 4742 Psilocin 673

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Executed search Topic: Biomarkers 191 matching records are displayed.

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191 matching records for Topic: Biomarkers.

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Low doses of psilocybin as adjunct pharmacological treatment to virtual reality exposure therapy for social anxiety disorder: A study protocol for a double-blind randomized controlled trial.

Abstract available at the source but not redistributed here. Read at source.

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PsyArXiv 2026-05-14 Jacob Cohen, Peter Parbo, Per Trads Ørskov, Dirk Wildgruber, Benjamin Kreifelts, ulrich kirk

PsyArXiv PREPRINT (not peer reviewed) psilocybin Anxiety Brain Imaging Biomarkers Randomized Controlled Trial More

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The Safety and Efficacy of Psilocybin Therapy Compared to Low-dose Control in Reducing Depressive Symptoms in Patients With COPD, ALS, MS, or APD.

Abstract available at the source but not redistributed here. Read at source.

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ClinicalTrials.gov 2026-05-08 University Medical Center Groningen

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression Anxiety End-of-Life Distress Clinical Trial More

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356. Psilocybin Therapy is Associated With Decreases in Markers of Mitochondrial Stress and Inflammation in an Open-Label Clinical Trial of Parkinson’s Disease

No abstract availability was recorded for this entry.

Details DOI 10.1016/j.biopsych.2026.03.590

Biological Psychiatry 2026-05-01 Bradley Ellen, Kelley D Parker, Picard Martin, Szigeti Balazs, Sakai Kimberly, Fernandes Gisele

Crossref Published psilocybin Biomarkers Mitochondrial Function Clinical Trial Clinical Trial More

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Insights from the psychedelic experience integration session: Verbatims differentiate 3-month abstinence in alcohol use disorder with depressive symptoms.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.jad.2026.121215 PubMed 41558304

Journal of affective disorders 2026-05-01 Garcia Garcia M, Belahda D, Graux C, Serrand C, Igounenc N, Sergent F

PubMed Published psilocybin Depression Addiction Chronic Pain Randomized Controlled Trial More

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Pharmacotherapy in Disorders of Consciousness: A Mechanism-Based Review.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1007/s40263-026-01274-z PubMed 41876835

CNS drugs 2026-05-01 Gillet A, Geron C, Vitello MM, Lejeune N

PubMed Published psilocin Addiction Brain Imaging Mechanism of Action Review Article More

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Effects of psilocybin and chronic mild stress on microglial activation in rat spinal cord: an ex vivo analysis.

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Details DOI 10.1007/s43440-026-00824-y PubMed 41557251

Pharmacological reports: PR 2026-04-01 Olejnik P, Kamińska K, Gołembiowska K, Kasarełło K

PubMed Published psilocybin Biomarkers Clinical Trial Animal Study Clinical Trial More

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Serotonergic modulation of cortical gamma synchronization: right-lateralized psilocin effects on 40 Hz auditory steady-state responses in rats

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Details DOI 10.1152/jn.00519.2025 PubMed 41779518

Journal of Neurophysiology 2026-04-01 Griškova-Bulanova Inga, Vejmola Čestmír, Páleníček Tomáš

Crossref Published psilocin Biomarkers Animal Study Animal Study More

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Psilocin fosters neuroplasticity in iPSC-derived human cortical neurons

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.7554/elife.104006 PubMed 41891829

eLife 2026-03-27 Schmidt Malin, Hoffrichter Anne, Davoudi Mahnaz, Horschitz Sandra, Lau Thorsten, Meinhardt Marcus W

Crossref Published psilocybin psilocin Depression Anxiety Neuroplasticity Other More

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The QUANTUM Trip Trial - Psilocybin-assisted Therapy for Reducing Alcohol Intake in Patients With Alcohol Use Disorder: A Randomized, Double-blinded, Placebo-controlled Clinical Trial.

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ClinicalTrials.gov 2026-03-24 Anders Fink-Jensen, MD, DMSci

ClinicalTrials.gov CLINICAL TRIAL psilocybin psilocin Addiction Brain Imaging Biomarkers Clinical Trial More

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Psilocybin, Lp(a), CAC, Niere und Darmkrebs - Evidenz-Quickies KW12

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.69156/quick/2026.03.00011

EvidenzUpdate 2026-03-22 Nößler Denis

Crossref Published psilocybin Depression Biomarkers Randomized Controlled Trial Randomized Controlled Trial More

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Precision Phenotyping of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies

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ClinicalTrials.gov 2026-03-20 University of New Mexico

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression PTSD Neuroplasticity Observational Study More

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Pilot Study of Psilocybin-assisted Treatment for Cannabis Use Disorder

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ClinicalTrials.gov 2026-03-18 Johns Hopkins University

ClinicalTrials.gov CLINICAL TRIAL psilocybin Biomarkers Other More

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The Effects of Psilocybin in Healthy Volunteers: Psychological, Biochemical and Electrophysiological Biomarkers.

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ClinicalTrials.gov 2026-02-25 Gabriella Gobbi

ClinicalTrials.gov CLINICAL TRIAL psilocybin psilocin Brain Imaging Receptor Pharmacology Biomarkers Other More

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Safety and Psychological Effects of Psilocybin and D-Serine Formulation in Healthy Volunteers

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ClinicalTrials.gov 2026-02-05 Hadassah Medical Organization

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression Anxiety Neuroplasticity Clinical Trial More

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MDMA and Psilocybin Regulate Oligodendrocyte-Lineage Cell Numbers and Anxiety-Like Behaviors in a Rat Model of Fear.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.biopsych.2026.01.016 PubMed 41644029

Biological psychiatry 2026-02-03 Bostancıklıoğlu M, Kaplan DS, Bal R, Yiğit E, Ulusal H, Temiz E

PubMed Published psilocybin Anxiety PTSD Neuroplasticity Animal Study More

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Pharmacodynamic biomarker - or psychotherapeutic process? Comment on "The role of the psychedelic experience in psilocybin treatment for treatment-resistant depression".

No abstract availability was recorded for this entry.

Details DOI 10.1016/j.jad.2025.120637 PubMed 41224017

Journal of affective disorders 2026-02-01 Wolff M, Kangaslampi S

PubMed Published psilocybin Depression Pharmacology Biomarkers Other More

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Psychedelics produce enduring behavioral effects and functional plasticity through mechanisms independent of structural plasticity.

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Details DOI 10.1038/s41386-025-02272-3 PubMed 41224969

Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology 2026-02-01 Kramer HM, Hibicke M, Middleton J, Jaster AM, Kristensen JL, Nichols CD

PubMed Published psilocybin Neuroplasticity Mechanism of Action Receptor Pharmacology Animal Study More

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Hope for Neurotic Disorders: A Summary of New Zealand Research on the Development of Biomarkers and Novel Treatments.

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Details DOI 10.1002/snz2.70002 PubMed 41798779

Journal of the Royal Society of New Zealand 2026-02-01 McNaughton N, Shadli SM, Beaglehole B, Glue P

PubMed Published psilocybin Depression Anxiety PTSD Other More

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The therapeutic efficacy of psilocybin in major depressive disorder: A review of recent clinical and mechanistic evidence

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.5281/zenodo.18375715

Zenodo (CERN European Organization for Nuclear Research) 2026-01-26 Fernando Mora López, Johynny Solís Solís, Ekaterina Daniela Hernández Baker, Olger Herrera Barboza, David Diaz Polo, Daniela Consumi Cordero

OpenAlex Published psilocybin Depression Chronic Pain Neuroplasticity Randomized Controlled Trial More

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[Clinical application and mechanistic studies of psychedelics for treatment of depression: progress and future challenges].

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Details DOI 10.12122/j.issn.1673-4254.2026.01.01 PubMed 41540686

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2026-01-20 Xia K, Gao T

PubMed Published psilocybin Depression Neuroplasticity Mechanism of Action Randomized Controlled Trial More