Qualitative analysis of synthetic opioids, synthetic hallucinogens and LSD in urine using LC-MS/MS

Synthetic opioids and synthetic hallucinogens continue to expand in the illicit drugs market where they are designed and synthesized to avoid detection in routine drug tests. It is therefore crucial for laboratories to develop analytical methods for the detection of these drugs in urine. A method for the simultaneous analysis of synthetic opioids (including ...

The effects of psilocybin microdosing on perception: a double-blind controlled study

Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels

Trait Openness and serotonin 2A receptors in healthy volunteers: A positron emission tomography study

Abstract Recent research found lasting increases in personality trait Openness in healthy individuals and patients after administration of the serotonin 2A receptor (5-HT2A R) agonist psilocybin. However, no studies have investigated whether 5-HT2A R availability as imaged using positron emission tomography (PET) is associated with this trait. In 159 healthy...

Effects of acute and repeated treatment with serotonin 5-HT2A receptor agonist hallucinogens on intracranial self-stimulation in rats.

The prototype 5-HT2A receptor agonist hallucinogens LSD, mescaline, and psilocybin are classified as Schedule 1 drugs of abuse by the U.S. Drug Enforcement Administration. Accumulating clinical evidence has also suggested that acute or repeated "microdosing" with these drugs may have utility for treatment of some mental health disorders, including drug abuse...

Personal

Personal James Davis (bio) Give me a faggot, fashion mags evenly fannedacross his coffee table, who serves drinksin snifters, tumblers, flutes, and says behind, not to euphemize ass, but to signal his nearing,e.g. on a bike. Give me a man like an otter,svelte swimmer with claws to tear flesh from pink varicellate shells, fur matted with saltwater.I want a mo...

Sprang

Sprang Arthur Sze (bio) 1 winter stars You will never forget corpses wrapped in flames-at dusk, you watched a congregation of crows gather in the orchard and sway on branches;in the dawn light, a rabbit moves and stops, moves and stops along the grass; and asyou pull a newspaper out of a box, glance at the headlines, you feel the dew on grassas the gleam of ...

Psilocybin-Assisted Therapy: A Double-Blind Randomized Controlled Trial

THE POTENTIAL THERAPEUTIC VALUE OF PSILOCYBIN: In Relation to Depression

Depression is one of the most disabling and prevalent mental disorders, which causes excessive feelings of sadness and despair. Unfortunately, there are a substantial number of patients that do not respond well to conventional interventions and new approaches are therefore needed. Recent studies have revealed that psilocybin can effectively reduce symptoms o...

Serotonergic Psychoactive Compounds as a Treatment for Addiction, Anxiety, and Depression: Their Efficacy and Legality

The United States is a leader in world-wide medical innovation, but currently we face an epidemic of mental health disorders. Serotonergic psychoactive compounds such as psilocybin, mescaline, DMT, and LSD are currently being studied as potential treatments to be used in psychiatric medicine. Currently these substances are prohibited and designated to the st...

The Psychedelic Altered State of Consciousness: An Assessment of the Current Status of Psychedelic Research

Classic psychedelic substances, such as lysergic acid diethylamide and the active compound in magic mushrooms, psilocybin, are being studied again in a renaissance of psychedelic research. Psychedelic substances have profound effects on perception, emotion, and cognition, as well as the capacity to induce mystical-type experiences and ego-dissolution. Recent...

Substance & Seduction: Ingested Commodities in Early Modern Mesoamerica ed. by Stacey Schwartzkopf and Kathyrn E. Sampeck

Reviewed by: Substance & Seduction: Ingested Commodities in Early Modern Mesoamerica ed. by Stacey Schwartzkopf and Kathyrn E. Sampeck Kent Mathewson Stacey Schwartzkopf and Kathyrn E. Sampeck, eds. Substance & Seduction: Ingested Commodities in Early Modern Mesoamerica. Austin: University of Texas Press, 2017. vxii and 220 pp. Figures., notes, bibliography,...

These fungi drug cicadas with psilocybin or amphetamine to make them mate nonstop

Use of MDMA & Psilocybin in the Treatment of PTSD

For years, the promise of psychedelics in therapeutic settings has been deterred by their general illegality. However, present day research shows promise in treating varying mental disorders. Amongst these disorders is Post Traumatic Stress Disorder (PTSD). According to the organization, PTSD United, PTSD presently effects about eight percent of Americans. M...

Psilocybin induces aberrant prediction error processing for tactile mismatch responses

Peak experiences in a consciousness landscape - report on the science of consciousness conference in Interlaken, Switzerland, 2019

Introduction 
\nThe Science of Consciousness (TSC) 2019 was the 26th international interdisciplinary conference in the series that started in Tucson in 1994. This one was held in late June in the beautiful Swiss town of Interlaken, between two lakes and surrounded by high alps. The local organizer was Harald Atmanspacher from Collegium Helveticum in Zuri...

Using the pharmacy retail model to examine perceptions and biases of a UK population sample towards regulation of specific psychoactive drugs

Background: Contemporary research indicates that the legal classifications of cannabis (Schedule 2, Class B), 3,4-methylenedioxymethamphetamine (MDMA) (Schedule 1, Class A) and psilocybin (Schedule 1, Class A) in the United Kingdom are not entirely based on considerations of harm and therapeutic utility. The legal classifications of the substances discussed ...

Effects of psilocybin on functional connectivity measured with fNIRS: Insights from a single-subject pilot study

The serotonergic hallucinogen psilocybin has characteristic effects on human brain activity and subjective experience. Previous functional magnetic resonance imaging (fMRI) studies showed alternations of functional connectivity (FC) under the influence of psilocybin in humans. No study, as yet, investigated psilocybin-induced changes in brain hemodynamics an...

Multi-targeting cytotoxic drug leads from mushrooms

Due to genetic and epigenetic mechanisms, cancer have become a resistant disease and there is a need for new molecules having multiple targeting action that promotes apoptosis. Phyto-molecules having multiple targeting anticancer activity are in high demand and there is less documentation or information available on these metabolites. It is evident that mush...

2018: A watershed year for psychedelic science

While interest in the study of psychedelic drugs has increased over much of the last decade, in this article, we argue that 2018 marked the true turning point for the field. Substantive advances in the scientific, public, and regulatory communities in 2018 significantly elevated the status and long-term outlook of psychedelic science, particularly in the Uni...