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Psilocybin and psilocin research index

Find psilocybin and psilocin papers, preprints, trials, and citations with clear source context.

Searches titles, authors, journals, identifiers, indexed metadata, and derived research topics. Use Filters to narrow by source, status, substance, study type, or date.

Database 4,967 indexed records Auto-updated on Aug 20, 2026 01:29 UTC

Executed search Evidence: preprint 437 matching records are displayed.

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Database

4,748 Psilocybin Records 673 Psilocin Records 1,461 Journals 66 Research Topics

Published 4,226 Peer-reviewed / formal records Preprints 437 Marked as not peer reviewed Clinical trials 301 ClinicalTrials.gov records R toolkit visNetwork Bibliometrics, live SQLite analysis, HTML graph, and PDF export

Top journals 1,461 indexed journals

Journal	Records
Journal of psychopharmacology (Oxford, England)	148
Journal of psychoactive drugs	97
Frontiers in psychiatry	90
Psychopharmacology	85
Neuroscience Applied	57
Journal of Psychedelic Studies	48
Psychedelic medicine (New Rochelle, N.Y.)	39
Scientific reports	37
Biological Psychiatry	32
Journal of affective disorders	32

Research topics 66 topic filters

Depression 1,738 Receptor Pharmacology 1,282 Safety 1,208 Review Article 1,075 Mechanism of Action 1,072 Clinical Trial 978 Anxiety 884 Addiction 825 Pharmacology 752 General 538 Animal Study 525 Aging 524 Observational Study 516 Brain Imaging 482 Treatment-Resistant Depression 417 Emotional Processing 409 PTSD 401 Neuroplasticity 399

Source coverage 8 active sources

Source	Count	Share	Status
PubMed	2,566	51.7%	Active
OpenAlex	1,156	23.3%	Active
Crossref	407	8.2%	Active
ClinicalTrials.gov	301	6.1%	Active
Europe PMC	188	3.8%	Active
PsyArXiv	186	3.7%	Active
bioRxiv	124	2.5%	Active

Publication timeline 3,864 dated records

3,864 records since 2020

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Substances Psilocybin 4748 Psilocin 673

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Executed search Evidence: preprint 437 matching records are displayed.

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437 matching records for Evidence: preprint.

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Delayed psilocybin treatment after repeated mild traumatic brain injury recovers chronic behavioural deficits, reduces microglial density, and enhances hippocampal neurogenesis in rats

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.21203/rs.3.rs-8555503/v1

Research Square 2026-02-23 Shultz S, Allen J, O'Regan G, Brand J, Liknaitzky P, O'Brien T

Europe PMC PREPRINT (not peer reviewed) psilocybin Neuroplasticity Neurogenesis Emotional Processing Other More

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Safety and Efficacy of Microdosing Psilocybin over 8 Weeks for Major Depressive Disorder: A Randomized Clinical Trial

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.21203/rs.3.rs-8319478/v1

Research Square 2026-02-23 Petranker R, Farb N, Syed O, Li E, Shore D, Anderson T

Europe PMC PREPRINT (not peer reviewed) psilocybin Depression Microdosing Clinical Trial Clinical Trial More

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Ethical Complexities and Best Practices in Informed Consent for Psychedelic Services: A Qualitative Study on Expert Perspectives

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PsyArXiv 2026-02-19 Christina Chwyl, Alissa Bazinet, Adie Wilson-Poe, Kim Hoffman, Kellie Pertl, Sara McCrimmon

PsyArXiv PREPRINT (not peer reviewed) psilocybin Clinical Trial Safety Clinical Trial More

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Mystical but Not Challenging Experiences Predict Symptom Improvement After Psilocybin for Treatment-Resistant OCD

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PsyArXiv 2026-02-11 Sarah Shnayder, Gabrielle Agin-Liebes, Troy Hubert, Terence Ching, Jamila Hokanson, Christopher Pittenger

PsyArXiv PREPRINT (not peer reviewed) psilocybin Depression Anxiety Addiction Clinical Trial More

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Can LLMs Get High? A Dual-Metric Framework for Evaluating Psychedelic Simulation and Safety in Large Language Models

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Details DOI 10.21203/rs.3.rs-8682370/v1

Research Square 2026-02-02 Ben-Zion Z, Simon G, Lazebnik T.

Europe PMC PREPRINT (not peer reviewed) psilocybin Consciousness Mystical Experience Safety Other More

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Psilocybin and the Evolutionary Significance of Altered Neural States: Interaction-Based Perspectives Beyond Deterrence Models

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Details DOI 10.32942/x2v66q

EcoEvoRxiv 2026-01-28 Rebensburg P.

Europe PMC PREPRINT (not peer reviewed) psilocybin Drug Interactions Genomics Other More

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Psychedelics distinctly alter brain entropy and complexity compared to psychostimulants

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Details DOI 10.64898/2026.01.15.26344193

medRxiv 2026-01-16 Larsen K, Fisher PM, McCulloch DE, Olsen AS, Mueller F, Liechti M

medRxiv PREPRINT (not peer reviewed) psilocybin Brain Imaging Mechanism of Action Other More

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Aquahenosis: A non-pharmacological altered state of consciousness induced by Floatation-REST

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PsyArXiv 2026-01-15 Theo Tobel, Aidan Cone, Emily M Choquette, McKenna Garland, Micah Johnson, Keller Mink

PsyArXiv PREPRINT (not peer reviewed) psilocybin Depression Anxiety Mechanism of Action Randomized Controlled Trial More

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Psilocybin rapidly, but not immediately, reverses reward learning deficits in a durable manner in an inflammatory rat model of depressive symptoms

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Details DOI 10.64898/2026.01.14.699553

bioRxiv 2026-01-15 Hinchcliffe JK, Thomas CW, Gilmour G, Robinson ES.

bioRxiv PREPRINT (not peer reviewed) psilocybin Depression Mechanism of Action Animal Study Animal Study More

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Psilocybin for Treatment-Resistant OCD: A Randomized Controlled Trial

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PsyArXiv 2026-01-15 Benjamin Kelmendi, Thomas Adams, Terence Ching, Rachael Grazioplene, Stephen Kichuk, Geena Fram

PsyArXiv PREPRINT (not peer reviewed) psilocybin Depression OCD Clinical Trial Randomized Controlled Trial More

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Psilocin fosters neuroplasticity in iPSC-derived human cortical neurons

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Details DOI 10.21203/rs.3.rs-4242829/v3

Research Square 2026-01-07 Koch P, Schmidt M, Hoffrichter A, Davoudi M, Horschitz S, Lau T

Europe PMC PREPRINT (not peer reviewed) psilocybin psilocin Depression Anxiety Neuroplasticity Other More

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The one that abstained: Psilocybe fuscofulva genome suggests two recent origins of the psilocybin gene cluster in Psilocybe

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Details DOI 10.64898/2025.12.30.697041

bioRxiv 2026-01-02 Slot J, Bradshaw A, Dentinger B, Borovička J, Konkel Z, Rockefeller A

bioRxiv PREPRINT (not peer reviewed) psilocybin Mechanism of Action Genomics Other More

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Self-Transcendent Perceptual Dynamics and the Effects of Dispositional Mindfulness on Altered States of Consciousness: A Prospective Longitudinal Observational Study of a Naturalistic Psychedelic Retreat

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PsyArXiv 2025-12-31 Sebastian Ehmann, Nikoloz Mosahvili, Angela White, John Cuzzupe, Brooke Tompkins, Jodi McKibben

PsyArXiv PREPRINT (not peer reviewed) psilocybin Consciousness Wellbeing Mystical Experience Observational Study More

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Psilocybin as a Serotonergic Therapy in Epilepsy: Narrative Review of Therapeutic Potentials and Seizure Risks

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Details DOI 10.22541/au.176701186.65064859/v1

Authorea Preprints 2025-12-29 Cervera-Sanchez MB, San-Juan D, Díaz-Peregrino R, Camacho-Castillo EZ, Bringas-Ortiz SA, Padilla-Cabezutd C.

Europe PMC PREPRINT (not peer reviewed) psilocybin psilocin Receptor Pharmacology Clinical Trial Review Article Clinical Trial More

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Psilocybin decreases reward-seeking behavior accompanied by increased activity of parvalbumin neurons with perineuronal nets in the medial prefrontal cortex

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Details DOI 10.64898/2025.12.22.696123

bioRxiv 2025-12-26 Houff J, Williams A, Allen O, Gisabella B, Pantazopoulos H, Del Arco A.

bioRxiv PREPRINT (not peer reviewed) psilocybin Addiction Receptor Pharmacology Biomarkers Clinical Trial More

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A Randomised, Triple-Blind, Dose-Finding Study of the Impact of Psilocybin on Motor Function in Healthy Participants

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Details DOI 10.64898/2025.12.22.25342874

medRxiv 2025-12-23 Bhagavan C, Carter O, Nielsen G, Berlowitz D, Issak S, Braat S

medRxiv PREPRINT (not peer reviewed) psilocybin Headache / Migraine Consciousness Clinical Trial Clinical Trial More

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Psilocybin modulates social behaviour in male and female mice in a time-dependent manner

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Details DOI 10.64898/2025.12.18.695064

bioRxiv 2025-12-22 Shadani S, McCoy K, Ong L, Greaves E, Conn K, Andrews ZB

bioRxiv PREPRINT (not peer reviewed) psilocybin Depression Anxiety Eating Disorders Animal Study More

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A Naturalistic Study on the Combined Neural and Psychological Effects of Psilocybin and Compassion Focused Imagery

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Details DOI 10.64898/2025.12.17.694940

bioRxiv 2025-12-22 Pallavicini C, Llobenes L, Cavanna F, de la Fuente LA, Muller S, Costa M

bioRxiv PREPRINT (not peer reviewed) psilocybin Brain Imaging Default Mode Network Aging Other More

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Psilocybin Treatment as an Adjunct to Cognitive Behavioral Therapy for Eating Disorders: Therapeutic Rationale & Considerations for Protocol Development

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Details DOI 10.20944/preprints202512.1705.v1

Preprints.org 2025-12-19 Koning E, Gamberg S, Keshen A.

Europe PMC PREPRINT (not peer reviewed) psilocybin Eating Disorders Neuroplasticity Emotional Processing Other More

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Wherefore the magic? The evolutionary role of psilocybin in nature

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Details DOI 10.64898/2025.12.17.694186

bioRxiv 2025-12-19 Matthews Nicholass K, Flis I, Hanley M, Knight M, Lane S, Littlejohn G

bioRxiv PREPRINT (not peer reviewed) psilocybin Mechanism of Action Receptor Pharmacology Drug Interactions Other More