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Publication history
Psilocybin-Assisted Therapy in Psychiatry: A Narrative Clinical Review of Mechanisms, Therapeutic Applications, and Emerging Evidence (2025-2026)Journal of Clinical Medicine · 2026-08-12A Phase 2a, Placebo-Controlled Randomized, Double-Blind Trial to Evaluate the Safety, Tolerability, and Preliminary Efficacy of Psilocybin Oral Solution in Adults With Generalized Anxiety DisorderClinicalTrials.gov · 2026-08-12A Phase III, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With Treatment-resistant DepressionClinicalTrials.gov · 2026-08-10Therapeutic potential of classic and non-classic psychedelics in neurodevelopmental disorders: Opportunities and challenges.Pharmacological research · 2026-08-06A Phase 3, Randomized, Double-Blind, Multicenter Study to Evaluate the Efficacy, Safety, and Tolerability of Psilocybin in Adults With Major Depressive Disorder (MDD)ClinicalTrials.gov · 2026-07-23Longitudinal neural and psychological changes following psilocybin under compassion imagery primingFrontiers in Human Neuroscience · 2026-07-22Psilocybin's effect on human brain synaptic plasticity.Translational psychiatry · 2026-07-15Psilocybin therapy for adult females with anorexia nervosa: pilot studyThe British Journal of Psychiatry · 2026-07-08Acceptability and safety of two sequential doses of psilocybin in bipolar II depression: protocol for an open-label single-arm feasibility studyBMJ Open · 2026-07-01An Open-Label Study of Single-Dose Psilocybin for Borderline Personality Disorder With Co-Occurring Major Depressive DisorderClinical Neuropharmacology · 2026-07-01Recreational drug poisonings reported to six European poison centres from 2021 to 2024.Clinical toxicology (Philadelphia, Pa.) · 2026-07-01Psychedelics and autism spectrum disorder: Mechanistic insights, translational evidence and ethical challenges.Journal of psychiatric research · 2026-06-23Mechanistic insights toward dissociating therapeutic from psychedelic effects: bridging the gap between psychedelic research and mental health careTranslational Psychiatry · 2026-06-23Psychedelic Use, Microdosing, Motives, and Information and Product Sources Among Young Adults in the United States.Journal of psychoactive drugs · 2026-06-19Psychedelics disrupt hierarchical cortical propagations in the default mode network of humans and mice.Proceedings of the National Academy of Sciences of the United States of America · 2026-06-16Expectations and Motivations for Participation in Clinical Trials Utilizing Psychedelics for Treatment-Resistant Depression: A Qualitative Study.Brain and behavior · 2026-06-01Therapeutic advances in fibromyalgia: one year in review 2026.Clinical and experimental rheumatology · 2026-06-01Psilocybin-assisted cognitive behavioral therapy for major depressive disorder: A pilot trialJournal of Affective Disorders · 2026-06-01U.S. Psychedelic Use and Microdosing in 2025: Insights from a Probability-Based and Nationally Representative Survey.Rand health quarterly · 2026-06-01Long-Term Efficacy of Psilocybin with Adjunct Psychotherapy in Treatment-Resistant Major Depression: 6- and 12-Month Naturalistic Follow-Up of a Phase 2b TrialPsychotherapy and Psychosomatics · 2026-05-27Active placebo control interventions in pharmacological trials: a scoping review of the development process and a terminological analysis.Journal of clinical epidemiology · 2026-05-25Efficacy and Safety of a Single Dose of Psilocybin for Chronic Suicidal IdeationThe Journal of Clinical Psychiatry · 2026-05-13A One-Year Observational Follow-up Study of Participants With Major Depressive Disorder Following a Randomized, Double-Blind Single-Dose of Psilocybin or Niacin-ControlClinicalTrials.gov · 2026-05-04Insights into psilocybin use among people with bipolar disorder: A thematic analysis of Reddit postsJournal of Affective Disorders · 2026-05-01Efficacy and Safety of Psilocybin in Treatment-Resistant Major DepressionJAMA Psychiatry · 2026-05-01Integrating the Mystical Experience Questionnaire Into a Broader Psychometric Framework: English Validation of the Psychedelic Experience Scale and Comparison of Psilocybin and LSD Sessions Across Two Controlled SettingsRepository for Publications and Research Data (ETH Zurich) · 2026-04-30A Randomized, Double-Blind Study of Single-Dose Psilocybin for Major Depressive Disorder (MDD)ClinicalTrials.gov · 2026-04-22Mystical dynamics: renewal, luminous light, and ego disintegration as key features associated with mystical oneness-a psychometric analysis using the PES100 in controlled psychedelic studiesReligion Brain & Behavior · 2026-03-31Psilocin fosters neuroplasticity in iPSC-derived human cortical neuronseLife · 2026-03-27Design, Synthesis, and Pharmacokinetic Profiling of Fluorinated Reversible N -Alkyl Carbamate Derivatives of Psilocin for Sub-Hallucinogenic Brain ExposureJournal of Medicinal Chemistry · 2026-02-12Attitudes and perceptions of Portuguese mental health professionals on the therapeutic use of psilocybin and methylenedioxymethamphetamine (MDMA).Professional Psychology Research and Practice · 2026-02-01Psilocybin use in bipolar disorder: A comprehensive review.Journal of affective disorders · 2026-02-01Approved and Pipeline Pharmacological Interventions for Eating Disorders (2010-2025): 15 Years of Progress (or Lack Thereof).CNS drugs · 2026-02-01Psilocybin-Induced Neuroplasticity and Sustained Antidepressant EffectsQuality in Sport · 2026-01-31Psychological Therapy Quantity and Depressive Symptom Reduction in Psychedelic-Assisted Therapy: A Systematic Review and Meta-Analysis.Open Access CRIS of the University of Bern · 2026-01-21Psilocin fosters neuroplasticity in iPSC-derived human cortical neuronsResearch Square · 2026-01-07An open-label pilot study of psilocybin-assisted therapy for binge eating disorder.Journal of eating disorders · 2026-01-03Psychological Therapy Quantity and Depressive Symptom Reduction in Psychedelic-Assisted Therapy: A Systematic Review and Meta-Analysis.JAMA network open · 2026-01-02Additional file 1 of An open-label pilot study of psilocybin-assisted therapy for binge eating disorderFigshare · 2026-01-01Additional file 2 of An open-label pilot study of psilocybin-assisted therapy for binge eating disorderFigshare · 2026-01-01A novel psychedelic 5-HT receptor agonist GM-2505: The pharmacokinetic, safety, and pharmacodynamic profile from a randomized trial healthy volunteer.Journal of psychopharmacology (Oxford, England) · 2026-01-015 Years of bipolar disorder conversations on Reddit: Methods, key topics and future directions.PloS one · 2026-01-01Effects of LSD and Psilocybin on Heart Rate in Patients Receiving Psychedelic Treatment for Depressive and Anxiety Disorders: A Retrospective Observational StudyPsychology International · 2025-12-19Psilocybin reporting in media (PRiMe) for the treatment of depression.Irish journal of psychological medicine · 2025-12-18Psychedelics for the Treatment of Substance Use DisordersSUCHT - Zeitschrift für Wissenschaft und Praxis / Journal of Addiction Research and Practice · 2025-12-01Real-World Effectiveness and Safety of Psychedelic-Assisted Psychotherapy: Outcomes from a Large-Scale Compassionate Use Cohort in SwitzerlandmedRxiv · 2025-12-01Psychedelics and ketamine/esketamine in depressive disorders: biological mechanisms and associated neuroimaging and clinical changes.Translational psychiatry · 2025-10-31The THRIVE Model of Psychedelic Integration: A Holistic Framework Bridging Indigenous Knowledge and Evidence-Based PracticeCurrent Treatment Options in Psychiatry · 2025-10-19Endocannabinoids, depression, and treatment resistance: Perspectives on effective therapeutic interventions.Psychiatry research · 2025-10-01Psilocybin as Transformative Fast-Acting Antidepressant: Pharmacological Properties and Molecular Mechanisms.Fundamental & clinical pharmacology · 2025-08-01A Scoping Review of Research in Naturalistic Studies with Psychedelics.Journal of psychoactive drugs · 2025-06-28Correction: Psilocybin's acute and persistent brain effects: a precision imaging drug trials.Scientific data · 2025-06-18Psilocybin's acute and persistent brain effects: a precision imaging drug trial.Scientific data · 2025-06-05Clinical treatment of cluster headache with the serotonergic indoleamine psychedelics psilocybin and LSD and with ketamine: A case seriesCephalalgia Reports · 2025-05-01Neuroplasticity and psychedelics: A comprehensive examination of classic and non-classic compounds in pre and clinical models.Neuroscience and biobehavioral reviews · 2025-05-01Precision Functional Mapping of Psilocybin’s Acute and Persistent Brain EffectsBiological Psychiatry · 2025-04-09630. Synthetic Psilocybin (COMP360) for Chronic Active Suicidal Ideation: An Open-Label StudyBiological Psychiatry · 2025-04-0913. Safety, Feasibility, and Tolerability of Psilocybin in Older Adults With Amnestic MCI: Preliminary Data From a SV2a PET Imaging StudyBiological Psychiatry · 2025-04-09BIOLOGICAL ACTIVITY OF PSILOCYBIN EXTRACTS FROM THE FRUITING BODIES OF PSILOCYBE CUBENSIS ANTIOXIDANT AND ANTIMICROBIAL POTENTIALJournal of Microbiology Biotechnology and Food Sciences · 2025-03-13Psychedelics for Substance Use Disorders: Updates for the Psychiatric TraineeAmerican Journal of Psychiatry Residents Journal · 2025-03-06Vermont Primary Care Provider Perspectives on Psychedelics - A Cross-Sectional Study.Journal of psychoactive drugs · 2025-03-05Consistent evidence that brain serotonin 2A receptor binding is positively associated with personality-based risk markers of depression.The British journal of psychiatry: the journal of mental science · 2025-03-01Correction: Clinical Pharmacokinetics of Psilocin After Psilocybin Administration: A Systematic Review and Post-Hoc AnalysisClinical Pharmacokinetics · 2025-03-01The Therapeutic Potential of Psychedelics in Treating Substance Use Disorders: A Review of Clinical Trials.Medicina (Kaunas, Lithuania) · 2025-02-06Single-Dose Psilocybin for Depression With Severe Treatment Resistance: An Open-Label Trial.The American journal of psychiatry · 2025-01-01Exploring Psychedelics Pharmacology: A Scoping Review Charting the Course of Psilocybin Pharmacokinetics.Clinical neuropharmacology · 2025-01-01Clinical Pharmacokinetics of Psilocin After Psilocybin Administration: A Systematic Review and Post-Hoc AnalysisClinical Pharmacokinetics · 2025-01-01Emerging Risks of Amanita Muscaria: Case Reports on Increasing Consumption and Health Risks.Acta medica Lituanica · 2025-01-01Psilocybin with psychotherapeutic support for treatment-resistant depression: a pilot clinical trial.Therapeutic advances in psychopharmacology · 2025-01-01Psychedelic-Assisted Therapy: The Emerging Role of the Psychiatric-Mental Health NurseSaudi Journal of Medicine and Public Health · 2024-12-31The revival of psilocybin between scientific excitement, evidence of efficacy, and real-world challenges.CNS spectrums · 2024-12-01Amid magic and menace: psychiatrists' attitudes to psilocybin therapy.Irish journal of psychological medicine · 2024-11-07Preliminary safety and effectiveness of psilocybin-assisted therapy in adults with fibromyalgia: An open-label, pilot clinical trialPsyArXiv · 2024-11-04Psilocybin restrains activity-based anorexia in female rats by enhancing cognitive flexibility: contributions from 5-HT1A and 5-HT2A receptor mechanisms.Molecular psychiatry · 2024-10-01Psilocybin increases optimistic engagement over time: computational modelling of behaviour in rats.Translational psychiatry · 2024-09-30A virtual clinical trial of psychedelics to treat patients with disorders of consciousnessbioRxiv · 2024-08-19Psilocybin desynchronizes the human brain.Nature · 2024-08-01Lifetime Depression and Psilocybin Mushroom Use in U.S. Adults, 2008-2019Drug and Alcohol Dependence · 2024-07-01Single-Dose Synthetic Psilocybin With Psychotherapy for Treatment-Resistant Bipolar Type II Major Depressive Episodes: A Nonrandomized Open-Label Trial.JAMA psychiatry · 2024-06-01300 Psilocybin-induced changes in neural reactivity to alcohol and emotional cues in patients with alcohol use disorder: An fMRI pilot studyJournal of clinical and translational science · 2024-04-24Post-traumatic stress symptoms, post-traumatic stress disorder, and post-traumatic growth among cancer survivors: a systematic scoping review of interventions.Health psychology review · 2024-03-01Effect of a single psilocybin treatment on Fos protein expression in male rat brain.Neuroscience · 2024-02-16Psilocybin-induced changes in neural reactivity to alcohol and emotional cues in patients with alcohol use disorder: an fMRI pilot study.Scientific reports · 2024-02-07In vivo validation of psilacetin as a prodrug yielding modestly lower peripheral psilocin exposure than psilocybinFrontiers in Psychiatry · 2024-01-08Insights into the serotonergic mechanisms of psilocybin-induced improvements in anorexia-like behaviour in female ratsNeuroscience Applied · 2024-01-01The revival of the psychedelic experience scale: Revealing its extended-mystical, visual, and distressing experiential spectrum with LSD and psilocybin studies.Journal of psychopharmacology (Oxford, England) · 2024-01-01CCH attack frequency reduction after psilocybin correlates with hypothalamic functional connectivity.Headache · 2024-01-01The Psychedelic Future of Post-Traumatic Stress Disorder Treatment.Current neuropharmacology · 2024-01-01Safety pharmacology of acute psilocybin administration in healthy participants.Neuroscience applied · 2024-01-01Study protocol for "Psilocybin in patients with fibromyalgia: brain biomarkers of action".Frontiers in psychiatry · 2024-01-01Unlocking the healing power of psilocybin: an overview of the role of psilocybin therapy in major depressive disorder, obsessive-compulsive disorder and substance use disorder.Frontiers in psychiatry · 2024-01-01Therapeutic Potential of Psilocybin for Treating Psychological Distress among Survivors of Adverse Childhood Experiences: Evidence on Acceptability and Potential Efficacy of Psilocybin Use.Journal of psychoactive drugs · 2024-01-01Domestication through clandestine cultivation constrained genetic diversity in magic mushrooms relative to naturalized populations.Current biology: CB · 2023-12-04Comparative acute effects of mescaline, lysergic acid diethylamide, and psilocybin in a randomized, double-blind, placebo-controlled cross-over study in healthy participants.Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology · 2023-10-01Classic Psychedelics for the Treatment of Depressive Disorders: An Update for Psychiatrists in TrainingAmerican Journal of Psychiatry Residents Journal · 2023-09-08Psilocybin for treatment resistant depression in patients taking a concomitant SSRI medication.Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology · 2023-09-01Medical Students' Attitudes and Beliefs Toward Psilocybin: Does Terminology and Personal Experience with Psychedelics Matter?Psychedelic medicine (New Rochelle, N.Y.) · 2023-09-01Psilocybin desynchronizes brain networks.medRxiv: the preprint server for health sciences · 2023-08-24Psilocybin prevents reinstatement of alcohol seeking by disrupting the reconsolidation of alcohol-related memories.Psychopharmacology · 2023-07-01Psychedelics promote plasticity by directly binding to BDNF receptor TrkB.Nature neuroscience · 2023-06-01Psychedelics for Medicinal Use: How Will This Alter the Collective Laboratory Consciousness?Clinical Chemistry · 2023-03-07Acute neurovascular effects of psilocybin administration in healthy humans: Implications for cerebral blood flow measurements using arterial spin labellingNeuroscience Applied · 2023-01-01Body mass index (BMI) does not predict responses to psilocybin.Journal of psychopharmacology (Oxford, England) · 2023-01-01Cannabis-assisted psychotherapy for complex dissociative posttraumatic stress disorder: A case report.Frontiers in psychiatry · 2023-01-01Changes in synaptic markers after administration of ketamine or psychedelics: a systematic scoping review.Frontiers in psychiatry · 2023-01-01DNA Authentication and Chemical Analysis of Mushrooms Reveal Widespread Misdeterminations in Fungaria and Inconsistencies in Metabolites.Applied and environmental microbiology · 2022-12-20The Watts Connectedness Scale: a new scale for measuring a sense of connectedness to self, others, and world.Psychopharmacology · 2022-11-01Psilocybin-assisted therapy for reducing alcohol intake in patients with alcohol use disorder: protocol for a randomised, double-blinded, placebo-controlled 12-week clinical trial (The QUANTUM Trip Trial).BMJ open · 2022-10-14Magic Mushrooms - an exploratory look at how mental health professionals feel and think about Psilocybin.Psychiatry research · 2022-10-01Natural language signatures of psilocybin microdosing.Psychopharmacology · 2022-09-01Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study.Translational psychiatry · 2022-08-02Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivitymedRxiv · 2022-07-10Assessment of Bioactivity-Modulating Pseudo-Ring Formation in Psilocin and Related TryptaminesChemBioChem · 2022-07-05Flashback phenomena after administration of LSD and psilocybin in controlled studies with healthy participants.Psychopharmacology · 2022-06-01Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects.Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology · 2022-05-01Socio-psychedelic imaginaries: envisioning and building legal psychedelic worlds in the United StatesEuropean Journal of Futures Research · 2022-04-30Acute psilocybin and ketanserin effects on cerebral blood flow: 5-HT2AR neuromodulatory effects in healthy humansNeuroscience Applied · 2022-01-01Comparison of subjective, autonomic, and endocrine effects of LSD and psilocybin in healthy subjectsNeuroscience Applied · 2022-01-01Psilocybin Conspectus: Status, Production Methods, and Considerations.International journal of medicinal mushrooms · 2022-01-01A whole genome atlas of 81 Psilocybe genomes as a resource for psilocybin production.F1000Res · 2021-12-17Psilocybin, a Naturally Occurring Indoleamine Compound, Could Be Useful to Prevent Suicidal Behaviors.Pharmaceuticals (Basel, Switzerland) · 2021-11-24Structure Elucidation and Spectroscopic Analysis of Chromophores Produced by Oxidative Psilocin DimerizationChemistry - A European Journal · 2021-08-19Safer Tripping: Serotonergic Psychedelics and Drug Checking. Submission and Detection Rates, Potential Harms, and Challenges for Drug AnalysisCurrent Addiction Reports · 2021-07-26A whole genome atlas of 81 Psilocybe genomes as a resource for psilocybin production.Zenodo (CERN European Organization for Nuclear Research) · 2021-07-02Future Directions for Clinical Psilocybin Research: The Relaxed Symptom NetworkPsyArXiv · 2021-05-19Future Directions for Clinical Psilocybin Research: The Relaxed Symptom NetworkPsyArXiv · 2021-05-19A draft sequence reference of the Psilocybe cubensis genomeF1000Research · 2021-04-09Investigation of the Structure-Activity Relationships of Psilocybin Analogues.ACS pharmacology & translational science · 2021-04-09Evaluating the Risk of Psilocybin for the Treatment of Bipolar Depression: A Review of the Research Literature and Published Case StudiesmedRxiv · 2021-04-07Taking Different Roads: l-Tryptophan as the Origin of Psilocybe Natural Products.ChemPlusChem · 2021-01-01A draft reference assembly of the genome.F1000Research · 2021-01-01Therapeutic Alliance and Rapport Modulate Responses to Psilocybin Assisted Therapy for Depression.Frontiers in pharmacology · 2021-01-01MDMA-induced changes in within-network connectivity contradict the specificity of these alterations for the effects of serotonergic hallucinogensNeuropsychopharmacology · 2020-11-19Scalable Hybrid Synthetic/Biocatalytic Route to Psilocybin.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020-07-02A single psilocybin dose is associated with long-term increased mindfulness, preceded by a proportional change in neocortical 5-HT2A receptor binding.European neuropsychopharmacology: the journal of the European College of Neuropsychopharmacology · 2020-04-01Psilocybin may help cancer patients with depression and anxiety for yearsAccess Science · 2020-01-01P.188 Long-term effects of psilocybin on cerebral serotonin 2A receptor levels and personalityEuropean Neuropsychopharmacology · 2019-12-01P.609 Therapeutic mechanisms of psychedelic drugs: Changes in amygdala and prefrontal functional connectivity during emotional processing after psilocybin for treatment-resistant depressionEuropean Neuropsychopharmacology · 2019-12-01Injury-Triggered Blueing Reactions of Psilocybe “Magic” MushroomsAngewandte Chemie · 2019-11-14Unpredictable Behavior Under the Influence of "Magic Mushrooms": A Case Report and Review of the Literature.Journal of forensic sciences · 2019-07-01Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levelsNeuropsychopharmacology · 2019-06-01Correction: Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levelsNeuropsychopharmacology · 2019-06-01New Psychoactive Substances (NPS), Psychedelic Experiences and Dissociation: Clinical and Clinical Pharmacological IssuesCurrent Addiction Reports · 2019-04-22Production Options for Psilocybin: Making of the Magic.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019-01-18Microcrystal Tests for the Identification of Illicit Drugs: Phencyclidine, Pseudoephedrine, and PsilocinThe Microscope · 2019-01-01[Trends in Abuse of Biogenic Drugs in Parts of Germany 2007-2013].Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)) · 2018-06-01On the Origin of the Genus Psilocybe and Its Potential Ritual Use in Ancient Africa and Europe1Economic Botany · 2016-05-10The “Endless Trip”: Psychopathology and psychopharmacology in the Hallucinogen Persisting Perception Disorder (HPPD)European Psychiatry · 2016-02-29Quantitative phosphoproteomics unravels biased phosphorylation of serotonin 2A receptor at Ser280 by hallucinogenic versus nonhallucinogenic agonists.Molecular & cellular proteomics: MCP · 2014-05-01[Suicide under the influence of "magic mushrooms"].Archiv fur Kriminologie · 2013-01-01Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin.Proceedings of the National Academy of Sciences of the United States of America · 2012-02-07Forensic analysis of hallucinogenic mushrooms and khat (Catha edulis Forsk) using cation-exchange liquid chromatography.Forensic science international · 2010-02-25Hallucinogen persisting perception disorder after psilocybin consumption: a case study.European psychiatry: the journal of the Association of European Psychiatrists · 2005-08-01Effects of the 5-HT2A agonist psilocybin on mismatch negativity generation and AX-continuous performance task: implications for the neuropharmacology of cognitive deficits in schizophrenia.Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology · 2003-01-01Detection of Psilocybin and Psilocin in Norwegian Species ofPluteusandConocybePlanta Medica · 1984-08-01The content of Psilocybin in Norwegian Psilocybe semilanceata.Planta medica · 1981-07-01Interaction of D-LSD with blood platelets of rabbits: shape change and specific binding.The Journal of pharmacology and experimental therapeutics · 1981-02-01Effects of mescaline and psilocin on acquisition, consolidation, and performance of light-dark discrimination in two inbred strains of micePsychopharmacology · 1978-01-01ChemInform Abstract: NEUER ZUGANG ZU PSILOCIN-DERIVATENChemischer Informationsdienst · 1974-12-10