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Psilocybin and psilocin research index

Find psilocybin and psilocin papers, preprints, trials, and citations with clear source context.

Searches titles, authors, journals, identifiers, indexed metadata, and derived research topics. Use Filters to narrow by source, status, substance, study type, or date.

Database 4,961 indexed records Auto-updated on Aug 19, 2026 01:24 UTC

Executed search Sources: PubMed 2,566 matching records are displayed.

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Database

4,742 Psilocybin Records 673 Psilocin Records 1,461 Journals 66 Research Topics

Published 4,223 Peer-reviewed / formal records Preprints 435 Marked as not peer reviewed Clinical trials 300 ClinicalTrials.gov records R toolkit visNetwork Bibliometrics, live SQLite analysis, HTML graph, and PDF export

Top journals 1,461 indexed journals

Journal	Records
Journal of psychopharmacology (Oxford, England)	148
Journal of psychoactive drugs	97
Frontiers in psychiatry	90
Psychopharmacology	85
Neuroscience Applied	57
Journal of Psychedelic Studies	48
Psychedelic medicine (New Rochelle, N.Y.)	39
Scientific reports	37
Biological Psychiatry	32
Journal of affective disorders	32

Research topics 66 topic filters

Depression 1,737 Receptor Pharmacology 1,281 Safety 1,203 Mechanism of Action 1,072 Review Article 1,072 Clinical Trial 977 Anxiety 883 Addiction 824 Pharmacology 752 General 538 Aging 524 Animal Study 524 Observational Study 515 Brain Imaging 481 Treatment-Resistant Depression 417 Emotional Processing 409 PTSD 400 Neuroplasticity 399

Source coverage 8 active sources

Source	Count	Share	Status
PubMed	2,566	51.7%	Active
OpenAlex	1,155	23.3%	Active
Crossref	405	8.2%	Active
ClinicalTrials.gov	300	6%	Active
Europe PMC	188	3.8%	Active
PsyArXiv	186	3.7%	Active
bioRxiv	123	2.5%	Active

Publication timeline 3,858 dated records

3,858 records since 2020

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Substances Psilocybin 4742 Psilocin 673

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Executed search Sources: PubMed 2,566 matching records are displayed.

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2,566 matching records for Sources: PubMed.

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Efficacy and safety of psilocybin in the treatment of Major Depressive Disorder (MDD): A dose-response network meta-analysis of randomized placebo-controlled clinical trials.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.psychres.2024.116337 PubMed 39754904

Psychiatry research 2025-02-01 Swieczkowski D, Kwaśny A, Pruc M, Gaca Z, Szarpak L, Cubała WJ

PubMed Published psilocybin Depression Clinical Trial Randomized Controlled Trial Randomized Controlled Trial More

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The Acceptability of Psychedelic-Assisted Therapy Amongst Mental Health Consumers: Utilising the Theory of Planned Behaviour.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1111/inm.70010 PubMed 39952893

International journal of mental health nursing 2025-02-01 Louie E, Towers E, Morse AR, Watt J, Bryant Z, Haber P

PubMed Published psilocybin Depression PTSD Observational Study Observational Study More

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Among Psychedelics, Only Psilocybin Has Demonstrated Benefit to Treat Depression.

No abstract availability was recorded for this entry.

Details PubMed 39964936

American family physician 2025-02-01 Shaughnessy AF

PubMed Published psilocybin Depression Other More

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Psychedelic-assisted treatment for substance use disorder: A narrative systematic review.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1111/add.16762 PubMed 39887551

Addiction (Abingdon, England) 2025-01-30 Piper T, Small F, Brown S, Kelleher M, Mitcheson L, Rucker J

PubMed Published psilocybin Addiction Clinical Trial Randomized Controlled Trial Randomized Controlled Trial More

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From relaxed beliefs under psychedelics (REBUS) to revised beliefs after psychedelics (REBAS).

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1038/s41598-023-28111-3 PubMed 39881126

Scientific reports 2025-01-29 Zeifman RJ, Spriggs MJ, Kettner H, Lyons T, Rosas FE, Mediano PAM

PubMed Published psilocybin Brain Imaging Wellbeing Other More

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Exploring Strains: Cultivation Techniques, Psychoactive Compounds, Genetics and Research Gaps.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.3390/jof11020099 PubMed 39997393

Journal of fungi (Basel, Switzerland) 2025-01-28 Kurzbaum E, Páleníček T, Shrchaton A, Azerrad S, Dekel Y

PubMed Published psilocybin psilocin Review Article Review Article More

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When death is desired: A case of MAiD & the CL psychiatrist.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1017/s1478951524002037 PubMed 39834190

Palliative & supportive care 2025-01-21 Ganguly A, James M, Alici Y

PubMed Published psilocybin End-of-Life Distress Review Article Cancer Patients Review Article More

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Uncovering Psychedelics: From Neural Circuits to Therapeutic Applications.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.3390/ph18010130 PubMed 39861191

Pharmaceuticals (Basel, Switzerland) 2025-01-19 Melani A, Bonaso M, Biso L, Zucchini B, Conversano C, Scarselli M

PubMed Published psilocybin Depression Anxiety PTSD Clinical Trial More

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Exploring the Potential of Psychedelics in the Treatment of Headache Disorders: Clinical Considerations and Exploratory Insights.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1007/s11916-024-01321-8 PubMed 39820774

Current pain and headache reports 2025-01-16 Henderson I, Elsaadany R, Chan G, Bajaj V, Duarte D, Goodman S

PubMed Published psilocybin Chronic Pain Headache / Migraine Mechanism of Action Review Article More

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Self-reported experiences and perspectives on using psychedelics to manage opioid use among participants of two Reddit communities.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1111/add.16767 PubMed 39821493

Addiction (Abingdon, England) 2025-01-16 Krawczyk N, Miller M, Gu EY, Irvine N, Ramirez E, Santaella-Tenorio J

PubMed Published psilocybin Addiction Mechanism of Action Wellbeing Qualitative Study More

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Single-dose psilocybin for U.S. military Veterans with severe treatment-resistant depression - A first-in-kind open-label pilot study.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.jad.2024.09.133 PubMed 39343309

Journal of affective disorders 2025-01-15 Ellis S, Bostian C, Feng W, Fischer E, Schwartz G, Eisen K

PubMed Published psilocybin Depression PTSD Consciousness Other More

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The association between study design and antidepressant effects in psychedelic-assisted therapy: A meta-analysis.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.jad.2024.10.016 PubMed 39389119

Journal of affective disorders 2025-01-15 Li JR, Chiang KT, Kao YC, Yu CL, Yang FC, Liang CS

PubMed Published psilocybin Depression Meta-Analysis Meta-Analysis More

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The immunomodulatory effects of classical psychedelics: A systematic review of preclinical studies.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.pnpbp.2024.111139 PubMed 39251080

Progress in neuro-psychopharmacology & biological psychiatry 2025-01-10 Low ZXB, Ng WS, Lim ESY, Goh BH, Kumari Y

PubMed Published psilocybin psilocin Receptor Pharmacology Biomarkers Clinical Trial Systematic Review More

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Comparing psilocybin to metformin as neuroprotective agents against Parkinson's dementia: A systematic review of evidence and efficacy.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.pnpbp.2024.111155 PubMed 39357666

Progress in neuro-psychopharmacology & biological psychiatry 2025-01-10 Ordovich-Clarkson RD, Jabbour M, Pelayo DA, Lara D, La Croix S, Mumman M

PubMed Published psilocybin Mechanism of Action Receptor Pharmacology Mitochondrial Function Systematic Review More

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Psychedelic-related deaths in England, Wales and Northern Ireland (1997-2022).

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.pnpbp.2024.111177 PubMed 39437962

Progress in neuro-psychopharmacology & biological psychiatry 2025-01-10 Kopra EI, Penttinen J, Rucker JJ, Copeland CS

PubMed Published psilocybin Addiction Safety Toxicity Other More

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Early psilocybin intervention alleviates behavioral despair and cognitive impairment in stressed Wistar rats.

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Details DOI 10.1016/j.pnpbp.2024.111243 PubMed 39756636

Progress in neuro-psychopharmacology & biological psychiatry 2025-01-10 Wang Z, Robbins B, Zhuang R, Sandini T, van Bruggen R, Li XM

PubMed Published psilocybin Depression Anxiety Biomarkers Other More

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Clinical and preclinical evidence of psilocybin as antidepressant. A narrative review.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.pnpbp.2025.111249 PubMed 39778644

Progress in neuro-psychopharmacology & biological psychiatry 2025-01-10 Erkizia-Santamaría I, Horrillo I, Meana JJ, Ortega JE

PubMed Published psilocybin psilocin Depression Anxiety Mechanism of Action Clinical Trial More

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Neurobiological mechanisms of antidepressant properties of psilocybin: A systematic review of blood biomarkers.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.pnpbp.2025.111251 PubMed 39788410

Progress in neuro-psychopharmacology & biological psychiatry 2025-01-10 Constantino JL, van Dalfsen JH, Massetti S, Kamphuis J, Schoevers RA

PubMed Published psilocybin Depression Mechanism of Action Receptor Pharmacology Systematic Review More

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Use of psychedelic treatments in psychiatric clinical practice: an EPA policy paper.

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Details DOI 10.1192/j.eurpsy.2024.1806 PubMed 39791347

European psychiatry: the journal of the Association of European Psychiatrists 2025-01-10 Destoop M, Mohr P, Butlen F, Kéri P, Samochowiec J, De Picker L

PubMed Published psilocybin Depression Mechanism of Action Other More

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Pain and Perception: Exploring Psychedelics as Novel Therapeutic Agents in Chronic Pain Management.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1007/s11916-024-01353-0 PubMed 39775134

Current pain and headache reports 2025-01-07 Strand NH, Whitney M, Johnson B, Dunn T, Attanti S, Maloney J

PubMed Published psilocybin Addiction Chronic Pain Headache / Migraine Review Article More