Microdoseren met psychedelica: wat weten we ervan?

BACKGROUND: The repeated use of small doses of psychedelics such as psilocybin and lsd over a period of time (microdosing, md) has gained popularity and scientific attention in recent years. Retrospective reports from users suggest clinical potential. AIM: To answer the question whether md with psychedelics could theoretically provide symptom relief for peop...

Is Psilocybin an Effective Treatment to Reduce Depression and Anxiety in Cancer Patients with a Diagnosis of an Anxiety Disorder, Mood Disorder, And/Or Stress Disorder?

Objective: The objective of this selective EBM review is to determine whether or not psilocybin is an effective treatment to reduce depression and anxiety in cancer patients with a diagnosis of an anxiety disorder, mood disorder, and/or stress disorder. Study design: Systematic review of three cross-over randomized placebo-controlled trials published in peer...

Heterologous production of biomedically relevant fungal metabolites in Aspergillus nidulans

Genetic engineering of molds to produce new pharmaceutical compounds In this master’s thesis project, I investigated natural chemicals produced by fungi which are interesting for the pharmaceutical industry. Fungi are a very large family of organisms that we are still working to understand, and we continue to discover many new species every year. Living by g...

Analysis of Newspaper Coverage of Psilocybin from January 1, 1989 to December 31, 2019

Psilocybin is a chemical compound that has received a lot of attention from medical researchers in recent years. However, this research is not merely a medical issue but a social and political one as well. In the 1960s, psilocybin and other psychedelic compounds were widely ingested outside of clinical settings. This alarmed some of the American public, resu...

Meetings with Mother Ayahuasca: The effects of the spiritual experience on mental processes and physiological responses

Research on using psychedelic substances for treating various psychological problems such as addiction, treatment resistant depression and death agony seem to indicate that under the right circumstances the use of psychedelics could have positive outcomes on mental health. Studies also suggest that the potentially positive outcomes on mental health cannot be...

Psilocybin and LSD in the Treatment of Depression and Anxiety

Psychiatry is in a crisis. Mental health disorders are on the rise worldwide and there are currently not enough efficient treatment methods that would meet the patients’ needs. Hence, the societal and economic costs of mental health problems are enormous, as well as the suffering of individuals afflicted by mental health problems. Lysergic acid diethylamide ...

Psychedelics: A Window To Mental Illness; Psilocybin And Depression

The Therapeutic Potential of Psilocybin and 3,4-Methylenedioxymethamphetamine in the Treatment of Depression and Post-Traumatic Stress Disorder

The psychedelic psilocybin and the entactogen 3,4-methylenedioxymethamphetamine (MDMA) are being scientifically studied again after a long hiatus, and especially for their potential in the treatment of psychiatric disorders. Their profound effect on cognitive, perceptual, and affective processes have led to several clinical studies during the last decade tha...

Predicting the Efficacy of Psilocybin in Treating Mental Health and Addiction

Machine Learning is used to predict the efficacy of psilocybin in treating mental health and addiction by using a random forest algorithm. Psilocybin is a chemical compound found in fungi. Following ingestion, it is converted to psilocin which acts as a serotonin agonist, producing altered states of consciousness and hallucinations. Research suggests the use...

Psilocybin's effects on the brain and implications for depression treatment

Mental illnesses, especially depression, are a global problem that require new treatment options to those whose symptoms are resistant to the current ones. Psilocybin, which is a naturally occurring drug in mushrooms, has become a potential candidate. It affects the brain by deactivating certain areas, causing not only changes in perception and consciousness...

Molecular docking and binding interaction between psychedelic drugs and human serum albumin

Drug-plasma protein interaction is a critical concern in monitoring drug circulation and drug-drug interactions. The present study aimed to investigate the interaction of psychedelic drugs such as lysergic acid diethylamide (LSD), dimethyltryptamine (DMT), 2,5-dimethoxy-4-iodoamphetamine (DOI), psilocybin, psilocin, and mescaline with human serum albumin (HS...

Elaboración y validación de un cuestionario para la detección del riesgo de reacciones adversas graves por empleo de drogas psicodélicas en terapia

Development and Validation of a Questionnaire to Detect the Risk of Serious Adverse Reactions Due to the Use of Psychedelic Drug in Therapy. \nThe use of psychedelic drugs for the treatment of some mental disorders is increasing. However, their use is associated to certain risks, being the most important the exacerbation of mental disorders, mainly psychosis...

Drugs and the Music Industry: How the Neurological and Visual Effects of LSD and Psilocybin Impact Creativity and Songwriting Abilities

Drugs and the Music Industry: How the Neurological and Visual Effects of LSD and Psilocybin Impact Creativity and Songwriting Abilities Ammar Jawad, Depts. of Biology and Chemistry, with Prof. Mary Boyes, VCU Honors College The 5-hydroxy-tryptamine 2A receptor, 5-HT2A, is a G protein-coupled receptor that belongs to a subtype of receptors known as serotonerg...

The Efficacy of Psilocybin Compared to Selective Serotonin Reuptake Inhibitors in the Treatment of Adults with Major Depressive Disorder

Psilocybin may help cancer patients with depression and anxiety for years

Development of an improved psilocybin synthesis

Psilocybin is a hallucinogenic compound found in fungi and is currently evaluated inclinical trials for treatment of depression, anxiety and addiction. Psilocybin is aprodrug of the pharmacologically active metabolite, psilocin. The synthetic route topsilocybin relies on synthesizing psilocin from the starting material, 4-hydroxyindoleand latter converting p...

Medicinal use of psilocybin: Reducing restrictions on research and treatment.

Improved colour blindness symptoms associated with recreational psychedelic use: Results from the Global Drug Survey 2017

It is well documented that psychedelic drugs can have a profound effect on colour perception. After previous research involving psychedelic drug ingestion, several participants had written to the authors describing how symptoms of their colour blindness had improved. The Global Drugs Survey runs the world’s largest annual online drug survey. In the Global Dr...

Reported effects of psychedelic use on those with low well-being given various emotional states and social contexts

Background It has been suggested that the outcome of the psychedelic experience is dependent on set and setting. While scientific research into the therapeutic potential of psychedelics is growing, it is clear that in clinical populations an optimal set and setting will not always be attainable. It was aimed to assess under which emotional and environmental ...

A qualitative descriptive analysis of effects of psychedelic phenethylamines and tryptamines

OBJECTIVE: The number of novel psychedelic phenethylamines and tryptamines has continued to increase, but little academic research has focused on the effects of these substances. We sought to determine and compare the subjective effects of various substances. METHODS: We conducted in-depth interviews with 39 adults (75.4% male and 87.2% White) who reported e...