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Psilocybin and psilocin research index

Find psilocybin and psilocin papers, preprints, trials, and citations with clear source context.

Searches titles, authors, journals, identifiers, indexed metadata, and derived research topics. Use Filters to narrow by source, status, substance, study type, or date.

Database 4,967 indexed records Auto-updated on Aug 20, 2026 01:29 UTC

Executed search Topic: Clinical Trial 978 matching records are displayed.

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Database

4,748 Psilocybin Records 673 Psilocin Records 1,461 Journals 66 Research Topics

Published 4,226 Peer-reviewed / formal records Preprints 437 Marked as not peer reviewed Clinical trials 301 ClinicalTrials.gov records R toolkit visNetwork Bibliometrics, live SQLite analysis, HTML graph, and PDF export

Top journals 1,461 indexed journals

Journal	Records
Journal of psychopharmacology (Oxford, England)	148
Journal of psychoactive drugs	97
Frontiers in psychiatry	90
Psychopharmacology	85
Neuroscience Applied	57
Journal of Psychedelic Studies	48
Psychedelic medicine (New Rochelle, N.Y.)	39
Scientific reports	37
Biological Psychiatry	32
Journal of affective disorders	32

Research topics 66 topic filters

Depression 1,738 Receptor Pharmacology 1,282 Safety 1,208 Review Article 1,075 Mechanism of Action 1,072 Clinical Trial 978 Anxiety 884 Addiction 825 Pharmacology 752 General 538 Animal Study 525 Aging 524 Observational Study 516 Brain Imaging 482 Treatment-Resistant Depression 417 Emotional Processing 409 PTSD 401 Neuroplasticity 399

Source coverage 8 active sources

Source	Count	Share	Status
PubMed	2,566	51.7%	Active
OpenAlex	1,156	23.3%	Active
Crossref	407	8.2%	Active
ClinicalTrials.gov	301	6.1%	Active
Europe PMC	188	3.8%	Active
PsyArXiv	186	3.7%	Active
bioRxiv	124	2.5%	Active

Publication timeline 3,864 dated records

3,864 records since 2020

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Substances Psilocybin 4748 Psilocin 673

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Executed search Topic: Clinical Trial 978 matching records are displayed.

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978 matching records for Topic: Clinical Trial.

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Psilocybin-Assisted Psychotherapy for Treatment-Resistant Depression: A Randomized Phase II Clinical Trial Comparing One Versus Two Psychedelic Doses of Psilocybin (PSI-1V2)

Abstract available at the source but not redistributed here. Read at source.

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ClinicalTrials.gov 2026-07-09 University Health Network, Toronto

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression Clinical Trial Observational Study Clinical Trial More

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Computationally, Electrophysiologically, and Qualitatively Characterizing Serotonergic Psychedelics; Transdiagnostic Therapeutic and Pro-Psychotic Effects

Abstract available at the source but not redistributed here. Read at source.

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ClinicalTrials.gov 2026-07-09 Yale University

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression PTSD Addiction Clinical Trial More

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Psilocybin therapy for adult females with anorexia nervosa: pilot study

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1192/bjp.2026.10687 PubMed 42414058

The British Journal of Psychiatry 2026-07-08 Douglass Hannah M., Spriggs Meg J., Godfrey Kate, Danby Jennifer L., de Magalhaes Frederico J. C., Macdonald Lauren

Crossref Published psilocybin Eating Disorders Headache / Migraine Clinical Trial Clinical Trial More

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Phase I Study of the Safety and Adjunctive Effects of Psilocybin in Adults With Opioid Use Disorder Maintained on a Buprenorphine/Naloxone Formulation

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ClinicalTrials.gov 2026-07-07 University of Wisconsin, Madison

ClinicalTrials.gov CLINICAL TRIAL psilocybin Addiction Chronic Pain Clinical Trial Clinical Trial More

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Policy Considerations for Psychedelics in Research and Medicine - What’s Next on the Schedule?

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.38126/jspg280103

Journal of Science Policy & Governance 2026-07-02 Matthew A. Boehm, Oriana Mayorga

OpenAlex Published psilocybin Depression Anxiety PTSD Clinical Trial More

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Psilocybin as a Transdiagnostic Treatment for Eating Disorders and Comorbid Psychopathology: Implications for Clinical Nosology and Research Directions

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1002/eat.70164 PubMed 42393007

International Journal of Eating Disorders 2026-07-02 Koning Elena, Richard Jérémie, Keshen Aaron

Crossref Published psilocybin Eating Disorders Mechanism of Action Receptor Pharmacology Clinical Trial More

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Acceptability and safety of two sequential doses of psilocybin in bipolar II depression: protocol for an open-label single-arm feasibility study

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1136/bmjopen-2026-118471 PubMed 42442821

BMJ Open 2026-07-01 Meyer Thomas D, Vale Lauren N, Ibrahim Maya, Olmos Carolina, Quevedo João, Soares Jair C

Crossref Published psilocybin Depression Clinical Trial Randomized Controlled Trial Randomized Controlled Trial More

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A Phase 2, Open-Label Study Investigating the Safety and Efficacy of Psilocybin-Assisted Therapy for Sexual Assault-Related Posttraumatic Stress Disorder (PTSD)

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ClinicalTrials.gov 2026-07-01 Sunstone Medical

ClinicalTrials.gov CLINICAL TRIAL psilocybin PTSD Clinical Trial Safety Clinical Trial More

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Provider perspectives on challenges in treatment during psychedelic therapy.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1007/s00213-025-06907-7 PubMed 41139739

Psychopharmacology 2026-07-01 Bender DA, Nayak SM, Siegel JS, Hellerstein DJ, Ercal BC, Lenze EJ

PubMed Published psilocybin PTSD Aging Clinical Trial Clinical Trial More

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An Open-Label Study of Single-Dose Psilocybin for Borderline Personality Disorder With Co-Occurring Major Depressive Disorder

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1097/wnf.0000000000000683 PubMed 41973961

Clinical Neuropharmacology 2026-07-01 Grant Jon E., Boutouis Sophia, O’Brien Margaret, Avila Laurie, Neelapu Megha, Ehsan Dustin

Crossref Published psilocybin Depression Personality Change Clinical Trial Clinical Trial More

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Blinding Integrity in Psychedelic Randomized Clinical Trials: A Systematic Review.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1001/jamapsychiatry.2026.0255 PubMed 41984443

JAMA psychiatry 2026-07-01 Orsini DK, Wong S, Di Luch S, Chan B, Vasudeva S, Lovell GFM

PubMed Published psilocybin Clinical Trial Randomized Controlled Trial Systematic Review Randomized Controlled Trial More

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Psychedelics, entactogens and psychoplastogens for depression and related disorders.

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Details DOI 10.1111/bph.70088 PubMed 40518133

British journal of pharmacology 2026-07-01 Hoyer D

PubMed Published psilocybin Depression Anxiety PTSD Clinical Trial More

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Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1111/bph.70181 PubMed 40891276

British journal of pharmacology 2026-07-01 Wittenkeller L, Gudelsky G, Winhusen TJ, Amato D

PubMed Published psilocybin Depression Addiction Mechanism of Action Clinical Trial More

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Study Protocol for “Exploring the safety and therapeutic potential of psilocybin in the treatment of anorexia nervosa in adolescents and young adults”

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1371/journal.pone.0352246 PubMed 42378255

PLOS One 2026-06-30 Sjöström David, Schau Rybäck Olea, Claesdotter Knutsson Emma, Kajonius Petri, Jensen Sondén Oskar, Carlbring Per

Crossref Published psilocybin Eating Disorders Brain Imaging Aging Randomized Controlled Trial More

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Psychedelics in treatment-resistant depression: a comprehensive review of mechanisms, clinical evidence, and recommendations.

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Details DOI 10.1007/s40211-026-00584-4 PubMed 42377806

Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation: Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater 2026-06-30 Estela-Fernandez CA, Mohamed Yousif Elsheikh R, Beatrice DB, A Alhendal A, Irene Ewe C, Montesinos SY

PubMed Published psilocybin Depression Neuroplasticity Mechanism of Action Clinical Trial More

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Naturally Derived Psilocybin for Therapeutic Use: A Six-Criterion Framework for Evidence, Safety, and Benefit-Risk Considerations in Policy and Clinical Development

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University of Groningen research database (University of Groningen / Centre for Information Technology) 2026-06-29 Stefanie Enriquez Geppert, Lisa Bevers, Arvid Rosander, Peter Fodran, Vince Polito

OpenAlex Published psilocybin Clinical Trial Safety Toxicity Clinical Trial More

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5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder

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ClinicalTrials.gov 2026-06-29 Johns Hopkins University

ClinicalTrials.gov CLINICAL TRIAL psilocybin Addiction Mechanism of Action Receptor Pharmacology Clinical Trial More

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Novel approaches in depression treatment: from rapid-acting antidepressants to personalized interventions.

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Details DOI 10.1038/s41380-026-03722-0 PubMed 42350785

Molecular psychiatry 2026-06-25 Guidetti C, Fava M, Papakostas GI

PubMed Published psilocybin Depression Brain Imaging Biomarkers Clinical Trial More

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Psychedelics and autism spectrum disorder: Mechanistic insights, translational evidence and ethical challenges.

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Details DOI 10.1016/j.jpsychires.2026.06.035 PubMed 42385294

Journal of psychiatric research 2026-06-23 Claudino Dos Santos JC, Bolan SJ, Lodetti G, Viana GL, Rico EP, Gonçalves CL

PubMed Published psilocybin Anxiety Neuroplasticity Mechanism of Action Clinical Trial More

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Mechanistic insights toward dissociating therapeutic from psychedelic effects: bridging the gap between psychedelic research and mental health care

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Details DOI 10.1038/s41398-026-04203-2 PubMed 42342649

Translational Psychiatry 2026-06-23 Mauro Pettorruso, Giacomo d’Andrea, Antonio Inserra, Clara Cavallotto, Stefano Censi, Étienne Billard

OpenAlex Published psilocybin Depression Anxiety Chronic Pain Clinical Trial More