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Psilocybin and psilocin research index

Find psilocybin and psilocin papers, preprints, trials, and citations with clear source context.

Searches titles, authors, journals, identifiers, indexed metadata, and derived research topics. Use Filters to narrow by source, status, substance, study type, or date.

Database 4,967 indexed records Auto-updated on Aug 20, 2026 01:29 UTC

Executed search Study type: Clinical Trial 952 matching records are displayed.

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Database

4,748 Psilocybin Records 673 Psilocin Records 1,461 Journals 66 Research Topics

Published 4,226 Peer-reviewed / formal records Preprints 437 Marked as not peer reviewed Clinical trials 301 ClinicalTrials.gov records R toolkit visNetwork Bibliometrics, live SQLite analysis, HTML graph, and PDF export

Top journals 1,461 indexed journals

Journal	Records
Journal of psychopharmacology (Oxford, England)	148
Journal of psychoactive drugs	97
Frontiers in psychiatry	90
Psychopharmacology	85
Neuroscience Applied	57
Journal of Psychedelic Studies	48
Psychedelic medicine (New Rochelle, N.Y.)	39
Scientific reports	37
Biological Psychiatry	32
Journal of affective disorders	32

Research topics 66 topic filters

Depression 1,738 Receptor Pharmacology 1,282 Safety 1,208 Review Article 1,075 Mechanism of Action 1,072 Clinical Trial 978 Anxiety 884 Addiction 825 Pharmacology 752 General 538 Animal Study 525 Aging 524 Observational Study 516 Brain Imaging 482 Treatment-Resistant Depression 417 Emotional Processing 409 PTSD 401 Neuroplasticity 399

Source coverage 8 active sources

Source	Count	Share	Status
PubMed	2,566	51.7%	Active
OpenAlex	1,156	23.3%	Active
Crossref	407	8.2%	Active
ClinicalTrials.gov	301	6.1%	Active
Europe PMC	188	3.8%	Active
PsyArXiv	186	3.7%	Active
bioRxiv	124	2.5%	Active

Publication timeline 3,864 dated records

3,864 records since 2020

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Substances Psilocybin 4748 Psilocin 673

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Executed search Study type: Clinical Trial 952 matching records are displayed.

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952 matching records for Study type: Clinical Trial.

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The Role of the Subjective Experience in Supporting Positive Effects Following Psilocybin: a Randomized, Controlled Clinical Trial Using Risperidone in Healthy Adults

Abstract available at the source but not redistributed here. Read at source.

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ClinicalTrials.gov 2026-06-02 University of Calgary

ClinicalTrials.gov CLINICAL TRIAL psilocybin Anxiety Biomarkers Wellbeing Clinical Trial More

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Trials, trips, and tribulations: pathways for implementing psychedelic therapy in Ireland.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1093/ijnp/pyag028 PubMed 42113605

The international journal of neuropsychopharmacology 2026-06-02 Kelly JR, Sheridan C, Iusan P, Coakley L, Burke L, Brennan C

PubMed Published psilocybin Depression Anxiety Addiction Clinical Trial More

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Psilocybin shows rapid relief for depression symptoms

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1002/mhw.34890

Mental Health Weekly 2026-06-01 Canady Valerie A.

Crossref Published psilocybin Depression Clinical Trial Clinical Trial More

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Impact of formulation variables on the quality attributes of psilocybin-loaded oral thin films for early-phase development

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.jddst.2026.108228

Journal of Drug Delivery Science and Technology 2026-06-01 Wongumpornpinit Vorawut, Ingkaninan Kornkanok, Temkitthawon Prapapan, Waranuch Neti, Copetti Pivetta Rhannanda, Zuo Jieyu

Crossref Published psilocybin General Clinical Trial More

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Psilocybin: Chemical Foundations and Emerging Therapeutic Potential

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.2174/0113895575429775260119043318 PubMed 41879500

Mini-Reviews in Medicinal Chemistry 2026-06-01 Patil Shivaputra A., Hunsberger Holly C.

Crossref Published psilocybin psilocin Depression Addiction Neuroplasticity Clinical Trial More

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Psilocybin for psychiatric disorders: History, clinical trials, neuroimaging, and regulations

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1111/pcn.70042 PubMed 41749057

Psychiatry and Clinical Neurosciences 2026-06-01 Yonezawa Kengo, Hirata Mayuko, Takano Hiroaki, Kusudo Keisuke, Tomiyama Sota, Harada Lisa

Crossref Published psilocybin Depression Addiction OCD Clinical Trial More

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Psychedelics for treatment of negative symptoms and depressive symptoms in schizophrenia spectrum disorder: A narrative review.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.schres.2026.03.003 PubMed 41830808

Schizophrenia research 2026-06-01 Sabé M, Grof P, Sackett NB, Tai S, Kryskow P, Bershad A

PubMed Published psilocybin Depression Neuroplasticity Receptor Pharmacology Clinical Trial More

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Global increases in brain glucose metabolism following acute N,N-dimethyltryptamine and harmine administration in healthy volunteers: A randomised [F]FDG-PET study.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1177/0271678x261454172 PubMed 42220002

Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism 2026-06-01 Egger K, Bozsak R, Aicher HD, Sari H, Poetzsch SN, Rominger A

PubMed Published psilocybin Brain Imaging Pharmacology Receptor Pharmacology Clinical Trial More

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Psilocybin Decreases Preference for Large Rewards Accompanied by Increased Activity of Parvalbumin Neurons With Perineuronal Nets in the Medial Prefrontal Cortex

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1111/ejn.70574 PubMed 42226515

European Journal of Neuroscience 2026-06-01 Houff Jenna, Williams Andrew, Allen Obie, Gisabella Barbara, Pantazopoulos Harry, Del Arco Alberto

Crossref Published psilocybin Addiction Receptor Pharmacology Biomarkers Clinical Trial More

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Expectations and Motivations for Participation in Clinical Trials Utilizing Psychedelics for Treatment-Resistant Depression: A Qualitative Study.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1002/brb3.71544 PubMed 42304595

Brain and behavior 2026-06-01 Poppe C, Lyck L, Bechtold L, Repantis D

PubMed Published psilocybin Depression Mechanism of Action Clinical Trial Clinical Trial More

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Meaning-Centered Psychotherapy for Psilocybin-Assisted Therapy Among Patients with Advanced Cancer and Depression: Rationale and Preliminary Evaluation of MCP-PSIL.

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Details DOI 10.1177/28314425251363983 PubMed 42311441

Psychedelic medicine (New Rochelle, N.Y.) 2026-06-01 Rosa WE, Napolitano S, McAndrew N, Jenkins B, Lichtenthal WG, Applebaum AJ

PubMed Published psilocybin Depression Aging Clinical Trial Clinical Trial More

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Therapeutic advances in fibromyalgia: one year in review 2026.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.55563/clinexprheumatol/xscnij PubMed 42328945

Clinical and experimental rheumatology 2026-06-01 Bazzichi L, Di Carlo M, Salaffi F, Farah S, Porta F, Ablin JN

PubMed Published psilocybin Chronic Pain Mitochondrial Function Oxidative Stress Clinical Trial More

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Psilocybin-induced neurocardiogenic syncope: a case report

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Details DOI 10.1007/s00213-026-07079-8 PubMed 42207275

Psychopharmacology 2026-05-28 Atiq Mazen A., Weisman Eli, Guerra Rodrigo B., Martinez Luis Luna, Yaden David B., Barrett Frederick S.

Crossref Published psilocybin Anxiety Brain Imaging Consciousness Clinical Trial More

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Transient multidomain functional improvement in advanced Alzheimer’s disease following high-dose psilocybin-containing mushroom administration: a case report

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.3389/fnins.2026.1813281 PubMed 42292331

Frontiers in Neuroscience 2026-05-28 Lago Marcos, Cerveira Mariana, Simonet Joe Xavier

Crossref Published psilocybin Neuroplasticity Mechanism of Action Emotional Processing Clinical Trial More

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Long-Term Efficacy of Psilocybin with Adjunct Psychotherapy in Treatment-Resistant Major Depression: 6- and 12-Month Naturalistic Follow-Up of a Phase 2b Trial

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1159/000552272 PubMed 42201843

Psychotherapy and Psychosomatics 2026-05-27 Mertens Lea J., Betzler Felix, Brand Manuela, Evens Ricarda, Jungaberle Andrea, Jungaberle Henrik

Crossref Published psilocybin Depression Clinical Trial Treatment-Resistant Depression Clinical Trial More

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The Safety and Acceptability of Psilocybin With Support and With Massed Prolonged Exposure Therapy for PTSD

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ClinicalTrials.gov 2026-05-26 Emory University

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression PTSD Safety Clinical Trial More

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The Use of Psilocybin for Managing Refractory Behavioral Health Conditions: A New and Promising Approach

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Digital Showcase Research, Scholarship, & Creative Works (University of Lynchburg) 2026-05-22 Rachel N Clark

OpenAlex Published psilocybin Depression Anxiety Addiction Clinical Trial More

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Group Psilocybin-Assisted Therapy for Post-Traumatic Stress Disorder

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ClinicalTrials.gov 2026-05-22 University of New Mexico

ClinicalTrials.gov CLINICAL TRIAL psilocybin PTSD Clinical Trial Healthcare Workers Clinical Trial More

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A Pilot Mechanistic Study of Psilocybin-Assisted Therapy as a Treatment for Depression

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ClinicalTrials.gov 2026-05-20 Washington University School of Medicine

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression Biomarkers Psychological Flexibility Clinical Trial More

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Short-Term and Late-Term Effects of Psilocybin on Symptoms in Major Depression

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Details DOI 10.1001/jamanetworkopen.2026.12589 PubMed 42138922

JAMA Network Open 2026-05-15 Yngwe Hampus, Plavén-Sigray Pontus, Ekman Carl Johan, Henje Eva, Berglund Anders, Tiger Mikael

Crossref Published psilocybin Depression Anxiety Clinical Trial Clinical Trial More