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Psilocybin and psilocin research index

Find psilocybin and psilocin papers, preprints, trials, and citations with clear source context.

Searches titles, authors, journals, identifiers, indexed metadata, and derived research topics. Use Filters to narrow by source, status, substance, study type, or date.

Database 4,955 indexed records Auto-updated on Aug 13, 2026 01:25 UTC

Executed search Cites DOI: 10.1080/1355621021000005937 24 matching records are displayed.

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Database

4,736 Psilocybin Records 673 Psilocin Records 1,461 Journals 66 Research Topics

Published 4,217 Peer-reviewed / formal records Preprints 435 Marked as not peer reviewed Clinical trials 300 ClinicalTrials.gov records R toolkit visNetwork Bibliometrics, live SQLite analysis, HTML graph, and PDF export

Top journals 1,461 indexed journals

Journal	Records
Journal of psychopharmacology (Oxford, England)	147
Journal of psychoactive drugs	97
Frontiers in psychiatry	90
Psychopharmacology	85
Neuroscience Applied	57
Journal of Psychedelic Studies	47
Psychedelic medicine (New Rochelle, N.Y.)	39
Scientific reports	37
bioRxiv : the preprint server for biology	33
Biological Psychiatry	32

Research topics 66 topic filters

Depression 1,735 Receptor Pharmacology 1,281 Safety 1,198 Mechanism of Action 1,069 Review Article 1,067 Clinical Trial 975 Anxiety 881 Addiction 822 Pharmacology 752 General 537 Aging 524 Animal Study 522 Observational Study 514 Brain Imaging 480 Treatment-Resistant Depression 417 Emotional Processing 408 PTSD 400 Neuroplasticity 398

Source coverage 8 active sources

Source	Count	Share	Status
PubMed	2,572	51.9%	Active
OpenAlex	1,152	23.2%	Active
Crossref	404	8.2%	Active
ClinicalTrials.gov	300	6.1%	Active
PsyArXiv	187	3.8%	Active
Europe PMC	180	3.6%	Active
bioRxiv	122	2.5%	Active

Publication timeline 3,852 dated records

3,852 records since 2020

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Substances Psilocybin 4736 Psilocin 673

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Executed search Cites DOI: 10.1080/1355621021000005937 24 matching records are displayed.

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24 matching records for Cites DOI: 10.1080/1355621021000005937.

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Exploring the In Vitro Effect of Psilocybin on the Composition and Metabolic Activity of Gut Microbiota in Individuals with Severe Anxiety

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.3390/ddc5030046

Drugs and Drug Candidates 2026-08-12 Salgaço Mateus Kawata, Farias David de Paulo, Souza Mariela Zucolo de, Sartoratto Adilson, Bottino Flavia, Barud Hernane da Silva

New this week Crossref Published psilocybin psilocin Anxiety Pharmacology Mechanism of Action In Vitro Study More

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Psilocybin: Chemical Foundations and Emerging Therapeutic Potential

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.2174/0113895575429775260119043318 PubMed 41879500

Mini-Reviews in Medicinal Chemistry 2026-06-01 Patil Shivaputra A., Hunsberger Holly C.

Crossref Published psilocybin psilocin Depression Addiction Neuroplasticity Clinical Trial More

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Psilocybin use in Puerto Rico: Patterns, motivations, and personality correlates from an online survey

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1556/2054.2026.00519

Journal of Psychedelic Studies 2026-04-15 Vélez Rodríguez Jean C., Duquesne-Maldonado Yanice, Hernández Torres Julián M., Da'Luz Sant'Ana Istoni, Nazario Cruz M.

Crossref Published psilocybin Addiction Personality Change Spirituality Observational Study More

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Psilocybin in Neuropsychiatric Disorders: Seeking Valuable Evidence in History, Pure Science, Clinical Trials and Real-World Data (RWD)

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.3390/brainsci16040358 PubMed 42041769

Brain Sciences 2026-03-26 Skalski Piotr, Pękacka-Falkowska Katarzyna, Pluto-Prądzyńska Agnieszka, Owecki Michał K.

Crossref Published psilocybin Depression Anxiety Addiction Randomized Controlled Trial More

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Psilocybin effects on brain functional connectivity: a systematic review of fMRI studies

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1007/s44192-026-00384-w PubMed 41854988

Discover Mental Health 2026-03-19 Farré-Colomés Àlvar, Rublinetska Olga, Soto-Angona Óscar

Crossref Published psilocybin Depression Brain Imaging Mechanism of Action Systematic Review More

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Synthesis and Characterization of Psilocybin Metabolites and Deuterated Analogs

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1021/acschemneuro.5c00879 PubMed 41773421

ACS Chemical Neuroscience 2026-03-18 Williamson Samuel E., Burkhartzmeyer Elise K., Faley Michael T., Ohana Rachel F., Guzei Ilia A., Valley Mike

Crossref Published psilocybin General Other More

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Explainable AI framework for psilocybin depression treatment optimization

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Details DOI 10.3389/fcomp.2025.1652190

Frontiers in Computer Science 2026-03-16 Sungheetha Akey, Rajesh Sharma R., Aroba Oluwasegun Julius, Mahapatra Sheila, Mahendhiran P. D.

Crossref Published psilocybin Depression Brain Imaging Pharmacology Randomized Controlled Trial More

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Elucidating the Phase I metabolism of psilocin in vitro

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1007/s00204-024-03952-7 PubMed 39751877

Archives of Toxicology 2025-03-01 Chen Junqi, Wang Ziteng, Yong Ching Yee, Goh Evelyn Mei Ling, Moy Hooi Yan, Chan Eric Chun Yong

Crossref Published psilocin Pharmacology Clinical Trial In Vitro Study Clinical Trial More

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Clinical Pharmacokinetics of Psilocin After Psilocybin Administration: A Systematic Review and Post-Hoc Analysis

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1007/s40262-024-01454-4 PubMed 39812743

Clinical Pharmacokinetics 2025-01-01 Otto Marije E., van der Heijden Katelijne V., Schoones Jan W., van Esdonk Michiel J., Borghans Laura G. J. M., Jacobs Gabriel E.

Crossref Published psilocybin psilocin Pharmacology Systematic Review Review Article Systematic Review More

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Quantification of psilocin in human whole blood using liquid chromatography-tandem mass spectrometry (LC-MS/MS)

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1111/1556-4029.15454 PubMed 38140718

Journal of Forensic Sciences 2024-03-01 Gomonit Munchelou M., Skillman Britni, Swortwood Madeleine J.

Crossref Published psilocybin psilocin Pharmacology Other More

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Determination of psilocybin and psilocin content in multiple Psilocybe cubensis mushroom strains using liquid chromatography - tandem mass spectrometry

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.aca.2023.342161 PubMed 38220293

Analytica Chimica Acta 2024-02-01 Goff Roman, Smith Morgan, Islam Sabrina, Sisley Sue, Ferguson Jonathan, Kuzdzal Scott

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Addressing the Current Knowledge and Gaps in Research Surrounding Lysergic Acid Diethylamide (LSD), Psilocybin, and Psilocin in Rodent Models

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.2174/1568026623666230705151922 PubMed 37409550

Current Topics in Medicinal Chemistry 2023-09-01 Ezeaka Udoka C., Kim Hye Ji J., Laprairie Robert B.

Crossref Published psilocybin psilocin Depression Anxiety Addiction Review Article More

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Development of a physiologically based pharmacokinetic (PBPK) model of psilocybin and psilocin from magic mushroom in rats and humans

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.12688/f1000research.28133.1

F1000Research 2021-03-15 Musikaphongsakul Prinya, Ya Kimheang, Subsoontorn Pakpoom, Lohitnavy Manupat

Crossref Published psilocybin psilocin Pharmacology Receptor Pharmacology Other More

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Development and validation of an LC-MS/MS method for the bioanalysis of psilocybin’s main metabolites, psilocin and 4-hydroxyindole-3-acetic acid, in human plasma

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.jchromb.2020.122486 PubMed 33485158

Journal of Chromatography B 2021-02-01 Kolaczynska Karolina E., Liechti Matthias E., Duthaler Urs

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Exposure-Response Analysis to Assess the Concentration-QTc Relationship of Psilocybin/Psilocin

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Details DOI 10.1002/cpdd.796 PubMed 32250059

Clinical Pharmacology in Drug Development 2021-01-01 Dahmane Elyes, Hutson Paul R., Gobburu Jogarao V. S.

Crossref Published psilocybin psilocin Depression Clinical Trial Clinical Trial More

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Psilocin and ketamine microdosing: effects of subchronic intermittent microdoses in the elevated plus-maze in male Wistar rats

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Details DOI 10.1097/fbp.0000000000000394 PubMed 29537989

Behavioural Pharmacology 2018-09-01 Horsley Rachel R., Páleníček Tomáš, Kolin Jan, Valeš Karel

Crossref Published psilocin Anxiety Receptor Pharmacology Microdosing Other More

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Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance

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Details DOI 10.1080/03602532.2016.1278228 PubMed 28074670

Drug Metabolism Reviews 2017-01-02 Dinis-Oliveira Ricardo Jorge

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DNA-based taxonomic identification of basidiospores in hallucinogenic mushrooms cultivated in “grow-kits” seized by the police: LC-UV quali-quantitative determination of psilocybin and psilocin

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Details DOI 10.1016/j.jpba.2016.03.043 PubMed 27021629

Journal of Pharmaceutical and Biomedical Analysis 2016-06-01 Gambaro Veniero, Roda Gabriella, Visconti Giacomo Luca, Arnoldi Sebastiano, Casagni Eleonora, Dell’Acqua Lucia

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Neurovascular and neuroimaging effects of the hallucinogenic serotonin receptor agonist psilocin in the rat brain

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Details DOI 10.1016/j.neuropharm.2015.07.018 PubMed 26192543

Neuropharmacology 2015-12-01 Spain Aisling, Howarth Clare, Khrapitchev Alexandre A., Sharp Trevor, Sibson Nicola R., Martin Chris

Crossref Published psilocin Brain Imaging Receptor Pharmacology Aging Animal Study More

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The Effect of Psilocin on Memory Acquisition, Retrieval, and Consolidation in the Rat

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Details DOI 10.3389/fnbeh.2014.00180 PubMed 24904332

Frontiers in Behavioral Neuroscience 2014-05-16 Rambousek Lukas, Palenicek Tomas, Vales Karel, Stuchlik Ales

Crossref Published psilocin Animal Study Animal Study More