Researcher index

Authors in the psilocybin and psilocin literature

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Charl Els

113 indexed publications match this author name.

ORCID: 0000-0002-1177-2984
OpenAlex: https://openalex.org/A5003495786

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Topics

Depression 39 Safety 39 Mechanism of Action 34 Clinical Trial 31 Review Article 26 Receptor Pharmacology 26 Addiction 24 Anxiety 22 Brain Imaging 18 Pharmacology 18 Aging 17 Consciousness 15

Journals

PsyArXiv 7 ClinicalTrials.gov 5 Psychedelic medicine (New Rochelle, N.Y.) 4 Frontiers in psychiatry 4 Scientific reports 4 Journal of Humanistic Psychology 3 Metabolic engineering 2 CNS drugs 2

Publication history

An Open-Label, Dose-Escalation Trial of Psilocybin-Assisted Therapy for Bipolar II Depression.The Journal of clinical psychiatry · 2026-09-21 Psilocybin in the Treatment of Methamphetamine Use DisorderClinicalTrials.gov · 2026-09-21 Psilocybin prevents chemotherapy-induced peripheral neuropathy through mitochondrial trafficking preservation.Science (New York, N.Y.) · 2026-09-03 Assessing The Readiness of Psychiatrists in Louisiana to Incorporate Psilocybin into Clinical Practice-Lessons Learned from a State Underrepresented in Clinical Psychedelic Research.Psychedelic medicine (New Rochelle, N.Y.) · 2026-09-01 A Nature-Themed Video Intervention Increases Nature Relatedness in Psilocybin-Assisted Psychotherapy for Alcohol Use Disorder.Psychedelic medicine (New Rochelle, N.Y.) · 2026-09-01 Genome-based optimization of psilocybin and N,N-dimethyltryptamine biosynthetic pathways in E. coli using CRISPR-associated transposases.Metabolic engineering · 2026-09-01 Psilocybin collapses visual change detection and drives cortical dynamics toward a state of surprisebioRxiv · 2026-08-25 Impact of Psilocybin on Motor Function in Healthy Participants: A Phase 1, Randomised, Triple-Blind, Dose-Finding Study.CNS drugs · 2026-08-07 Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology.British journal of pharmacology · 2026-07-01 Psychedelics in treatment-resistant depression: a comprehensive review of mechanisms, clinical evidence, and recommendations.Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation: Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026-06-30 Psilocybin-assisted Physiotherapy for Refractory Motor Functional Neurological Disorder: A Randomized Dose-comparison Pilot Study (P7-17.001)Neurology · 2026-06-09 Examining the effects of psilocybin-assisted psychotherapy on anhedonia in treatment-resistant depressionJournal of Affective Disorders · 2026-06-01 Psilocin glucuronide in whole blood: a stable and useful biomarker of psilocybin intakeJournal of Analytical Toxicology · 2026-05-23 361 Effect of intravenous psilocybin on mechanical hypersensitivity in a rat model of reserpine-induced chronic centralized painJournal of clinical and translational science · 2026-05-20 Psilocybin use among Basotho healers and non-healers in southern AfricaOSF Preprints · 2026-04-23 Safety and Psychological Effects of Psilocybin and D-Serine Formulation in Healthy VolunteersClinicalTrials.gov · 2026-02-05 Psychedelic research and sexuality: opportunities and pitfallsThe Journal of Sexual Medicine · 2026-01-28 Group Retreat Psilocybin Therapy for People with Metastatic Cancer with Symptoms of Anxiety and Depression: Safety and Efficacy Outcomes of a Phase 1/2 StudyPsychedelic Medicine · 2026-01-18 Intentions, Spirituality, Set, and Setting Are Associated with Mystical Experiences in Psilocybin-Assisted TherapyPsychedelic Medicine · 2026-01-12 Behavioral effects of psychedelic and non-psychedelic serotonin 2A receptor agonist drugs in pigsNeuroscience Applied · 2026-01-01 Development of Psilocybe Mushroom Species Reference Material-Cultivation Parameters and Chemical Profiles.Journal of AOAC International · 2026-01-01 Metastability of resting-state bold fMRI as a reliable biomarker of individual brain dynamics: An interrogation of within-subject variability as a function of total acquisition time.Network neuroscience (Cambridge, Mass.) · 2026-01-01 A Randomised, Triple-Blind, Dose-Finding Study of the Impact of Psilocybin on Motor Function in Healthy ParticipantsmedRxiv · 2025-12-23 Psilocybin-assisted physiotherapy for refractory motor functional neurological disorder: protocol for a randomised dose-comparison pilot study.Acta neuropsychiatrica · 2025-11-04 Intravenous Administration of Serotonergic Psychedelics Produce Short-lasting Changes in Sleep-Wake Behavior and High Gamma Functional Connectivity in Rats.bioRxiv: the preprint server for biology · 2025-10-14 Natural hallucinogens of fungal and animal origin: action and potentialapplications - a narrative review.Folia medica Cracoviensia · 2025-07-31 Stronger visual surround suppression under psilocybin: A psychophysical and EEG pilot studyJournal of Vision · 2025-07-15 Deconstructing Psychedelic Phenomenology: A Thematic Analysis of Discrete Phases of the Psychedelic ExperienceBrain and Behavior · 2025-06-30 Molecular, haemodynamic and functional effects of LSD in the human brainmedRxiv · 2025-06-18 Synthesis and In Vitro Profiling of Psilocin Derivatives: Improved Stability and Synthetic PropertiesJournal of Medicinal Chemistry · 2025-04-10 187. Changes in Symptoms of Anhedonia With Psilocybin-Assisted Psychotherapy: A Secondary Analysis of a Randomized Clinical Trial for Treatment-Resistant DepressionBiological Psychiatry · 2025-04-09 Intravenous psilocybin induces dose-dependent changes in functional network organization in rat cortex.Translational psychiatry · 2025-03-25 A Field-Wide Review and Analysis of Study Materials Used in Psilocybin Trials: Assessment of Two Decades of Research.Psychedelic medicine (New Rochelle, N.Y.) · 2025-03-01 High-quality draft genomes of ecologically and geographically diverse species.Microbiology resource announcements · 2025-02-11 Exploring the Potential of Psychedelics in the Treatment of Headache Disorders: Clinical Considerations and Exploratory Insights.Current pain and headache reports · 2025-01-16 Acute and post-dosing effects of single-dose psilocybin for obsessive-compulsive disorder in a randomized, double-blind, placebo-controlled trial: an interpretative phenomenological analysis.Frontiers in psychiatry · 2025-01-01 Psilocybin Therapy for Clinicians With Symptoms of Depression From Frontline Care During the COVID-19 Pandemic: A Randomized Clinical Trial.JAMA network open · 2024-12-02 Enhanced visual contrast suppression during peak psilocybin effects: Psychophysical results from a pilot randomized controlled trial.Journal of vision · 2024-11-04 Psychedelics as a potential treatment for tobacco use disorder: a systematic review.Discover mental health · 2024-09-17 Single-Dose Psilocybin Therapy for Alcohol Use Disorder: Pharmacokinetics, Feasibility, Safety, and Efficacy in an Open-Label StudyResearch Square · 2024-08-23 A 24-Week, Multicentre, Randomised, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 2 Clinical Trial to Evaluate Efficacy and Safety of Psilocybin-Assisted Psychotherapy in Adults With Alcohol Use Disorder (AUD)ClinicalTrials.gov · 2024-08-15 Psilocybin-Assisted Therapy for Severe Alcohol Use Disorder: Feasibility, Clinical Efficacy & (Neuro)Cognitive MechanismsClinicalTrials.gov · 2024-08-07 Psilocybin desynchronizes the human brain.Nature · 2024-08-01 Comparing Neural Correlates of Consciousness: From Psychedelics to Hypnosis and Meditation.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024-05-01 Author Correction: Psilocybin enhances insightfulness in meditation: a perspective on the global topology of brain imaging during meditation.Scientific reports · 2024-04-23 Psilocybin enhances insightfulness in meditation: a perspective on the global topology of brain imaging during meditation.Scientific reports · 2024-03-26 Psilocybin induces dose-dependent changes in functional network organization in rat cortex.bioRxiv: the preprint server for biology · 2024-02-15 Reports of self-compassion and affect regulation in psilocybin-assisted therapy for alcohol use disorder: An interpretive phenomenological analysis.Psychology of addictive behaviors: journal of the Society of Psychologists in Addictive Behaviors · 2024-02-01 Abstract C001: A pilot study of palliadelic treatment with psilocybin to reduce psychological distress and improve quality of life in patients with advanced pancreatic adenocarcinomaCancer Research · 2024-01-15 Enhanced visual contrast suppression during peak psilocybin effects: A psychophysical studyPsyArXiv · 2024-01-11 Enhanced visual contrast suppression during peak psilocybin effects: A psychophysical studyPsyArXiv · 2024-01-11 Psychedelic Therapy: A Primer for Primary Care Clinicians-Historical Perspective and Overview.American journal of therapeutics · 2024-01-01 Psychedelic Therapy: A Primer for Primary Care Clinicians-Psilocybin.American journal of therapeutics · 2024-01-01 Psilocybin and Motor Function: A Triple-Blind, Dose-Finding Study in Healthy Participants.Psychiatric research and clinical practice · 2024-01-01 Beyond Psilocybin: Reviewing the Therapeutic Potential of Other Serotonergic Psychedelics in Mental and Substance Use Disorders.Journal of psychoactive drugs · 2024-01-01 Psychedelic Therapy: A Primer for Primary Care Clinicians - Part I. Historical Perspective and OverviewPsyArXiv · 2023-12-26 Psychedelic Therapy: A Primer for Primary Care Clinicians - Part IV. PsilocybinPsyArXiv · 2023-12-26 A Systematic Review of Reporting Practices in Psychedelic Clinical Trials: Psychological Support, Therapy, and Psychosocial Interventions.Psychedelic medicine (New Rochelle, N.Y.) · 2023-12-01 Is psilocybin effective for treatment of depression?Evidence-Based Practice · 2023-10-19 Psilocybin-induced changes in cerebral blood flow are associated with acute and baseline inter-individual differences.Scientific reports · 2023-10-14 Single-Dose Psilocybin Treatment for Major Depressive Disorder: A Randomized Clinical Trial.JAMA · 2023-09-05 “Why would you open someone’s brain up?” Lived experience insights inform a psilocybin-assisted psychotherapy treatment manual for body image disturbanceResearch Square · 2023-07-27 A Systematic Review of Reporting Practices in Psychedelic Clinical Trials: Psychological Support, Therapy, and Psychosocial InterventionsPsyArXiv · 2023-07-18 A Systematic Review of Reporting Practices in Psychedelic Clinical Trials: Psychological Support, Therapy, and Psychosocial InterventionsPsyArXiv · 2023-07-18 Psychedelics promote plasticity by directly binding to BDNF receptor TrkB.Nature neuroscience · 2023-06-01 Subacute effects of a single dose of psilocybin on biomarkers of inflammation in healthy humans: An open-label preliminary investigation.Comprehensive psychoneuroendocrinology · 2023-02-01 Past Is Prologue: Ethical Issues in Pediatric Psychedelics Research and Treatment.Perspectives in biology and medicine · 2023-01-01 Safety, tolerability, and clinical and neural effects of single-dose psilocybin in obsessive-compulsive disorder: protocol for a randomized, double-blind, placebo-controlled, non-crossover trial.Frontiers in psychiatry · 2023-01-01 Persons With Spinal Cord Injury Report Peripherally Dominant Serotonin-Like Syndrome After Use of Serotonergic Psychedelics.Neurotrauma reports · 2023-01-01 Safety, feasibility, tolerability, and clinical effects of repeated psilocybin dosing combined with non-directive support in the treatment of obsessive-compulsive disorder: protocol for a randomized, waitlist-controlled trial with blinded ratings.Frontiers in psychiatry · 2023-01-01 Single-dose psilocybin for treatment-resistant obsessive-compulsive disorder: A case report.Heliyon · 2022-12-01 Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression.The New England journal of medicine · 2022-11-03 Psychedelic drugs for psychiatric disorders.Journal of the neurological sciences · 2022-09-15 A Review of Aeruginascin and Potential Entourage Effect in Hallucinogenic MushroomsEuropean psychiatry: the journal of the Association of European Psychiatrists · 2022-09-01 Psilocybin use patterns and perception of risk among a cohort of Black individuals with Opioid Use Disorder.Journal of psychedelic studies · 2022-09-01 Don't be afraid, try to meditate- potential effects on neural activity and connectivity of psilocybin-assisted mindfulness-based intervention for social anxiety disorder: A systematic review.Neuroscience and biobehavioral reviews · 2022-08-01 The Effects of Psilocybin in Adults with Major Depressive Disorder and the General Population: Findings from Neuroimaging Studies.Psychiatry research · 2022-07-01 Psychoactive Drugs in the Management of Post Traumatic Stress Disorder: A Promising New Horizon.Cureus · 2022-05-01 Psilocybin: Characterization of the Metastable Zone Width (MSZW), Control of Anhydrous Polymorphs, and Particle Size Distribution (PSD).ACS omega · 2022-02-15 Molecular Mechanisms of Psilocybin and Implications for the Treatment of Depression.CNS drugs · 2022-01-01 Music programming for psilocybin-assisted therapy: Guided Imagery and Music-informed perspectives.Frontiers in psychology · 2022-01-01 P.0623 The clinical relevance of the pharmacokinetics of psilocybinEuropean Neuropsychopharmacology · 2021-12-01 Psychedelics and Mindfulness: A Systematic Review and Meta-AnalysisPsyArXiv · 2021-10-11 Ethnoracial health disparities and the ethnopsychopharmacology of psychedelic-assisted psychotherapies.Experimental and clinical psychopharmacology · 2021-10-01 Psychedelics as a Training Experience for Psychedelic Therapists: Drawing on History to Inform Current PracticeJournal of Humanistic Psychology · 2021-06-23 Psilocybin in the treatment of obsessive-compulsive disorder: What do we know so far?European Psychiatry · 2021-04-01 Draft Genome Sequence of the Termite-Associated "Cuckoo Fungus," () sp. TMB Strain TB5.Microbiology resource announcements · 2021-01-07 Development and Evaluation of a Therapist Training Program for Psilocybin Therapy for Treatment-Resistant Depression in Clinical Research.Frontiers in psychiatry · 2021-01-01 Psychedelic Harm Reduction and Integration: A Transtheoretical Model for Clinical Practice.Frontiers in psychology · 2021-01-01 P300-mediated modulations in self-other processing under psychedelic psilocybin are related to connectedness and changed meaning: A window into the self-other overlap.Human brain mapping · 2020-12-01 The emerging role of psilocybin and MDMA in the treatment of mental illness.Expert review of neurotherapeutics · 2020-12-01 P.804A single dose of psilocybin increases synaptic density and decreases 5-HT2A receptor density in the pig brainEuropean Neuropsychopharmacology · 2020-11-01 The Psilocin (4-hydroxy-N,N-dimethyltryptamine) and Bufotenine (5-hydroxy-N,N-dimethyltryptamine) Case: Ensuring the Correct Isomer has Been IdentifiedJournal of Forensic Sciences · 2020-09-01 Direct Phosphorylation of Psilocin Enables Optimized cGMP Kilogram-Scale Manufacture of PsilocybinACS Omega · 2020-07-14 Metabolic engineering of Saccharomyces cerevisiae for the de novo production of psilocybin and related tryptamine derivatives.Metabolic engineering · 2020-07-01 Characterization and prediction of acute and sustained response to psychedelic psilocybin in a mindfulness group retreat.Scientific reports · 2019-10-24 Psilocybin-assisted mindfulness training modulates self-consciousness and brain default mode network connectivity with lasting effects.NeuroImage · 2019-08-01 DARK Classics in Chemical Neuroscience: Psilocybin.ACS chemical neuroscience · 2018-10-17 The influence of therapists’ first-hand experience with psychedelics on psychedelic-assisted psychotherapy research and therapist trainingJournal of Psychedelic Studies · 2018-10-05 High dose psilocybin is associated with positive subjective effects in healthy volunteers.Journal of psychopharmacology (Oxford, England) · 2018-07-01 The Psychedelic Debriefing in Alcohol Dependence Treatment: Illustrating Key Change Phenomena through Qualitative Content Analysis of Clinical Sessions.Frontiers in pharmacology · 2018-01-01 Individual Experiences in Four Cancer Patients Following Psilocybin-Assisted Psychotherapy.Frontiers in pharmacology · 2018-01-01 Psilocybin and Depression - Assessing the Long-term Effects of a Single Administration of Psilocybin on the Psychiatric Symptoms and Brain Activity of Patients With Severe DepressionClinicalTrials.gov · 2017-12-21 Pharmacokinetics of Escalating Doses of Oral Psilocybin in Healthy Adults.Clinical pharmacokinetics · 2017-12-01 Two dose investigation of the 5-HT-agonist psilocybin on relative and global cerebral blood flow.NeuroImage · 2017-10-01 Cancer at the Dinner Table: Experiences of Psilocybin-Assisted Psychotherapy for the Treatment of Cancer-Related DistressJournal of Humanistic Psychology · 2017-06-14 Patient Experiences of Psilocybin-Assisted Psychotherapy: An Interpretative Phenomenological AnalysisJournal of Humanistic Psychology · 2017-04-28 Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial.Journal of psychopharmacology (Oxford, England) · 2016-12-01 Fungal Hallucinogens Psilocin, Ibotenic Acid, and MuscimolTherapeutic Drug Monitoring · 2013-08-01 Alternative headache treatments: nutraceuticals, behavioral and physical treatments.Headache · 2011-03-01 Investigating the Mechanisms of Hallucinogen-Induced Visions Using 3,4-Methylenedioxyamphetamine (MDA): A Randomized Controlled Trial in HumansPLoS ONE · 2010-12-01 Apical regional wall motion abnormalities reminiscent to Tako-Tsubo cardiomyopathy following consumption of psychoactive fungi.International journal of cardiology · 2009-05-01 Aeruginascin, a trimethylammonium analogue of psilocybin from the hallucinogenic mushroom Inocybe aeruginascens.Planta medica · 2006-06-01

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