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Psilocybin and psilocin research index

Find psilocybin and psilocin papers, preprints, trials, and citations with clear source context.

Searches titles, authors, journals, identifiers, indexed metadata, and derived research topics. Use Filters to narrow by source, status, substance, study type, or date.

Database 4,961 indexed records Auto-updated on Aug 19, 2026 01:24 UTC

Executed search Topic: Drug Interactions 272 matching records are displayed.

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Database

4,742 Psilocybin Records 673 Psilocin Records 1,461 Journals 66 Research Topics

Published 4,223 Peer-reviewed / formal records Preprints 435 Marked as not peer reviewed Clinical trials 300 ClinicalTrials.gov records R toolkit visNetwork Bibliometrics, live SQLite analysis, HTML graph, and PDF export

Top journals 1,461 indexed journals

Journal	Records
Journal of psychopharmacology (Oxford, England)	148
Journal of psychoactive drugs	97
Frontiers in psychiatry	90
Psychopharmacology	85
Neuroscience Applied	57
Journal of Psychedelic Studies	48
Psychedelic medicine (New Rochelle, N.Y.)	39
Scientific reports	37
Biological Psychiatry	32
Journal of affective disorders	32

Research topics 66 topic filters

Depression 1,737 Receptor Pharmacology 1,281 Safety 1,203 Mechanism of Action 1,072 Review Article 1,072 Clinical Trial 977 Anxiety 883 Addiction 824 Pharmacology 752 General 538 Aging 524 Animal Study 524 Observational Study 515 Brain Imaging 481 Treatment-Resistant Depression 417 Emotional Processing 409 PTSD 400 Neuroplasticity 399

Source coverage 8 active sources

Source	Count	Share	Status
PubMed	2,566	51.7%	Active
OpenAlex	1,155	23.3%	Active
Crossref	405	8.2%	Active
ClinicalTrials.gov	300	6%	Active
Europe PMC	188	3.8%	Active
PsyArXiv	186	3.7%	Active
bioRxiv	123	2.5%	Active

Publication timeline 3,858 dated records

3,858 records since 2020

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Substances Psilocybin 4742 Psilocin 673

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Executed search Topic: Drug Interactions 272 matching records are displayed.

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272 matching records for Topic: Drug Interactions.

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Computational Analysis of Psilocybin Effects on Three-Choice Touchscreen Reversal Learning in Rats: A Pilot Study

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1177/28314425251386879

Psychedelic Medicine 2026-02-03 Anton T. Gregersen, Tobias Whelan, Caroline T. Golden, T. Blackmore, Mikael Palner

OpenAlex Published psilocybin Chronic Pain Toxicity Drug Interactions Other More

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Psychedelic experiences elicited by serotonergic psychedelics: Molecular mechanisms and functional connectivity changes in the brain.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.neubiorev.2025.106529 PubMed 41412413

Neuroscience and biobehavioral reviews 2026-02-01 Vollebregt R, Storm AEM, Lucassen PJ, Somers M

PubMed Published psilocybin Depression Neuroplasticity Mechanism of Action Systematic Review More

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Psilocybin and Bipolar Depression: Promise and Prudence.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1007/s40263-025-01255-8 PubMed 41485178

CNS drugs 2026-02-01 Marques MG, Patarroyo-Rodriguez L, Singh B

PubMed Published psilocybin Depression Pharmacology Aging Clinical Trial More

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Psychedelic research and sexuality: opportunities and pitfalls

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1093/jsxmed/qdag025 PubMed 41722098

The Journal of Sexual Medicine 2026-01-28 H. Knegtering, Thalia Herder, Nynke Boonstra, S. K. Spoelstra

OpenAlex Published psilocybin Depression PTSD Addiction Review Article More

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Psilocybin and the Evolutionary Significance of Altered Neural States: Interaction-Based Perspectives Beyond Deterrence Models

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.32942/x2v66q

EcoEvoRxiv 2026-01-28 Rebensburg P.

Europe PMC PREPRINT (not peer reviewed) psilocybin Drug Interactions Genomics Other More

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Psychological Therapy Quantity and Depressive Symptom Reduction in Psychedelic-Assisted Therapy: A Systematic Review and Meta-Analysis.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.48620/94398

Open Access CRIS of the University of Bern 2026-01-21 Florineth, Gianluca Andri, Klima, Isabell, Boeker, Anna Laura

OpenAlex Published psilocybin Depression Microdosing Clinical Trial Randomized Controlled Trial More

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Psychological Therapy Quantity and Depressive Symptom Reduction in Psychedelic-Assisted Therapy: A Systematic Review and Meta-Analysis.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1001/jamanetworkopen.2025.54843 PubMed 41563753

JAMA network open 2026-01-02 Florineth GA, Klima I, Boeker AL, Catzeflis P, Wopfner A, Denier N

PubMed Published psilocybin Depression Microdosing Clinical Trial Meta-Analysis More

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COMBINATION OF PSILOCYBIN AND COGNITIVE BEHAVIORAL THERAPY IMPROVES OXYTOCIN LEVELS AND DEPRESSIVE SYMPTOMS IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.4238/e91xh631

Genetics and Molecular Research 2026-01-01 Mahvash Khan, Muhammad Omar Malik, Sara Sajjad, Muhammad Uzair, Inayat Shah, Muhammad Ismail Bhatti

OpenAlex Published psilocybin Depression Anxiety OCD Randomized Controlled Trial More

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Toxicology and Pharmacological Interactions of Classic Psychedelics.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1007/7854_2024_508 PubMed 39042251

Current topics in behavioral neurosciences 2026-01-01 Thomas K

PubMed Published psilocybin Pharmacology Toxicity Drug Interactions Other More

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Pharmacological Properties of Psychedelics with a Special Focus on Potential Harms.

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Details DOI 10.1007/7854_2024_510 PubMed 39080236

Current topics in behavioral neurosciences 2026-01-01 Holze F, Liechti ME, Müller F

PubMed Published psilocybin Anxiety Pharmacology Receptor Pharmacology Other More

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Psilocybin in late-life mental health: Addressing depression, loneliness, and existential anxiety.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.genhosppsych.2025.12.005 PubMed 41401486

General hospital psychiatry 2026-01-01 Konstantinou GN, Rosenblat J, Hales S, Husain MI, Blumberger DM

PubMed Published psilocybin Depression Anxiety Neuroplasticity Clinical Trial More

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The Effect of Magic Mushroom (Psilocybe azurescens) on Social Interaction, Anxiety- and Depressive-Like Behaviors in Male Rats; the Role of Neuroinflammation, Oxidative Stress, and Neurotrophic Factors.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1002/jnr.70107 PubMed 41493855

Journal of neuroscience research 2026-01-01 Moghadam H, Akbari P, Beirami E, Nabavifard S, Ameli A, Valian N

PubMed Published psilocybin psilocin Depression Anxiety Mechanism of Action Other More

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The Use of Psilocybin in the Treatment of Depressive Disorders: A Narrative Review.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.7759/cureus.102694 PubMed 41777966

Cureus 2026-01-01 Siwek L, Nowocien M, Balajewicz B, Samborska A, Szukalska S, Karczewska M

PubMed Published psilocybin Depression Anxiety Receptor Pharmacology Review Article More

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Psychedelics and neuroanesthesia: A narrative review of converging mechanisms

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Details DOI 10.65929/jsia.2026.1.2.002

Journal of Scientific Innovations in Anesthesiology 2025-12-31 Kunal Kumar Sharma

OpenAlex Published psilocybin Depression Anxiety PTSD Review Article More

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A Naturalistic Study on the Combined Neural and Psychological Effects of Psilocybin and Compassion Focused Imagery

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.64898/2025.12.17.694940

bioRxiv 2025-12-22 Pallavicini C, Llobenes L, Cavanna F, de la Fuente LA, Muller S, Costa M

bioRxiv PREPRINT (not peer reviewed) psilocybin Brain Imaging Default Mode Network Aging Other More

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Effects of LSD and Psilocybin on Heart Rate in Patients Receiving Psychedelic Treatment for Depressive and Anxiety Disorders: A Retrospective Observational Study

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.3390/psycholint8010001

Psychology International 2025-12-19 Mylène Cheng, Tatiana Aboulafia Brakha, Albert Buchard, Raya Anastasova, Léa Girani, Anna Breitenmoser

OpenAlex Published psilocybin Depression Anxiety Chronic Pain Observational Study More

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Wherefore the magic? The evolutionary role of psilocybin in nature

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.64898/2025.12.17.694186

bioRxiv 2025-12-19 Matthews Nicholass K, Flis I, Hanley M, Knight M, Lane S, Littlejohn G

bioRxiv PREPRINT (not peer reviewed) psilocybin Mechanism of Action Receptor Pharmacology Drug Interactions Other More

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The Psychedelic Psilocin Suppresses Activity of Central Amygdala Corticotropin-Releasing Factor Receptor 1 Neurons and Decreases Ethanol Drinking in Female Mice

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Details DOI 10.1523/jneurosci.0652-25.2025 PubMed 41213805

The Journal of Neuroscience 2025-12-10 Magee Sarah N., Sereno Allison C., Echeveste-Sanchez Maria, Shannon Elizabeth G., Mohsin Abir, Mott Sarah E.

Crossref Published psilocybin psilocin Addiction Mechanism of Action Receptor Pharmacology Animal Study More

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[Psilocybin in the setting of treatment-resistant unipolar depression: A case report].

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.encep.2025.02.007 PubMed 40413068

L'Encephale 2025-12-01 Dumenil M, Cordova G, El-Hage W

PubMed Published psilocybin Depression Anxiety Chronic Pain Clinical Trial More

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Psychedelics as a Therapeutic Opportunity or Threat: A Narrative Review.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.7759/cureus.99942 PubMed 41583322

Cureus 2025-12-01 Liszka P, Ogórek A, Olejnik-Chlewicka KM, Puchalski K, Zasiadła M, Patrzykąt KM

PubMed Published psilocybin Depression Anxiety PTSD Clinical Trial More