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Psilocybin Research Publication Tracker

Search, analyze, export, and monitor psilocybin and psilocin literature across peer-reviewed papers, preprints, reviews, protocols, and clinical trials.

Database up to date Last update: Jul 2, 2026 20:33 UTC
Indexed records 3,813 SQLite literature index
Published 3,046 Peer-reviewed / formal records
Preprints 480 Marked as not peer reviewed
Clinical trials 287 ClinicalTrials.gov records
Source coverage
Source Count Share Status
Europe PMC 2,665 69.9% Active
PubMed 302 7.9% Active
ClinicalTrials.gov 287 7.5% Active
PsyArXiv 218 5.7% Active
Crossref 165 4.3% Active
bioRxiv 142 3.7% Active
medRxiv 34 0.9% Active
Publication growth 2,995 records since 2020
Annual records Cumulative line
3,813Total Publications
3,680Psilocybin Records
538Psilocin Records
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251Journals
66Research Topics

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Latest Publications

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Last updated: Jul 2, 2026 20:33 UTC
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Contribution of the Serotonin 5-HT2A Receptor to the Therapeutic Effect of Psilocin on Social Behavior Deficits in Mice Repeatedly Exposed to Social Defeat Stress

Neuropsychopharmacology Reports · 2026-08-31

Ibi Daisuke, Takaba Rika, Yoshida Keisuke, Kawase Ririna, Kitagawa Hiroko, Matsushita Momoko, Ito Kana, Uno Shoya, Nishimura Fumiya, Kitagaki Shinji, Hiramatsu Masayuki

Crossref Published psilocybinpsilocin DepressionAnxietyReceptor PharmacologyResilienceAnimal StudyTreatment-Resistant Depression Animal Study

Investigating the impact of serotonergic psychedelic drugs, MDMA and ketamine on social cognition in psychiatric disorders: A scoping review.

Unknown journal · 2026-06-30

Smith SA, Mohammad H, Lee LHN, Dennett L, Smith S, Burback L, Winkler O, Greenshaw A, Jetly R, Kennedy SH, Bhat V, Swainson J, Vermetten E, Cao B, Li XM, Zhang Y.

Europe PMC Published psilocybin DepressionAnxietyPTSDEmotional ProcessingClinical TrialReview Article Clinical Trial

Modeled Long-Term Effects of Psilocybin on Dynamic Activity and Effective Connectivity of Fronto-Striatal-Thalamic Circuits.

Unknown journal · 2026-06-30

Pasquini L, Vohryzek J, Escrichs A, Perl YS, Ponce-Alvarez A, Idesis S, Girn M, Roseman L, Mitchell JM, Gazzaley A, Kringelbach M, Nutt DJ, Lyons T, Carhart-Harris RL, Deco G.

Europe PMC Published psilocybin DepressionEating DisordersBrain ImagingMechanism of ActionReceptor PharmacologyAgingHealthy Volunteers Other

Blinding Integrity in Psychedelic Randomized Clinical Trials: A Systematic Review.

Unknown journal · 2026-06-30

Orsini DK, Wong S, Di Luch S, Chan B, Vasudeva S, Lovell GFM, Le GH, Jones BDM, Chisamore N, Mollica A, Johnson DE, Kaczmarek ES, Goel A, Burke MJ, Mansur R, McIntyre RS, Husain MI, Rosenblat JD.

Europe PMC Published psilocybin Clinical TrialRandomized Controlled TrialSystematic ReviewReview Article Randomized Controlled Trial
Page 5 of 138

“I even saw four deer grazing”: online-offline entanglements in the psilocybin pluriverse

Purpose This paper aims to examine evolving practices and discourses surrounding psilocybin mushrooms on an online drug forum. Situating use within hybrid digital and ecological contexts, it traces shifts in user engagement before and after the 2020 COVID-19 pandemic to contextualize localized realities of the contemporary psychedelic renaissance. Design/met...

Drugs, Habits and Social Policy 2026-06-14 Wanke Michał, Matuszewski Paweł, Siuda Piotr
Crossref Published psilocybin AgingSafety Qualitative Study

Music Playlist Use in Clinical Trials of Psychedelic Assisted Psychotherapy: A Systematic Review.

Recent studies have shown promising results for psychedelics in the treatment of psychiatric disorders. Both in clinical and recreational settings, contextual elements, such as music, can influence the experience of users and may be linked to positive outcomes. This systematic review identifies how music is being selected and used in psychedelisc-assisted ps...

Unknown journal 2026-06-14 Cruz L, Beserra FR, Freind JMK, Rodrigues SE, Mograbi DC.
Europe PMC Published psilocybin DepressionPTSDClinical TrialSystematic ReviewReview Article Systematic Review

Unmixing the Psychedelic Connectome: Brain Network Traits of Psilocybin

Abstract Psilocybin induces profound alterations in consciousness, yet prevailing neural models often describe a monolithic change in brain connectivity that may not fully capture the multifaceted nature of the psychedelic state. To test the hypothesis of a composite neural state, this study applied a data-driven framework, Connectome Independent Component A...

Network Neuroscience 2026-06-13 Bhavaraju Kirshna Prasad, Mason Natasha L., Mallaroni Pablo, Heinke Dietmar, Toennes Stefan W., Ramaekers Johannes G., Amico Enrico
Crossref Published psilocybinpsilocin Brain ImagingConsciousnessHealthy Volunteers Other

Balancing safety and access in Oregon's psilocybin services.

As jurisdictions across the U.S. consider enacting policies that facilitate access to psychedelics, they must determine how the desire to expand access to these substances should be weighed against the need to adequately protect safety. Oregon's psilocybin services program offers an important early case study of this balance in practice. Under the Psilocybin...

Unknown journal 2026-06-12 Cheung K, Propes C, Yaden DB.
Europe PMC Published psilocybin DepressionAnxietyWellbeingSafety Other

Genome-based optimization of psilocybin and N,N-dimethyltryptamine biosynthetic pathways in E. coli using CRISPR-associated transposases.

Stable, high-level biosynthesis of complex natural products requires precise control of heterologous pathway expression, yet transcriptional architectures optimized on plasmids often fail when transferred to the chromosome. Here, we present ePathIntegrate, a genome-centric pathway engineering strategy that leverages CRISPR-associated transposases (CASTs) to ...

Unknown journal 2026-06-12 Abrahms ZN, Majdi M, Madsen SM, Morton CJ, Sen AK, Fried NB, Sawyer LE, Cegielski ER, Spezzano SJ, Jones JA.
Europe PMC Published psilocybin Mechanism of ActionGenomics Other

Barriers and Facilitators for Psychedelic Research and Regulation in Brazil: Insights From Diverse Stakeholders.

The interest in psychedelics for health-related purposes has grown significantly over the past decade. However, there is an insufficient representation of stakeholders (eg, Indigenous groups, activists, policymakers) in discussions about research and regulation. Many psychedelics originate from traditional practices historically developed in low- and middle-...

Clinical therapeutics 2026-06-12 Guimarães AL, Beserra FR, Cruz L, Bienemmann B, Freind JMK, Guinle V, Rodrigues RS, Regalado JA, Mograbi DC
PubMed Published psilocybin Mystical ExperienceHealthcare WorkersSafety Other AyahuascaDrug policy

Altered States, Enhanced Potential: Psychedelics and Physical Performance

Interest in psychedelics has expanded beyond clinical treatment contexts, yet little empirical work has examined how users describe psychedelic use in relation to sport and physical activity. This study conducted a qualitative content analysis of Reddit discussions involving psychedelics and physical performance. A Reddit search for “sports psychedelics” ret...

PsyArXiv 2026-06-11 Qarni Z, Richard J.
PsyArXiv PREPRINT (not peer reviewed) psilocybin Chronic PainConsciousnessMicrodosingEmotional ProcessingSafety Qualitative Study

Altered States, Enhanced Potential: Psychedelics and Physical Performance

Interest in psychedelics has expanded beyond clinical treatment contexts, yet little empirical work has examined how users describe psychedelic use in relation to sport and physical activity. This study conducted a qualitative content analysis of Reddit discussions involving psychedelics and physical performance. A Reddit search for “sports psychedelics” ret...

PsyArXiv 2026-06-11 Qarni Z, Richard J.
PsyArXiv PREPRINT (not peer reviewed) psilocybin Chronic PainConsciousnessMicrodosingEmotional ProcessingSafety Qualitative Study

Altered States, Enhanced Potential: Psychedelics and Physical Performance

Interest in psychedelics has expanded beyond clinical treatment contexts, yet little empirical work has examined how users describe psychedelic use in relation to sport and physical activity. This study conducted a qualitative content analysis of Reddit discussions involving psychedelics and physical performance. A Reddit search for “sports psychedelics” ret...

PsyArXiv 2026-06-11 Authors unavailable
PsyArXiv PREPRINT (not peer reviewed) psilocybin Chronic PainConsciousnessMicrodosingEmotional ProcessingSafety Qualitative Study exerciseflow state

EEG microstate dynamics during psilocybin intoxication relate to acute experience and persisting psychological changes

Psilocybin and other serotonergic psychedelics show therapeutic promise for psychiatric disorders, yet objective neural correlates linking the acute psychedelic state to persisting psychological outcomes remain limited. Electroencephalography (EEG) microstate analysis characterizes the rapid spatiotemporal organization of large-scale brain activity, offering...

bioRxiv 2026-06-11 Jajcay N, Vejmola Č, Korčák J, Tylš F, Viktorinová M, Viktorin V, Bravermanová A, Androvičová R, Balíková M, Horáček J, Brunovský M, Hlinka J, Páleníček T.
bioRxiv PREPRINT (not peer reviewed) psilocybin Brain ImagingConsciousnessBiomarkersLongevityHealthy Volunteers Clinical Trial

Psilocybin restores behavior and 5-HT2A signaling while reducing microglial density after chronic traumatic brain injury in rats.

Traumatic brain injury (TBI) causes persistent neurobehavioral deficits and increases the risk of psychiatric disorders, including depression, anxiety, and cognitive dysfunction linked to disrupted neuroplasticity, neuroinflammation, and serotonergic (5-HT) signaling. No effective pharmacotherapies exist for chronic TBI. Psilocybin, a psychedelic 5-HT2A rece...

Unknown journal 2026-06-11 Allen J, Jupp B, Baker TL, Haskali MB, Brkljača R, Plummer Z, Sun M, Brand J, Christie BR, Debert CT, McDonald SJ, O'Brien TJ, Casillas-Espinosa PM, Shultz SR.
Europe PMC Published psilocybin DepressionAnxietyNeuroplasticityMechanism of ActionReceptor PharmacologySafetyInflammation Other

Aquahenosis: A non-pharmacological altered state of consciousness induced by Floatation-REST in individuals with anxiety and depression

Floatation-REST (Reduced Environmental Stimulation Therapy) systematically alters sensory and bodily input by combining neutral buoyancy, thermal and proprioceptive neutrality, attenuation of exteroceptive stimulation, and enhancement of cardiorespiratory signaling to the brain. Here we examined whether this non-pharmacological sensory perturbation induces a...

PsyArXiv 2026-06-09 Tobel T, Cone A, Choquette E, Garland M, Johnson M, Mink K, Lynch C, Frohlich J, Feinstein J, Reggente N, Khalsa SS.
PsyArXiv PREPRINT (not peer reviewed) psilocybin DepressionAnxietyMechanism of ActionConsciousnessRandomized Controlled Trial Randomized Controlled Trial

The entropic brain today.

Introduced in 2014 and revised in 2018, the entropic brain hypothesis has accrued a wealth of supportive evidence. The hypothesis states that-along a dimension of the size of phenomenal consciousness-expansive states reliably exhibit increased brain entropy whereas the inverse applies for states of no or reduced consciousness. Examples of expansive states in...

Unknown journal 2026-06-09 Carhart-Harris RL.
Europe PMC Published psilocybin ConsciousnessAgingWellbeing Other

Aquahenosis: A non-pharmacological altered state of consciousness induced by Floatation-REST in individuals with anxiety and depression

Floatation-REST (Reduced Environmental Stimulation Therapy) systematically alters sensory and bodily input by combining neutral buoyancy, thermal and proprioceptive neutrality, attenuation of exteroceptive stimulation, and enhancement of cardiorespiratory signaling to the brain. Here we examined whether this non-pharmacological sensory perturbation induces a...

PsyArXiv 2026-06-09 Authors unavailable
PsyArXiv PREPRINT (not peer reviewed) psilocybin DepressionAnxietyMechanism of ActionConsciousnessRandomized Controlled Trial Randomized Controlled Trial NeuroscienceSocial and Behavioral Sciences

The effects of psychedelics on attention deficit and hyperactivity disorder - a systematic review.

ObjectivesAttention deficit and hyperactivity disorder (ADHD) is a prevalent neuropsychiatric disorder (Drechsler et al., 2020). Recently, psychedelics have become of interest regarding developing treatment options for ADHD. The aim of this systematic review is to find all studies from the APA PsychInfo and MEDLINE databases, where psychedelics have been use...

Unknown journal 2026-06-09 Raikkerus H, Bujour A, Kennedy M, Tiihonen J.
Europe PMC Published psilocybin DepressionRandomized Controlled TrialSystematic ReviewReview Article Randomized Controlled Trial

Psilocybin as a Treatment for Chronic Pain in Smokers

The purpose of this study is to understand whether psilocybin therapy is safe and well tolerated in improving chronic pain and increasing motivation to quit smoking for people who have chronic pain and smoke cigarettes. Psilocybin is a psychedelic drug and the active ingredient in "magic mushrooms." Psilocybin is currently being studied in clinical trials bu...

ClinicalTrials.gov 2026-06-08 Yale University
ClinicalTrials.gov CLINICAL TRIAL psilocybin AddictionChronic PainHeadache / MigraineClinical TrialObservational StudySafety Clinical Trial Smokers With Chronic PainPsilocybin (drug)

Alcohol consumption and substance use among French medical students: A nationwide cross-sectional study: Consommation d'alcool et de substances chez les étudiants en médecine de France: une étude transversale nationale.

ObjectivesMedical students are known to face significant psychological distress, making them vulnerable to substance use. There are few data on alcohol and drug consumption among medical students. The aim was to assess the prevalence of substance use, especially alcohol, in French medical students.MethodsThis cross-sectional nationwide study was conducted on...

Unknown journal 2026-06-08 Gillet M, Doudeau N, Vilain F, Sadat K, Morvan Y, Frajerman A.
Europe PMC Published psilocybin AddictionObservational Study Observational Study

PRISMatic: A Phase 1b Randomized, Double-Armed, Parallel-Group, Placebo-Controlled Trial of Psilocybin Efficacy With or Without Pimavanserin Pretreatment

Twenty healthy adults (≥21 years old) will be enrolled to evaluate the efficacy of a single oral dose of psilocybin (25 mg) administered with or without pretreatment using oral pimavanserin (34 mg) or placebo. Outcome assessments will occur at 1 week and 1 month following psilocybin administration. The purpose of this study is to clarify the receptor-level m...

ClinicalTrials.gov 2026-06-07 Johns Hopkins University
ClinicalTrials.gov CLINICAL TRIAL psilocybin Brain ImagingPharmacologyMechanism of ActionReceptor PharmacologyBiomarkersWellbeingClinical Trial Clinical Trial Mood (Psychological Function)Well Being

Live source coverage

3,813 indexed records across 7 active sources.

3,046Published
480Preprints
287Clinical trials
  1. Europe PMC 2,665 records · 69.9%
  2. PubMed 302 records · 7.9%
  3. ClinicalTrials.gov 287 records · 7.5%
  4. PsyArXiv 218 records · 5.7%
  5. Crossref 165 records · 4.3%
  6. bioRxiv 142 records · 3.7%
  7. medRxiv 34 records · 0.9%

Counts exclude hidden records and curated false positives. Preprints remain labeled as not peer reviewed in search results and exports.