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Psilocybin and psilocin research index

Find psilocybin and psilocin papers, preprints, trials, and citations with clear source context.

Searches titles, authors, journals, identifiers, indexed metadata, and derived research topics. Use Filters to narrow by source, status, substance, study type, or date.

Database 4,967 indexed records Auto-updated on Aug 20, 2026 01:29 UTC

Executed search Topic: Randomized Controlled Trial 310 matching records are displayed.

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Database

4,748 Psilocybin Records 673 Psilocin Records 1,461 Journals 66 Research Topics

Published 4,226 Peer-reviewed / formal records Preprints 437 Marked as not peer reviewed Clinical trials 301 ClinicalTrials.gov records R toolkit visNetwork Bibliometrics, live SQLite analysis, HTML graph, and PDF export

Top journals 1,461 indexed journals

Journal	Records
Journal of psychopharmacology (Oxford, England)	148
Journal of psychoactive drugs	97
Frontiers in psychiatry	90
Psychopharmacology	85
Neuroscience Applied	57
Journal of Psychedelic Studies	48
Psychedelic medicine (New Rochelle, N.Y.)	39
Scientific reports	37
Biological Psychiatry	32
Journal of affective disorders	32

Research topics 66 topic filters

Depression 1,738 Receptor Pharmacology 1,282 Safety 1,208 Review Article 1,075 Mechanism of Action 1,072 Clinical Trial 978 Anxiety 884 Addiction 825 Pharmacology 752 General 538 Animal Study 525 Aging 524 Observational Study 516 Brain Imaging 482 Treatment-Resistant Depression 417 Emotional Processing 409 PTSD 401 Neuroplasticity 399

Source coverage 8 active sources

Source	Count	Share	Status
PubMed	2,566	51.7%	Active
OpenAlex	1,156	23.3%	Active
Crossref	407	8.2%	Active
ClinicalTrials.gov	301	6.1%	Active
Europe PMC	188	3.8%	Active
PsyArXiv	186	3.7%	Active
bioRxiv	124	2.5%	Active

Publication timeline 3,864 dated records

3,864 records since 2020

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Substances Psilocybin 4748 Psilocin 673

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Executed search Topic: Randomized Controlled Trial 310 matching records are displayed.

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310 matching records for Topic: Randomized Controlled Trial.

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Study Protocol for 'PsilOCD: A Pharmacological Challenge Study Evaluating the Effects of the 5-HT2A Agonist Psilocybin on the Neurocognitive and Clinical Correlates of Compulsivity'.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.7759/cureus.78171 PubMed 39882198

Cureus 2025-01-01 O'Connor S, Godfrey K, Reed S, Peill J, Rohani-Shukla C, Healy M

PubMed Published psilocybin OCD Neuroplasticity Brain Imaging Other More

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Hypertensive Emergency Secondary to Combining Psilocybin Mushrooms, Extended Release Dextroamphetamine-Amphetamine, and Tranylcypromine.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1080/02791072.2024.2368617 PubMed 38903003

Journal of psychoactive drugs 2025-01-01 Barnett BS, Koons CJ, Van den Eynde V, Gillman PK, Bodkin JA

PubMed Published psilocybin Depression Chronic Pain Headache / Migraine Other More

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Psilocybin-assisted psychotherapy for depression and anxiety associated with life threatening illness: A phase 2b randomized controlled trial.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1016/j.genhosppsych.2025.08.001 PubMed 40858059

General hospital psychiatry 2025-01-01 Ross ML, Iyer R, Williams ML, Boughey M, O'Callaghan C, Hiscock R

PubMed Published psilocybin Depression Anxiety End-of-Life Distress Randomized Controlled Trial More

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Effect of psilocybin therapy on suicidal ideation, attempts, and deaths in people with psychiatric diagnoses: a systematic review and meta-analysis.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1177/20451253251372449 PubMed 40933784

Therapeutic advances in psychopharmacology 2025-01-01 Wong S, Meckling G, Fabiano N, Lee S, Jones BDM, Shorr R

PubMed Published psilocybin Depression Randomized Controlled Trial Meta-Analysis Randomized Controlled Trial More

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Comparative Efficacy of Hallucinogens in Treating Mood Disorders Through a Meta-Analysis of Symptom Reduction, Dosage, and Duration

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Journal of International Crisis and Risk Communication Research 2024-12-31 Muniz, John Marco D.F.

OpenAlex Published psilocybin Depression Anxiety End-of-Life Distress Randomized Controlled Trial More

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Psilocybin as a Disease-Modifying Drug-A Salutogenic Approach in Psychiatry.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.3238/arztebl.m2024.0224 PubMed 39628414

Deutsches Arzteblatt international 2024-12-27 Spangemacher M, Mertens LJ, Färber LV, Jungaberle A, Jungaberle H, Gründer G

PubMed Published psilocybin Depression Anxiety Addiction Randomized Controlled Trial More

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The impact of antidepressant discontinuation prior to treatment with psilocybin for treatment-resistant depression.

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Details DOI 10.1016/j.jpsychires.2024.10.009 PubMed 39427449

Journal of psychiatric research 2024-12-01 Marwood L, Croal M, Mistry S, Simmons H, Tsai J, Young MB

PubMed Published psilocybin Depression Clinical Trial Randomized Controlled Trial Randomized Controlled Trial More

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Comparative antidepressant effects and safety of intravenous racemic ketamine, psilocybin and theta burst stimulation for major depressive disorder: A systematic review and network meta-analyses of randomized controlled trials.

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Details DOI 10.1002/pcn5.70042 PubMed 39641126

PCN reports: psychiatry and clinical neurosciences 2024-12-01 Terao I, Kodama W

PubMed Published psilocybin Depression Randomized Controlled Trial Systematic Review Randomized Controlled Trial More

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Preliminary safety and effectiveness of psilocybin-assisted therapy in adults with fibromyalgia: An open-label, pilot clinical trial

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.31234/osf.io/j8zb5

PsyArXiv 2024-11-04 Aday JS, McAfee J, Conroy DA, Hosanagar A, Tarnal V, Weston C

PsyArXiv PREPRINT (not peer reviewed) psilocybin Anxiety Chronic Pain Headache / Migraine Randomized Controlled Trial More

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Enhanced visual contrast suppression during peak psilocybin effects: Psychophysical results from a pilot randomized controlled trial.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1167/jov.24.12.5 PubMed 39499526

Journal of vision 2024-11-04 Swanson LR, Jungers S, Varghese R, Cullen KR, Evans MD, Nielson JL

PubMed Published psilocybin Depression Mechanism of Action Randomized Controlled Trial Randomized Controlled Trial More

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Preliminary safety and effectiveness of psilocybin-assisted therapy in adults with fibromyalgia: An open-label, pilot clinical trial

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PsyArXiv 2024-11-04 Jacob S. Aday, Jenna McAfee, Deirdre A. Conroy, Avinash Hosanagar, Vijay Tarnal, Cody Weston

PsyArXiv PREPRINT (not peer reviewed) psilocybin Anxiety Chronic Pain Headache / Migraine Randomized Controlled Trial More

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Neuroprotective effects of psilocybin in a rat model of stroke.

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Details DOI 10.1186/s12868-024-00903-x PubMed 39379834

BMC neuroscience 2024-10-08 Yu SJ, Wu KJ, Wang YS, Bae E, Chianelli F, Bambakidis N

PubMed Published psilocybin Mechanism of Action Receptor Pharmacology Randomized Controlled Trial Animal Study More

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Rapid and Prolonged Antidepressant and Antianxiety Effects of Psychedelics and 3,4-Methylenedioxy-methamphetamine-A Systematic Review and Meta-Analysis

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Details DOI 10.3390/psychoactives3040029

Psychoactives 2024-10-03 Dimy Fluyau, Vasanth Kattalai Kailasam, Neelambika Revadigar

OpenAlex Published psilocybin Depression Anxiety PTSD Randomized Controlled Trial More

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PR012/#955 Psilocybin assisted psychotherapy for patients with ovarian caner: a subset analysis of a randomized, double-blind, placebo-controlled, phase II clinical trial

No abstract availability was recorded for this entry.

Details DOI 10.1136/ijgc-2024-igcs.54

International Journal of Gynecological Cancer 2024-10-01 Daniel Spinosa, Stacy M. Fischer, Richard J. Zeifman, Carolyn Lefkowits, Petros Petridis, Stephen Ross

OpenAlex Published psilocybin Clinical Trial Randomized Controlled Trial Randomized Controlled Trial More

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From efficacy to effectiveness: evaluating psychedelic randomised controlled trials for trustworthy evidence-based policy and practice.

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Details DOI 10.31234/osf.io/uxhv7

PsyArXiv 2024-10-01 Schenberg EE.

PsyArXiv PREPRINT (not peer reviewed) psilocybin Depression PTSD Randomized Controlled Trial Randomized Controlled Trial More

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From efficacy to effectiveness: evaluating psychedelic randomised controlled trials for trustworthy evidence-based policy and practice.

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.31234/osf.io/uxhv7_v1

PsyArXiv 2024-10-01 Schenberg EE.

PsyArXiv PREPRINT (not peer reviewed) psilocybin Depression PTSD Randomized Controlled Trial Randomized Controlled Trial More

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Psilocybin for clinical indications: A scoping review.

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Details DOI 10.1177/02698811241269751 PubMed 39135496

Journal of psychopharmacology (Oxford, England) 2024-10-01 Madden K, Flood B, Young Shing D, Ade-Conde M, Kashir I, Mark M

PubMed Published psilocybin Depression Anxiety Addiction Randomized Controlled Trial More

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Psychedelic-assisted therapy for treating anxiety, depression, and existential distress in people with life-threatening diseases.

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Details DOI 10.1002/14651858.cd015383.pub2 PubMed 39260823

The Cochrane database of systematic reviews 2024-09-12 Schipper S, Nigam K, Schmid Y, Piechotta V, Ljuslin M, Beaussant Y

PubMed Published psilocybin Depression Anxiety End-of-Life Distress Randomized Controlled Trial More

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Efficacy and safety of eight enhanced therapies for treatment-resistant depression: A systematic review and network meta-analysis of RCTs.

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Details DOI 10.1016/j.psychres.2024.116018 PubMed 38924903

Psychiatry research 2024-09-01 Guo Q, Guo L, Wang Y, Shang S

PubMed Published psilocybin Depression Randomized Controlled Trial Meta-Analysis Randomized Controlled Trial More

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G33 Psychedelic drugs for the treatment of chronic pain: is ketamine included?

Abstract available at the source but not redistributed here. Read at source.

Details DOI 10.1136/rapm-2024-esra.582

Ask the expert - Psychedelic substances 2024-08-31 Amany E. Ayad

OpenAlex Published psilocybin Depression PTSD Addiction Randomized Controlled Trial More