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Psilocybin and psilocin research index

Find psilocybin and psilocin papers, preprints, trials, and citations with clear source context.

Searches titles, authors, journals, identifiers, indexed metadata, and derived research topics. Use Filters to narrow by source, status, substance, study type, or date.

Database 4,975 indexed records Auto-updated on Aug 24, 2026 01:23 UTC

Executed search Topic: Clinical Trial 981 matching records are displayed.

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Database

4,756 Psilocybin Records 674 Psilocin Records 1,463 Journals 66 Research Topics

Published 4,233 Peer-reviewed / formal records Preprints 438 Marked as not peer reviewed Clinical trials 301 ClinicalTrials.gov records R toolkit visNetwork Bibliometrics, live SQLite analysis, HTML graph, and PDF export

Top journals 1,463 indexed journals

Journal	Records
Journal of psychopharmacology (Oxford, England)	149
Journal of psychoactive drugs	97
Frontiers in psychiatry	90
Psychopharmacology	85
Neuroscience Applied	57
Journal of Psychedelic Studies	48
Psychedelic medicine (New Rochelle, N.Y.)	39
Scientific reports	37
Biological Psychiatry	32
Journal of affective disorders	32

Research topics 66 topic filters

Depression 1,741 Receptor Pharmacology 1,284 Safety 1,211 Review Article 1,076 Mechanism of Action 1,073 Clinical Trial 981 Anxiety 887 Addiction 826 Pharmacology 753 General 539 Aging 526 Animal Study 525 Observational Study 518 Brain Imaging 483 Treatment-Resistant Depression 417 Emotional Processing 410 Neuroplasticity 401 PTSD 401

Source coverage 8 active sources

Source	Count	Share	Status
PubMed	2,566	51.6%	Active
OpenAlex	1,156	23.2%	Active
Crossref	408	8.2%	Active
ClinicalTrials.gov	301	6.1%	Active
Europe PMC	194	3.9%	Active
PsyArXiv	186	3.7%	Active
bioRxiv	124	2.5%	Active

Publication timeline 3,872 dated records

3,872 records since 2020

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Substances Psilocybin 4756 Psilocin 674

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Executed search Topic: Clinical Trial 981 matching records are displayed.

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981 matching records for Topic: Clinical Trial.

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Mapping cognitive-behavioral approach in psychedelic-assisted treatment: a systematic review across phases with classic and non-classic psychedelics.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1007/s00406-025-02188-5 PubMed 41902950

European archives of psychiatry and clinical neuroscience 2026-06-01 Varela YM, de O Tavares VD, Delgado LM, de Faria HAT, Menezes LQ, Almeida RM

PubMed Published psilocybin Clinical Trial Systematic Review Review Article Systematic Review More

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Global increases in brain glucose metabolism following acute N,N-dimethyltryptamine and harmine administration in healthy volunteers: A randomised [F]FDG-PET study.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1177/0271678x261454172 PubMed 42220002

Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism 2026-06-01 Egger K, Bozsak R, Aicher HD, Sari H, Poetzsch SN, Rominger A

PubMed Published psilocybin Brain Imaging Pharmacology Receptor Pharmacology Clinical Trial More

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Psilocybin Decreases Preference for Large Rewards Accompanied by Increased Activity of Parvalbumin Neurons With Perineuronal Nets in the Medial Prefrontal Cortex

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1111/ejn.70574 PubMed 42226515

European Journal of Neuroscience 2026-06-01 Houff Jenna, Williams Andrew, Allen Obie, Gisabella Barbara, Pantazopoulos Harry, Del Arco Alberto

Crossref Published psilocybin Addiction Receptor Pharmacology Biomarkers Clinical Trial More

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Expectations and Motivations for Participation in Clinical Trials Utilizing Psychedelics for Treatment-Resistant Depression: A Qualitative Study.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1002/brb3.71544 PubMed 42304595

Brain and behavior 2026-06-01 Poppe C, Lyck L, Bechtold L, Repantis D

PubMed Published psilocybin Depression Mechanism of Action Clinical Trial Clinical Trial More

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Meaning-Centered Psychotherapy for Psilocybin-Assisted Therapy Among Patients with Advanced Cancer and Depression: Rationale and Preliminary Evaluation of MCP-PSIL.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1177/28314425251363983 PubMed 42311441

Psychedelic medicine (New Rochelle, N.Y.) 2026-06-01 Rosa WE, Napolitano S, McAndrew N, Jenkins B, Lichtenthal WG, Applebaum AJ

PubMed Published psilocybin Depression Aging Clinical Trial Clinical Trial More

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Blinding integrity in psychedelic research: Evidence from a comparative randomized controlled trial of psilocybin, MDMA, and methylphenidate in healthy volunteers.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.48620/98266

Open Access CRIS of the University of Bern 2026-05-28 L Belinger, N M Rieser, E J E Engeli, L Becciolini, M Clamote, M Pribis

OpenAlex Published psilocybin Addiction Chronic Pain Clinical Trial Randomized Controlled Trial More

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Psilocybin-induced neurocardiogenic syncope: a case report

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Details DOI 10.1007/s00213-026-07079-8 PubMed 42207275

Psychopharmacology 2026-05-28 Atiq Mazen A., Weisman Eli, Guerra Rodrigo B., Martinez Luis Luna, Yaden David B., Barrett Frederick S.

Crossref Published psilocybin Anxiety Brain Imaging Consciousness Clinical Trial More

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Long-Term Efficacy of Psilocybin with Adjunct Psychotherapy in Treatment-Resistant Major Depression: 6- and 12-Month Naturalistic Follow-Up of a Phase 2b Trial

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1159/000552272 PubMed 42201843

Psychotherapy and Psychosomatics 2026-05-27 Mertens Lea J., Betzler Felix, Brand Manuela, Evens Ricarda, Jungaberle Andrea, Jungaberle Henrik

Crossref Published psilocybin Depression Clinical Trial Treatment-Resistant Depression Clinical Trial More

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Active placebo control interventions in pharmacological trials: a scoping review of the development process and a terminological analysis.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.jclinepi.2026.112345 PubMed 42190765

Journal of clinical epidemiology 2026-05-25 Laursen DRT, Salazar J, Jürgens G, Hróbjartsson A

PubMed Published psilocybin Depression Chronic Pain Clinical Trial Randomized Controlled Trial More

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Psilocybin for Treatment-Resistant Depression: A Comprehensive Review of Mechanisms and Therapeutic Potential

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Digital Showcase Research, Scholarship, & Creative Works (University of Lynchburg) 2026-05-22 Dallas T Mason

OpenAlex Published psilocybin Depression Chronic Pain Brain Imaging Randomized Controlled Trial More

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The Use of Psilocybin for Managing Refractory Behavioral Health Conditions: A New and Promising Approach

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Digital Showcase Research, Scholarship, & Creative Works (University of Lynchburg) 2026-05-22 Rachel N Clark

OpenAlex Published psilocybin Depression Anxiety Addiction Clinical Trial More

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Group Psilocybin-Assisted Therapy for Post-Traumatic Stress Disorder

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ClinicalTrials.gov 2026-05-22 University of New Mexico

ClinicalTrials.gov CLINICAL TRIAL psilocybin PTSD Clinical Trial Healthcare Workers Clinical Trial More

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A Pilot Mechanistic Study of Psilocybin-Assisted Therapy as a Treatment for Depression

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ClinicalTrials.gov 2026-05-20 Washington University School of Medicine

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression Biomarkers Psychological Flexibility Clinical Trial More

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Short-Term and Late-Term Effects of Psilocybin on Symptoms in Major Depression

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Details DOI 10.1001/jamanetworkopen.2026.12589 PubMed 42138922

JAMA Network Open 2026-05-15 Yngwe Hampus, Plavén-Sigray Pontus, Ekman Carl Johan, Henje Eva, Berglund Anders, Tiger Mikael

Crossref Published psilocybin Depression Anxiety Clinical Trial Clinical Trial More

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Exploring the Safety, Acceptability, and Efficacy of Psilocybin Among Non-Small Cell Lung Cancer Patients With Major Depressive Disorder: A Proof-of-Concept Trial (DREAM LUNG STUDY)

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ClinicalTrials.gov 2026-05-14 Alan Davis

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression Anxiety Clinical Trial Clinical Trial More

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Low doses of psilocybin as adjunct pharmacological treatment to virtual reality exposure therapy for social anxiety disorder: A study protocol for a double-blind randomized controlled trial.

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PsyArXiv 2026-05-14 Jacob Cohen, Peter Parbo, Per Trads Ørskov, Dirk Wildgruber, Benjamin Kreifelts, ulrich kirk

PsyArXiv PREPRINT (not peer reviewed) psilocybin Anxiety Brain Imaging Biomarkers Randomized Controlled Trial More

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Safety and Efficacy of Psilocybin in the Management of Treatment-Resistant Depression: A Systematic Review

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.21203/rs.3.rs-9283280/v1

Research Square 2026-05-11 Walters CK, Chetty S, Rants’o TA, Gossayn S, Lerotholi LJ.

Europe PMC PREPRINT (not peer reviewed) psilocybin Depression Anxiety Headache / Migraine Systematic Review More

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From Trials to Clinics: Considerations for Implementing Psychedelic-Assisted Therapy Into Clinical Practice

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Details DOI 10.1002/prp2.70262 PubMed 42108552

Pharmacology Research & Perspectives 2026-05-10 Jessie Kim, Liam Lochhead, Cory R. Weissman

OpenAlex Published psilocybin Depression Neuroplasticity Mechanism of Action Clinical Trial More

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The Safety and Efficacy of Psilocybin Therapy Compared to Low-dose Control in Reducing Depressive Symptoms in Patients With COPD, ALS, MS, or APD.

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ClinicalTrials.gov 2026-05-08 University Medical Center Groningen

ClinicalTrials.gov CLINICAL TRIAL psilocybin Depression Anxiety End-of-Life Distress Clinical Trial More

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1080 Psilocybin Elicits Non-Linear Night to Night Changes in Sleep Spectral Power

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Details DOI 10.1093/sleep/zsag091.1079

SLEEPJ 2026-05-08 Reid Matthew, Weisman Eli, Martinez Luis Luna, Coon William, Barrett Frederick

Crossref Published psilocybin Depression Addiction Brain Imaging Clinical Trial More