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Psilocybin and psilocin research index

Find psilocybin and psilocin papers, preprints, trials, and citations with clear source context.

Searches titles, authors, journals, identifiers, indexed metadata, and derived research topics. Use Filters to narrow by source, status, substance, study type, or date.

Database 4,967 indexed records Auto-updated on Aug 20, 2026 01:29 UTC

Executed search Topic: Aging 666 matching records are displayed.

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Database

4,748 Psilocybin Records 673 Psilocin Records 1,461 Journals 66 Research Topics

Published 4,226 Peer-reviewed / formal records Preprints 437 Marked as not peer reviewed Clinical trials 301 ClinicalTrials.gov records R toolkit visNetwork Bibliometrics, live SQLite analysis, HTML graph, and PDF export

Top journals 1,461 indexed journals

Journal	Records
Journal of psychopharmacology (Oxford, England)	148
Journal of psychoactive drugs	97
Frontiers in psychiatry	90
Psychopharmacology	85
Neuroscience Applied	57
Journal of Psychedelic Studies	48
Psychedelic medicine (New Rochelle, N.Y.)	39
Scientific reports	37
Biological Psychiatry	32
Journal of affective disorders	32

Research topics 66 topic filters

Depression 1,738 Receptor Pharmacology 1,282 Safety 1,208 Review Article 1,075 Mechanism of Action 1,072 Clinical Trial 978 Anxiety 884 Addiction 825 Pharmacology 752 General 538 Animal Study 525 Aging 524 Observational Study 516 Brain Imaging 482 Treatment-Resistant Depression 417 Emotional Processing 409 PTSD 401 Neuroplasticity 399

Source coverage 8 active sources

Source	Count	Share	Status
PubMed	2,566	51.7%	Active
OpenAlex	1,156	23.3%	Active
Crossref	407	8.2%	Active
ClinicalTrials.gov	301	6.1%	Active
Europe PMC	188	3.8%	Active
PsyArXiv	186	3.7%	Active
bioRxiv	124	2.5%	Active

Publication timeline 3,864 dated records

3,864 records since 2020

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Substances Psilocybin 4748 Psilocin 673

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Executed search Topic: Aging 666 matching records are displayed.

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666 matching records for Topic: Aging.

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Elucidating the Relevance of the Psychedelic Experience to Psilocybin's Anti-Anhedonic Effects: A Randomized, Open-Label, Cross-Over Functional Magnetic Resonance Imaging Trial

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ClinicalTrials.gov 2026-03-24 Medical University of Vienna

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression Neuroplasticity Brain Imaging Clinical Trial More

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Precision Phenotyping of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies

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ClinicalTrials.gov 2026-03-20 University of New Mexico

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression PTSD Neuroplasticity Observational Study More

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Psilocybin effects on brain functional connectivity: a systematic review of fMRI studies

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1007/s44192-026-00384-w PubMed 41854988

Discover Mental Health 2026-03-19 Farré-Colomés Àlvar, Rublinetska Olga, Soto-Angona Óscar

Crossref Published psilocybin Depression Brain Imaging Mechanism of Action Systematic Review More

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Safety and Efficacy of Psilocybin-assisted Psychotherapy for Demoralization Syndrome in Patients Diagnosed With Advanced Stage Cancer: a Pilot Study

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ClinicalTrials.gov 2026-03-18 Gustavo Vazquez

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression Anxiety End-of-Life Distress Clinical Trial More

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Explainable AI framework for psilocybin depression treatment optimization

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.3389/fcomp.2025.1652190

Frontiers in Computer Science 2026-03-16 Sungheetha Akey, Rajesh Sharma R., Aroba Oluwasegun Julius, Mahapatra Sheila, Mahendhiran P. D.

Crossref Published psilocybin Depression Brain Imaging Pharmacology Randomized Controlled Trial More

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Digital Intervention for Psychedelic Preparation (DIPP): protocol for a randomised controlled feasibility trial comparing meditation- and music-based programmes in healthy volunteers.

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Details DOI 10.1136/bmjopen-2025-107512 PubMed 41819589

BMJ open 2026-03-12 McAlpine R, Jaglinska M, Jedlovszky K, Kuc J, Castro A, Piot A

PubMed Published psilocybin Brain Imaging Aging Wellbeing Randomized Controlled Trial More

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Exploratory Study of the Effects of Low-Dose Psilocybin on Sensory Processing, Neurophysiological Arousal, and Emotional Health

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ClinicalTrials.gov 2026-03-11 University of Alabama at Birmingham

ClinicalTrials.gov CLINICAL TRIAL psilocybin Brain Imaging Mechanism of Action Microdosing Clinical Trial More

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Age moderates the relationship between psychedelics use and mental health in naturalistic settings

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Details DOI 10.21203/rs.3.rs-9022170/v1

Research Square 2026-03-10 Gregorio GD, Basset S, Manmohan H, Nixon WC, Pogaku A, Zhou J

Europe PMC PREPRINT (not peer reviewed) psilocybin Depression Anxiety Aging Clinical Trial More

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“Diversity makes the richness of humanity”: The emergence and persistence of mental imagery after self-reported psilocybin truffles intake in an autistic woman with “blind imagination” (aphantasia): A33-month retrospective case report

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1556/2054.2025.00320

Journal of Psychedelic Studies 2026-03-09 Rebecchi Kevin

Crossref Published psilocybin Neuroplasticity Aging Case Report Case Report More

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[Perspectives opened up by the physiopathological understanding of psychiatric disorders].

Abstract available at the source but not redistributed here. Read at source.

Details PubMed 41878960

La Revue du praticien 2026-03-01 Girault N, Quiroga L, Jedrecy S, Bertin S, Djonouma N, Fossati P

PubMed Published psilocybin Depression Anxiety Brain Imaging Other More

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Psilocybin-induced alterations in EEG power, connectivity and network dynamics in healthy subjects: Correlations with subjective experience and implications for therapeutic applications

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Details DOI 10.1016/j.pnpbp.2026.111626 PubMed 41611012

Progress in Neuro-Psychopharmacology and Biological Psychiatry 2026-03-01 Ip Cheng-Teng, Olbrich Sebastian, de Bardeci Mateo, Monn Anna, Ort Andres, Smallridge John W.

Crossref Published psilocybin Brain Imaging Other More

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Does Psilocybin Change Synaptic Density in the Brains of Patients With Amnestic Mild Cognitive Impairment

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ClinicalTrials.gov 2026-02-25 Centre for Addiction and Mental Health

ClinicalTrials.gov CLINICAL TRIAL psilocybin Neuroplasticity Brain Imaging Clinical Trial Clinical Trial More

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The Effects of Psilocybin in Healthy Volunteers: Psychological, Biochemical and Electrophysiological Biomarkers.

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ClinicalTrials.gov 2026-02-25 Gabriella Gobbi

ClinicalTrials.gov CLINICAL TRIAL psilocybin psilocin Brain Imaging Receptor Pharmacology Biomarkers Other More

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Effects of Psilocybin and Select Pharmaceutical Interactions

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Details DOI 10.31542/bcek6t76

MacEwan University Student eJournal 2026-02-18 Jordan McDowell, Jada Middleton, Alanna Bluett, Alisa Kozachenko, Bayan Attar, Yuvraj Singh Saini

OpenAlex Published psilocybin Depression Anxiety Pharmacology Clinical Trial More

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Sense-Making Around Psilocybin in UK Women Experiencing Cancer-Related Existential Distress: An Interpretative Phenomenological Analysis.

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Details DOI 10.1177/10497323261419338 PubMed 41700878

Qualitative health research 2026-02-17 Khan Z, Weaver S, Dando RV, Schlag AK, Neill JC, Wainwright V

PubMed Published psilocybin Depression Anxiety Aging Clinical Trial More

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A Phase 1 Translational Study to Assess Brain Activity Using Functional Magnetic Resonance Imaging (fMRI) and to Evaluate the Safety, Tolerability, and Pharmacokinetics of Multiple Doses of MLS101 (Psilocybin) in Healthy Volunteers

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ClinicalTrials.gov 2026-02-13 MycoMedica Life Sciences PBC

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression Addiction Brain Imaging Clinical Trial More

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Activity-Dependent Neural Rewiring: Mechanisms of Psilocybin-Induced Cortical Network Reorganization

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Details DOI 10.5281/zenodo.18501568

Zenodo (CERN European Organization for Nuclear Research) 2026-02-06 Zen Revista

OpenAlex Published psilocybin Chronic Pain Neuroplasticity Brain Imaging Review Article More

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Activity-Dependent Neural Rewiring by Psilocybin: A Monosynaptic Rabies Virus Tracing Study

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Details DOI 10.5281/zenodo.18501514

Zenodo (CERN European Organization for Nuclear Research) 2026-02-06 Zen Revista

OpenAlex Published psilocybin Depression Chronic Pain Neuroplasticity Review Article More

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Safety and Psychological Effects of Psilocybin and D-Serine Formulation in Healthy Volunteers

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ClinicalTrials.gov 2026-02-05 Hadassah Medical Organization

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression Anxiety Neuroplasticity Clinical Trial More

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A Phase 2a, Open-label, Pilot Study to Assess the Safety and Efficacy of Oral Psilocybin (TRP-8802) Administration in Concert With Psychotherapy Among Adult Patients With Irritable Bowel Syndrome: A Randomized Delayed Treatment Control Design

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ClinicalTrials.gov 2026-02-05 TRYP Therapeutics

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression Anxiety Chronic Pain Clinical Trial More