THE PSYCHEDELIC RENAISSANCE: A SYSTEMATIC REVIEW OF PSILOCYBIN AND LSD IN THE TREATMENT OF PSYCHIATRIC DISORDERS

The escalating global burden of mental health disorders, coupled with the stagnation of innovation in traditional monoaminergic pharmacotherapy (e.g., SSRIs), has precipitated a critical need for novel therapeutic paradigms. This article presents a comprehensive systematic review of the so-called "Psychedelic Renaissance," focusing on the clinical resurgence...

Group Retreat Psilocybin Therapy for People with Metastatic Cancer with Symptoms of Anxiety and Depression: Safety and Efficacy Outcomes of a Phase 1/2 Study

Background: Psilocybin is a promising therapy for cancer-related distress, but existing individual treatment models are resource intensive. In this study, we designed and tested a group model of psilocybin therapy for people with metastatic cancer and cancer-related anxiety and depression. Method: Eligibility criteria included metastatic cancer, moderate-to-...

Preclinical evaluation of psilocybin as an anti-inflammatory agent

Psilocybin increases connectivity between unimodal and transmodal networks in healthy volunteers listening to music

Psilocibina en cuidados paliativos: revisión sistemática de los efectos a nivel emocional y espiritual-existenciales

Anxiety, depression, and existential distress are common symptoms in palliative care and significantly impair patients’ quality of life. Psilocybin-assisted therapy, based on preparation, therapeutic support, and psychotherapeutic integration, has emerged as a promising intervention to alleviate this complex cluster of suffering. The aim of this systematic r...

Effects of low-dose psilocybin on EEG markers of sensory processing in autistic and non-autistic adults

Mismatch between psilocybin-induced head-twitch behaviour and psilocin brain levels in mice

Preliminary results from an ongoing naturalistic survey study investigating dose-finding practices and effects of self-administered small amounts of psilocybin

Temporal effects of a single oral dose of psilocybin on plasma circulating miRNAs in humans

Behavioral and neuronal effects of psilocybin in mice

Towards "unmakable" psychedelics: SAR exploration of psilocin analogs obtained by a HATU-mediated amide coupling strategy

In vitro assessment of psilocin for CYP-dependent drug-drug interaction potential using rapid luminescent assays

Pharmacokinetics (PK) of psilocybin and psilocin in plasma following intravenous administration of psilocin and oral administration of psilocybin to male beagle dogs

Theoretical Description for Psilocin and Coprine Electrochemical Determination in Mushroom Pulp and Biological Liquids over Cobalt (II) Oxyhydroxide-Modified Electrode

The possibility of the electrochemical determination of poisonous mushroom toxins psilocin and coprine on CoO(OH)-modified electrode has been evaluated theoretically. The analysis of the correspondent mathematical model confirms the efficiency of the electrochemical sensor for detecting both mycotoxins in mushrooms and biological liquids for either investiga...

Inhibition of cytochrome P450 3A4 enzyme activity by alkaloid psilocin from magic mushrooms: potential for drug interactions

Problems of Qualification of Trafficking in Plants and Plant Parts Containing Psychoactive Substances and Mushrooms Containing Psilocybin and (or) Psilocin

Purpose: research of such items of illicit drug trafficking as plants and plant parts containing psychoactive substances. Methodology: study and analysis of judicial practice of higher courts and scientific research of natural science specialists; formal legal and technical legal methods. Conclusions: there is a lack of due attention to the problem of sellin...

Pharmacological characterization of psilocin affinity towards different 5-HT receptors and receptor regulation after psilocybin administration in pigs

CHIẾT XUẤT PSILOCIN TỪ NẤM THỨC THẦN LÀM NGUYÊN LIỆU THIẾT LẬP CHUẨN

Nghiên cứu đã xây dựng thành công phương pháp chiết xuất, phân lập và nhận dạng psilocin từ nấm Thức thần để làm nguyên liệu thiết lập chuẩn thứ cấp, phục vụ công tác giám định tư pháp về ma túy. Phương pháp sử dụng nhiệt để khử photphat, chuyển psilocybin thành psilocin. Kĩ thuật chiết pha lỏng và phân lập bằng sắc kí cột được sử dụng để thu psilocin tinh k...

CROSS-SPECIES EVIDENCE FOR PSILOCIN-INDUCED VISUAL HALLUCINATIONS: RATS PERCEIVE QUALITATIVELY SIMILAR CHANGES AS HUMANS

P05-02: Assessment of the CYP450 inhibitory activity of psilocybin, psilocin, LSD, 5-MeO-DMT and mescaline: An in vitro study