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Psilocybin and psilocin research index

Find psilocybin and psilocin papers, preprints, trials, and citations with clear source context.

Searches titles, authors, journals, identifiers, indexed metadata, and derived research topics. Use Filters to narrow by source, status, substance, study type, or date.

Database 4,961 indexed records Auto-updated on Aug 19, 2026 01:24 UTC

Executed search Topic: Biomarkers 191 matching records are displayed.

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Database

4,742 Psilocybin Records 673 Psilocin Records 1,461 Journals 66 Research Topics

Published 4,223 Peer-reviewed / formal records Preprints 435 Marked as not peer reviewed Clinical trials 300 ClinicalTrials.gov records R toolkit visNetwork Bibliometrics, live SQLite analysis, HTML graph, and PDF export

Top journals 1,461 indexed journals

Journal	Records
Journal of psychopharmacology (Oxford, England)	148
Journal of psychoactive drugs	97
Frontiers in psychiatry	90
Psychopharmacology	85
Neuroscience Applied	57
Journal of Psychedelic Studies	48
Psychedelic medicine (New Rochelle, N.Y.)	39
Scientific reports	37
Biological Psychiatry	32
Journal of affective disorders	32

Research topics 66 topic filters

Depression 1,737 Receptor Pharmacology 1,281 Safety 1,203 Mechanism of Action 1,072 Review Article 1,072 Clinical Trial 977 Anxiety 883 Addiction 824 Pharmacology 752 General 538 Aging 524 Animal Study 524 Observational Study 515 Brain Imaging 481 Treatment-Resistant Depression 417 Emotional Processing 409 PTSD 400 Neuroplasticity 399

Source coverage 8 active sources

Source	Count	Share	Status
PubMed	2,566	51.7%	Active
OpenAlex	1,155	23.3%	Active
Crossref	405	8.2%	Active
ClinicalTrials.gov	300	6%	Active
Europe PMC	188	3.8%	Active
PsyArXiv	186	3.7%	Active
bioRxiv	123	2.5%	Active

Publication timeline 3,858 dated records

3,858 records since 2020

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Substances Psilocybin 4742 Psilocin 673

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Executed search Topic: Biomarkers 191 matching records are displayed.

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191 matching records for Topic: Biomarkers.

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Psilocybin-Assisted Therapy for Physician Well-Being and Burnout: Feasibility, Safety, Clinical Effectiveness and Biomarkers of Response [PAT-B (Psilocybin-Assisted Therapy for Physician Well-Being and Burnout)]

Abstract available at the source but not redistributed here. Read at source.

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ClinicalTrials.gov 2026-07-21 University of California, San Diego

New this month ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression Addiction Brain Imaging Other More

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A Randomized, Double-Blind, Single Ascending Dose Study to Identify a Safe and Non-Psychedelic Dose of Psilocybin

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ClinicalTrials.gov 2026-07-17 Diamond Therapeutics Inc.

ClinicalTrials.gov CLINICAL TRIAL psilocybin psilocin Depression Anxiety Addiction Clinical Trial More

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Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Trauma-Related Major Depressive Disorder: Randomized Controlled Trial

Abstract available at the source but not redistributed here. Read at source.

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ClinicalTrials.gov 2026-07-14 Khyber Medical University Peshawar

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression Anxiety PTSD Randomized Controlled Trial More

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Mechanistic Studies of Psilocybin in Headache Disorders

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ClinicalTrials.gov 2026-07-13 Yale University

ClinicalTrials.gov CLINICAL TRIAL psilocybin Headache / Migraine Neuroplasticity Brain Imaging Clinical Trial More

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CSF galanin and noradrenaline downregulation by psilocybin therapy in major depressive disorder

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1038/s41386-026-02490-3 PubMed 42414566

Neuropsychopharmacology 2026-07-07 Paslawski Wojciech, Doyon Daniel, Ekman Carl Johan, Yngwe Hampus, Mamula Dejan, Zareba-Paslawska Justyna

Crossref Published psilocybin Depression Pharmacology Mechanism of Action Clinical Trial More

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Psychedelics, entactogens and psychoplastogens for depression and related disorders.

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Details DOI 10.1111/bph.70088 PubMed 40518133

British journal of pharmacology 2026-07-01 Hoyer D

PubMed Published psilocybin Depression Anxiety PTSD Clinical Trial More

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Psilocybin reduces fear memory and restores neuroplasticity in the hippocampus and medial prefrontal cortex

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1177/02698811261453819 PubMed 42365496

Journal of Psychopharmacology 2026-06-28 Du Yingjie, Zhao Xiangting, Yao Yishan, Li Yunfeng, Wang Guyan, Zhang Liming

Crossref Published psilocybin Depression PTSD Neuroplasticity Animal Study More

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A Pilot Mechanistic RCT of Psilocybin With Mindfulness-based Therapy vs Support for Posttraumatic Stress Disorder (PTSD)

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ClinicalTrials.gov 2026-06-25 Anthony P King

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression Anxiety PTSD Randomized Controlled Trial More

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Novel approaches in depression treatment: from rapid-acting antidepressants to personalized interventions.

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Details DOI 10.1038/s41380-026-03722-0 PubMed 42350785

Molecular psychiatry 2026-06-25 Guidetti C, Fava M, Papakostas GI

PubMed Published psilocybin Depression Brain Imaging Biomarkers Clinical Trial More

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Distinct brain responses to psilocybin and escitalopram in depression captured by the Fluctuation-Dissipation Theorem

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.64898/2026.06.12.731811

bioRxiv 2026-06-16 Dagnino PC, Acero-Pousa I, Zamora-López G, Escrichs A, Erritzoe D, Nutt DJ

bioRxiv PREPRINT (not peer reviewed) psilocybin Depression Brain Imaging Mechanism of Action Randomized Controlled Trial More

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EEG microstate dynamics during psilocybin intoxication relate to acute experience and persisting psychological changes

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.64898/2026.06.09.731183

bioRxiv 2026-06-12 Jajcay N, Vejmola Č, Korčák J, Tylš F, Viktorinová M, Viktorin V

bioRxiv PREPRINT (not peer reviewed) psilocybin Brain Imaging Consciousness Biomarkers Clinical Trial More

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A Double Blind, Randomized Trial Investigating the Safety, Feasibility, and Mechanisms of Psychedelics in Healthy Older Adults With Low Well-being as Moderated by Biomarkers for Preclinical Alzheimer's Disease

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ClinicalTrials.gov 2026-06-08 Jennifer Mitchell

ClinicalTrials.gov CLINICAL TRIAL psilocybin Brain Imaging Mechanism of Action Biomarkers Clinical Trial More

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The Role of the Subjective Experience in Supporting Positive Effects Following Psilocybin: a Randomized, Controlled Clinical Trial Using Risperidone in Healthy Adults

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ClinicalTrials.gov 2026-06-02 University of Calgary

ClinicalTrials.gov CLINICAL TRIAL psilocybin Anxiety Biomarkers Wellbeing Clinical Trial More

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A Molecule-Resolved Bibliometric Analysis of PubMed-Indexed Psychedelic Research (2015-2025): Volume, Temporal Trends, and Publication Types

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Details DOI 10.1192/j.eurpsy.2026.11510

European Psychiatry 2026-06-01 M. Pastuszak, K. Jakuszkowiak-Wojten, M. Gałuszko-Węgielnik, A. W. Kwaśny, A. Mechlińska, D. Świeczkowski

OpenAlex Published psilocybin psilocin Mechanism of Action Biomarkers Meta-Analysis Meta-Analysis More

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Spatiotemporal mapping of brain organisation following the administration of 2C-B and psilocybin.

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Details DOI 10.1038/s41380-026-03447-0 PubMed 41634136

Molecular psychiatry 2026-06-01 Mallaroni P, Singleton SP, Mason NL, Satterthwaite TD, Ramaekers JG

PubMed Published psilocybin Pharmacology Receptor Pharmacology Biomarkers Other More

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Sex-dependent developmental changes in behavior, brain structure, functional connectivity, and sensory perception following exposure to psilocybin during adolescence.

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Details DOI 10.1038/s41386-026-02356-8 PubMed 41708994

Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology 2026-06-01 Sahoo I, Masadi S, Maheswari A, Utama R, Abeer MI, Soltanpour S

PubMed Published psilocybin Neuroplasticity Brain Imaging Biomarkers Animal Study More

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Psilocybin Decreases Preference for Large Rewards Accompanied by Increased Activity of Parvalbumin Neurons With Perineuronal Nets in the Medial Prefrontal Cortex

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Details DOI 10.1111/ejn.70574 PubMed 42226515

European Journal of Neuroscience 2026-06-01 Houff Jenna, Williams Andrew, Allen Obie, Gisabella Barbara, Pantazopoulos Harry, Del Arco Alberto

Crossref Published psilocybin Addiction Receptor Pharmacology Biomarkers Clinical Trial More

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Psilocin glucuronide in whole blood: a stable and useful biomarker of psilocybin intake

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Details DOI 10.1093/jat/bkag015 PubMed 41723823

Journal of Analytical Toxicology 2026-05-23 Bergh Marianne Skov-Skov, Bogen Inger Lise, Vevelstad Merete, Øiestad Åse Marit Leere

Crossref Published psilocybin psilocin Biomarkers Other More

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A Pilot Mechanistic Study of Psilocybin-Assisted Therapy as a Treatment for Depression

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ClinicalTrials.gov 2026-05-20 Washington University School of Medicine

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression Biomarkers Psychological Flexibility Clinical Trial More

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Psilocybin-assisted Therapy for Post-Traumatic Stress Disorder in Survivors of Intimate Partner Violence

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ClinicalTrials.gov 2026-05-14 University of Calgary

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression Anxiety PTSD Randomized Controlled Trial More