Effects of psilocin on the striatal monoamine contents in mice and rats

LSD und Psilocybin als Selbstmedikation

Die Mikrodosierung von Psychedelika wie LSD oder Psilocybin zur Leistungssteigerung und Förderung kreativer Prozesse erfährt zunehmend mediale Aufmerksamkeit. Beim Microdosing werden zwischen 5 und 10 % einer Standarddosis nach einem festgelegten Plan (z. B. alle 3 Tage) eingenommen, wobei kein Rauschzustand intendiert ist. Eine noch überschaubare Anzahl kle...

Richard Alpert (Ram Dass): Harvard psychologist who experimented with psychedelic drugs and became one of America’s most prominent and respected spiritual leaders

Credit: Dassima Kathleen Murphy Nothing in Richard Alpert’s early life could have predicted that he would come to embody the spirit of the psychedelic 1960s. He was born in Boston, Massachusetts, the youngest of three sons, to George and Gertrude (Levin) Alpert. His father, a prominent lawyer in Boston, was a founder of Brandeis University and went on to bec...

P.324 Acute effects of psilocybin on glutamate concentration levels, functional connectivity and subjective state

Psychedelic therapy: Fresh promise for mental health

Psychedelic-assisted psychotherapy is seeing a resurgence as a treatment approach for mental health disorders. It melds pharmacology and psychotherapy, using substances such as lysergic acid diethylamide (LSD) and psilocybin, under medical supervision, to treat conditions such as post-traumatic stress disorder (PTSD) and extreme depression.

Use of Methylphenidate Analogues as Cognitive Enhancers: The Prelude to Cosmetic Neurology and an Ethical Issue

Drugs involved in the treatment of Alzheimer’s disease and other cognitive deficits such as attention deficit hyperactivity disorder (ADHD), strokes, schizophrenia, and aging are medically defined as cognitive enhancers (1). Amphetamines were the first drugs used to stimulate memory consolidation and improve concentration, and were followed by non-amphetamin...

Persisting Reductions in Cannabis, Opioid, and Stimulant Misuse After Naturalistic Psychedelic Use: An Online Survey

BACKGROUND: Observational data and preliminary studies suggest serotonin 2A agonist psychedelics may hold potential in treating a variety of substance use disorders (SUDs), including opioid use disorder (OUD). AIMS: The study aim was to describe and analyze self-reported cases in which naturalistic psychedelic use was followed by cessation or reduction in ot...

Transformative experience and social connectedness mediate the mood-enhancing effects of psychedelic use in naturalistic settings

Past research suggests that use of psychedelic substances such as LSD or psilocybin may have positive effects on mood and feelings of social connectedness. These psychological effects are thought to be highly sensitive to context, but robust and direct evidence for them in a naturalistic setting is scarce. In a series of field studies involving over 1,200 pa...

Therapeutic mechanisms of psilocybin: Changes in amygdala and prefrontal functional connectivity during emotional processing after psilocybin for treatment-resistant depression

BACKGROUND: Psilocybin has shown promise as a treatment for depression but its therapeutic mechanisms are not properly understood. In contrast to the presumed actions of antidepressants, we recently found increased amygdala responsiveness to fearful faces one day after open-label treatment with psilocybin (25 mg) in 19 patients with treatment-resistant depre...

[Addictions].

This article describes a new form of administration of inhaled prescribed heroin currently under investigation. It underlines the particularity of opioid agonist prescription in jail and presents new perspectives in using psilocybin in addiction medicine treatment. A brief literature review about vaping confirms its interest in quitting cigarette, with a cos...

Comparative Acute Effects of LSD, Psilocybin and Mescaline

Matthew Oram, The Trials of Psychedelic Therapy: LSD Psychotherapy in America

Psychedelics are back in vogue. In popular culture, political legislation, and scientific research, we appear to be witnessing an early twenty-first century renaissance of the heady acid days of the 1960s. The success of Michael Pollan’s 2018 New York Times bestseller, How to Change Your Mind, the decriminalization of psilocybin-containing mushrooms in Denve...

Psilocybin Induces Time-Dependent Changes in Global Functional Connectivity

Med Check: Sage’s Treatment; Cannabidiol Products; Pimavanserin; Cognitive Supplements

Back to table of contents Previous article Next article Med CheckFull AccessMed Check: Sage's Treatment; Cannabidiol Products; Pimavanserin; Cognitive SupplementsTerri D'ArrigoTerri D'ArrigoPublished Online:9 Jan 2020https://doi.org/10.1176/appi.pn.2020.1a1Sage's Treatment for Major Depression Fails Phase 3In December Sage Therapeutics announced that its inv...

Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer

BACKGROUND: A recently published randomized controlled trial compared single-dose psilocybin with single-dose niacin in conjunction with psychotherapy in participants with cancer-related psychiatric distress. Results suggested that psilocybin-assisted psychotherapy facilitated improvements in psychiatric and existential distress, quality of life, and spiritu...

An Improved, Practical, and Scalable Five-Step Synthesis of Psilocybin

Described herein is an improved synthesis of 3-[2-(dimethylamino)ethyl]-1H-indol-4-yl dihydrogen phosphate (psilocybin). The protocol outlines: synthesis of multigram quantities of psilocybin, identification of critical in-process parameters, and isolation of psilocybin without the use of chromatography, TLC, or aqueous workup. The synthesis furnishes psiloc...

Social Work and Psychedelic-Assisted Therapies: Practice Considerations for Breakthrough Treatments

Repeat Dosing of Psilocybin in Migraine Headache

The mystical experience and its neural correlates.

Despite their different etiologies, three types of spiritually transformative experiences (STEs)--near-death experiences, psilocybin experiences, and meditative experiences of cosmic consciousness--appear to have attributes that are common to a broad range of mystical experiences, including an experience of expanded awareness. In addition, all three appear t...

Addictions

This article describes a new form of administration of inhaled prescribed heroin currently under investigation. It underlines the particularity of opioid agonist prescription in jail and presents new perspectives in using psilocybin in addiction medicine treatment. A brief literature review about vaping confirms its interest in quitting cigarette, with a cos...