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Psilocybin Research MCP

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Neurochemical properties of psilocybin in comparison to ketamine in vivo

Neuroscience Applied 2022-01-01 A. Wojtas, A. Bysiek, Z. Szych, M. Herian, K. Gołembiowska DOI 10.1016/j.nsa.2022.100408

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Depression Pharmacology Receptor Pharmacology Other All topics and provenance

The role of psilocybin in memory consolidation in the animal model

Neuroscience Applied 2022-01-01 K. Šíchová, K. Chona, Lucie Olejníková Ladislavová, T. Páleníček DOI 10.1016/j.nsa.2022.100953

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Depression Anxiety Addiction Animal Study All topics and provenance

Comparison of subjective, autonomic, and endocrine effects of LSD and psilocybin in healthy subjects

Neuroscience Applied 2022-01-01 Friederike Holze, Laura Ley, F. Müller, V. Nimmy, Anne Eckert, Matthias E. Liechti DOI 10.1016/j.nsa.2022.100075

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Depression Pharmacology Biomarkers Other All topics and provenance

The efficacy of COMP360 psilocybin therapy in treatment-resistant depression: exploratory results from a phase IIb randomised controlled trial

Neuroscience Applied 2022-01-01 G. Goodwin, Scott T. Aaronson, Boadie W. Dunlop, D. Feifel, David J. Hellerstein, L. Marwood DOI 10.1016/j.nsa.2022.100213

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Depression Headache / Migraine Clinical Trial Randomized Controlled Trial All topics and provenance

The safety and efficacy of COMP360 psilocybin therapy in treatment-resistant depression: results from a phase IIb randomised controlled trial

Neuroscience Applied 2022-01-01 G.M. Goodwin, Scott T. Aaronson, Boadie W. Dunlop, David Feifel, David J. Hellerstein, N. Hewitt DOI 10.1016/j.nsa.2022.100511

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Depression Clinical Trial Randomized Controlled Trial Randomized Controlled Trial All topics and provenance

The safety and efficacy of COMP360 psilocybin therapy in treatment-resistant depression: results from a long-term observational follow-up study

Neuroscience Applied 2023-01-01 Guy M. Goodwin, Lindsey Marwood, S. Mistry, Anna Nowakowska, Zainib Shabir, H. Clifton Simmons DOI 10.1016/j.nsa.2023.102906

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Depression Observational Study Treatment-Resistant Depression Observational Study All topics and provenance

Effect of co-administration of low doses of psilocybin and mGluR2/3 antagonist LY341495 in chronic restraint stress model of depression

Neuroscience Applied 2023-01-01 Agata Machaczka, Jane Turek, Dorota Bederska-Łojewska, Bartłomiej Pochwat, Łukasz Gąsior, Bernadeta Szewczyk DOI 10.1016/j.nsa.2023.102939

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Depression Receptor Pharmacology Other All topics and provenance

Change in whole blood BDNF after escitalopram or psilocybin intervention in patients with depression and healthy controls

Neuroscience Applied 2023-01-01 Miriam L. Navarro, Alberte Wollesen Breum, Annette Johansen, Brice Ozenne, Vibe G. Frøkjær, Gitte M. Knudsen DOI 10.1016/j.nsa.2023.103646

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Depression Anxiety Personality Change Other All topics and provenance

Therapeutic mechanism of psilocybin in the treatment of depression and other psychiatric disorders.

Neuroscience Applied 2023-01-01 O. Shahar, A. Botvinik, T. Lifschytz, B. Lerer DOI 10.1016/j.nsa.2023.101067

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Depression Other All topics and provenance

Changes in positive and negative affect in participants with treatment-resistant depression following COMP360 psilocybin treatment

Neuroscience Applied 2024-01-01 Matthew B. Young, J. Chai-Rees, Anna Nowakowska, Jeng-Yu Tsai, Guy M. Goodwin DOI 10.1016/j.nsa.2024.104163

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Depression Treatment-Resistant Depression Other All topics and provenance

Psilocybin vs Escitalopram for depression: 6-month follow-up

Neuroscience Applied 2024-01-01 Thomas Barba, David Erritzøe, Kyle T. Greenway, Rinki Murphy, John Martell, Christopher Timmermann DOI 10.1016/j.nsa.2024.104377

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Depression Anxiety Other All topics and provenance

Neural effects of psilocybin-treatment in patients with treatment-resistant depression

Neuroscience Applied 2024-01-01 C. Schmitz, Hana Adolphi, Michael Frank, E. Seeger, Maciej Musiał, Moritz Spangemacher DOI 10.1016/j.nsa.2024.105028

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Depression Anxiety Treatment-Resistant Depression Other All topics and provenance

Exploring the molecular basis of treatment-resistant depression: Discoveries from a rat model and psilocybin therapy

Neuroscience Applied 2024-01-01 Agata Korlatowicz, Katarzyna Latocha, Paulina Pabian, Ryszard Bugno, Adam S. Hogendorf, Tamás Kovács DOI 10.1016/j.nsa.2024.104020

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Depression Receptor Pharmacology Animal Study Animal Study All topics and provenance

Investigational COMP360 psilocybin treatment for treatment-resistant depression: assessing altered states of consciousness

Neuroscience Applied 2024-01-01 N. Hewitt, J. Chai-Rees, Megan Croal, S. Mistry, Jeng-Yu Tsai, Matthew B. Young DOI 10.1016/j.nsa.2024.104391

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Depression Anxiety Consciousness Other All topics and provenance

Effects of escitalopram and psilocybin therapy on mesolimbic resting-state functional connectivity in depression

Neuroscience Applied 2025-01-01 Rebecca Harding, Natalie Ertl, Rabia Zafar, Magnus Wall, Rajkanya Das, David Erritzøe DOI 10.1016/j.nsa.2025.105421

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Depression Brain Imaging Other All topics and provenance

Efficacy and safety of psilocybin in treatment-resistant major depression (EPIsoDE): Results of a randomized active placebo-controlled trial

Neuroscience Applied 2026-01-01 L.J. Mertens, M. Koslowski, F. Betzler, M. Brand, R. Evens, L. Krätner DOI 10.1016/j.nsa.2025.105779

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Depression Anxiety Chronic Pain Randomized Controlled Trial All topics and provenance

An open-label study of single-dose COMP360 psilocybin for post-traumatic stress disorder: safety, tolerability, and secondary efficacy outcomes

Neuroscience Applied 2026-01-01 N. Mcgowan, J. Rucker, R. Yehuda, M. Agrawal, H. Simmons, S. Das DOI 10.1016/j.nsa.2025.106821

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Depression PTSD Chronic Pain Clinical Trial All topics and provenance

Relationship between cardiovascular effects and psychedelic experiences under psilocybin in patients with treatment-resistant depression

Neuroscience Applied 2026-01-01 L. Puhl, L. Kunz, M. Berger, G. Gründer, L. Mertens, M. Spangemacher DOI 10.1016/j.nsa.2025.106390

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Depression Anxiety Chronic Pain Other All topics and provenance

Research guides and tools

Database details

4,921 Psilocybin records 695 Psilocin records 1,491 Journal labels 66 Research topics

Published 4,369 Published / formal records Preprints 460 Marked as not peer reviewed Clinical trial registrations 310 ClinicalTrials.gov records Protocols 3 Study protocol records

Substance categories overlap; their counts must not be summed. Journal labels exclude preprint and trial-registry venues and may include name variants. Research topics are derived screening categories. Publication status does not independently verify peer review.

Publication timeline

4,040 records since 2020

Annual records Cumulative line

R toolkit visNetwork Bibliometrics, live SQLite analysis, HTML graph, and PDF export

Top journals 1,491 indexed journals

Journal	Records
Journal of psychopharmacology (Oxford, England)	154
Journal of psychoactive drugs	100
Frontiers in psychiatry	93
Psychopharmacology	91
Neuroscience Applied	57
Journal of Psychedelic Studies	49
Psychedelic medicine (New Rochelle, N.Y.)	39
Scientific reports	37
Journal of affective disorders	34
Psychiatric News	33

Research topics 66 topic filters

Depression 1,812 Receptor Pharmacology 1,312 Safety 1,267 Mechanism of Action 1,122 Review Article 1,120 Clinical Trial 1,030 Anxiety 921 Addiction 848 Pharmacology 776 Animal Study 551 General 548 Observational Study 541 Aging 539 Brain Imaging 494 Treatment-Resistant Depression 441 Emotional Processing 426 Neuroplasticity 422 PTSD 411

Source coverage 8 active sources

Source	Count	Share	Status
PubMed	2,589	50.4%	Active
OpenAlex	1,190	23.1%	Active
Crossref	430	8.4%	Active
ClinicalTrials.gov	310	6%	Active
Europe PMC	260	5.1%	Active
PsyArXiv	188	3.7%	Active
bioRxiv	130	2.5%	Active

Psilocybin research database

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Psilocybin Research MCP

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